Category: 55666-43-8

Reference of 55666-43-8, The chemical industry reduces the impact on the environment during synthesis 55666-43-8, name is tert-Butyl 3-bromopropanoate, I believe this compound will play a more active role in future production and life.

5. To a solution of alcohol 3 (12.8 g, 40.84 mmol) in toluene (200 ml) was added Bu4NCI (3.7 g, 13.48 mmol). The reaction mixture was cooled to 0 0C after which aqueous 35% NaOH (250 ml) was added followed by a dropwise addition of tert- butyl 3-bromopropionate (4, 8.2 ml, 49.01 mmol) in toluene (50 ml). The mixture was stirred overnight at room temperature. The organic layer was separated and washed with H?O until neutral, dried (Na2SO4), concentrated and co-evaporated with CH2CI2 (3x). Purification by column chromatography (silica, heptane/EtOAc 4:1) gave 5 (11.2 g, 62%) as a yellow oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 3-bromopropanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GRUeNENTHAL GMBH; WO2009/124746; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 55666-43-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 55666-43-8 as follows.

Preparation 12; 1,1-Dimethylethyl 3-[7-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl]propan-oate 2-[(1-Methylethyl)oxy]-5-[3-(2,3,4,5-tetrahydro-1H-2-benzazepin-7-yl)-1,2,4-oxadiazol-5-yl]benzonitrile hydrochloride (Example 3) (70 mg, 0.170 mmol) and caesium carbonate (167 mg, 0.511 mmol) were stirred in dry DMF (5 ml) and treated with 1,1-dimethylethyl 3-bromopropanoate (0.043 ml, 0.256 mmol) then stirred at 60 C. for 2 hours. Further quantities of 1,1-dimethylethyl 3-bromopropanoate (44 mul) were added and the reaction stirred at 60 C. for 3 hours. The reaction was left standing overnight. 1,1-Dimethylethyl 3-bromopropanoate (43 mul) was added and the reaction mixture stirred at 60 C. for 7 hours then left standing overnight. EtOAc (50 ml) was added and the reaction mixture washed with water (2¡Á50 ml), dried over anhydrous MgSO4 and evaporated to yield a clear, colourless oil (100 mg). The oil slowly solidified. Trituration with ether/hexane to yielded the title compound (70 mg) as a white solid. MS (ES) C29H34N4O4 requires 502. found 503.0 (M+H).

According to the analysis of related databases, 55666-43-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; US2010/174065; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 55666-43-8, name is tert-Butyl 3-bromopropanoate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H13BrO2

REFERENCE EXAMPLE 13 4,5-Dichloro-2-{2-(t-butoxycarbonyl)ethyl}-3(2H) pyridazinone STR20 In the same manner as in Reference Example 10, a mixture comprising 19.3 g of 4,5-dichloro-3(2H) pyridazinone, 29.4 g of 2-(t-butoxycarbonyl)ethylbromide, 19.3 g of potassium carbonate, 1.75 g of sodium iodide and 60 ml of dimethylformamide, was reacted, and the oily substance thus obtained was purified by silica gel column chromatography (developer: benzene:ethyl acetate=10:1, v/v) to obtain 8.1 g of the above identified compound as a pale yellow oily substance.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 55666-43-8.

Reference:
Patent; Nissan Chemical Industries Ltd.; US4892947; (1990); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 55666-43-8,Some common heterocyclic compound, 55666-43-8, name is tert-Butyl 3-bromopropanoate, molecular formula is C7H13BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of [2- (4-METHYLSULFANYL-PHENYLSULFANYL) ETHYLAMINE HYDROCHLORIDE] salt (0.63 g, 2.69 [MMOLS)] in anhydrous tetrahydrofuran (20 ml) was added triethylamine (0.78 ml, 5.64 mmols) at [0C] under nitrogen. The mixture was stirred for 30 mins. To this was added dropwise a solution of [TERT-BUTYL] bromo acetate (0.42 [ML,] 2.82 [MMOLS)] in anhydrous tetrahydrofuran (10 [ML).] The mixture was warmed to room temperature and stirred fro 18 hours. The solvent was removed under reduced pressure and the residue partitioned between water (50 ml) and diethyl ether (30 [ML).] The aqueous was extracted with diethyl ether (2 x 30 [ML),] the combined organics dried over magnesium sulfate, filtered and the solvent removed under reduced pressure. The residue was purified by flash chromatography on silica gel eluting with a solvent gradient of heptane: ethyl acetate (1: 1) to give the title compound (0.25 g, 29 %) as a colourless oil. [‘H-NMR] (400 MHz, CD30D) : [A] = 1.44 (s, 9H), 2.45 (s, 3H), 2.75 (t, 2H), 3.01 (t, 2H), 3.20 (brs, 2H), 7.20 (d, 2H), 7.33 (d, 2H). LRMS [(ELECTROSPRAY)] : m/z [M + [H] + 314.] Microanalysis : Found: C, 57.28 ; H, 7.38 ; N, 4.41. [C15H23NO2S2] requires C, 57.47 ; H, 7.39 ; N, 4.47%.

The synthetic route of 55666-43-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/16583; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 55666-43-8, name is tert-Butyl 3-bromopropanoate, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H13BrO2

To a stirred mixture of 3-[(methylamino)methyl]benzonitrile (6.1 g, 41.7 mmol) and sodium bicarbonate (7.0 g, 83.4 mmol) in ACN (70 mL) was added dropwise tert-butyl 3-bromo- propanoate (7 mL, 41.7 mol). After being stirred at RT for 12 hours, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by chromatography (silica, pet ether/EtOAc) to afford the title compound as a pale yellow liquid. 1H NMR (DMSOd6, 400 MHz) delta 7.70 (s, 2H), 7.60 (m, 1 H), 7.51 (m, 1 H), 3.49 (s, 2H), 2.58 (m, 2H), 2.36 (m, 2H), 2.09 (s, 3H), 1.38 (s, 9H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MERCK SERONO S.A.; QUATTROPANI, Anna; MONTAGNE, Cyril; SAUER, Wolfgang; CROSIGNANI, Stefano; BOMBRUN, Agnes; WO2010/112461; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 55666-43-8, name is tert-Butyl 3-bromopropanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55666-43-8, 55666-43-8

Preparation in accordance with scheme 6. To a solution of 6-((2,6- dichlorobenzyl)oxy) -1,2,3, 4-tetrahydro-2, 7 -naphthyridine (80 mg; 0.259 mmol; 1 eq) in 10 mL acetonitrile were added tert-butyl 3-bromopropanoate (56.8 mg; 0.272 mmol; 1.05 eq) and triethylamine (131 mg; 1.29 mmol; 5 eq). The mixture wasstirred at RT overnight. The mixture was extracted with water/ethylacetate. The organic phase was washed with water, dried with MgSO4, and evaporated. The residue was purified by flash chromatography (4g silica gel; 3-10% MeOH in DCM) giving the product with a yield of 40 mg (0.09 1 mmol; 35.3%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 3-bromopropanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG; LANGE, Udo; OCHSE, Michael; VAN DER KAM, Elizabeth; VAN BERGEIJK, Jeroen; TURNER, Sean; OELLIEN, Frank; WALLESER, Patrick; AMBERG, Wilhelm; HORNBERGER, Wilfried; GENESTE, Herve; MEZLER, Mario; HUTCHINS, Charles; (301 pag.)WO2017/36978; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics