Category: 5003-48-5

Application of principal components analysis to TLC data for 596 basic and neutral drugs in four eluent systems was written by Musumarra, Giuseppe;Scarlata, Giuseppe;Romano, Guido;Clementi, Sergio;Wold, Svante. And the article was included in Journal of Chromatographic Science in 1984.SDS of cas: 5003-48-5 The following contents are mentioned in the article:

Principal component anal. of the R_f values for 596 basic and neutral drugs in 4 eluent mixtures provided a significant 2-component model which explained 77% of the total variance. Each drug was characterized on a plane by 2 principal component scores. The loading plot shows that 3 eluent mixtures are clustered into the same group providing similar information. For identification of unknowns, the method provided a drastic reduction of the range of possibilities to a few candidates. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5SDS of cas: 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.SDS of cas: 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Topological modeling of analgesia was written by Mathur, K. C.;Gupta, Sunita;Khadikar, P. V.. And the article was included in Bioorganic & Medicinal Chemistry in 2003.Name: 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Analgesic activity (log IC) of a large series of 97 analgesics was modeled topol. using a series of distance-based topol. indexes. The results show that analgesic activity (log IC) exhibit inter familial correlation and these can only be modeled by splitting 97 analgesics into five different categories. The regression analyses of the data show that the Wiener (W)-, branching (B)- and first-order connectivity (χ)- indexes are the better topol. indexes for modeling the activity (log IC), and that the W index gave excellent results. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Name: 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Name: 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Selective actions of aspirin- and sulfasalazine-like drugs against prostaglandin synthesis and breakdown was written by Moore, P. K.;Hoult, J. R. S.. And the article was included in Biochemical Pharmacology in 1982.Reference of 5003-48-5 The following contents are mentioned in the article:

Groups of 10 aspirin- and 5 sulfasalazine-like drugs were tested as inhibitors of prostaglandin synthesis and breakdown. The aspirin-like drugs exhibited selectivity against formation but also inhibited breakdown at higher doses. The sulfasalazine-like drugs exhibited selectivity against breakdown and some, but not all, inhibited formation at higher doses. It is proposed that there are 2 pharmacol. distinct groups of drugs, and that they can be characterized by the ratios of ID₅₀ values against breakdown and formation. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Reference of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discrimination and selection of new potential antibacterial compounds using simple topological descriptors was written by Murcia-Soler, Miguel;Perez-Gimenez, Facundo;Garcia-March, Francisco J.;Salabert-Salvador, M. Teresa;Diaz-Villanueva, Wladimiro;Medina-Casamayor, Piedad. And the article was included in Journal of Molecular Graphics & Modelling in 2003.SDS of cas: 5003-48-5 The following contents are mentioned in the article:

The aim of the work was to discriminate between antibacterial and non-antibacterial drugs by topol. methods and to select new potential antibacterial agents from among new structures. The method used for antibacterial activity selection was a linear discriminant anal. (LDA). It is possible to obtain a QSAR interpretation of the information contained in the discriminant function. We make use of the pharmacol. distribution diagrams (PDDs) as a visualizing technique for the identification and selection of new antibacterial agents. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5SDS of cas: 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.SDS of cas: 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Comparative experimental study of acute toxicity and gastric tolerance of eterylate, benorylate and acetylsalicylic acid was written by Alonso, S.;Armijo, M.;Pina, M.. And the article was included in Archivos de Farmacologia y Toxicologia in 1978.Category: esters-buliding-blocks The following contents are mentioned in the article:

In acute (10-day) toxicity studies in mice, eterylate (I) [62992-61-4] was 2- and 2.5-fold less toxic than benorylate (II) [5003-48-5], and acetylsalicylic acid (III) [50-78-2], resp.; all 3 compounds were administered orally. In chronic (4- and 24-wk) toxicity studies with the same 3 compounds, the order of toxicity was III > II > I. I was the best tolerated compound with respect to ulcerogenesis. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Category: esters-buliding-blocks).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dehydrative Beckmann rearrangement and the following cascade reactions was written by Wei, Yongjiao;Liu, Yinghui;Xie, Lan-Gui. And the article was included in Chinese Chemical Letters in 2022.Recommanded Product: 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

The Beckmann rearrangement has been predominantly studied for the synthesis of amide and lactam. By strategically using the in situ generated Appel’s salt or Mitsunobu’s zwitterionic adduct as the dehydrating agent, a series of Beckmann rearrangement and following cascade reactions have been developed herein. The protocol allows the conversion of various ketoximes into amide, thioamide, tetrazole and imide products in modular procedures. The generality and tolerance of functionalities of this method have been demonstrated. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Recommanded Product: 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Protection against paracetamol-induced glutathione depletion following a paracetamol-acetylsalicylic acid mixture or benorilate in phenobarbital-treated rats was written by De Vries, J.;Jansen, J. D.;Kroese, E. D.;Van Bree, L.;Van Ginneken, C. A. M.. And the article was included in Toxicology Letters in 1981.Related Products of 5003-48-5 The following contents are mentioned in the article:

benorilate (I) [5003-48-5] as well as a combination of paracetamol  [103-90-2] and acetylsalicylic acid (ASA) [50-78-2] depressed rat liver glutathione  [70-18-8] to level comparable with those produced by paracetamol. In phenobarbital  [50-06-6]-treated rats, however, ASA protected against paracetamol-induced glutathione depletion following a paracetamol-ASA mixture or I. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Related Products of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Related Products of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Determination of Benorilate Dispersible Tablets by HPLC was written by Cheng, Zheng;You, Yu-zhou;Xing, Jian-hui;Liu, Hu. And the article was included in Guangzhou Huagong in 2016.Formula: C17H15NO5 The following contents are mentioned in the article:

A method for determination of Benorilate Dispersible Tablets by HPLC was established. Ultimate XB-C₁₈ column (250 mm×4.6 mm×5μm) was used, the mobile phases consisted of methanol and water (60:40), the detection wavelength was at 240 nm, the column temperature was 30°C, the flow rate was 1 mL/min. Results showed that the linear range of benorilate was at 4.96-118.92 mg/mL, r = 0.99989. The average recovery was 99.47%, RSD = 0.21% (n = 6). The method was accurate. It could be used for determination of Benorilate Dispersible Tablets. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Formula: C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Optimization of a mathematical topological pattern for the prediction of antihistaminic activity was written by Duart, M. J.;Garcia-Domenech, R.;Anton-Fos, G. M.;Galvez, J.. And the article was included in Journal of Computer-Aided Molecular Design in 2001.Name: 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Mol. topol. was used to develop a math. model capable of classifying compounds according to antihistaminic activity. The equations used for this purpose were derived using multi-linear regression and linear discriminant anal. The topol. pattern of activity obtained allows the reliable prediction of antihistaminic activity in drugs frequently used for other therapeutic purposes. Based on the results, the proposed pattern is seemingly only valid for drugs that interact with histamine through competitive inhibition with H1 receptors. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Name: 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Name: 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cleavage of Carboxylic Esters by Aluminum and Iodine was written by Sang, Dayong;Yue, Huaxin;Fu, Yang;Tian, Juan. And the article was included in Journal of Organic Chemistry in 2021.Formula: C17H15NO5 The following contents are mentioned in the article:

A one-pot procedure for deprotecting carboxylic esters such as ArC(O)OR [Ar = Ph, 2-HOC₆H₄, 4-BrC₆H₄, etc.; R = Me, Bn, iPr, t-But] using aluminum and iodine under nonhydrolytic conditions was described. Cleavage of lactones afforded the corresponding ω-iodoalkylcarboxylic acids ICH₂(CH₂)nC(O)OH [n = 2, 4, 12]. Aryl acetylates undergo deacetylation with the participation of the neighboring group. This method enabled the selective cleavage of alkyl carboxylic esters in the presence of aryl esters. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Formula: C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics