Category: 517-23-7

Li, Shuangshuang; Qiu, Ju; Li, Bowen; Sun, Zuolian; Xie, Peizhong; Loh, Teck-Peng published an article in 2021, the title of the article was Practical allylation with unactivated allylic alcohols under mild conditions.Recommanded Product: 517-23-7 And the article contains the following content:

A practical palladium/calcium catalytic system was developed for dehydrative allylation with unactivated allylic alcs. EtOH solvent with a H2O additive was identified as powerful medium to accelerate proton transfer. This catalytic system and environmentally benign medium enabled a variety of soft carbonic nucleophiles and allylic alcs. to react smoothly at room temperature with water as the only byproduct. A wide spectrum of allylic compounds bearing a variety of functional groups I [R = Me, CN, CO2Et, etc.; R1 = CO2Me, CO2Et; R2 = CN, NO2, CO2Me, CO2Et; R3 = H, Me; R4 = H, Me; R5 = Ph, 2-FC6H4, 2-thienyl, etc.] could be obtained with high to excellent yields. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Recommanded Product: 517-23-7

The Article related to allylic compound green preparation, carbonic nucleophile allylic alc allylation palladium catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 517-23-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 5, 2021, Nugent, Jeremy; Sterling, Alistair J.; Frank, Nils; Mousseau, James J.; Anderson, Edward A. published an article.Category: esters-buliding-blocks The title of the article was Synthesis of α-quaternary bicyclo[1.1.1]pentanes through synergistic organophotoredox and hydrogen atom transfer catalysis. And the article contained the following:

Bicyclo[1.1.1]pentanes (BCPs) are of importance in drug design as sp3-rich bioisosteres of arenes and tert-Bu groups, however the preparation of BCPs with adjacent quaternary carbons is barely known. Authors report a facile synthesis of α-quaternary BCPs using organophotoredox and hydrogen atom transfer catalysis in which α-keto radicals, generated through oxidation of β-ketocarbonyls, underwent efficient addition to [1.1.1]propellane. The BCP products can be transformed into a variety of useful derivatives including enantioenriched BCPs featuring α-quaternary stereocenters. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Category: esters-buliding-blocks

The Article related to quaternary bicyclopentane preparation, ketoester ketoamide diketone ketonitrile synergistic organophotoredox hydrogen atom transfer, General Organic Chemistry: Synthetic Methods and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 5, 2022, Gao, Ya; Qin, Wei; Tian, Ming-Qing; Zhao, Xuefei; Hu, Xu-Hong published an article.COA of Formula: C6H8O3 The title of the article was Defluorinative Alkylation of Trifluoromethyl Alkenes with Soft Carbon Nucleophiles Enabled by a Catalytic Amount of Base. And the article contained the following:

Direct manipulation of readily accessible trifluoromethyl alkenes (TAs) represents an attractive approach to the preparation of diversified fluorine-containing compounds In this study, defluorinative alkylation reactions of TAs with a broad array of soft carbon nucleophiles have been documented. Nucleophilic substitutions occur enabled by a catalytic amount of base, providing access to tertiary alkyl substituted gem-difluoroalkenes and 2-fluoro-4H-pyrans. By extending the nucleophiles to silyl enol ethers, defluorination can be achieved in the absence of base to give gem-difluoroalkenes. This process, which eliminates the requirement of organometallic reagents, transition metals, or strong bases for the C-F bond cleavage, is applicable to late-stage modification of complex mols. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).COA of Formula: C6H8O3

The Article related to gem difluoroalkene fluoro pyran preparation, trifluoromethyl alkene soft carbon nucleophile defluorinative alkylation, General Organic Chemistry: Synthetic Methods and other aspects.COA of Formula: C6H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Delamare, Aline; Naulet, Guillaume; Kauffmann, Brice; Guichard, Gilles; Compain, Guillaume published an article in 2022, the title of the article was Hexafluoroisobutylation of enolates through a tandem elimination/allylic shift/hydrofluorination reaction.Recommanded Product: 517-23-7 And the article contains the following content:

The first general method to introduce the hexafluoroisobutyl group into ketoesters, malonates, 1,3-diketones, Schiff base esters and malononitrile C(R)(R1)(R2)CH2CH(CF3)2 [R = C(O)Me, C(O)OEt, C(O)C6H5, etc.; R1 = C(O)OEt, C(O)Me, CN, etc.; R2 = Me, i-Pr, Bn, etc.] was reported. The reaction occurs through an elimination/allylic shift/hydrofluorination cascade process which efficiently overcomes the usual fluoride β-elimination observed with α-CF3-vinyl groups. The alkali metal bases, a pentafluorinated alkene is obtained predominantly, whereas the use of tetrabutylammonium fluoride (TBAF) allows hydrofluorination to occur. This tandem process represents a conceptually new pathway to synthesize bis-trifluoromethylated compounds This methodol. was applied to the multigram-scale synthesis of enantiopure (S)-5,5,5,5′,5′,5′-hexafluoroleucine. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Recommanded Product: 517-23-7

The Article related to hexafluoisobutyl ester malononitrile preparation, enolate bromomethyl hexafluoropropane tandem hexafluoroisobutylation elimination hydrofluorination reaction, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 517-23-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Xin; He, Songtao; Song, Qiuling published an article in 2020, the title of the article was Enantio- and diastereoselective diarylmethylation of 1,3-dicarbonyl compounds.Computed Properties of 517-23-7 And the article contains the following content:

A Cu-catalyzed enantio- and diastereoselective diarylmethylation of 1,3-dicarbonyl compounds RC(O)CH(R1)C(O)R2 (R = Et, 4-methoxyphenyl, cyclohexyl, thiophen-2-yl, etc.; R1 = H, Me; R2 = Me, OMe, OEt, O(i-Pr); RR1 = -(CH2)3-, -(CH2)4-, -(CH2)2O-) and Me 1-oxo-2-indancarboxylate is described. It is a successful example of constructing all-carbon quaternary stereocenters from 3°C-H nucleophiles, a challenging topic in synthetic chem. In the present work, two contiguous stereocenters I (R3 = R4 = Me, t-Bu, i-Pr, TMS, Ph; R3 = Me, R4 = t-Bu; Ar = naphthalen-2-yl, 1-benzofuran-2-yl, 2,3-dihydro-1,4-benzodioxin-6-yl, thiophen-2-yl, etc.) are constructed with high levels of stereoselectivity and atom economy. The broad scope of 1,3-dicarbonyl nucleophiles and the tolerance of a wide range of functional groups make this protocol of great importance in the synthesis of chiral diarylmethane compounds I. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Computed Properties of 517-23-7

The Article related to chiral diarylmethane preparation enantioselective diastereoselective, dicarbonyl compound quinone methide diarylmethylation copper indenooxazole catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Computed Properties of 517-23-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 23, 2020, Tanemura, Kiyoshi; Rohand, Taoufik published an article.Name: 3-Acetyldihydrofuran-2(3H)-one The title of the article was Silica gel-mediated catalyst-free and solvent-free Michael addition of 1,3-dicarbonyl compounds to highly toxic methyl vinyl ketone without volatilization. And the article contained the following:

Silica gel-mediated Michael addition of 1,3-dicarbonyl compounds to Me vinyl ketone (MVK) and Et vinyl ketone (EVK) was carried out to give the corresponding adducts in quite excellent yields. The reactions could be carried out without any catalysts and solvents. In addition, highly toxic MVK and EVK could be employed without significant volatilization. Silica gel could be recycled five times without the decrease of the yields. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Name: 3-Acetyldihydrofuran-2(3H)-one

The Article related to dicarbonyl compound methyl vinyl ketone silica gel michael addition, ethyl vinyl ketone dicarbonyl compound silica gel michael addition, General Organic Chemistry: Synthetic Methods and other aspects.Name: 3-Acetyldihydrofuran-2(3H)-one

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 8, 2020, Qin, Zezhao; Yu, Xiaofeng; Wu, Haiyang; Yang, Lei; Lv, Hongying; Yang, Xiaoniu published an article.Related Products of 517-23-7 The title of the article was Injectable and Cytocompatible Dual Cross-Linking Hydrogels with Enhanced Mechanical Strength and Stability. And the article contained the following:

Injectable hydrogels have become increasingly important in the fields of tissue engineering and drug delivery. However, their biol. applications are greatly limited by the weak mechanics and poor stability under a physiol. environment. Herein, we developed a stable, strong, and injectable hydrogel by linking strong micelle crosslinking with tetra-armed PEG. This dual crosslinking strategy has not only made hydrogels nonswelling but also maintained the relative integrity of the gel network during the degradation process, both of which work together to ensure the mech. strength and stability of our hydrogel under a physiol. environment. A compressive stress of 40 MPa was achieved at 95% strain, and the mech. properties could remain stable even after immersion into a physiol. environment for two months. Besides, it also showed outstanding antifatigue properties, good tissue adhesion, and good cytocompatibility. On the basis of these characteristics, these dual crosslinking injectable hydrogels would find appealing application in biomedicine especially for the repair of load-bearing soft tissues. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Related Products of 517-23-7

The Article related to injectable cytocompatible crosslinking hydrogel strength stability, degradation, high strength, hydrogel, injectable, stability, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Related Products of 517-23-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 1, 2021, Wang, Mengdan; Yang, Yajie; Yin, Liqiang; Feng, Ye; Li, Yanzhong published an article.Category: esters-buliding-blocks The title of the article was Selective Synthesis of Pyrano[3,2-b]indoles or Cyclopenta[b]indoles Tethered with Medium-Sized Rings via Cascade C-C σ-Bond Cleavage and C-H Functionalization. And the article contained the following:

Highly atom-economical tandem reactions have been developed for the synthesis of pyrano[3,2-b]indoles or cyclopenta[b]indoles tethered with 7-, 8-, or 9-membered rings. These reactions first undergo a carbon-carbon σ-bond cleavage reaction of cyclic β-ketoesters. Next, in the presence of CuCl2 and Ag2CO3, intramol. O-H/C-H coupling occurs to give pyrano[3,2-b]indoles. This is the first example for capture of the enoloxyl radical of the intramol. C-O bond formation reaction, whereas C3 nucleophilic addition afforded cyclopenta[b]indoles using TsOH·H2O. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Category: esters-buliding-blocks

The Article related to pyranoindole tethered ring preparation cascade cyclization alkynone cyclic ketone, cyclopenta indole tethered ring preparation cascade cyclization alkynone, Heterocyclic Compounds (One Hetero Atom): Pyrans and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 5, 2021, Kieslich, David; Christoffers, Jens published an article.Application of 517-23-7 The title of the article was Formation of δ-Lactones by Cyanide Catalyzed Rearrangement of α-Hydroxy-β-oxoesters. And the article contained the following:

δ-Valerolactone derivatives such as I are formed by cyanide-catalyzed ring-transformation of cyclic α-hydroxy-β-oxoesters such as II (R = HO). This unprecedented reaction defines a new synthetic methodol., and the products are obtained in up to quant. yields. Several alkyl substitutions as well as different ester residues are tolerated. Furthermore, benzo- and heteroarene-annulated starting materials such as II (R = HO) are converted without difficulty. As an addnl. benefit, the starting materials are straightforwardly accessed by cerium-catalyzed aerobic α-hydroxylation of readily available β-oxoesters such as II (R = H). The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Application of 517-23-7

The Article related to valerolactone preparation, cyclic hydroxyoxoester preparation ring transformation cyanide catalyst, oxoester aerobic hydroxylation cerium catalyst, Heterocyclic Compounds (One Hetero Atom): Pyrans and other aspects.Application of 517-23-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 2020, Rajmani Singh, Rahul Kumar; Karsili, Tolga N. V.; Srivastava, Radhey published an article.Related Products of 517-23-7 The title of the article was Copper-catalyzed enantioselective direct α-C-H amination of β-dicarbonyl derivatives with aryl hydroxylamines and mechanistic insights. And the article contained the following:

Authors report a novel and efficient Cu-catalyzed direct asym. amination of tertiary β-carbonyl compounds using aryl hydroxylamine as electrophilic nitrogen donor. The process facilitates the convenient and direct synthesis of chiral α-amino carbonyl derivatives, without the need for any post-reaction manipulation. This method reveals an effective strategy for the synthesis of enantioenriched α-C-H aminated derivatives which is hitherto challenging. The choice of the robust chiral indabox ligand was ascertained to be very crucial for the desired enantioselectivity in the contemporary transformation. The reaction mechanism is fully supported by ab initio electronic structure calculations The reaction is facile, efficient and performs well at room temperature with an enantiomeric excess (ee) up to 93%. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Related Products of 517-23-7

The Article related to anilino benzoyl tetrahydrofuranone preparation enantioselective copper catalyst, carbonyl beta lactone hydroxylamine amination, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Related Products of 517-23-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics