Category: 517-23-7

Zhang, Liang published the artcileSulfonium Salts Enable the Direct Sulfenylation of Activated C(sp³)-H Bonds, Synthetic Route of 517-23-7, the publication is European Journal of Organic Chemistry (2021), 2021(9), 1365-1369, database is CAplus.

Herein, the direct α-sulfenylation of a series of β-dicarbonyl, β-ketophosphonate, and β-ketonitrile compounds, mediated by sulfonium salts has been described. Traditionally, sulfonium salts which are synthesized by activation of dialkylsulfoxides serve as oxidizing agents or precursors of sulfur ylide. In this transformation, sulfonium salts as readily prepared and operationally simple sulfenylation reagents firstly achieved alkylsulfenylation of various activated C(sp³)-H bonds with the formation of tetra-substituted carbon center. Thus, e.g., sulfenylation of Me 2-oxocyclopentanecarboxylate with DMSO in presence of AcCl as activator and NaSbF₆ in MeCN afforded I (79%).

European Journal of Organic Chemistry published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C3H7NO2, Synthetic Route of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yu, Eric published the artcileHigh-yielding continuous-flow synthesis of antimalarial drug hydroxychloroquine, COA of Formula: C6H8O3, the publication is Beilstein Journal of Organic Chemistry (2018), 583-592, database is CAplus and MEDLINE.

Numerous synthetic methods for the continuous preparation of fine chems. and active pharmaceutical ingredients (API’s) have been reported in recent years resulting in a dramatic improvement in process efficiencies. Herein authors report a highly efficient continuous synthesis of the antimalarial drug hydroxychloroquine (HCQ). Key improvements in the new process include the elimination of protecting groups with an overall yield improvement of 52% over the current com. process. The continuous process employs a combination of packed bed reactors with continuous stirred tank reactors for the direct conversion of the starting materials to the product. This high-yielding, multigram-scale continuous synthesis provides an opportunity to achieve increase global access to hydroxychloroquine for treatment of malaria.

Beilstein Journal of Organic Chemistry published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C9H5ClO2, COA of Formula: C6H8O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Yongtao published the artcile1,5,7-Triazabicyclo[4.4.0]dec-5-ene Enhances Activity of Peroxide Intermediates in Phosphine-Free α-Hydroxylation of Ketones, SDS of cas: 517-23-7, the publication is Angewandte Chemie, International Edition (2021), 60(12), 6631-6638, database is CAplus and MEDLINE.

The critical role of double hydrogen bonds was addressed for the aerobic α-hydroxylation of ketones catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD), in the absence of either a metal catalyst or phosphine reductant. Exptl. and theor. investigations were performed to study the mechanism. In addition to initiating the reaction by proton abstraction, a more important role of TBD was revealed, i.e., to enhance the oxidizing ability of peroxide intermediates, allowing DMSO to be used rather than commonly used phosphine reductants. Further characterizations with nuclear Overhauser effect spectroscopy (NOESY) confirmed the presence of double hydrogen bonds between TBD and the ketone, and kinetic studies suggested the attack of dioxygen on the TBD-enol adduct to be the rate-determining step. This work should encourage the application of TBD as a catalyst for oxidations

Angewandte Chemie, International Edition published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C9H4F6O, SDS of cas: 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xie, Haopu published the artcileNovel titin-inspired high-performance polyurethanes with self-healing and recyclable capacities based on dual dynamic network, Category: esters-buliding-blocks, the publication is Polymer (2021), 124096, database is CAplus.

It is still a huge challenge that integrating excellent mech. performance and high healing efficiency into self-healing materials at the same time, even if numerous dynamic bonds have been explored in preparing of self-healing materials in the last 20 years. Herein, we reported a novel titin-inspired strategy to prepare the polyurethanes via introducing dual dynamic network which contained the phys. crosslinking of quadruple hydrogen bonds formed by 5-(2-hydroxyethyl)-6-methyl-2-aminouracil (UPy) dimers and the covalent crosslinking of Diels-Alder (D-A) bonds. Specially, relying on the synergistic effect of the dual dynamic network, the resulting polyurethane F50U50-PU exhibited admirable mech. performance, such as a super-high strength of 51.9 MPa, a superb toughness of 166.7 MJ/m3 and a large elongation at break of 930%. Meanwhile, on account of the dynamic feature of quadruple hydrogen bonds and D-A bonds, the resulting polyurethane showed a high heat-induced healing efficiency of 91.2%. More importantly, the polyurethanes could be recycled by hot-pressing process to regain their initial mech. properties and integrity. And it was also used as substrate to construct self-healing conductive device, which displayed splendid self-healing of elec. conductivity after damage. It can be envisioned that the polyurethanes with both superior mech. performance and high healing efficiencies have great application prospect in multifarious fields.

Polymer published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C15H21BO3, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wu, Bo published the artcileMutually-complementary structure design towards highly stretchable elastomers with robust strength and autonomous self-healing property, HPLC of Formula: 517-23-7, the publication is Polymer (2020), 122003, database is CAplus.

Achieving good transparency, high strength and superior extensibility simultaneously in autonomic self-healing elastomers remains challenging and fascinating. Herein, a complementary design strategy of combining densely distributed multiple hydrogen bonds and loosely packed spacer units in supramol. elastomer was reported to address the inherent contradiction of robust strength and room temperature self-healing. The chem. structure can be tuned to achieve a good compromise between the mech. properties and self-healing efficiency. The representative elastomers can achieve robust strength (6.81 MPa), high extensibility (2520%) and superior toughness with the dissipated energy up to 63.7 MJ/m³. Moreover, this elastomer is capable of recovering mech. fractures and routine scratches with the self-healing efficiency up to 90%, which are comparable to that of room-temperature self-healable counterparts. Spacer units with steric hindrance effect can facilitate segmental motions and dynamic changes of H-bonds. Meanwhile, the randomly distributed multiple H bonds crosslinking such spacers contribute to the good mech. performance and intriguing self-healing. In contrast to previous reports, this strategy provides an uncomplicated and cost-effective route to prepare robust elastomers that can self-heal at room temperature without any need of external assistance.

Polymer published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C11H22N2O4, HPLC of Formula: 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhao, Shilin published the artcileInfluence of Interactions among Three Biomass Components on the Pyrolysis Behavior, Computed Properties of 517-23-7, the publication is Industrial & Engineering Chemistry Research (2018), 57(15), 5241-5249, database is CAplus.

Pyrolysis experiments between 25 and 800° for three main components (cellulose, hemicellulose, and lignin) mixed in different proportions were conducted on a thermogravimetric analyzer (TGA) and pyrolysis-gas chromatog./mass spectrometer (Py-GC/MS). The interactions between the three main components during the pyrolysis of biomass were explored from two aspects, namely thermogravimetric properties and pyrolysis products. The results indicate that interactions existed among the three biomass components in the co-pyrolysis process. The presence of lignin significantly reduces the pyrolysis rate of cellulose and inhibits the formation of sugars (mainly levoglucosan) in the pyrolysis of cellulose and hemicellulose. However, the existence of cellulose or hemicellulose greatly promotes the pyrolysis of lignin to produce phenolic compounds This finding is meaningful for the application of biomass pyrolysis.

Industrial & Engineering Chemistry Research published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H6N2O, Computed Properties of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jiang, Meifen published the artcileFully Continuous Flow Synthesis of 3-Chloro-4-oxopentyl Acetate: An Important Intermediate for Vitamin B1, Quality Control of 517-23-7, the publication is Organic Process Research & Development (2021), 25(9), 2020-2028, database is CAplus.

A fully continuous flow synthesis of 3-chloro-4-oxopentyl acetate, an important intermediate for vitamin B1, was developed. This continuous flow manufacturing included two chem. transformations and an inline extraction step without intermediate purification and solvent exchange. In this work, the traditional synthetic route for batch operation was efficiently simplified via a series of separated screening tests in flows under various conditions. The authors found that the chlorination reaction can be carried out in only 30 s at room temperature by flow. The decarboxylation/acylation step was also simplified by using a cross-mixer, so that acetic anhydride was no longer required in the acylation reaction. A computational fluid dynamics simulation was carried out to study the improved micromixing of liquid-liquid two-phase streams. Finally, 3-chloro-4-oxopentyl acetate was obtained in a 90% isolated yield with a product purity of 96% and a total residence time of approx. 32 min. This fully continuous process was operated smoothly for 12 h, and approx. 19.1 g of the desired product was generated with a production rate of 1.79 g h^-1.

Organic Process Research & Development published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Quality Control of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Liang published the artcileHydroxymethylation of active methenyl compounds: DMSO as methylene source and H₂O as oxygen source, HPLC of Formula: 517-23-7, the publication is Tetrahedron Letters (2022), 153663, database is CAplus.

A mild and efficient method for hydroxymethylation of active methenyl compounds was described. In this transformation, the widely available solvents DMSO and water served as methylene and oxygen sources, resp. Under promotion of activator and base, the reaction could be used for the construction of a series of α-hydroxymethylated carbonyl compounds R¹COC(CH₂OH)R²R³ [R¹ = Me, Ph, Bn, 2-furyl, 2-thienyl; R² = CN, MeCO, MeO₂C, EtO₂C, t-BuO₂C, PhNHCO; R³ = Me, Et, Bn, etc.; R¹R³ = (CH₂)₃, H₂COCH₂, (CH₂)₄, etc.] with all-carbon quaternary carbon center in good to excellent yield.

Tetrahedron Letters published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C12H6NNaO4, HPLC of Formula: 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhao, Shilin published the artcileInfluence of Interactions among Three Biomass Components on the Pyrolysis Behavior, Computed Properties of 517-23-7, the publication is Industrial & Engineering Chemistry Research (2018), 57(15), 5241-5249, database is CAplus.

Pyrolysis experiments between 25 and 800° for three main components (cellulose, hemicellulose, and lignin) mixed in different proportions were conducted on a thermogravimetric analyzer (TGA) and pyrolysis-gas chromatog./mass spectrometer (Py-GC/MS). The interactions between the three main components during the pyrolysis of biomass were explored from two aspects, namely thermogravimetric properties and pyrolysis products. The results indicate that interactions existed among the three biomass components in the co-pyrolysis process. The presence of lignin significantly reduces the pyrolysis rate of cellulose and inhibits the formation of sugars (mainly levoglucosan) in the pyrolysis of cellulose and hemicellulose. However, the existence of cellulose or hemicellulose greatly promotes the pyrolysis of lignin to produce phenolic compounds This finding is meaningful for the application of biomass pyrolysis.

Industrial & Engineering Chemistry Research published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H6N2O, Computed Properties of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jiang, Meifen published the artcileFully Continuous Flow Synthesis of 3-Chloro-4-oxopentyl Acetate: An Important Intermediate for Vitamin B1, Quality Control of 517-23-7, the publication is Organic Process Research & Development (2021), 25(9), 2020-2028, database is CAplus.

A fully continuous flow synthesis of 3-chloro-4-oxopentyl acetate, an important intermediate for vitamin B1, was developed. This continuous flow manufacturing included two chem. transformations and an inline extraction step without intermediate purification and solvent exchange. In this work, the traditional synthetic route for batch operation was efficiently simplified via a series of separated screening tests in flows under various conditions. The authors found that the chlorination reaction can be carried out in only 30 s at room temperature by flow. The decarboxylation/acylation step was also simplified by using a cross-mixer, so that acetic anhydride was no longer required in the acylation reaction. A computational fluid dynamics simulation was carried out to study the improved micromixing of liquid-liquid two-phase streams. Finally, 3-chloro-4-oxopentyl acetate was obtained in a 90% isolated yield with a product purity of 96% and a total residence time of approx. 32 min. This fully continuous process was operated smoothly for 12 h, and approx. 19.1 g of the desired product was generated with a production rate of 1.79 g h^-1.

Organic Process Research & Development published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Quality Control of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics