Category: 59410-82-1

Reiners, I.; Wilken, J.; Martens, J. published their research in Tetrahedron: Asymmetry on December 31 ,1995. The article was titled 《Intramolecular vs. intermolecular induction in the diastereoselective catalytic reduction of enantiomerically pure ketones with borane in the presence of cyclic β-amino alcohols》.Electric Literature of C10H14ClNO2 The article contains the following contents:

Asym. reduction of various enantiomerically pure ketones was carried out by using oxazaborolidine catalysts with a variety of achiral and chiral ligands. The efficiency of chiral 1,2-amino alcs. as well as the effect of the stereogenic centers in the substrate on the catalytic asym. reduction were studied. The products obtained from (2S-trans)-5-methyl-2-(1-methylethyl)cyclohexanone (menthone) were (1R-endo)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol [(+)-borneol] and (1R-exo)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol [(-)-isoborneol]. The products from (1R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one [(+)-camphor] were [1R-1α,2β,5α]-5-methyl-2-(1-methylethyl)cyclohexanol [(+)-neoisomenthol] and [(+)-neoisomenthol]. It was found that the corresponding secondary alcs. were obtained with extremely high stereoselectivities with the proper choice of chiral ligands although a considerably large double asym. induction was observed in some cases. The experimental process involved the reaction of H-Phg-OEt.HCl(cas: 59410-82-1Electric Literature of C10H14ClNO2)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Electric Literature of C10H14ClNO2 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2011,Pharma Chemica included an article by Naidu, K. Reddi Mohan; Reddy, C. Bhupendra; Rasheed, S.; Raju, C. Naga. Category: esters-buliding-blocks. The article was titled 《Synthesis and bioassay of 2-substituted-1,3,2-oxazaphosphole 2-ones》. The information in the text is summarized as follows:

A series of new phosphorus heterocycles has been synthesized by the condensation of octahydro-1H-indol(3aS,7aS)-2-yl(2S) methanol with phosphorus oxychloride in the presence of triethylamine in dry THF, followed by the reaction with various phenols and amino acid ester hydrochlorides. All the title compounds were characterized by elemental and spectral analyses. Their antimicrobial activity was also evaluated. In the part of experimental materials, we found many familiar compounds, such as H-Phg-OEt.HCl(cas: 59410-82-1Category: esters-buliding-blocks)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Name: H-Phg-OEt.HClOn March 1, 2017, Nishikawa, Yasuhiro; Nakamura, Hidetsugu; Ukai, Norimitsu; Adachi, Wakana; Hara, Osamu published an article in Tetrahedron Letters. The article was 《Tetraethylorthosilicate as a mild dehydrating reagent for the synthesis of N-formamides with formic acid》. The article mentions the following:

The synthesis of N-formamides with formic acid as a formyl source under mild conditions was achieved using tetraethylorthosilicate (TEOS), a low cost and environmentally benign reagent. The mild conditions in this system enable the formylation of a variety of amino acid derivatives including stereochem. labile phenylglycine Et ester with 96% ee. This new protocol could also be applied to simple amines including weakly basic aniline derivatives, giving various primary and secondary formamides. In the experimental materials used by the author, we found H-Phg-OEt.HCl(cas: 59410-82-1Name: H-Phg-OEt.HCl)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Name: H-Phg-OEt.HCl They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《The synthesis and anticancer activities of peptide 5-fluorouracil derivatives》 was written by Yan, Xiaowei; Hu, Maolin; Miao, Qian; Wang, Shun; Zhao, Kejian. Computed Properties of C10H14ClNO2 And the article was included in Journal of Chemical Research on April 30 ,2009. The article conveys some information:

A new series of peptide 5-fluorouracil derivatives was designed and synthesized in order to test in vitro anticancer activities. The results indicated that peptide 5-fluorouracil derivatives possessed anticancer activities against human HL-60 and Bel-7402 cell lines. The structures of the compounds were determined by means of 1H NMR, 13C NMR, IR, mass spectra and elemental analyses. The experimental part of the paper was very detailed, including the reaction process of H-Phg-OEt.HCl(cas: 59410-82-1Computed Properties of C10H14ClNO2)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Computed Properties of C10H14ClNO2 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Bin; Dong, Yue; Lei, Kang; Wang, Jian; Zhao, Liyu; Liu, Min published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors》.COA of Formula: C10H14ClNO2 The author mentioned the following in the article:

Based on the anal. of the squalene cyclooxygenase (SE) and 14α-demethylase (CYP51) inhibitors pharmacophore feature and the dual-target active sites, a series of compounds with amide-pyridine scaffolds have been designed and synthesized to treat the increasing incidence of drug-resistant fungal infections. In vitro evaluation showed that these compounds have a certain degree of antifungal activity. The most potent compounds 11a, 11b with MIC values in the range of 0.125-2 μg/mL had a broad-spectrum antifungal activity and exhibited excellent inhibitory activity against drug-resistant pathogenic fungi. Preliminary mechanism studies revealed that the compound 11b might play an antifungal role by inhibiting the activity of SE and CYP51. Notably compounds did not show the genotoxicity through plasmid binding assay. Finally, this study of mol. docking, ADME/T prediction and the construction of 3D QSAR model were performed. These results can point out the direction for further optimization of the lead compound In the part of experimental materials, we found many familiar compounds, such as H-Phg-OEt.HCl(cas: 59410-82-1COA of Formula: C10H14ClNO2)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.COA of Formula: C10H14ClNO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 1976,Journal of the Chemical Society included an article by Clark, John C.; Phillipps, Gordon H.; Steer, Margaret R.; Stephenson, Leslie; Cooksey, A. Roy. Recommanded Product: H-Phg-OEt.HCl. The article was titled 《Resolution of esters of phenylglycine with (+)-tartaric acid》. The information in the text is summarized as follows:

The Me, Et, and iso-Pr esters of DL-PhCH(NH2)CO2H were resolved with 1 mol. equivalent of (+)-tartaric acid in aqueous alcs. to give 25-42% D-ester hydrogen (+)-tartrate salts. The L-salts in the filtrates from the resolutions were racemized in EtOH containing polar cosolvents. The resolution and racemization stages can be combined so that DL-PhCH(NH2)CO2Et underwent a second order asymmetric transformation to give 65% Et D-phenylglycinate hydrogen (+)-tartrate. The resolved salts were hydrolyzed to give 66-91% D-PhCH(NH2)CO2H. In the experiment, the researchers used H-Phg-OEt.HCl(cas: 59410-82-1Recommanded Product: H-Phg-OEt.HCl)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Recommanded Product: H-Phg-OEt.HCl Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quality Control of H-Phg-OEt.HClOn March 31, 2003, Vicente, Virginie; Fruchier, Alain; Cristau, Henri-Jean published an article in Magnetic Resonance in Chemistry. The article was 《Determination of 31P, 31P coupling constants in cyclotriphosphazenes and their influence on 1H and 13C NMR spectra of phosphorus substituents》. The article mentions the following:

1H and 13C NMR spectra of sym. substituted cyclotriphenylosphazenes exhibit second-order effect0. The influence of the 31P,31P coupling constants between ring P atoms on these effects was studied. Some values of this coupling constant between P bearing identical substituents were measured using 13C satellites of the 31P signals or by introduction of a chiral substituent on the third P atom. In the experiment, the researchers used H-Phg-OEt.HCl(cas: 59410-82-1Quality Control of H-Phg-OEt.HCl)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Quality Control of H-Phg-OEt.HCl They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lyttle, Matthew H.; Hocker, Michael D.; Hui, Hon C.; Caldwell, Colby G.; Aaron, Decius T.; Engqvist-Goldstein, Asa; Flatgaard, Jeffrey E.; Bauer, Karin E. published an article on January 7 ,1994. The article was titled 《Isoenzyme-specific glutathione-S-transferase inhibitors: design and synthesis》, and you may find the article in Journal of Medicinal Chemistry.Application In Synthesis of H-Phg-OEt.HCl The information in the text is summarized as follows:

Glutathione-S-transferase (GST) isoenzyme-selective inhibitors H-Glu[Cys(R)-X-OH]-OH [I; R = (CH2)5Me, CH2Ph, CH2C6H4R1-4, R1 = Me, Cl, NO2, CMe3, OMe; X = Gly, β-Ala, (R)-phenylglycine] were designed by an empirically guided strategy. In the first phase, literature data were used to select C-terminal modifications which generated maximum variation in the catalytic efficiency (Vmax/Km) for I used as substrates with different rat GSTs. Also, on the basis of literature data, the sulfhydryl group was functionalized with a selection of alkyl and aryl groups to maximize potential isoenzyme specificity. Affinity chromatog. sorbents were prepared from I which showed isoenzyme selectivity for both rat tissue and recombinant human GST isoenzymes. Some I also showed selective inhibition of GST activity in catalysis of the reaction of 1-chloro-2,4-dinitrobenzene with glutathione (GSH). In the second phase, electronic effects were explored through synthesis of an isostructural series of S-benzyl GSH ligands with different substituents on the aromatic ring. GST isoenzyme specificity for these ligands, measured by binding to derivatized sorbents, varied substantially, with hydrophobic substituents favoring the human GST M1a isoenzyme and electroneg. moieties favoring GST P1. In the third phase, information obtained from testing both series of compounds was combined and used to prepare GSH analogs with chem. features responsible for isoenzyme specificity at both the C-terminus and the sulfur. This approach gave I [R = CH2C6H4Me-4, X = β-Ala; R = CH2C6H4Cl-4, X = (R)-phenylglycine], which showed improved potency while still maintaining selectivity in the inhibition of GSTs. A detailed discussion of the logic used in the selection of functional groups for maximum potency and selectivity is included. After reading the article, we found that the author used H-Phg-OEt.HCl(cas: 59410-82-1Application In Synthesis of H-Phg-OEt.HCl)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Application In Synthesis of H-Phg-OEt.HCl They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

An, Yunfei; Liu, Wenxia; Xie, Honglei; Fan, Haiyan; Han, Jun; Sun, Bin published an article on January 5 ,2022. The article was titled 《Construction and activity evaluation of novel benzodioxane derivatives as dual-target antifungal inhibitors》, and you may find the article in European Journal of Medicinal Chemistry.Electric Literature of C10H14ClNO2 The information in the text is summarized as follows:

Ergosterol exert the important function in maintaining the fluidity and osmotic pressure of fungal cells, and its key biosynthesis enzymes (squalene epoxidase, SE; 14 α-demethylase, CYP51) displayed the obvious synergistic effects. Therefore, authors expected to discover the novel antifungal compounds with dual-target (SE/CYP51) inhibitory activity. In the progress, authors screened the different kinds of potent fragments based on the dual-target features, and the method of fragment-based drug discovery (FBDD) was used to guide the construction of three different series of benzodioxane compounds Subsequently, their chem. structures were synthesized and evaluated. These compounds displayed the obvious biol. activity against the pathogenic fungal strains. Notably, (R)-N-(1-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide and N-((S)-3-methyl-1-oxo-1-(((R)-1-phenyl-2-(1H-1,2,4-triazol-1-yl)ethyl)amino)butan-2-yl)-2,3-dihydrobenzo[b] [1,4]dioxine-5-carboxamide possessed the excellent broad-spectrum anti-fungal activity (MIC50, 0.125-2.0μg/mL) and the activity against drug-resistant strains (MIC50, 0.5-2.0μg/mL). Preliminary mechanism studies have confirmed that these compounds effectively inhibited the dual-target activity, they could cause fungal rupture and death by blocking the bio-synthetic pathway of ergosterol. Further experiments discovered that above compounds also maintained a certain of anti-fungal effect in vivo. The experimental part of the paper was very detailed, including the reaction process of H-Phg-OEt.HCl(cas: 59410-82-1Electric Literature of C10H14ClNO2)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Electric Literature of C10H14ClNO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Heterocycles from nitrile oxides. II. 1,2,4-Oxadiazin-6-ones》 was written by Hussein, Ahmad Q.; El-Abadelah, Mustafa M.; Sabri, Wail S.. Product Details of 59410-82-1 And the article was included in Journal of Heterocyclic Chemistry on April 30 ,1984. The article conveys some information:

Condensation of RC6H4CCl:NOH (I, R = H, Br, Cl, Me, NO2), precursors of nitrile oxides, with α-amino acid esters, except those of glycine and alanine, gives oxadiazinones II (R1 = H, Me; R2 = CHMe2, CHMeEt, CH2CHMe2, CH2Ph, Ph; R1R2 = CH2CH2CH2). α-Amino alcs., treated with I, give RC6H4C(:NOH)NHCHR2CH2OH, which are also obtained by borohydride reduction of II. In contrast, the products formed from I and α-amino acids decompose readily into the aldehyde, derived from the amino acid, together with the aldoxime. Both products are also formed by mild hydrolysis of II.H-Phg-OEt.HCl(cas: 59410-82-1Product Details of 59410-82-1) was used in this study.

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Product Details of 59410-82-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics