Category: 5340-78-3

Pirkle, William H. published the artcileAn improved chiral stationary phase for the facile separation of enantiomers, Category: esters-buliding-blocks, the publication is Journal of Chromatography (1988), 441(2), 311-22, database is CAplus.

A chiral stationary phase (CSP) derived from cis-3-(1,1-dimethylethyl)-4-phenyl-2-azetidinone is quite effective for the chromatog. separation of the enantiomers of a variety of compounds This CSP has two stereogenic centers. For many enantiomers, it exhibits superior performance to that of a widely used phenylglycine-derived CSP.

Journal of Chromatography published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chuchani, Gabriel published the artcileThe pyrolysis kinetics of ethyl esters in the gas phase. The alkyl substituent effect at the acyl carbon, Name: Ethyltert-butylacetate, the publication is International Journal of Chemical Kinetics (1983), 15(5), 455-9, database is CAplus.

The gas-phase elimination of Et 3-methylbutanoate and Et 3,3-dimethylbutanoate was studied, in a static system, at 360-420° and 71-286 torr. The reactions are homogeneous, unimol., and follow a 1st-order rate law. The temperature dependence of the rate coefficient were determined from the Arrhenius equations. Alkyl substituents at the acyl carbon of Et esters yield very close values in rates. Consequently it is rather difficult to offer some conclusion concerning the effect of these substituents.

International Journal of Chemical Kinetics published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Name: Ethyltert-butylacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Reetz, Manfred T. published the artcileGeneral synthesis of active antiviral α-adamantyl carbonyl compounds, Safety of Ethyltert-butylacetate, the publication is Angewandte Chemie (1979), 91(1), 78-9, database is CAplus.

Silyl enol ethers R¹(Me₃SiO)C:CR²R³ [R¹ = MeO, Et, Me₂CH, EtO, Me₃C, R² = H, Me, Et, Me₃C, R¹R² = (CH₂)_n (n = 3, 4, 6), (CH₂)₂CHMeCH₂; R³ = H, Me] and 1-(trimethylsilyloxy)-4-methyl-3,4-dihydronaphthalene, easily obtained from R¹COCHR²R³ and Me₃SiCl, reacted with 1-bromoadamantane and TiCl₄ at -40 to -50° to give 62-89% α-adamantyl ketones I, useful as virucides. I (R¹R² = CH₂CH₂CHMeCH₂, R³ = H) was 3 times as active against the virus of Newcastle disease as 1-aminoadamantane, but only half as toxic.

Angewandte Chemie published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Safety of Ethyltert-butylacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ayala, Leticia published the artcileStereochemistry of Nucleophilic Substitution Reactions Depending upon Substituent: Evidence for Electrostatic Stabilization of Pseudoaxial Conformers of Oxocarbenium Ions by Heteroatom Substituents, Application In Synthesis of 5340-78-3, the publication is Journal of the American Chemical Society (2003), 125(50), 15521-15528, database is CAplus and MEDLINE.

Lewis acid-mediated nucleophilic substitution reactions of substituted tetrahydropyran acetates reveal that the conformational preferences of six-membered-ring cations depend significantly upon the electronic nature of the substituent. Nucleophilic substitutions of C-3 and C-4 alkyl-substituted tetrahydropyran acetates proceeded via pseudoequatorially substituted oxocarbenium ions, as would be expected by consideration of steric effects. Substitutions of C-3 and C-4 alkoxy-substituted tetrahydropyran acetates, however, proceeded via pseudoaxially oriented oxocarbenium ions. The unusual selectivities controlled by the alkoxy groups were demonstrated for a range of other heteroatom substituents, including nitrogen, fluorine, chlorine, and bromine. It is believed that the pseudoaxial conformation is preferred in the ground state of the cation because of an electrostatic attraction between the cationic carbon center of the oxocarbenium ion and the heteroatom substituent. This anal. is supported by the observation that selectivity diminishes down the halogen series, which is inconsistent with electron donation as might be expected during anchimeric assistance. The C-2 heteroatom-substituted systems gave moderately high 1,2-cis selectivity, while small alkyl substituents showed no selectivity. Only in the case of the tert-Bu group at C-2 was high 1,2-trans selectivity observed These studies reinforce the idea that ground-state conformational effects need to be considered along with steric approach considerations.

Journal of the American Chemical Society published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Application In Synthesis of 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Olmos, Andrea published the artcileMeasuring the Relative Reactivity of the Carbon-Hydrogen Bonds of Alkanes as Nucleophiles, Recommanded Product: Ethyltert-butylacetate, the publication is Angewandte Chemie, International Edition (2018), 57(42), 13848-13852, database is CAplus and MEDLINE.

We report quant. measurements of the relative reactivities of a series of C-H bonds of gaseous or liquid C_nH_2n+2 alkanes (n = 1-8, 29 different C-H bonds) towards in situ generated electrophiles (copper, silver, and rhodium carbenes), with methane as the reference This strategy surpasses the drawback of previous model reactions of alkanes with strong electrophiles suffering from C-C cleavage processes, which precluded direct comparison of the relative reactivities of alkane C-H bonds.

Angewandte Chemie, International Edition published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Recommanded Product: Ethyltert-butylacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Polanski, Jaroslaw published the artcileThe comparison of molecular surfaces by neural networks and its applications to quantitative structure activity studies, Safety of Ethyltert-butylacetate, the publication is Quantitative Structure-Activity Relationships (1998), 17(1), 27-36, database is CAplus.

Self-organizing Kohonen neural networks are used to obtain quant. structure-activity relationships. Simple mols. were selected to discuss the essential features of the transformation. Descriptors calculated from maps obtained from comparative studies with template mols. applied to the anal. of compounds derived from butane, as well as Et carboxylates and nitroanilines and aminobenzonitriles (sweet-tasting compounds) can be correlated with various mol. effects.

Quantitative Structure-Activity Relationships published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Safety of Ethyltert-butylacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Brown, Herbert C. published the artcileDicyclohexyliodoborane/triethylamine – a new reagent which achieves the facile enolboration of esters and tertiary amides, Application In Synthesis of 5340-78-3, the publication is Tetrahedron Letters (1992), 33(24), 3421-4, database is CAplus.

A smooth, rapid, quant. enolboration of esters and tertiary amides was achieved for the first time with dicyclohexyliodoborane, Chx₂BI, a new reagent, in the presence of triethylamine. E.g., treating EtCO₂Et with Chx₂BI and Et₃N in CCl₄ gave 96% (Z)-MeCH:C(OEt)OBChx₂, whereas EtCONMe₂ gave 96% (E)-MeCH:C(NMe₂)OBChx₂.

Tetrahedron Letters published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Application In Synthesis of 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Moore, Gordon G. published the artcilePreparation of hindered esters by the alkylation of carboxylate salts with simple alkyl halides, Category: esters-buliding-blocks, the publication is Journal of Organic Chemistry (1979), 44(14), 2425-9, database is CAplus.

Sterically hindered esters were prepared in excellent yields by the use of anion-exchange resins in both biphase and triphase systems. In addition, quant. yields of a variety of esters were obtained by the displacement reactions of simple aliphatic and aromatic K carboxylate salts and alkyl halides in Me₂CO or aqueous Me₂CO. Esters prepared in quant. yields included Et hexadecanoate in 95% Me₂CO and Et 2,4,6-trimethylbenzoate, 1-methylheptyl 2,4,6-trimethylbenzoate, and Et 9,10-epoxyoctadecanoate in pure Me₂CO. The 2nd-order rate constant for the reaction of K 2,4,6-trimethylbenzoate with iodoethane in 95% acetone was 2.67 × 10^-4 mL^-1s^-1 at 40°.

Journal of Organic Chemistry published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lion, Claude published the artcileSynthesis of hindered acid chlorides. Study of their condensation with Grignard reagents in the presence of copper salts. Preparation of highly branched ketones, Recommanded Product: Ethyltert-butylacetate, the publication is Journal of Chemical Research, Synopses (1978), 46, database is CAplus.

Sequential treatment of RCH₂CO₂R¹ (I; R = iso-Pr, R¹ = H) with R²X (R² = Me, Et, X = halide), SOCl₂, and EtOH gave 97-8% RCHR²CO₂Et (II). Similar alkylation of I (R = Me₃C, R¹ = Et) gave 92-6% II (R = Me₃C, R² = Me, Et). Further alkylation of the esters II (R = iso-Pr, Me₃C, R² = Me, Et) with R³X (R³ = iso-Pr, Et, X = halide) gave 32-81% RCR²R³CO₂Et, which on saponification gave 78-91% RCR²R³CO₂H (III). Treatment of III (R = iso-Pr, Me₃C, R² = Me, Et, R³ = iso-Pr; R = Me₃C, R² = R³ = Et) with SOCl₂ gave the corresponding acid chlorides which reacted with R⁴MgX (R⁴ = Me, X = I; R = neopentyl, Me₃C, X = Cl) in presence of CuCl to give 39-93% RCR²R³COR⁴.

Journal of Chemical Research, Synopses published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Recommanded Product: Ethyltert-butylacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

MacPhee, John A. published the artcileSteric limits to ester alkylation; synthesis of highly hindered esters via hexamethylphosphoramide-favored enolization, SDS of cas: 5340-78-3, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1977), 694-6, database is CAplus.

The steric limits to alkylation of carboxylic esters by alkyl iodides with LiN(CHMe2)2 as base in the presence of (Me2N)3PO were studied using a modification of R. H. Schlessinger et al. (1973) and the influence of (Me2N)3PO inpromoting ester enolization, as opposed to its influence on the alkylation step, was examined The formation of α,α-disubstituted from α-monosubstituted esters takes place in high yield and is only slightly influenced by the nature of the alkylating agent, whereas the formation of α,α,α-trisubstituted from α,α-disubstituted esters is sensitive to the steric nature of the ester to be alkylated. Thus in the synthesis of trisubstituted from monosubstituted esters the order of introduction of alkyl groups is critical. The failure of esters to react is interpreted by an inability to undergo enolization.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, SDS of cas: 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics