Category: 5003-48-5

Study on synthesis of some paracetamol derivatives was written by Truong, Phuong;Huynh, Thi Hai Van;Trinh, My Hoang. And the article was included in Tap Chi Duoc Hoc in 2009.Reference of 5003-48-5 The following contents are mentioned in the article:

Propacetamol hydrochloride and benorilate (paracetamol derivatives) were obtained from low-cost materials, such as aspirin [i.e., 2-(acetyloxy)benzoic acid], paracetamol, SOCl₂, chloroacetic acid and diethylamine. The process was simple and appropriate for Vietnamese manufacturing conditions. The purity of propacetamol hydrochloride and benorilate was confirmed by thin layer chromatog. Propacetamol hydrochloride was assayed by non-aqueous titration method while benorilate was determined by application of a nitrogen method. Both products conformed to standards by BP 2005. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Reference of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Studies on the antinflammatory and analgesic effects of eterylate, benorylate and acetylsalicylic acid was written by Pina, M.;Armijo, M.. And the article was included in Archivos de Farmacologia y Toxicologia in 1978.Related Products of 5003-48-5 The following contents are mentioned in the article:

In rats in which edema was provoked by injection of carrageen, eterylate (I) [62992-61-4], benorylate (II) [5003-48-5], and acetylsalicylic acid (III) [50-78-2] (100,158.48, and 251.18 mg/kg, resp.) showed the same degree of antiinflammatory activity. III, at 200, 300, and 450 mg/kg, and the equivalent doses of I and II had the same analgesic effect in rats. The 50% EDs were 156.13, 185.51, and 251.41 for I, II, and III, resp. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Related Products of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Optimization of synthesis process of benorilate was written by Ma, Yan. And the article was included in Huagong Shikan in 2014.Computed Properties of C17H15NO5 The following contents are mentioned in the article:

The purpose of the research is to optimize the synthesis process of benorilate by designing orthogonal test using esterification reaction solvent, esterification time and phase transfer catalyst as single factors. The influence degree of esterification reaction solvent, esterification time and phase transfer catalyst to the yield of benorilate is: solvent >time >phase transfer catalyst. The best combination on synthesis of benorilate was as follows: using benzene as solvent, esterification time of 1.5h, and using tetrabutylammonium bromide as phase transfer catalyst. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Computed Properties of C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Determination of benorilate in benorilate tablets by HPLC was written by Gu, Qiuzin. And the article was included in Zhongguo Yaoshi (Wuhan, China) in 2007.Computed Properties of C17H15NO5 The following contents are mentioned in the article:

An HPLC method was established for determination of benorilate in benorilate tablets. The chromatog. column was ZORBAX Eclipse XDB-C₁₈ column (150 mm × 4.6 mm, 5 μm) at 30°, using methanol-water (50:50) as mobile phase at a flow rate of 1.0 mL/min. The detection wavelength was set at 240 nm. The calibration curve was linear within the range of 20-180 μg/mL (r = 0.999 9) for benorilaten. The average recovery of benorilate was 100.0% with RSD of 1.2% (n = 6). The method is suitable for the determination of benorilate in benorilate tablets. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Computed Properties of C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identification of benorilate tablets by infrared spectrophotometric method was written by Lu, Hong. And the article was included in Heilongjiang Yiyao in 2008.Electric Literature of C17H15NO5 The following contents are mentioned in the article:

The objective of this paper is to establish a rapid and exclusive method for the identification of benorilate tablets. The sample crystallized with methanol, and identified by the IR spectrophotometric method. The results show that the IR absorption spectrum of the benorilate tablets was completely in conformity with that of the reference substance and the standard spectrum of paracetamol in IR spectrum album of drugs issued by Chinese Pharmacopeia Committee. It was concluded that the method is specific, rapid and convenient and it can be used for the identification of benorilate tablets. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Electric Literature of C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Electric Literature of C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Comparative effectiveness of topically applied nonsteroid antiinflammatory agents on guinea pig skin was written by Sarkany, I.;Gaylarde, P. M.;Brock, A. P.. And the article was included in Clinical and Experimental Dermatology in 1981.Safety of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Twelve nonsteroid antiinflammatory agents and 2 antioxidants, known to have prostaglandin synthesis inhibitory activity, were tested for their ability to suppress irritant-induced epidermal thickening in the guinea pig. Salicylates and indomethacin [53-86-1] were the most active. From previous experience, this activity is thought to correspond to the behavior of these drugs in human skin. Since no antiinflammatory activity was demonstrated by the antioxidants, the unifying concept of prostaglandin synthesis inhibition as an explanation for suppression of inflammation is questioned. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Safety of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Studies on effectiveness of diclofenac potassium was written by Yang, Fangju;Fang, Zhiping;Yang, Xiaomin;Zhang, Qi;Zhou, Suzhen. And the article was included in Huaxi Yaoxue Zazhi in 2000.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

The effectiveness and acute toxicity of diclofenac K (DK) manufactured in China were studied in rats and mice with carrageenin-induced paw edema and ear edema . DK (5-10 mg kg^-1, oral) significantly inhibited carrageenin-induced paw edema and ear edema in rats and mice and also inhibited the pain in writhing model and hot plate method in mice. The LD₅₀ for DK po in mice was (160.04 ± 43.49) mg kg^-1 compared with that of (182.58 ± 30.64) mg.kg^-1 for DK i.p. The results showed that the anti-inflammatory and analgesic effects of DK were better than those of benorilate. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Comprehensive drug screening in urine using solid-phase extraction and combined TLC and GC/MS identification was written by Lillsunde, P.;Korte, T.. And the article was included in Journal of Analytical Toxicology in 1991.Safety of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

A simple and sensitive identification system for the detection of a broad spectrum of drugs is described. ChemElut extraction tubes were used for the isolation of drugs from human urine. Specimens were screened by TLC and confirmed by GC/mass spectrometry. Special procedures for buprenorphine, cannabinoids, cocaine, LSD, morphine, phencyclidine, halogenated hydrocarbons, paracetamol, and alcs. were used. This system is useful for screening samples in misuse, impaired driving, poisoning, and other forensic cases. It covers about 300 substances including all potentially abused drugs and their metabolites. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Safety of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Safety of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Study of the inhibition of platelet aggregation provoked by etherylate, benorylate and its molecular components in comparison with acetylsalicylic acid was written by Ortega, P.;Alonso, S.;Navarro, J. L.. And the article was included in Archivos de Farmacologia y Toxicologia in 1978.Reference of 5003-48-5 The following contents are mentioned in the article:

In vitro platelet aggregation was inhibited by eterylate (I) [62992-61-4] to a greater extent than by benorylate [5003-48-5] or acetylsalicylic acid [50-78-2]. In rats given a single dose of I the inhibition of platelet aggregation induced by ADP was 2 times greater than that of rats treated with acetylsalicylic acid, whereas in rats given 7 doses of either drug the inhibition of platelet aggregation by I was 1.2 times that observed in rats treated with acetylsalicylic acid. When the inducing agent was collagen the activity of both drugs was equal. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Reference of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Reference of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Exploring QSARs of some analgesic compounds by PC-ANN was written by Deeb, Omar;Drabh, Mojahed. And the article was included in Chemical Biology & Drug Design in 2010.Synthetic Route of C17H15NO5 The following contents are mentioned in the article:

Quant. structure-activity relationship study was performed to understand analgesic activity for a set of 95 heterogeneous analgesic compounds This study was performed by using the principal component-artificial neural network modeling method, with application of eigenvalue ranking factor selection procedure. The results obtained by principal component-artificial neural network give advanced regression models with good prediction ability using a relatively low number of principal components. A 0.834 correlation coefficient was obtained using principal component-artificial neural network with six extracted principal components. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Synthetic Route of C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Synthetic Route of C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics