Category: 5003-48-5

The comparative gastric ulcerogenic activities of nonsteroid antiinflammatory drugs was written by Rainsford, K. D.. And the article was included in Agents and Actions in 1977.Synthetic Route of C17H15NO5 The following contents are mentioned in the article:

A new gastric assay was employed to screen for the ulcerogenic activity of non-steroid antiinflammatory (NSAI) analgesics. The technique involves exposing rats to brief periods of cold stress, which is not itself sufficient to cause mucosal damage, but does specifically sensitize the stomach to irritant or ulcerogenic actions of NSAI drugs. The assessment of gastric ulcerogenicity of some well-known antiinflammatory/analgesic drugs using this new assay was shown to agree well with clin. reports of the occurrence of gastric ulceration and hemorrhage. This assay was employed to screen for the ulcerogenicity of some new antiinflammatory drugs and for potential drug interactions resulting from administration of certain frequently used combinations of these drugs. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Synthetic Route of C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Use of inhibitors of prostaglandin synthesis in patients with breast cancer was written by Powles, T. J.;Dady, P. J.;Williams, Judith;Easty, G. C.;Coombes, R. C.. And the article was included in Advances in Prostaglandin and Thromboxane Research in 1980.Product Details of 5003-48-5 The following contents are mentioned in the article:

Effects of antiinflammatory and antiosteolytic agents were studied in patients with breast cancer, since it is known that some human breast tumors release osteolytic substances which cause breakdown of bone. Benoral (I) [5003-48-5], an aspirin-paracetamol conjugate, prevented bone metastasis in rats, but I (4 g twice a day for 18 mo) given to patients with breast cancer did not affect overall development of bone metastasis. In breast cancer patients with osteolytic bone metastasis, aspirin [50-78-2] and indomethacin [53-86-1] had no antiosteolytic activity; flurbiprofen [5104-49-4], calcitonin [9007-12-9], and mithramycin [18378-89-7] had some antiosteolytic activity but in terms of cancer therapy this was trivial. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Product Details of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and pharmacological properties of eterylate, a new derivative of acetylsalicylic acid was written by Sunkel, C.;Cillero, F.;Armijo, M.;Pina, M.;Alonso, S.. And the article was included in Arzneimittel-Forschung in 1978.Recommanded Product: 5003-48-5 The following contents are mentioned in the article:

Eterylate (I) [62992-61-4] was prepared by coupling p-(2-hydroxyethoxy)acetanilide [50375-15-0] with o-acetoxybenzoyl chloride [5538-51-2] and tested for antiinflammatory and analgesic activities. The activities of I were similar to those of acetylsalicylic acid and benorylate in equimol. doses. The oral LD₅₀ in mice for I, benorylate, and acetylsalicylic acid, were 3160, 1551, and 1259 mg/kg, resp. The gastrointestinal lesions observed after treatment for 30 days revealed that both I and benorylate were tolerated better than acetylsalicylic acid. Further, I had the advantage of causing less gastric lesioning and less hemorrhaging. Phys. and chem. properties of I are discussed. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Recommanded Product: 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esterase activity in rat hepatocytes was written by Williams, Faith M.;Mutch, Elaine;Blain, Peter G.. And the article was included in Biochemical Pharmacology in 1991.Product Details of 5003-48-5 The following contents are mentioned in the article:

Hydrolysis of acetylsalicylate, benorylate, phenetsal, fluazifop Bu, and paraoxon has been studied with freshly isolated rat hepatocytes maintained as a monolayer. Acetylsalicylate and paraoxon were the poorest substrates for hydrolysis, whereas benorylate was hydrolyzed 100-fold faster. Phenetsal and fluazifop Bu were both hydrolyzed at 1/10 of the rate of benorylate. Inhibitor studies with paraoxon, BNPP, and physostigmine indicated the involvement of different carboxylesterase isoenzymes. Studies with acetylsalicylate indicated that uptake of the substrate into the hepatocyte may influence the rate of formation of the hydrolysis product. Studies of hydrolysis in hepatocytes more closely reflect in vivo hepatic hydrolysis than subcellular fractions as cytosolic and microsomal esterases can act in parallel. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Product Details of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Determination of residual solvents in Benorilate by headspace gas chromatography was written by Yang, Xujian;You, Qiuping;Huang, Yanna;Chen, Haitao;Chen, Zilong. And the article was included in Jinri Yaoxue in 2014.Recommanded Product: 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Objective: To establish a method of headspace gas chromatog. for the determination of the residual solvents in Benorilate. Methods: The Anal. Technol. AT · OV-1301 capillary column (30 m × 0.32 mm × 1.00 μm) with a flame ionization detector (FID) was adopted, and nitrogen gas was used as carrier. The temperatures of the injector inlet and the detector were set at 200°C and 250, resp. Split ratio was 2 : 1, and the flow rate was 1.0 mL/min. The column temperature was 100°C. Samples were equilibrated at 85°C for 30 min. External standard method was used with the dimethylacetylamide as solvent. Results: Excellent resolution and good linear calibration curves of the residual solvents were obtained. Conclusion: This accurate and sensitive method can be applied in the detection of residual solvents in Benorilate. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Recommanded Product: 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Determination of benorilate in pharmaceutical formulations and its metabolite in urine at carbon paste electrode modified by silver nanoparticles was written by Wang, Cheng Yin;Hu, Xiao Ya. And the article was included in Talanta in 2005.Related Products of 5003-48-5 The following contents are mentioned in the article:

Benorilate was determined by the differential pulse voltammetry (DPV) using a carbon paste electrode modified by silver nanoparticles in 1.25 × 10^-3 mol l^-1 KH₂PO₄ and Na₂HPO₄ buffer solution (pH = 6.88, 25 °C) . The anodic peak potential was +0.970 V (vs. SCE). A good linear relationship was realized between the anodic peak currents and benorilate concentrations in the range of 1.0 × 10^-7 to 2.5 × 10^-4 mol l^-1 with the detection limit of 1.0 × 10^-8 mol l^-1. The recovery was 95.2-103.6% with the relative standard deviation of 3.6% (n = 9). The pharmaceutical preparations, benorilate tablets samples and its metabolite (salicylic acid) in urine were determined with the desirable results. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Related Products of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Determination of pediatric benorilate and vitamin B₁ granules by HPLC was written by Gu, Qiuqin. And the article was included in Zhongguo Yaoshi (Wuhan, China) in 2010.Safety of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

The objective of this study is to establish an HPLC method for the determination of benorilate and vitamin B₁ in pediatric benorilate and vitamin B₁ granules. The Shim-pack VP-ODS (150 mm × 4.6 mm, 5 μm) column was used. The mobile phase consisted of methanol and 0.005 mol/L^-1 heptane sulfonic acid sodium solution(50:50, pH adjusted to 3.5 with phosphoric acid). The flow rate was 1.0 mL/min^-1 with a detector wavelength at 260 nm and column temperature was 30°. The linear range of benorilate was 18.052-162.468 mg/L^-1 (r = 0.9999, n = 5), the average recovery was 100.2% (RSD = 1.2%, n = 6). The linear range of vitamin B₁ was 5.956-53.604 mg/L^-1 (r = 0.9999, n = 5), the average recovery was 99.3% (RSD = 2.1%, n = 6). This method is simple, accurate, and suitable. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Safety of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Safety of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Decrease of inorganic blood sulfate following treatment with selected antirheumatic drugs: potential consequence for articular cartilage was written by De Vries, B. J.;Van der Kraan, P. M.;Van den Berg, W. B.. And the article was included in Agents and Actions in 1990.Reference of 5003-48-5 The following contents are mentioned in the article:

The elimination kinetics of inorganic blood sulfate in mice was followed for 4 h after a single, oral administration of an antirheumatic drug. Sodium salicylate, aspirin, diflunisal, and benorylate, all in a dose of 1.25 mmol/kg, reduced the sulfate level to less than half that of control. This phenomenon was also demonstrated by phenylbutazone, oxyphenbutazone (both 1 mmol/kg), chloroquine diphosphate (0.6 mmol/kg), and tiaprofenic acid (0.02-0.35 mmol/kg). Niflumic acid (1.08 mmol/kg), piroxicam (0.03 mmol/kg), indomethacin (6.10^-3 mmol/kg), diclofenac (5.10^-3 mmol/kg), ketoprofen (0.2 mmol/kg), naproxen (0.08 mmol/kg), and ibuprofen (0.24 mmol/kg) possessed no sulfate-lowering properties. The potential relevance of the use of sulfate-lowering drugs for articular cartilage integrity is discussed. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Reference of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Reference of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Evaluation of benorylate and its active metabolites by HPLC and comparative bioavailability investigation in human plasma was written by Chen, Jun;Tu, Xide;Gao, Jie. And the article was included in Zhongguo Yaoke Daxue Xuebao in 1995.Formula: C17H15NO5 The following contents are mentioned in the article:

An anal. method of HPLC was developed which detected benorylate and its active metabolites in order to compare the bioavailability in human plasma. Extraction from plasma was carried out in two steps with ether and acetate. The separation was performed on the YWG C₁₈ column with mobile phase of methanol-pH 2.1 phosphate buffer (60:50) at 238 nm of detection wavelength. The lowest limit was 50 ng for paracetamol and salicylic acid. The mean recoveries in plasma were 97.57 ± 6.15%, 97.43 ± 4.39% for SA and PA resp. The plasma concentration of 8 healthy volunteers after taking benorylate tablet A (500 mg × 9) and B (400 mg × 9) was detected. The results showed that the maximum plasma concentration of SA was 113.05 μg/mL from tablet A and 131.78 μg/mL from B; the top time was 2.5 and 2.0 h for A and B resp. The relative bioavailability of B to A was 125.59%. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Formula: C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Influence factors of the release rate of benorilate from sustained-release matrix tablets was written by Chen, Daiyong;Zang, Zhihe;Yang, Wanqing;Zhao, Miao. And the article was included in Di-San Junyi Daxue Xuebao in 2004.Category: esters-buliding-blocks The following contents are mentioned in the article:

To study the influence factors of the release rate of benorilate from sustained-release matrix tablets, the matrix tablets of benorilate were prepared by using hydroxypropylmethylcellulose (HPMC) as the matrix material. The effects of the contents of HPMC, polyvinyl pyrrolidone (PVP), and microcrystaline cellulose (MCC), and the method of preparation on in vitro drug release were studied by evaluating the n value in the Peppas equation. The results showed that the increasing HPMC content led to the decrease of benorilate release. However, PVP and MCC used in this experiment accelerated the benorilate release from the tablets. The drug released from the tablet prepared by dry method was faster than that by wet method. The contents of HPMC, PVP and MCC, especially HPMC, have effects on the release rate of benorilate, but the two preparation methods have less effect. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Category: esters-buliding-blocks).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics