Category: 50413-30-4

Adding a certain compound to certain chemical reactions, such as: 50413-30-4, name is Methyl 2-amino-4-methoxylbenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50413-30-4, Quality Control of Methyl 2-amino-4-methoxylbenzoate

Methyl 2-amino-4-(methyloxy) benzoate (3.78 g, 20.86 mmol) was dissolved in 25 mL of water, 15 mL of ethanol and 2.2 mL of concentrated HCl. A solution of ICl (1.1 mL, 21.9 mmol) in 3.8 mL concentrated HCl and 14 mL of water at 5 C was added to the aniline solution. The reaction was stirred overnight and was then filtered to obtain 6.9 g of a light brown solid. MS: m/z: 308 [M+H]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-4-methoxylbenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GlaxoSmithKline Intellectual Property Development Limited; BURY, Michael, Jonathan; CASILLAS, Linda, N.; CHARNLEY, Adam, Kenneth; DEMARTINO, Michael, P.; DONG, Xiaoyang; EIDAM, Patrick, M.; HAILE, Pamela, A.; MARQUIS, Robert, W., Jr.; RAMANJULU, Joshi, M.; ROMANO, Joseph, J.; SINGHAUS, Robert, R., Jr.; SHAH, Ami, Lakdawala; WANG, Gren; (82 pag.)EP2744501; (2016); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50413-30-4, name is Methyl 2-amino-4-methoxylbenzoate, This compound has unique chemical properties. The synthetic route is as follows., Safety of Methyl 2-amino-4-methoxylbenzoate

Example 1 : methyl 4-methoxy-2-[(3-UQ-methgammal-lH-imidazol-4-yl)sulfonyllamino} quinoxalin-2-yl)aminolbenzoate; N-(3-chloroquinoxalin-2-yl)-l -methyl- lH-imidazole-4-sulfonamide (2 g; 6.2 mmol; 1 eq) and methyl 2-amino-4-methoxybenzoate (1.2 g; 6.8 mmol; 1.1 eq) are taken up in water (60 mL) and acetic acid (160 muL; 3.65 mmol; 0.6 eq) is added. The suspension is heated up to 1700C in the microwave under normal absorption for 20 min. The reaction is stopped by filtration of the solid and washing with water until neutral. The orange powder obtained is dried under vaccum at 400C overnight then taken up in DCM. Triethylamine (1.72 mL) is added. After sonication, the solvents are removed under reduced pressure and the residue obtained is washed with water then dried under vacuum at 400C overnight. The powder is taken up in MeOH and refluxed then the suspension is left at 4C for Ih. The precipitate is filtered and washed with MeOH then dried under vacuum at 4O0C for 2 days, to afford 1.68 g (58%) of the title compound as a yellow powder. 1H NMR (DMSO-Ci6) O 11.77 (s, IH), 9.05 (d, J= 2.3 Hz, IH), 8.10-7.95 (m, 2H), 7.90 (s, IH), 7.85-7.76 (m, IH), 7.73-7.60 (m, IH), 7.55-7.35 (m, 2H), 6.73 (dd, J= 8.6, 2.2 Hz, IH), 3.91 (s, 6H), 3.72 (s, 3H). HPLC (max plot) 100%; Rt 4.12 min. LC/MS: (ES+): 469.0, (ES-): 467.1 .

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 50413-30-4.

Reference:
Patent; LABORATOIRES SERONO SA; WO2008/101979; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics