Category: 5003-48-5

Benorylate interaction with ethoxybenzamide and lorazepam was written by Huh, In Hoi;Lee, Myung Hwan. And the article was included in Yakhak Hoechi in 1979.COA of Formula: C17H15NO5 The following contents are mentioned in the article:

Concurrent administration of equal doses of benorylate (I) [5003-48-5] and ethoxybenzamide [27043-22-7] increased the inhibiting effect on the acetic acid-induced writhing syndrome of mice over that obtained with each drug alone and similarly increased the analgesic response to the hot plate method. The synergistic analgesic effect of the combined administration of I and lorazepam [846-49-1] was also significant. The antipyretic effect of the combined administration of half-doses of I and ethoxybenzamide on rat pyrexia induced by yeast or TTG was similar to that obtained with each drug sep. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5COA of Formula: C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.COA of Formula: C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The effect of anti-inflammatory drugs on retinal dystrophy in the rat was written by Dewar, A. J.;Barron, Gillian;Reading, H. W.. And the article was included in Toxicology and Applied Pharmacology in 1977.Application In Synthesis of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

The effects of acetylsalicylate [50-78-2], cortisone acetate [50-04-4], and Benorylate and (4-acetamidophenyl 2-acetoxybenzoate) [5003-48-5] on the process of retinal degeneration in albino and pigmented retinal dystrophic rats were examined Chronic administration of these agents for periods up to 8 wk elicited no improvement observable histol. in either the albino or pigmented strains, although all 3 drugs produceda marginal reduction in the loss of retinal DNA in the former. Thus, chronic antiinflammatory drug administration is largely ineffective in retarding the progress of retinal degeneration in the retinal dystrophic rat. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Application In Synthesis of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effect of eterylate, benorylate and acetylsalicylic acid on glycemia in normal and experimental diabetic rats was written by Alonso, S.;Ortega, M. P.;Armijo, M.. And the article was included in Archivos de Farmacologia y Toxicologia in 1983.Computed Properties of C17H15NO5 The following contents are mentioned in the article:

The effects of acetylsalicylic acid (I) [50-78-2] on blood sugar levels in normal and streptozotocin-diabetic rats were compared with those of its (acetylamino)phenyl ester, benorylate (II) [5003-48-5], and its [(acetylamino)phenoxy]ethyl ester, eterylate [62992-61-4], at equimolar doses. All 3 drugs had a hypoglycemic effect in diabetic animals when administered orally at a high dose (500 mg/100 g feed, calculated as I), but only II decreased blood sugar levels in normal rats. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Computed Properties of C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Preparation and characterization of aspirin and benorilate was written by Wang, Jin;Sun, Wei. And the article was included in Huaxue Yu Nianhe in 2009.SDS of cas: 5003-48-5 The following contents are mentioned in the article:

Aspirin was synthesized with using sodium acetate as the catalyst. The dosage of the catalyst, the reaction time and temperature which had effects on the yield of aspirin was studied. The results showed that sodium acetate had better catalytic activity, when the dosage of sodium acetate, in the system was 3%, reaction temperature was 55 °C, reaction time was 50 min, and the yield of aspirin could reach 81.9%. The synthesis process of benorilate which taken aspirin and acetaminophen as raw materials was improved and the effect of different solvents on the yield of benorilate was investigated. The yield of benorilate was up to 90% in the system of toluene-water medium. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5SDS of cas: 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.SDS of cas: 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effect of indomethacin on the cyclic AMP-dependent protein kinase was written by Catalan, R. Edgardo;Aragones, Maria D.;Martinez, A. M.;Armijo, Manuel;Pina, Manuel. And the article was included in European Journal of Pharmacology in 1980.Safety of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Indomethacin (I) [53-86-1] inhibited cyclic AMP-dependent protein kinase [9026-43-1] activity in small intestine in in vivo experiments An inverse pattern of variation was exhibited by acetylsalicylic acid [50-78-2], eterylate [62992-61-4], and benorylate [5003-48-5]; acetyl-p-aminophenol [103-90-2] was inactive. Indomethacin, acetylsalicylic acid, eterylate, and benorylate increased protein kinase activity in liver, lung, and heart. The in vivo effect of indomethacin was confirmed by in vitro experiments with small intestine and heart protein kinases. Indomethacin may affect protein kinase activity in a tissue-specific way. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Safety of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Safety of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Absence of mutagenic activity of benorylate, paracetamol and aspirin in the Salmonella/mammalian microsome test was written by Jasiewicz, M. L.;Richardson, J. C.. And the article was included in Mutation Research Letters in 1987.Application of 5003-48-5 The following contents are mentioned in the article:

Benorylate  [5003-48-5] and its 2 major hydrolysis products, paracetamol  [103-90-2], and aspirin  [50-78-2], were examined for mutagenicity in the Salmonella/mammalian microsome screening test. The compounds were tested in 6 strains of S. typhimurium in the presence and absence of a rat-liver microsome activation system. Benorylate did not show evidence of mutagenic activity, with or without metabolic activation, at 0.006-3 mg/plate. Paracetamol and aspirin likewise did not show any evidence of mutagenic activity at 0.1-50 and 0.01-50 mg/plate, resp. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Application of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Specificity data of the salicylate assay by fluorescent polarization immunoassay was written by Koel, Marlies;Nebinger, Peter. And the article was included in Journal of Analytical Toxicology in 1989.Product Details of 5003-48-5 The following contents are mentioned in the article:

The recently developed Abbott Laboratories fluorescent polarization immunoassay (FPIA) for salicylates in serum was studied. The cross-reactivity test of the assay was performed with 20 substances that showed a similar chem. structure as salicylic acid. A chem. substitution on the 5-position of the salicylate formula enhanced the cross-reactivity. 5-Methylsalicylic acid, diflunisal, salazosulfapyridin, and 5-aminosalicylic acid (5-ASA) showed a significant cross-reactivity with 1200%, 222%, 153%, and 122%, resp. Diflunisal and salazosulfapyridin at a similar therapeutic serum level as salicylic acid can produce false pos. salicylate results, in case of unknown medication of these compounds This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Product Details of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Passive absorption simulated by active principles on artificial lipid membranes was written by Robert, H.;Guyot-Herdmann, A. M.;Lefebvre, C.. And the article was included in Lille Medical (1956-1981) in 1980.Recommanded Product: 5003-48-5 The following contents are mentioned in the article:

The apparatus of Dibbern and Resomat was used for the study of the simulation of the digestive absorption of active ingredients, alone or in the galenic form, as a function of pH. The artificial membrane was made of a polyamide or cellulose acetate impregnated with lipids and phospholipids. The plasmatic phase used was a phosphate buffer (pH 7.35) and the digestive medium was an enzyme-free artificial gastric liquid (pH 1.2). Absorption curves of compounds such as Na salicylate [54-21-7], phenobarbital [50-06-6], and papaverine [58-74-2], as a function of pH are given. The effect of excipients on the absorption of active ingredients in galenic form was also studied by this apparatus This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Recommanded Product: 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Comparative studies of the acute and chronic toxicity of eterylate, benorylate and acetylsalicylic acid was written by Alonso, S.;Priego, J.;Maroto, L.;Ortega, P.. And the article was included in Archivos de Farmacologia y Toxicologia in 1978.Computed Properties of C17H15NO5 The following contents are mentioned in the article:

The acute toxicity of acetylsalicylic acid (I) [50-78-2], was greater than that of benorylate (II) [5003-48-5], and this was greater than that of eterylate (III) [62992-61-4]. In rats given 250 mg I or its equivalent of II or III/100 g, body weight was decreased by I and not affected by II or III. Gastric alterations and kidney lesions were some of the signs of chronic toxicity observed Coagulation time was increased most markedly in II-treated animals. No alterations in blood and liver parameters were noted. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Computed Properties of C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Preparation and quality control of benorilate dispersible tablets was written by Zhang, Hua;Xu, Yuhua;Wang, Xiaona;Cheng, Suoming;Wu, Shuxia. And the article was included in Zhongguo Yaoye in 2011.Product Details of 5003-48-5 The following contents are mentioned in the article:

The preparation technol. and the quality control method of benorilate dispersible tablets were studied. The variety of auxiliary materials was selected by the disintegration time as index, and the 5 min accumulation of dissolution was determined by UV spectrophotometry. The optimal prescription was screened by the orthogonal design method. The optimal formulation contained 20% microcrystalline cellulose, 6.0% sodium carboxymethyl starch, 1.0% starch. Benorilate dispersible tablets prepared by the optimal prescription had better dissolution, 90% was dissol. in 15 min and complete disintegration was within 2.5 min, which accorded with the other indexes of the dispersible tablets. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Product Details of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics