Category: 57486-69-8

These common heterocyclic compound, 57486-69-8, name is Methyl 2-(2-bromophenyl)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Methyl 2-(2-bromophenyl)acetate

General procedure: In a three neck round bottom flask, CaCl2 (1.12 g, 10.2 mmol) was dissolved in ethanol (50 mL) under argon atmosphere. The resulting solution was cooled to 0 ?C, followed by the addition of NaBH4 (0.19 g, 5.1 mmol) at the same temperature. The resulting suspension was allowed to stir at 0 ?C for 30 min, after which a solution of S5a (1.0 g, 3.4 mmol) in 60 mL of Ethanol was added at the same temperature. The resulting reaction mixture was allowed to stir at 0 ?C for another 30 min, and then at rt for 15 h. After 15 h, 50 mL of a mixture of water and dichloromethane (1:1) was added to the reaction mixture which was then sonicated for 1 h. The resulting mixture was then subjected to vacuumfiltration over celite. The filtrate was collected and evaporated under reduced pressure. 50 mL of water was added to the resulting crude, which was then extracted with three portions of dichloromethane (30 mL each). The combined organic layer was dried over Na2SO4, and evaporated under reduced pressure to afford S6 2-(2-bromo-4,5-dimethoxyphenyl)ethanol (S6a): Brown Oil; (2.56 g, 60 %). 2-(2-bromo-5-methoxyphenyl)ethanol (S6b): Clear Oil; (1.29 g, 42 %). 2-(2-bromo-4-methoxyphenyl)ethanol (S6c): Clear Oil; (1.03 g, 55 %). 2-(2-bromophenyl)ethanol (S6d): Clear Oil; (2.41 g, 55 %).

The synthetic route of Methyl 2-(2-bromophenyl)acetate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kapadia, Nirav; Harding, Wayne; Tetrahedron; vol. 69; 42; (2013); p. 8914 – 8920;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 57486-69-8, name is Methyl 2-(2-bromophenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows., Formula: C9H9BrO2

Degas a suspension of methyl 2-(2-bromophenyl)acetate (156.6 g, 684 Tnmoi), bis(inacoiato)diboron (194.9 g, 752 mmoi), and potassium acetate (135,6 g, 1.4 mol) in N-methylpyrroiidone (940 mL) with three vacuuni?nitrogen cycles, Add (1,1 bis(diphenyiphosphino)ferrocene)palladiurn(H) chloride (11,4 g, 13,7 nunol) and heat at 80C. After 15 hours add (1 , I -bis(diphenyiphosphino)ferrocene)palladiuni(II) chloride(11,4 g, 13.7 mmoi) and stir at 90 C for 24 hours, Cool to ambient tern perare and pour over a mixture of ice and water (3 L), and methyl tertiary butyl ether (1 L) was added, Stir mixture, filter through a pad of Celite and separate layers, Extract from aqueous with methyl tertiary hutyl ether (2×500 niL), Wash combined organics with water (2×500 mL), brine (500 mL), dry over sodium sulfate and concentrate. Purify the residue byflash chromatography, elating with hexane: ethyl acetate (9:1) to give the title compound as a white solid (160,6 g, 581.6 mrnol, 85%). MS (rn/z): 277(M+i),

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 57486-69-8.

Reference:
Patent; ELI LILLY AND COMPANY; BENHADJI, Karim A.; MASSARD, Christophe; SORIA, Jean-Charles; (43 pag.)WO2016/168014; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 57486-69-8, These common heterocyclic compound, 57486-69-8, name is Methyl 2-(2-bromophenyl)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Methyl 2-bromophenylacetate (3.8 g) in tetrahydrofuran (50 mL) cool to -78 C,1.6 mol / L lithium hexamethyldisilazide(13.3 mL, 21 mmol) was added dropwise and the mixture was stirred for 1 hour. Subsequently, methyl iodide was added, the temperature was raised to room temperature, and the mixture was stirred for 3 hours. Saturated ammonium chloride aqueous solution was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate, After filtration, the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography,The target compound was obtained (3.0 g, 75%).

Statistics shows that Methyl 2-(2-bromophenyl)acetate is playing an increasingly important role. we look forward to future research findings about 57486-69-8.

Reference:
Patent; SUMITOMO DAINIPPON PHARMA COMPANY LIMITED; SUMIYOSHI, TAKAAKI; TAKAHASHI, YOKO; URUNO, YOSHIHARU; TAKAI, KENTARO; SUWA, ATSUSHI; MURATA, YASUKO; (58 pag.)JP2015/83543; (2015); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics