Category: 539-88-8

Zhao, Geng published the artcileConversion of furfuryl alcohol into ethyl levulinate over glucose-derived carbon-based solid acid in ethanol, COA of Formula: C7H12O3, the main research area is furfuryl alc ethyl levulinate carbon solid acid ethanol conversion; carbon-based solid acid; ethanol; ethyl levulinate; furfuryl alcohol.

In this study, a carbon-based solid acid was created through the sulfonation of carbon obtained from the hydrothermal pretreatment of glucose. Addnl., Et levulinate, a viable liquid biofuel, was produced from furfuryl alc. using the environmentally benign and low-cost catalyst in ethanol. Studies for optimizing the reaction conditions, such as reaction time, temperature, and catalyst loading, were performed. Under the optimal conditions, a maximum Et levulinate yield of 67.1% was obtained. The recovered catalyst activity (Et levulinate yield 57.3%) remained high after being used four times, and it was easily regenerated with a simple sulfonation process. Moreover, the catalyst was characterized using FT-IR, XRD, SEM, elemental anal., and acid-base titration techniques.

Molecules published new progress about Density Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, COA of Formula: C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zakrzewska, Malgorzata E. published the artcileHigh-pressure phase equilibrium studies of multicomponent (alcohol-water-ionic liquid-CO2) systems, Synthetic Route of 539-88-8, the main research area is alc water ionic liquid carbon dioxide phase equilibrium system.

Selective water (byproduct) separation from reaction mixtures stands as an important process intensification strategy for equilibrium-limited reactions. In this work, the possibility of using a high-pressure biphasic reaction media composed of a hydrophobic ionic liquid, 1-hexy-3-methylimidazolium tetracyanoborate, and carbon dioxide was explored for levulinic acid production from 1,4-butanediol. Vapor-liquid equilibrium measurements were performed for the binary (diol + CO2), ternary (diol + CO2+ IL), and quaternary systems (diol + CO2+ IL + water), at 313.2 K and pressures up to 18 MPa. The static anal. method was used in a high-pressure phase equilibrium apparatus equipped with a visual sapphire cell. The capability of the quaternary system to perform phys. water separation is discussed in this paper.

Cells published new progress about Ionic liquids. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Synthetic Route of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alexandre da Silva, Vivaldo Jr. published the artcileEffect of supercritical carbon dioxide over the esterification of levulinic acid with ethanol using montmorillonite K10 as catalyst, Formula: C7H12O3, the main research area is carbon dioxide levulinic acid ethanol montmorillonite catalyst.

Alkyl levulinates are green chems. that have the ability to modify phys. properties of both gasoline and diesel, which makes their use as fuel additives of great importance. An interesting route for their production is the Et esterification using solid catalysts, which still needs improvement. The use of supercritical CO2 (scCO2) as solvent may enhance the reaction yield, in such a way that the objective of this work was to combine the use of a solid catalyst (montmorillonite K10) and scCO2 to achieve the esterification of levulinic acid to obtain Et levulinate. Moreover, understanding the relationship between the amount of CO2, reactants and the catalyst can be a key to determine how scCO2 works in this type of reaction. The results obtained after a systematic study have shown that the combined effect of scCO2 and montmorillonite K10 allow the obtainment of 90.9 % of conversion after 126 min of reaction at 180 °C, with a molar ratio of 6:1 and 10 wt% of catalyst, while reactions performed using the same conditions and without scCO2 provided 82.9 % of conversion after 138 min. Furthermore, the presence of scCO2 also helped montmorillonite K10 to retain its catalytic activity after 4 reuse cycles, while under the absence of scCO2, a decrease in the levulinic acid conversion was already observed in the first reuse cycle. The results presented in this work are a step further for the use of montmorillonite K10 along with scCO2 in industrial scale.

Journal of CO2 Utilization published new progress about Gasoline Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Formula: C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Lin published the artcileHighly efficient synthesis of pharmaceutically relevant chiral 3-N-substituted-azacyclic alcohols using two enantiocomplementary short chain dehydrogenases, SDS of cas: 539-88-8, the main research area is keto ester dehydrogenase catalyst enantioselective reduction; hydroxy ester preparation; ketoarene dehydrogenase catalyst enantioselective reduction; aryl alc preparation.

Two stereocomplementary alc. dehydrogenases from Flavobacterium psychrophilum (FpADH) and Flavobacterium sp. was reported. (FsADH), which showed the potential industrial application in highly efficient synthesis of a series of enantiomerically pure 3-N-substituted-azacyclic alochols. Both the enzymes showed high catalytic activity toward the model substrate N-Boc-4-piperidone (NBPO) and presented a strict enantioselectivity for the corresponding alc. products. In addition, both enzymes showed broad substrate scope, including ketoesters, acryl ketones and heterocyclic ketones. Using glucose dehydrogenase coexpressed with each of the enzymes to realize the efficient coenzyme recycling, various pharmaceutically relevant chiral 3-N-Boc azacyclic alcs. were asym. synthesized at high substrate concentrations (343.7-643.8 g/L) and low equilvelent of NADP+ (0.1 mM) with excellent enantioselectivity (> 99.5% e.e), which have met the requirements of biocatalytic processes in the industry and demonstrated the feasibility of FpADH and FsADH for industrial application in the biotransformation of chiral 3-N-substituted-azacyclic alcs. The mol. basis of the enantioselectivity and catalytic efficiency of both enzymes were revealed the by mol. docking and MD simulation anal.

Biochemical Engineering Journal published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, SDS of cas: 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mulik, Nagesh published the artcileSynergetic combination of H2Zr1PW12O40 and Sn-Beta as potential solid acid catalyst for direct one-step transformation of glucose to ethyl levulinate, a biofuel additive, SDS of cas: 539-88-8, the main research area is Bronsted Lewis acid catalyst glucose ethyl levulinate biofuel additive.

Et levulinate (EL) has found wide applications as chems. and biofuel additives. Efficient catalytic conversion of abundantly available glucose to ELs over solid acid catalyst having optimum Bronsted (B) and Lewis (L) acidity is highly appreciated. Present work demonstrated, direct one-step synthesis of EL from glucose over synergized Bronsted (H2Zr1PW12O40) and Lewis (Sn-Beta) acid catalyst. H2Zr1PW12O40 is prepared by exchanging H+ of tungstophosphoric acid (H3PW12O40-heteropolyacid) with Zr, improves the heterogeneity in polar medium by 50%. The combination of a phys. mixture of H2Zr1PW12O40 + Sn-Beta with 80:20 weight ratio was found to be optimum for the maximum EL yield formation of 54% from glucose at 180°C for 3 h, which is probably the highest than reported over the heterogeneous catalyst in ethanol medium. An optimal combination of B and L catalyst and its ratio is found to be crucial for the direct transformation of glucose to EL in one step. The present study also explored that this combined phys. mixture of H2Zr1PW12O40 + Sn-Beta can tolerate glucose concentration up to 30 g/L, which is probably the higher than reported. © 2019 American Institute of Chem. Engineers Environ Prog, 2019

Environmental Progress & Sustainable Energy published new progress about Phase composition Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, SDS of cas: 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sahu, Preeti published the artcileZeolite-β based molecular sieves: A potential catalyst for esterification of biomass derived model compound levulinic acid, Application of Ethyl 4-oxopentanoate, the main research area is levulinic acid zeolite mol sieve potential catalyst esterification.

A series of hetero ions (iron, boron, gallium, titanium, and zinc [Fe3+, B3+, Ga3+, Ti4+, and Zn2+, resp.)] incorporated zeolite-β is prepared via a simple hydrothermal method within 48 h at 170°. Fourier transform-IR spectroscopy anal. and powder X-ray diffraction (FT-IR and XRD, resp.) studies demonstrated the formation of the crystalline phase of the zeolite framework with BEA structure. Scanning electron microscope (SEM) images showed a uniform spherical shape with a particle size of <1μm. The presence of strong acidic sites and the microporous nature of the materials was evident from sorption studies. The resulting Al-, Ga-, Zn-, and Ti- containing zeolite-β materials showed excellent activity for the esterification of levulinic acid using several alcs. (such as methanol, n-butanol, and amyl alc.) with a levulinate ester yield of more than 95%. Significant advantages of the protocol include good activity, the use of a green solvent, and easy removal of the catalyst via filtration. The catalyst activity remained almost intact even after several reaction cycles. Materials Science for Energy Technologies published new progress about Biomass. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Application of Ethyl 4-oxopentanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Zeyu published the artcileEfficient asymmetric synthesis of chiral alcohols using high 2-propanol tolerance alcohol dehydrogenase SmADH2 via an environmentally friendly TBCR system, Application In Synthesis of 539-88-8, the main research area is asym synthesis chiral alc propanol oxidation alc dehydrogenase; thermostatic bubble column reactor system alc dehydrogenase ketone reduction.

Alc. dehydrogenases (ADHs) together with the economical substrate-coupled cofactor regeneration system play a pivotal role in the asym. synthesis of chiral alcs.; however, severe challenges concerning the poor tolerance of enzymes to 2-propanol and the adverse effects of the byproduct, acetone, limit its applications, causing this strategy to lapse. Herein, a novel ADH gene smadh2 was identified from Stenotrophomonas maltophilia by traditional genome mining technol. The gene was cloned into Escherichia coli cells and then expressed to yield SmADH2. SmADH2 has a broad substrate spectrum and exhibits excellent tolerance and superb activity to 2-propanol even at 10.5 M (80%, volume/volume) concentration Moreover, a new thermostatic bubble column reactor (TBCR) system is successfully designed to alleviate the inhibition of the byproduct acetone by gas flow and continuously supplement 2-propanol. The organic waste can be simultaneously recovered for the purpose of green synthesis. In the sustainable system, structurally diverse chiral alcs. are synthesized at a high substrate loading (>150 g L-1) without adding external coenzymes. Among these, about 780 g L-1 (6 M) Et acetoacetate is completely converted into Et (R)-3-hydroxybutyrate in only 2.5 h with 99.9% ee and 7488 g L-1 d-1 space-time yield. Mol. dynamics simulation results shed light on the high catalytic activity toward the substrate. Therefore, the high 2-propanol tolerance SmADH2 with the TBCR system proves to be a potent biocatalytic strategy for the synthesis of chiral alcs. on an industrial scale.

Catalysis Science & Technology published new progress about Biochemical cofactors Role: BCP (Biochemical Process), BPN (Biosynthetic Preparation), BUU (Biological Use, Unclassified), BIOL (Biological Study), PROC (Process), PREP (Preparation), USES (Uses) (regeneration of). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Application In Synthesis of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

McCourt, Ruairi O. published the artcileAtmospheric Oxygen Mediated Radical Hydrothiolation of Alkenes, Safety of Ethyl 4-oxopentanoate, the main research area is alkene thiol atm oxygen mediated radical hydrothiolation; green chemistry; hydrothiolation; initiation; radical; thiol-ene.

A mild, metal-free, atm. oxygen-mediated radical hydrothiolation of alkenes (and alkyne) was reported. A variety of sulfur containing motifs including alkanethiols, thiophenols and thioacids undergo an atm. oxygen-mediated radical hydrothiolation reaction with a plethora of alkenes in good yield with excellent functional group compatibility, typically with short reaction times to furnished a range of functionalized products. Biomols. proved tolerant to the conditions and the procedure was robust and easily executable requiring no specialized equipment. Concise mechanistic studies confirmed that the process proceeded through radical intermediates in a thiol-ene reaction manifold. The methodol. offered an efficient “”green”” approach for thiol-ene mediated “”click”” ligation and a milder alternative to thermally initiated hydrothiolation processes.

Chemistry – A European Journal published new progress about Green chemistry. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Safety of Ethyl 4-oxopentanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bernhard, Yann published the artcileOne-Pot Synthesis of 2,5-Disubstituted Furans through In Situ Formation of Allenes and Enolization Cascade, Product Details of C7H12O3, the main research area is furan preparation ketoacid enolization cyclization cascade.

A one-pot synthesis of 2,5-disubstituted furans from γ-ketoacids is reported. In situ formation of allenoates by action of chloroformate on carboxylic acid following by enolization of ketone affords furan derivatives by cyclization. The reaction was extended to a wide scope of ketoacids and phosphonium salts. This methodol. was applied on levulinic acid and derivatives, one of the biosourced platform chems.

European Journal of Organic Chemistry published new progress about Carboxylic acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Product Details of C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wei, Duo published the artcileIron-Catalysed Switchable Synthesis of Pyrrolidines vs Pyrrolidinones by Reductive Amination of Levulinic Acid Derivatives via Hydrosilylation, Related Products of esters-buliding-blocks, the main research area is acid amine iron catalyst reductive amination hydrolysis; pyrrolidine preparation; pyrrolidinone preparation; heterocyclic amine preparation.

A selective production of pyrrolidines vs pyrrolidinones via hydrosilylation of levulinic acid and levulinates by switching of the iron complex catalyst was presented. The reactions proceeded efficiently with various anilines and alkylamines under both visible light irradiation and thermal conditions with 43 examples in isolated yields up to 93%. Noticeably, under similar conditions, cyclic amines such as piperidines and azepanes were efficiently synthesized with yields up to 92%, by reaction of anilines with 1,5- or 1,6-keto acids, resp. Similarly, N-arylinsolidoline compounds was prepared from 2-formylbenzoic acid in 57-93% yields.

Advanced Synthesis & Catalysis published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Related Products of esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics