609-08-5 Archives - Page 7 of 9 - Esters-buliding-blocks

Tappin, Nicholas D. C.’s team published research in Advanced Synthesis & Catalysis in 2021 | CAS: 609-08-5

Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Safety of Diethyl 2-methylmalonate

Safety of Diethyl 2-methylmalonateIn 2021 ,《Methyl Radical Initiated Kharasch and Related Reactions》 was published in Advanced Synthesis & Catalysis. The article was written by Tappin, Nicholas D. C.; Renaud, Philippe. The article contains the following contents:

An improved procedure to run halogen atom and related chalcogen group transfer radical additions is reported. The procedure relies on the thermal decomposition of di-tert-butylhyponitrite (DTBHN), a safer alternative to the explosive diacetyl peroxide, to produce highly reactive Me radicals that can initiate the chain process. This mode of initiation generates byproducts that are either gaseous (N2) or volatile (acetone and Me halide) thereby facilitating greatly product purification by either flash column chromatog. or distillation In addition, remarkably simple and mild reaction conditions (refluxing EtOAc during 30 min under normal atm.) and a low excess of the radical precursor reagent (2 equiv) make this protocol particularly attractive for preparative synthetic applications. This initiation procedure has been demonstrated with a broad scope since it works efficiently to add a range of electrophilic radicals generated from iodides, bromides, selenides and xanthates over a range of unactivated terminal alkenes. A diverse set of radical trap substrates exemplifies a broad functional group tolerance. Finally, di-tert-Bu peroxyoxalate (DTBPO) is also demonstrated as alternative source of tert-butoxyl radicals to initiate these reactions under identical conditions which gives gaseous byproducts (CO2). The results came from multiple reactions, including the reaction of Diethyl 2-methylmalonate(cas: 609-08-5Safety of Diethyl 2-methylmalonate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Yoonseob’s team published research in Journal of the American Chemical Society in 2019 | CAS: 609-08-5

In 2019,Journal of the American Chemical Society included an article by Kim, Yoonseob; Wang, Yanming; France-Lanord, Arthur; Wang, Yichong; Wu, You-Chi Mason; Lin, Sibo; Li, Yifan; Grossman, Jeffrey C.; Swager, Timothy M.. HPLC of Formula: 609-08-5. The article was titled 《Ionic Highways from Covalent Assembly in Highly Conducting and Stable Anion Exchange Membrane Fuel Cells》. The information in the text is summarized as follows:

A major challenge in the development of anion exchange membranes for fuel cells is the design and synthesis of highly stable (chem. and mech.) conducting membranes. Membranes that can endure highly alk. environments while rapidly transporting hydroxides are desired. Herein, we present a design using cross-linked polymer membranes containing ionic highways along charge-delocalized pyrazolium cations and homoconjugated triptycenes. These ionic highway membranes show improved performance. Specifically, a conductivity of 111.6 mS cm-1 at 80°C was obtained with a low 7.9% water uptake and 0.91 mmol g-1 ion exchange capacity. In contrast to existing materials, ionic highways produce higher conductivities at reduced hydration and ionic exchange capacities. The membranes retain more than 75% of their initial conductivity after 30 days of an alk. stability test. The formation of ionic highways for ion transport is confirmed by d. functional theory and Monte Carlo studies. A single cell with platinum metal catalysts at 80°C showed a high peak d. of 0.73 W cm-2 (0.45 W cm-2 from a silver-based cathode) and stable performance throughout 400 h tests. After reading the article, we found that the author used Diethyl 2-methylmalonate(cas: 609-08-5HPLC of Formula: 609-08-5)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kuwano, Ryoichi’s team published research in Organic Process Research & Development in 2019 | CAS: 609-08-5

In 2019,Organic Process Research & Development included an article by Kuwano, Ryoichi; Yokogi, Masashi; Sakai, Ken; Masaoka, Shigeyuki; Miura, Takashi; Won, Sungyong. Quality Control of Diethyl 2-methylmalonate. The article was titled 《Room-Temperature Benzylic Alkylation of Benzylic Carbonates: Improvement of Palladium Catalyst and Mechanistic Study》. The information in the text is summarized as follows:

The palladium catalyst for the nucleophilic substitution of benzyl carbonates was improved by using 1,1′-bis(diisopropylphosphino)ferrocene (DiPrPF) as the ligand. The [Pd(η3-C3H5)(cod)]BF4-DiPrPF catalyst allows the benzylic substitution with soft carbanions to proceed even at 30 °C, affording the desired products in high yields (up to 99% yield). Thermally unstable pyridylmethyl esters are employable as the electrophilic substrates for the benzylic alkylation with the improved catalyst. Furthermore, we investigated the mechanism of the catalytic benzylic alkylation by means of DiPrPF ligand. The palladium(0) complex bearing DiPrPF activates the benzylic C-O bond to form the (benzyl)palladium(II) intermediate at room temperature The coordination mode of the benzyl ligand would be equilibrium between the η1- and η3-manner. The nucleophile would preferentially react with the η3-benzyl ligand to give the desired product. In the experiment, the researchers used Diethyl 2-methylmalonate(cas: 609-08-5Quality Control of Diethyl 2-methylmalonate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yamaguchi-Sasaki, Toru’s team published research in ACS Medicinal Chemistry Letters in 2020 | CAS: 609-08-5

《Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins》 was written by Yamaguchi-Sasaki, Toru; Tokura, Seiken; Ogata, Yuya; Kawaguchi, Takanori; Sugaya, Yutaka; Takahashi, Ryo; Iwakiri, Kanako; Abe-Kumasaka, Tomoko; Yoshida, Ippei; Arikawa, Kaho; Sugiyama, Hiroyuki; Kanuma, Kosuke. Safety of Diethyl 2-methylmalonate And the article was included in ACS Medicinal Chemistry Letters in 2020. The article conveys some information:

A series of macrocyclic pyrazolo[1,5-a]pyrimidine derivatives as respiratory syncytial virus (RSV) fusion glycoprotein (F protein) inhibitors were designed and synthesized based on docking studies of acyclic inhibitors. This effort resulted in the discovery of several macrocyclic compounds with low nanomolar to subnanomolar activities against the wild-type RSV F protein A2. In addition, compound I showed a single-digit nanomolar potency against the previously reported drug-resistant mutant D486N. Mol. modeling and computational analyses suggested that I binds to the D486N mutant while maintaining a rigid bioactive conformation via macrocyclization and that it interacts with a hydrophobic cavity of the mutant using a new interaction surface of I. This report describes the rational design of macrocyclic compounds with dual inhibitory activities against wild-type and mutant RSV F proteins. In the part of experimental materials, we found many familiar compounds, such as Diethyl 2-methylmalonate(cas: 609-08-5Safety of Diethyl 2-methylmalonate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Qingrong’s team published research in Indian Journal of Heterocyclic Chemistry in 2021 | CAS: 609-08-5

Sun, Qingrong; Wang, Xingyi; Xu, Yinan; Yang, Weiqing; Ma, Menglin published their research in Indian Journal of Heterocyclic Chemistry in 2021. The article was titled 《One-step synthesis of 3-unsubstituted 4-hydroxy-2(1H)-quinoline》.Electric Literature of C8H14O4 The article contains the following contents:

3-Unsubstituted 4-hydroxy-2(1H)-quinolone (DHQ) derivatives were synthesized from aniline derivatives and di-Et malonate at low temperature using AlCl3 as catalyst and Eaton reagent as acidic environment. A reaction mechanism was proposed and elucidated. Different synthetic intermediates were specially prepared or purified and used to understand the reaction and validation mechanism.Diethyl 2-methylmalonate(cas: 609-08-5Electric Literature of C8H14O4) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Baumann, Thomas’s team published research in Angewandte Chemie, International Edition in 2019 | CAS: 609-08-5

In 2019,Angewandte Chemie, International Edition included an article by Baumann, Thomas; Brueckner, Reinhard. Synthetic Route of C8H14O4. The article was titled 《Atropselective Dibrominations of a 1,1′-Disubstituted 2,2′-Biindolyl with Diverging Point-to-Axial Asymmetric Inductions. Deriving 2,2′-Biindolyl-3,3′-diphosphane Ligands for Asymmetric Catalysis》. The information in the text is summarized as follows:

On the 1H NMR timescale, 2,2′-biindolyls with (R)-configured (1-alkoxyprop)-2-yl, (1-hydroxyprop)-2-yl, or (1-siloxyprop)-2-yl substituents at C-1 and C-1′ are atropisomerically stable at <0° and interconvert at >30°. A 1,1′-Bis[(R)-1-hydroxyprop-2-yl]-2,2′-biindolyl a of that kind and achiral (!) brominating reagents gave the atropisomerically stable 3,3′-dibromobiindolyls (M)- and/or (P)-18 a at best atropselectively-because of point-to-axial asym. inductions-and atropdivergently, exhibiting up to 95% (M)- and as much (P)-atropselectivity. This route to atropisomerically pure biaryls is novel and should extend to other substrates and/or different functionalizations. The dibromobiindolyls (M)- and (P)-18 a furnished the biindolyldiphosphines (M)- and (P)-14 without atropisomerization. These syntheses did not require the resolution of a racemic mixture, which distinguishes them from virtually all biaryldiphosphine syntheses known to date. (M)- and (P)-14 acted as ligands in catalytic asym. allylations and hydrogenations. Remarkably, the Et tetralonecarboxylate was hydrogenated trans-selectively with 98% ee; this included a dynamic kinetic resolution In the experiment, the researchers used many compounds, for example, Diethyl 2-methylmalonate(cas: 609-08-5Synthetic Route of C8H14O4)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

El-Essawy, Farag A.’s team published research in Russian Journal of General Chemistry in 2022 | CAS: 609-08-5

HPLC of Formula: 609-08-5In 2022 ,《Synthesis and Anti-HIV Activity of Poly-Heterocyclic Compounds Containing Quinoline Moiety》 appeared in Russian Journal of General Chemistry. The author of the article were El-Essawy, Farag A.; Ali, Noora T. G.; Boshta, Nader M.. The article conveys some information:

A novel series of poly-heterocyclic compounds containing quinoline as antiviral agents against HIV was designed and synthesized. Structures of these novel derivatives was confirmed by IR, NMR, and EI-MS spectra. Most of the products was tested for their HIV inhibitory activity and characterized by high to moderate activity. The experimental process involved the reaction of Diethyl 2-methylmalonate(cas: 609-08-5HPLC of Formula: 609-08-5)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jung, Sebastian T.’s team published research in European Journal of Organic Chemistry in 2020 | CAS: 609-08-5

HPLC of Formula: 609-08-5In 2020 ,《Stereoelectronic Effects: Perlin Effects in Thiane-Derived Compounds》 was published in European Journal of Organic Chemistry. The article was written by Jung, Sebastian T.; Basche, Luis; Reinsperger, Tony; Luy, Burkhard; Podlech, Joachim. The article contains the following contents:

Stereoelectronic effects in thianes and thiane-derived sulfoxides, sulfones, sulfilimines, and sulfoximines were investigated by measuring 1JC,H coupling constants and by identification of normal and reversed Perlin effects, i.e., of differences in the coupling constants for equatorial and axial C-H bonds in the methylene groups of six-membered rings. The Perlin effects were correlated with results from natural bond orbital (NBO) analyses. NMR experiments were performed with conformationally restricted dimethyl- or tert-butyl-substituted derivatives, while the parent compounds were used for calculations It turned out that the coupling constants are not only strongly influenced by stereoelectronic interactions with antiperiplanar C-H, C-C, C-O, and C-N bonds, but by the s character of the resp. C-H bonds’ carbon orbital as well. The experimental part of the paper was very detailed, including the reaction process of Diethyl 2-methylmalonate(cas: 609-08-5HPLC of Formula: 609-08-5)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lopez-Magano, Alberto’s team published research in Applied Catalysis, B: Environmental in 2020 | CAS: 609-08-5

《Incorporation of photocatalytic Pt(II) complexes into imine-based layered covalent organic frameworks (COFs) through monomer truncation strategy》 was written by Lopez-Magano, Alberto; Platero-Prats, Ana E.; Cabrera, Silvia; Mas-Balleste, Ruben; Aleman, Jose. SDS of cas: 609-08-5 And the article was included in Applied Catalysis, B: Environmental in 2020. The article conveys some information:

A new photoactive Pt (II) hydroxyquinoline complex has been covalently linked into the structure of an imine-based layered covalent organic framework (COF) through the monomer truncation strategy. Such strategy allows the incorporation of mol. fragments with only one functional group able to condensate into the imine-framework. The photocatalytic activity of the resulting Pt@COF has been applied to the oxidation of sulfides to sulfoxides, obtaining excellent results for all the studied cases, and showing that this reaction goes through both photoredox and energy transfer processes. The results obtained showed a great enhancement of the catalytic activity (up to 25,000 turnover number, TON), stability and a significant decrease on the reaction times, as a consequence of immobilization and isolation of Pt(II) centers into the organic framework. In addition, Pt@COF has been proved to be an excellent heterogeneous photocatalyst also in exclusive photoredox processes, reaching 7500 TON in hydrodebromination reactions. In addition to this study using Diethyl 2-methylmalonate, there are many other studies that have used Diethyl 2-methylmalonate(cas: 609-08-5SDS of cas: 609-08-5) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

El-Essawy, Farag A.’s team published research in Revista de Chimie (Bucharest, Romania) in 2020 | CAS: 609-08-5

《Design, synthesis, and evaluation of novel 3-, 4-substituted, and 3,4-di substituted quinazoline derivatives as antimicrobial agents》 was published in Revista de Chimie (Bucharest, Romania) in 2020. These research results belong to El-Essawy, Farag A.; Alharthi, Abdulrahman I.; Alotaibi, Mshari A.; Wahba, Nancy E.; Boshta, Nader M.. Computed Properties of C8H14O4 The article mentions the following:

A novel series of 3-, 4-substituted, and 3,4-di substituted quinazoline derivatives were prepared via various cyclized regents and most of the newly prepared compounds evaluated for their antimicrobial activities in vitro against Gram-pos., Gram-neg. bacterial strains and fungi strains. The structures of the quinazoline derivatives have been confirmed using spectroscopic analyses (IR, NMR, and EI-MS). Some of the synthesized derivatives displayed a moderate antimicrobial activity in comparison with reference drugs, for example compounds 13d, 15a, 17b, 18b, 18d, 25, and 29a-c. Among the synthesized compounds, the pyrimidoqunazoline derivative 6c elicited the highest activity. In the part of experimental materials, we found many familiar compounds, such as Diethyl 2-methylmalonate(cas: 609-08-5Computed Properties of C8H14O4)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics