Category: 6038-19-3

On May 1, 2015, Zhang, Ze; You, Ye-Zi; Wu, De-Cheng; Hong, Chun-Yan published an article.SDS of cas: 6038-19-3 The title of the article was A novel multicomponent reaction and its application in sequence-ordered functional polymer synthesis. And the article contained the following:

Multicomponent reactions are of substantial significance not only for organic synthesis but also for polymer synthesis due to their more bond-forming events per synthetic operation. Generally due to that there are two or more reactions in one multicomponent reaction system, synergistic catalysis, in which the two or more reactions are activated by two or more different catalysts at the same time, is very important for achieving high-efficiency transformations. However, achieving synergistic catalysis via using two or more different catalyst simultaneously is a great challenge. Here, we propose a new reactant-synergistically catalyzed multicomponent reaction, in which the units coming from the reactant can synergistically catalyze the two reactions at the same time. Moreover, this multicomponent reaction can be extended to multicomponent polymerization, which is a very promising method for the preparation of functional polymers with defined-sequence. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).SDS of cas: 6038-19-3

The Article related to polyamide polyester polythioether multicomponent sequence polymer, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.SDS of cas: 6038-19-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 2015, Yang, Lu; Zhang, Ze; Cheng, Bofei; You, Yezi; Wu, Decheng; Hong, Chunyan published an article.Category: esters-buliding-blocks The title of the article was Two tandem multicomponent reactions for the synthesis of sequence-defined polymers. And the article contained the following:

Multicomponent polymerizations have become powerful tools for the construction of sequence-defined polymers. Although the Passerini multicomponent reaction has been widely used in the synthesis of sequence-defined polymers, the tandem usage of the Passerini multicomponent reaction and other multicomponent reactions in one-pot for the synthesis of sequence-defined polymers has not been developed until now. In this contribution, we report the tandem usage of the Passerini three-component reaction and the three-component amine-thiol-ene conjugation reaction in one pot for the synthesis of sequence-defined polymers. The Passerini reaction between methacrylic acid, adipaldehyde, and 2-isocyanobutanoate was carried out, affording a new mol. containing two alkene units. Subsequently, an amine and a thiolactone were added to the reaction system, whereupon the three-component amine-thiol-ene conjugating reaction occurred to yield a sequence-defined polymer. This method offers more rapid access to sequence-defined polymers with high mol. diversity and complexity. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Category: esters-buliding-blocks

The Article related to passerini reaction amine thiolene conjugation sequence polymer, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 14, 2014, Goethals, Fabienne; Martens, Steven; Espeel, Pieter; van den Berg, Otto; Du Prez, Filip E. published an article.Related Products of 6038-19-3 The title of the article was Diversely Substituted Polyamide Structures through Thiol-Ene Polymerization of Renewable Thiolactone Building Blocks. And the article contained the following:

A thiolactone derivative of 10-undecenoic acid was used as a renewable AB’ monomer for the one-pot synthesis of diversely substituted polyamide structures, containing amide moieties both in the polymer backbones and in their side chains. Nucleophilic aminolysis of the thiolactone entity liberates a thiol, which further reacts in a stepwise thiol-ene photopolymerization reaction. Using different primary amines, several structurally diverse polyamides, with phys. properties dependent on the length and chem. identity of the side chain, were obtained. Postpolymn. oxidation of the sulfide linkages in the polymer backbone to their corresponding sulfoxides and sulfones altered the material, with the degree of oxidation having an impact on the final mech. properties. Furthermore, this mild and straightforward polymerization procedure was applied for the synthesis of functional polymer networks. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Related Products of 6038-19-3

The Article related to thio ene polymerization thiolactone derivative undecenoic acid, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Related Products of 6038-19-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhong, Ai-Guo published an article in 2012, the title of the article was Crystal structure of S-1-[(carboxymethyl)sulfanyl]-N-(2-oxotetrahydro-3-thienyl)acetamide, C8H11NO4S2.SDS of cas: 6038-19-3 And the article contains the following content:

Crystal structure of S-1-[(carboxymethyl)sulfanyl]-N-(2-oxotetrahydro-3-thienyl)acetamide has been determined Adjacent mols. are bridged by O-H···O hydrogen bonds, and further joined by the C-H···O weak hydrogen bonds between the carbon and oxygen atoms to form a 3D supramol. structure. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).SDS of cas: 6038-19-3

The Article related to carboxymethylsulfanyloxotetrahydrothienylacetamide crystal mol structure hydrogen bond, Crystallography and Liquid Crystals: Polytypism, Polymorphism, Crystal Phase Transitions, Ordering, Amorphization and other aspects.SDS of cas: 6038-19-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 31, 2018, Frank, Daniel; Espeel, Pieter; Badi, Nezha; Du Prez, Filip published an article.Electric Literature of 6038-19-3 The title of the article was Structurally diverse polymers from norbornene and thiolactone containing building blocks. And the article contained the following:

Ste xA wide set of norbornene-derived polymers with a diversity in backbone and side chain structures has been prepared based on norbornene building blocks that also include a thiolactone group. For this purpose, two thiolactone monomers with differently substituted norbornene moieties were synthesized and their reactivity compared using three different polymerization strategies. First, their potential for amine-thiol-ene polymerization was evaluated using different amines, solvents and initiator concentrations in order to screen their influence on the mol. weight and glass transition temperature Free radical (co-)polymerization and ring-opening metathesis polymerization were also applied and the obtained polymers were submitted to post-polymerization modification. The results showed that only the monomer 5-norbornenemethyl thiolactone carbamate results in polymer formation under the tested conditions. The obtained compounds were characterized by SEC, TGA, DSC and NMR. Not 26062942. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Electric Literature of 6038-19-3

The Article related to norbornene thiolactone ring opening amidation polymer synthesis, amine thiol ene addition norbornene thiolactone polymer synthesis, radical polymerization norbornene thiolactone and other aspects.Electric Literature of 6038-19-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jungen, Stefan; Chen, Peter published an article in 2018, the title of the article was Alkyl Radical Generation by an Intramolecular Homolytic Substitution Reaction between Iron(II) and Trialkylsulfonium Groups.Related Products of 6038-19-3 And the article contains the following content:

Intramol., homolytic substitution reactions between iron(II) species and various trialkylsulfonium groups were directly observed in the gas phase upon collision-induced dissociation (CID). In spite of the notoriously low reduction potential of trialkylsulfonium species and the mismatched oxidation potential of iron(II), the reactions proceed at moderate collision energies, forming an alkyl radical as well as a thioether coordinated to the iron. In contrast to classical homolytic substitutions, the attacking radical is a “metalloradical”, namely iron(II) that is oxidized to iron(III) during the reaction. With this process we demonstrate that the conceptually analogous, putative radical generation step in radical S-adenosyl methionine (SAM) enzymes is possible and plausible. Further, we show that this kind of reaction only occurs in constrained systems with a defined geometry. Combining exptl. measurements with DFT studies and NBO analyses allowed us to gain insights into the reactivity and transition states of these systems. Based on our findings, we challenge the notion of a collinear transition state in the radical generation step of radical SAM enzymes and propose it to be bent instead. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Related Products of 6038-19-3

The Article related to iron metalloradical reductive cleavage trialkylsulfonium intramol homolytic substitution, esi-ms, homolytic substitution, iron, transition-state geometry, trialkylsulfonium groups and other aspects.Related Products of 6038-19-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 13, 2022, Soete, Matthieu; Du Prez, Filip E. published an article.Related Products of 6038-19-3 The title of the article was Sequencing of Uniform Multifunctional Oligoesters via Random Chain Cleavages. And the article contained the following:

Sequence-defined polymers have been the object of many fascinating studies that focus on their implementation in both material and life science applications. In parallel, iterative synthetic methodologies have become more efficient, whereas the structure elucidation of these mols. is generally dependent on MS/MS anal. Here, we report an alternative, simple strategy for the determination of the monomer order of uniform oligo(thioether ester)s. This approach, which relies on random cleavages of ester units within the macromol. backbone via a basic treatment, enables the swift characterization of these macromols. without the need for MS/MS. Consequently, this method can be used for decoding any information stored within the primary structure of oligoesters by means of ESI- or LC-MS. Finally, we speculate that a range of structurally diverse backbones could be susceptible towards this approach, which could promptly expand the library of chem. sequenceable macromols. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Related Products of 6038-19-3

The Article related to sequencing uniform multifunctional oligoester random chain cleavage, polymer degradation, random chain cleavages, sequence-controlled polymers, sequence-defined macromolecules, sequencing and other aspects.Related Products of 6038-19-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Ren-Ming; Zhang, Min; Han, Xiao-Xue; Liu, Xiong-Li; Pan, Bo-Wen; Tian, You-Ping; Peng, Li-Jun; Yuan, Wei-Cheng published an article in 2022, the title of the article was Catalytic asymmetric Michael/cyclization reaction of 3-isothiocyanato thiobutyrolactone: an approach to the construction of a library of bispiro[pyrazolone-thiobutyrolactone] skeletons.Formula: C4H8ClNOS And the article contains the following content:

The first example of 3-isothiocyanato thiobutyrolactone serving as a useful building block in the Michael/cyclization reaction with alkylidene pyrazolones for the enantioselective construction of optically active structural bispiro[pyrazolone-thiobutyrolactone] skeletons containing three contiguous stereocenters with two spiroquaternary stereocenters was demonstrated. These products were smoothly afforded in up to 90% yield, >20 : 1 dr and >99% ee with chiral squaramide as the catalyst under mild conditions. Notably, this is also the first example of the merger of a spirocyclic pyrazolone scaffold with a spirocyclic thiobutyrolactone scaffold, potentially useful in medicinal chem. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Formula: C4H8ClNOS

The Article related to isothiocyanato thiobutyrolactone alkylidene pyrazolone squaramide tandem michael spirocyclization reaction, bispiro pyrazolone thiobutyrolactone preparation diastereoselective enantioselective and other aspects.Formula: C4H8ClNOS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Van Lysebetten, Dorien; Felissati, Stefania; Antonatou, Eirini; Carrette, Lieselot L. G.; Espeel, Pieter; Focquet, Evelien; Du Prez, Filip E.; Madder, Annemieke published an article in 2018, the title of the article was A thiolactone strategy for straight-forward synthesis of disulfide-linked side-chain-to-tail cyclic peptides featuring an N-terminal modification handle.Name: 3-Aminodihydrothiophen-2(3H)-one hydrochloride And the article contains the following content:

The development of straight-forward and versatile peptide cyclization methods is highly desired to meet the demand for more stable peptide-based drugs. Herein, a new method for the synthesis of side-chain-to-tail cyclic peptides with the simultaneous introduction of an N-terminal handle, based on the introduction of an N-terminal thiolactone building block, is described. A primary amine liberates a homocysteine analog from the thiolactone building block, which further enables cyclization of the peptide through disulfide-bond formation with a C-terminal cysteamine. Postcyclisation modification can be achieved by using small bifunctional amines. Alternatively, the synthesis of lipopeptides is demonstrated through direct thiolactone opening with long-chain alkyl amines. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Name: 3-Aminodihydrothiophen-2(3H)-one hydrochloride

The Article related to cyclic peptide synthesis disulfide thiolactone strategy, solid phase peptide synthesis cyclization aminolysis, lipopeptide synthesis thiolactone ring opening aminolysis, cyclisation, lactones, peptides, sulfur, synthesis design and other aspects.Name: 3-Aminodihydrothiophen-2(3H)-one hydrochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Holloway, Joshua O.; Mertens, Chiel; Du Prez, Filip E.; Badi, Nezha published an article in 2019, the title of the article was Automated synthesis protocol of sequence-defined oligo-urethane-amides using thiolactone chemistry.Electric Literature of 6038-19-3 And the article contains the following content:

An automated, iterative protocol for the synthesis of multifunctional, sequence-defined oligo-urethane-amides using thiolactone chem. is reported. Here, sequenced functionalization of the backbone is easily introduced using com. available primary amines. The chem. is carried out on solid phase using different supports for better optimization of the synthetic protocol and in order to demonstrate the versatility of the approach. This technique is very effective for iterative synthesis and solid-phase chem. and enables the exploration of full automation of this approach using a robotic peptide synthesizer. As a result, this automated protocol allows for the synthesis of a sequence-defined nonamer of high purity. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Electric Literature of 6038-19-3

The Article related to sequence defined oligo urethane amide synthesis peptide, amine solid phase peptide synthesis robotic synthesizer thiolactone aminolysis, aminolysis reaction kinetics, automated synthesis, sequence-controlled polymers, solid-phase, thiolactone and other aspects.Electric Literature of 6038-19-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics