Category: 604-69-3

One-pot four-component tandem synthesis of novel sulfonamide-1, 2, 3-triazoles catalyzed by reusable copper (II)-adsorbed on mesoporous silica under ultrasound irradiation was written by Talha, Aicha;Mourhly, Asmae;Tachallait, Hamza;Driowya, Mohsine;El Hamidi, Adnane;Arshad, Suhana;Karrouchi, Khalid;Arsalane, Said;Bougrin, Khalid. And the article was included in Tetrahedron in 2021.Synthetic Route of C16H22O11 The following contents are mentioned in the article:

A green and efficient synthesis of new sulfonamide-1,2,3-triazoles in heterogeneous conditions was developed. The procedure involved one-pot four-component tandem sulfonamidation/azidation/1,3-dipolar cycloaddition (1,3-DC) reactions under a cooperative effect of ultrasound irradiation and Cu (II) supported on amorphous mesoporous silica [mSiO₂-Cu (II)] catalysis at room temperature in aqueous medium. In addition, the 1,4-disubstituted 1,2,3-triazoles were synthesized by regioselective and chemoselective methods to afford the pure products in excellent yields and short reaction times under ultrasonic irradiation The supported catalyst was prepared from copper (II) nitrate by simple method using ultrasound activation and characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) method and Barrett-Joyner-Halenda (BJH) method. Also, the catalyst was easily prepared, stable, efficient, selective and reusable under ultrasonic conditions. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Synthetic Route of C16H22O11).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Synthetic Route of C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Click Pt(IV)-carbohydrates pro-drugs for treatment of osteosarcoma was written by Moynihan, Eoin;Bassi, Giada;Ruffini, Andrea;Panseri, Silvia;Montesi, Monica;Velasco-Torrijos, Trinidad;Montagner, Diego. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2021.Synthetic Route of C16H22O11 The following contents are mentioned in the article:

The selectivity vs. cancer cells has always been a major challenge for chemotherapeutic agents and in particular for cisplatin, one of the most important anticancer drugs for the treatment of several types of tumors. One strategy to overtake this challenge is to modify the coordination sphere of the metallic center with specific vectors whose receptors are overexpressed in the tumoral cell membrane, such as monosaccharides. In this paper, we report the synthesis of four novel glyco-modified Pt(IV) pro-drugs, based on cisplatin scaffold, and their biol. activity against osteosarcoma (OS), a malignant tumor affecting in particular adolescents and young adults. The sugar moiety and the Pt scaffold are linked exploiting the Copper Azide Alkyne Cycloaddition (CUAAC) reaction, which has become the flagship of click chem. due to its versatility and mild conditions. Cytotoxicity and drug uptake on three different OS cell lines as well as CSCs (Cancer Stem Cell) are described. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Synthetic Route of C16H22O11).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Structure/activity virtual screening and in vitro testing of small molecule inhibitors of 8-hydroxy-5-deazaflavin:NADPH oxidoreductase from gut methanogenic bacteria was written by Cuccioloni, Massimiliano;Bonfili, Laura;Cecarini, Valentina;Cocchioni, Filippo;Petrelli, Dezemona;Crotti, Elena;Zanchi, Raffaella;Eleuteri, Anna Maria;Angeletti, Mauro. And the article was included in Scientific Reports in 2020.HPLC of Formula: 604-69-3 The following contents are mentioned in the article:

Virtual screening techniques and in vitro binding/inhibitory assays were used to search within a set of more than 8,000 naturally occurring small ligands for candidate inhibitors of 8-hydroxy-5-deazaflavin:NADPH oxidoreductase (FNO) from Methanobrevibacter smithii, the enzyme that catalyzes the bidirectional electron transfer between NADP+ and F420H2 during the intestinal production of CH4 from CO2. In silico screening using mol. docking classified the ligand-enzyme complexes in the range between – 4.9 and – 10.5 kcal/mol. Mol. flexibility, the number of H-bond acceptors and donors, the extent of hydrophobic interactions, and the exposure to the solvent were the major discriminants in determining the affinity of the ligands for FNO. In vitro studies on a group of these ligands selected from the most populated/representative clusters provided quant. kinetic, equilibrium, and structural information on ligands behavior, in optimal agreement with the predictive computational results. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3HPLC of Formula: 604-69-3).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 604-69-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

One pot synthesis of thio-glycosides via aziridine opening reactions was written by Hribernik, Nives;Tamburrini, Alice;Falletta, Ermelinda;Bernardi, Anna. And the article was included in Organic & Biomolecular Chemistry in 2021.Computed Properties of C16H22O11 The following contents are mentioned in the article:

A one-pot aziridine opening reaction by glycosyl thiols generated in situ from the corresponding anomeric thio-acetates affords thio-glycosides with a pseudo-disaccharide structure and an N-linked tether. The scope of the one-pot aziridine opening reaction was explored on a series of mono- and disaccharides, creating a class of pseudo-glycosidic compounds with potential for further functionalization. Unexpected anomerization of glycosyl thiols was observed under the reaction conditions and the influence of temperature, base and solvent on the isomerization was investigated. Single isomers were obtained in good to acceptable yields for mannose, rhamnose and sialic acid derivatives The class of thio-glycomimetics synthesized can potentially be recognized by various lectins, while presenting hydrolytic and enzymic stability. The nitrogen functionality incorporated in the glycomimetics can be exploited for further functionalization, including tethering to linkers, scaffolds or peptide residues. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Computed Properties of C16H22O11).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Computed Properties of C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reactivity-Stereoselectivity Mapping for the Assembly of Mycobacterium marinum Lipooligosaccharides was written by Hansen, Thomas;Ofman, Tim P.;Vlaming, Joey G. C.;Gagarinov, Ivan A.;van Beek, Jessey;Gote, Tessa A.;Tichem, Jacoba M.;Ruijgrok, Gijs;Overkleeft, Herman S.;Filippov, Dmitri V.;van der Marel, Gijsbert A.;Codee, Jeroen D. C.. And the article was included in Angewandte Chemie, International Edition in 2021.Safety of (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate The following contents are mentioned in the article:

The assembly of complex bacterial glycans presenting rare structural motifs and cis-glycosidic linkages is significantly obstructed by the lack of knowledge of the reactivity of the constituting building blocks and the stereoselectivity of the reactions in which they partake. We here report a strategy to map the reactivity of carbohydrate building blocks and apply it to understand the reactivity of the bacterial sugar, caryophyllose, a rare C₁2-monosaccharide, containing a characteristic tetra-substituted stereo-center. We mapped reactivity-stereoselectivity relationships for caryophyllose donor and acceptor glycosides by a systematic series of glycosylations in combination with the detection and characterization of different reactive intermediates using exptl. and computational techniques. The insights garnered from these studies enabled the rational design of building blocks with the required properties to assemble mycobacterial lipooligosaccharide fragments of M. marinum. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Safety of (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Safety of (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On-Chip Neo-Glycopeptide Synthesis for Multivalent Glycan Presentation was written by Mende, Marco;Tsouka, Alexandra;Heidepriem, Jasmin;Paris, Grigori;Mattes, Daniela S.;Eickelmann, Stephan;Bordoni, Vittorio;Wawrzinek, Robert;Fuchsberger, Felix F.;Seeberger, Peter H.;Rademacher, Christoph;Delbianco, Martina;Mallagaray, Alvaro;Loeffler, Felix F.. And the article was included in Chemistry – A European Journal in 2020.Related Products of 604-69-3 The following contents are mentioned in the article:

Single glycan-protein interactions are often weak, such that glycan binding partners commonly use multiple, spatially defined binding sites to enhance binding avidity and specificity. Current array technologies usually neglect defined multivalent display. Laser-based array synthesis technol. allows for flexible and rapid on-surface synthesis of different peptides. By combining this technique with click chem., neo-glycopeptides were produced directly on a functionalized glass slide in the microarray format. D. and spatial distribution of carbohydrates can be tuned, resulting in well-defined glycan structures for multivalent display. The two lectins Con A and langerin were probed with different glycans on multivalent scaffolds, revealing strong spacing-, d.-, and ligand-dependent binding. In addition, the authors could also measure the surface dissociation constant This approach allows for a rapid generation, screening, and optimization of a multitude of multivalent scaffolds for glycan binding. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Related Products of 604-69-3).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Related Products of 604-69-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Development of novel carbohydrate based compounds for better antipyretic activity was written by Grover, Parul;Singh, Jitender;Mehta, Lovekesh;Kapoor, Garima;Nagarajan, K.. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2021.Synthetic Route of C16H22O11 The following contents are mentioned in the article:

Carbohydrate-based therapeutics are extremely potent, and many carbohydrate-based drugs are in the stage of preclin. or clin. trials. There is a growing interest in developing carbohydrate analogs for novel drug discovery as most of the recently used carbohydrate drugs display significant pharmacol. activities and low toxicity. Also, the search for an antipyretic drug is a never-ending challenge. This research aimed at the development and synthesis of a series of amide-linked sugars (PV1-PV20) by coupling brominated sugars with varying amino acids coupled with nicotinic acid (GP1-GP10). Characterization of the derivatives synthesized was done by IR and NMR Spectroscopy. These congeners were tested to analyze their antipyretic potential, and eight analogs out of twenty showed significant antipyretic activity. Thus, the carbohydrate-based amide derivatives show important action in obstruction and therapy of fever. Further work on these lines may play an important role in maintaining good health at a low cost. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Synthetic Route of C16H22O11).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Synthetic Route of C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Acetylation of cellulose – Another pathway of natural cellulose aging during library storage of books and papers was written by Potthast, Antje;Ahn, Kyujin;Becker, Manuel;Eichinger, Thomas;Kostic, Mirjana;Boehmdorfer, Stefan;Jeong, Myung Joon;Rosenau, Thomas. And the article was included in Carbohydrate Polymers in 2022.Computed Properties of C16H22O11 The following contents are mentioned in the article:

Gaseous acetic acid is formed under conditions of storage of historic paper objects. Its presence not only promotes hydrolytic cleavage of cellulose, but also causes acetylation of the cellulosic material to very small degree. The acetylation reaction proceeds under ambient conditions and without catalyst. Different anal. methods were used to prove the presence of organic acetates on cellulosic paper matrixes. DESI-MS in combination with ²H-isotopic labeling showed the presence of sugar fragments with different acetylation patterns. A method based on Zemplen saponification was applied and worked also in the presence of a large excess of acetic acid and/or inorganic acetates. The acetylation effect was quantified for model papers and original, naturally aged paper samples. While cellulose acetylation was clearly proven to be another general pathway of paper aging, further studies of this acetylation phenomenon are needed with regard to conservational aspects and suitable paper storage conditions. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Computed Properties of C16H22O11).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and immunological studies of β-1,2-mannan-peptide conjugates as antifungal vaccines was written by Liao, Jun;Pan, Bo;Liao, Guochao;Zhao, Qingjie;Gao, Yun;Chai, Xiaoyun;Zhuo, Xiaobin;Wu, Qiuye;Jiao, Binghua;Pan, Weihua;Guo, Zhongwu. And the article was included in European Journal of Medicinal Chemistry in 2019.Synthetic Route of C16H22O11 The following contents are mentioned in the article:

Fungal cell surface carbohydrates and proteins are useful antigens for the development of antifungal vaccines. In this study, glycopeptides consisting of the β-1,2-mannan and N-terminal peptide epitopes of Candida albicans (C. albicans) cell wall phosphomannan complex and Als1p (rAls1p-N) protein, resp., were synthesized and covalently conjugated with keyhole limpet hemocyanin (KLH) and human serum albumin (HSA) through homobifunctional disuccinimidyl glutarate. The resultant KLH-conjugates were immunol. evaluated using Balb/c mice to reveal that they induced high levels of IgG antibodies. Furthermore, these conjugates showed self-adjuvanting property, as they could promote robust antibody responses without the presence of an external adjuvant. More significantly, the obtained antisera could effectively recognize both the carbohydrate and the Als1 peptide epitopes and immunofluorescence and flow cytometry assays also demonstrated that the elicited antibodies could react with the cell surface of a number of fungi, including C. albicans, C. tropicalis, C. lusitaniae and C. glabrata. These results suggested the great potential of these conjugates as antifungal vaccines. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Synthetic Route of C16H22O11).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Synthetic Route of C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Straightforward synthesis, antiproliferative screening, and density functional theory study of some pyrazolylpyrimidine derivatives was written by Halim, Karema N. M.;Rizk, Sameh A.;El-Hashash, Maher A.;Ramadan, Sayed K.. And the article was included in Journal of Heterocyclic Chemistry in 2021.Category: esters-buliding-blocks The following contents are mentioned in the article:

Tetrahydropyrimidinone derivative was synthesized through one-pot three components condensation of 1,3-diphenylpyrazole-4-carbaldehyde with pentan-2,4-dione and urea under Biginelli reaction conditions. The corresponding chloro- and hydrazino derivatives were synthesized and utilized for the construction of some valuable N-heterocycles encompassing both pyrazole and pyrimidine cores, such as triazolopyrimidine, tetrazolopyrimidine, pyrazole, and pyrazolone derivatives through condensation with nitrogen nucleophiles and carbon electrophiles. The antiproliferative activity evaluation of the synthesized compounds against four human carcinoma cell lines namely, liver carcinoma (HepG2), breast adenocarcinoma (MCF7), prostate cancer (PC3), and colon cancer (HCT-116) cell lines revealed that some of them, e.g. I, provided significant potency, as well as the d.-functional theory (DFT) was studied. The permeability of various hydrophilic and hydrophobic synthesized compounds across both normal and cancer cells is confirmed via DFT simulation in which the much higher permeability through aquaporin channels revealed the selective cytotoxicity toward cancer cells. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Category: esters-buliding-blocks).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics