Category: 539-88-8

Gu, Jing published the artcileHyper-cross-linked polymer based carbonaceous materials as efficient catalysts for ethyl levulinate production from carbohydrates, Product Details of C7H12O3, the main research area is carbohydrate ethyl levulinate hypercrosslinked polymer carbonaceous material catalyst.

Catalytic upgrading of biomass into various alkyl levulinates has gained wide attention recently. Particularly, Et levulinate (EL) shows great potential as gasoline additive and substitute of biodiesel fuels. Hypercrosslinked organic polymer based carbonaceous materials with large surface areas and strong Bronsted acidity were synthesized and developed as highly efficient solid acids for the direct transformation of biomass derived carbohydrates into biofuel candidate Et levulinate (EL). Controllable Brunauer-Emmett-Teller (BET) surface area and proper acid d. of as-prepared carbonaceous materials were demonstrated to be crucial for the successful synthesis of EL. Among the catalysts, α,α’-dichloro-p-xylene derived hypercrosslinked organic carbocatalyst (HDS-3.6) exhibited the best results for EL formation with the optimal yield of 70.3% at a temperature of 423 K, which was comparable with those of frequently-used solid acids such as com. Amberlyst-15 and metal oxides. The presence of DMSO (DMSO) in the catalytic system facilitated the production of intermediates 5-hydroxymethylfurfural (HMF) and 5-ethoxymethylfurfural. Notably, the hypercrosslinked organic polymers with abundant Bronsted acid sites were much more effective in the catalytic synthesis of levulinate esters from ketoses. The prepared hypercrosslinked organic polymers were efficient and robust catalysts to produce various biomass derived alkyl levulinates with high activity and stability.

Journal of Chemical Technology and Biotechnology published new progress about Bronsted acidity. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Product Details of C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ganji, Parameswaram published the artcileConversion of levulinic acid to ethyl levulinate using tin modified silicotungstic acid supported on Ta2O5, Computed Properties of 539-88-8, the main research area is levulinic acid esterification tin modified silicotungstic acid catalyst property.

Tin modified silicotungstic acid (STA) deposited on Ta2O5 was explored as suitable catalyst for the conversion of levulinic acid to Et levulinate. The microwave synthesized catalysts of varying amounts of STA were characterized by N2 adsorption, powder XRD, FT-IR, FE-SEM, XPS, pyridine-FT-IR, TGA-DTA and NH3-TPD. Among the synthesized catalysts, 50% Sn2STA/Ta2O5 catalyst exhibited excellent catalytic activity for the esterification of levulinic acid providing 78% of Et levulinate yield and stable recyclability up to three cycles. The rate of esterification was 6.6 × 10-3 mol/g/min, which is significantly higher compared to reported values in the open literature. Mechanistic investigations revealed that the high catalytic activity was influenced by the presence of appropriate Bronsted acid sites, surface area and porosity.

Catalysis Communications published new progress about Bronsted acidity. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Computed Properties of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wan, Feifei published the artcileThe transfer hydrogenation of high concentration levulinic acid to γ-valerolactone catalyzed by glucose phosphate carbamide zirconium, Quality Control of 539-88-8, the main research area is glucose phosphate carbamide zirconium levulinic acid transfer hydrogenation catalyst; gamma valerolactone turnover frequency.

Zr-Based catalysts have been extensively applied in Meerwein-Ponndorf-Verley type catalytic transfer hydrogenation (CTH) reactions, but they are easily deactivated in the CTH conversion of high concentrations of levulinic acid (LA) to γ-valerolactone (γ-GVL). This work discloses that by using cheap glucose and ZrCl4 as two main raw materials, glucose phosphate carbamide zirconium (GluPC-Zr) is easily synthesized at large scale and low cost via a simple two-step conversion. The constructed GluPC-Zr has enhanced Lewis acid-base properties and good porosity, thus exhibiting outstanding activity for the CTH reactions of LA or its esters with isopropanol (IPA), providing 95-98% γ-GVL yields. Because of the excellent esterification performance of the introduced acidic phosphate groups, GluPC-Zr also works well at high LA concentrations, achieving a much higher turnover frequency (TOF, 8.2 mmol γ-GVL per g catalyst per h) than previously reported Zr-based catalysts (TOF, 0.2-2.4). And it shows excellent reusability in the reaction of LA with IPA, still providing ca. 95% γ-GVL yield after the seventh cycle run. This work provides a preferential esterification strategy for LA to hamper catalyst deactivation, which is of special significance for the large-scale production of γ-GVL from biomass-derived LA and a low-cost GluPC-Zr catalyst.

Green Chemistry published new progress about Bronsted acidity. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Quality Control of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

He, Jian published the artcileDual acidic mesoporous KIT silicates enable one-pot production of γ-valerolactone from biomass derivatives via cascade reactions, Recommanded Product: Ethyl 4-oxopentanoate, the main research area is zirconium silica catalyst biomass derivative valerolactone one pot synthesis; morphol physicochem property.

γ-Valerolactone (GVL) is an interesting bio-based platform mol. that is utilized as green solvent and a versatile building block for the synthesis of bio-fuels and chems. Herein, an investigation on the efficient production of GVL from biomass-based carbonyl compounds such as furfural, levulinic acid, and its esters using 2-propanol as H-donor and solvent over stable Zr-incorporated mesoporous silica (KIT-5) catalysts was presented. Both Lewis and Bronsted acid sites were generated by the introduction of Zr into KIT-5, and the acid d. of the resulting Zr-KIT-5(Si/Zr) could be controlled by simply adjusting Si/Zr molar ratio. Among these bifunctional catalysts, Zr-KIT-5(10) showed superior catalytic performance in the production of GVL (>91% selectivity) from biomass-derived carboxides (ca. 94% conversion), which was demonstrated to pos. correlate with its large amount of acidic sites and facile access of active sites to interconnected pores. Moreover, the spent catalyst held about 90% of its original activity in the sixth run. Due to the presence of Bronsted and Lewis dual acidic sites in Zr-KIT-5, the direct conversion of furfural to GVL was also permitted in a single pot via tandem reactions involving hydrogenation, ring-opening, secondary hydrogenation, and subsequent cyclization.

Renewable Energy published new progress about Bronsted acidity. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Recommanded Product: Ethyl 4-oxopentanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wanmolee, Wanwitoo published the artcileOne step liquefaction of hardwood lignin to oligomers soluble in polymerizable solvents, Application In Synthesis of 539-88-8, the main research area is liquefaction hardwood lignin oligomer soluble polymerizable solvent solubility.

Today tech. lignins produced from different industrial processes are underutilized because they possess recalcitrant C-C bonds and reduced proportion of ether bonds, making it difficult to produce building block compounds in high yields. Current methods being developed to process tech. lignin and improve its usefulness involve multiple steps and the use of toxic chems. We report an innovative cleave and couple one step catalytic process on eucalyptus lignin (EUL) to form unique aromatics oligomers with aliphatic side chains using KOH/HCOOH mixture with methanol as the solvent. Under optimum condition, 71 wt% of predominantly dimers and oligomers are formed which are readily soluble in polymerizable solvents such as Me methacrylate. In this one pot process, the KOH not only acts as the catalyst but ensures complete solubilization of EUL, allowing easier cleavage of bonds to form phenolic monomers and quinone groups (which undergo ring opening) followed by repolymn. to form oligomers. The study has opened pathways toward sustainable catalytic conversion of tech. lignin to reactive macromol. building blocks to produce soft nanomaterials.

Industrial Crops and Products published new progress about Depolymerization. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Application In Synthesis of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Peng published the artcileA fast and efficient way for recovering organic carbon resources from a coal byproduct: separation and structural evaluation, HPLC of Formula: 539-88-8, the main research area is coal byproduct organic carbon resources separation structural evaluation.

Solvent extraction is an efficient and nondestructive approach to produce ash-free organic matters from direct coal liquefaction residue (DCLR). Isometric acetone/CS2 mixture (IACM) was adopted to extract DCLR to produce IACM-soluble fraction (IACM-SF) with a yield of 86.5%. The IACM-SF is of ash-free and high carbon content of 90.18%. The typical structural features of IACM-SF are substituted aromatic structures, nonsubstituted condensed and biphenyl aromatic structures, alkyl bridged linkages, hydrogenated aromatic structures, and heteroatom-containing structures. Therefore, the IACM-SF is a useful and valuable carbon resource that can be used for producing aromatics and preparation of carbon materials.

Separation Science and Technology (Philadelphia, PA, United States) published new progress about Ashes (residues). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, HPLC of Formula: 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Yuefang published the artcileSynergy of Al2(SO4)3 and H3PO4 in co-solvents converts starch to 5-ethoxymethylfurfural, Computed Properties of 539-88-8, the main research area is synergy Al2SO4 H3PO4 solvent starch ethoxymethylfurfural.

Efficient synthesis of promising biofuel 5-ethoxymethylfurfural (EMF) directly from starch was developed over a mixed-acid system composed of Al2(SO4)3 and H3PO4 in ethanol-DMSO co-solvent medium. The reaction proceeds through the depolymerization of starch to form glucose over Bronsted acidic H3PO4, which is then isomerized to fructose by Al2(SO4)3, a Lewis acid catalyst. The mixed-acid system then synergistically catalyzes the formation of EMF. At 170°C, 36.9%, 39.8%, and 34.7% yields of EMF can be captured from corn starch, amylose and amylopectin, resp. Moreover, the conversion of cellobiose and wood pulp cellulose produces 38.5% and 9.5% yields of EMF.

Catalysis Communications published new progress about Aprotic solvents. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Computed Properties of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Knies, Christine published the artcileSynthesis of new potential lipophilic co-drugs of 2-Chloro-2′-deoxyadenosine (Cladribine, 2-CdA, Mavenclad, Leustatin) and 6-Azauridine (z6U) with valproic acid, Application In Synthesis of 539-88-8, the main research area is cladribine azauridine valproate synthesis lipophilic anticancer; biological activity; cancerostatic/cancerotoxic activity; cladribine; drug profiling; glioblastoma; multiple sclerosis; nucleolipids.

2-Chloro-2′-deoxyadenosine (cladribine, 1) was acylated with valproic acid (2) under various reaction conditions yielding 2-chloro-2′-deoxy-3′,5′-O-divalproyladenosine (3) as well as the 3′-O- and 5′-O-monovalproylated derivatives, 2-chloro-2′-deoxy-3′-O-valproyladenosine (4) and 2-chloro-2′-deoxy-5′-O-valproyladenosine (5), as new co-drugs. In addition, 6-azauridine-2′,3′-O-(Et levulinate) (8) was valproylated at the 5′-OH group (â†?). All products were characterized by 1H- and 13C-NMR spectroscopy and ESI mass spectrometry. The structure of the byproduct 6 (N-cyclohexyl-N-(cyclohexylcarbamoyl)-2-propylpentanamide), formed upon valproylation of cladribine in the presence of N,N-dimethylaminopyridine and dicyclohexylcarbodiimide, was analyzed by X-ray crystallog. Cladribine as well as its valproylated co-drugs were tested upon their cancerostatic/cancerotoxic activity in human astrocytoma/oligodendroglioma GOS-3 cells, in rat malignant neuro ectodermal BT4Ca cells, as well as in phorbol-12-myristate 13-acetate (PMA)-differentiated human THP-1 macrophages. The most important result of these experiments is the finding that only the 3′-O-valproylated derivative 4 exhibits a significant antitumor activity while the 5′-O- as well as the 3′,5′-O-divalproylated cladribine derivatives 3 and 5 proved to be inactive.

Chemistry & Biodiversity published new progress about Antitumor agents. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Application In Synthesis of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Vila, Laura published the artcileSynthesis and biological studies of “”Polycerasoidol”” and “”trans-δ-Tocotrienolic acid”” derivatives as PPARα and/or PPARγ agonists, Recommanded Product: Ethyl 4-oxopentanoate, the main research area is polycerasoidol trans tocotrienolic acid PPAR agonist receptor mol docking; 2-Prenylated benzopyrans; Grignard/Johnson-Claisen rearrangement; Polycerasoidol analogs; Tocotrienol analogs; Wittig olefination; hPPAR activity.

2-Prenylated benzopyrans represent a class of natural and synthetic compounds showing a wide range of significant activities. Polycerasoidol is a natural prenylated benzopyran isolated from the stem bark of Polyalthia cerasoides (Annonaceae) that exhibits dual PPARα/γ agonism and an anti-inflammatory effect by inhibiting mononuclear leukocyte adhesion to the dysfunctional endothelium. Herein, we report the synthesis of three new series of prenylated benzopyrans containing one (series 1), two (series 2, “”polycerasoidol”” analogs) and three (series 3, “”trans-δ-tocotrienolic acid”” analogs) isoprenoid units in the hydrocarbon side chain at the 2-position of the chroman-6-ol (6-hydroxy-dihydrobenzopyran) scaffold. Isoprenoid moieties were introduced through a Grignard reaction sequence, followed by Johnson-Claisen rearrangement and subsequent Wittig olefination. HPPAR transactivation activity and the structure activity relationships (SAR) of eleven novel synthesized 2-prenylated benzopyrans were explored. PPAR transactivation activity demonstrated that the seven-carbon side chain analogs (series 1) displayed selectivity for hPPARα, while the nine-carbon side chain analogs (polycerasoidol analogs, series 2) did so for hPPARγ. The side chain elongation to 11 or 13 carbons (series 3) resulted in weak dual PPARα/γ activation. Therefore, 2-prenylated benzopyrans of seven- and nine-carbon side chain (polycerasoidol analogs) are good lead compounds for developing useful candidates to prevent cardiovascular diseases associated with metabolic disorders.

Bioorganic & Medicinal Chemistry published new progress about Molecular docking. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Recommanded Product: Ethyl 4-oxopentanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Hongjie published the artcileSimultaneous Construction of Planar and Central Chiralities as Well as Unprecedented Axial Chirality on and around a Ferrocene Backbone, Quality Control of 539-88-8, the main research area is chiral spirocyclic cyclopentadienyltetrahydropentalenyliron pyrrolidine preparation crystal structure; crystal structure chiral spirocyclic cyclopentadienyltetrahydropentalenyliron pyrrolidine derivative; mol structure chiral spirocyclic cyclopentadienyltetrahydropentalenyliron pyrrolidine.

Simultaneous generation of planar, central and axial chiralities on and around a ferrocene backbone via a D-phenylglycinol-induced intramol. iminium cyclization was disclosed, which is rare and differs from known methods. Chiral spiro[cyclopentadienyl-1,2,3,3a-tetrahydropentalenyliron(II)-1,2′-pyrrolidine] derivatives were prepared according to the new method, and their structures were characterized unambiguously. The axial chirality caused by the ferrocene backbone and the rigid spiral structure was verified by NOESY and variable-temperature NMR experiments and single-crystal XRD analyses. Mechanism for the stereoselective iminium cyclization reaction was suggested, which was influenced by steric hindrance and H bonding.

Journal of Organic Chemistry published new progress about Crystal structure. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Quality Control of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics