Category: 5003-48-5

Improved synthesis of benorilate was written by Chen, Xubing;Chen, Guangyong;Shi, Guirong;Liu, Guangming. And the article was included in Dali Xueyuan Xuebao in 2009.SDS of cas: 5003-48-5 The following contents are mentioned in the article:

Objective: To optimize the synthetic method of benorilate. Methods: When acetylsalicyl chloride was synthesized, DMF was added as catalyst, and benorilate was obtained in the presence of tetra-Bu ammonium bromide phase transfer catalyst. Results: Benorilate was synthesized with an overall yield of 90.8%. Conclusion: This synthetic route had a mild reaction condition and improved yield, and was easily controlled. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5SDS of cas: 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.SDS of cas: 5003-48-5

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Structure-activity relationships in salicylic and benzoic acid derivatives was written by Mager, P. P.;Wenzel, U.. And the article was included in Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriumsdiagnostik in 1979.Synthetic Route of C17H15NO5 The following contents are mentioned in the article:

Structure activity relationships of benzoic- and salicylic acid derivatives on antiinflammatory and antirheumatic activities, membrane permeability, protein binding, etc., by using multivariable anal. in combination with variant bioassay are described. The study demonstrated the significance of a variable spectrum of activities. The multidimensional correlation indicates that the information obtained in this case is not only additive but multiplicative. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Synthetic Route of C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

New bronchodilators selected by molecular topology was written by Rios-Santamarina, I.;Garcia-Domenech, R.;Galvez, J.;Cortijo, J.;Santamaria, P.;Morcillo, E.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1998.Safety of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Mol. topol. has been applied to find new lead compounds with bronchodilator activity. Among the selected compounds stands out 3-(1H-tetrazol-5yl)-9H-thioxanthene-9-one-10,10-dioxide, anthrarobin, 9-oxo-9H-thioxantene-3-carboxylic-10,10-dioxide acid, acenocoumarol and griseofulvin, with a percentage of relaxation, at 0.1 mM, of 91, 92, 85, 69 and 74 %, resp. Theophylline shows a correspondent value of 77% (E_max=100% at 1 mM). This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Safety of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Safety of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mechanism of skin penetration by cercariae of S. japonicum and screening of preventive drugs was written by Wang, Yusheng;Chen, Jiayu;Song, Peizhao;Wang, Wenni;Zhou, Xiankun;Hu, Huiqin. And the article was included in Huaxi Yike Daxue Xuebao in 1989.Reference of 5003-48-5 The following contents are mentioned in the article:

The prostaglandin inhibitors aspirin and ibuprofen given orally or i.p. to mice inhibited skin penetration by Schistosoma japonicum cercariae; the penetration was not affected by the receptor antagonists diphenhydramine, chlorpheniramine, atropine, and practolol, but was inhibited by praziquantel. PGE₁ in the cercaria-penetrated mouse skin was higher than that in normal skin, suggesting that prostaglandins are necessary for the penetration. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Reference of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Comparative experimental studies in animals and humans on gastrointestinal blood loss following antirheumatic pharmacotherapy was written by Palme, G.;Koeppe, P.. And the article was included in Arzneimittel-Forschung in 1978.Recommanded Product: 5003-48-5 The following contents are mentioned in the article:

Oral administration of equimolar amounts of the antirheumatic drugs acetylsalicylic acid (I) [50-78-2] (4.5 g/70 kg) and benorilate (II) [5003-48-5] (6.0 g/70 kg) to rats and human subjects caused gastrointestinal blood loss, as measured by whole-body ⁵⁹FeCl₃-retention studies. In both rats and man, the daily blood loss caused by I was ∼2-fold greater than that by II. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Recommanded Product: 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A screening test for pharmaceuticals, drugs and insecticides with reversed-phase liquid chromatography – retention data of 560 compounds was written by Daldrup, T.;Michalke, P.;Boehme, W.. And the article was included in Chromatography Newsletter in 1982.SDS of cas: 5003-48-5 The following contents are mentioned in the article:

High-performance reversed-phase liquid chromatog. retention data are given. The relative retention times were calculated as the ratio of retention times of compound and reference compound 5-(p-methylphenyl)-5-phenylhydantoin. The UV detector wavelength was 220 nm, where most of the compounds gave a good response. The sensitivity of the method for each compound is rated from very good to bad. Two solvent programs and a prepacked column C-18 SIL-X-10 were used for the anal. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5SDS of cas: 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.SDS of cas: 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Studies on benorylate capsules formulation and their pharmacokinetics in humans was written by Chen, Jun;Tu, Xide. And the article was included in Zhongguo Yaoke Daxue Xuebao in 1997.Formula: C17H15NO5 The following contents are mentioned in the article:

Benorylate capsules were developed by triturating the material drug with the surfactant, with the purpose of improving the bioavailability compared to the tablets. The dissolution rate in vitro was determined by a paddle method and surfactant solution medium. The plasma concentration of the hydrolyzates which are salicylic acid and paracetamol from benorylate in vivo were measured by HPLC. The pharmacokinetics and bioavailability of the prepared capsules and tablets were studied. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Formula: C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Formula: C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Determination of Benorilate tablets by HPLC was written by Zhang, Lei;Ma, Jing;Zhang, Yun-ting;Wang, Yu. And the article was included in Huaxi Yaoxue Zazhi in 2009.Computed Properties of C17H15NO5 The following contents are mentioned in the article:

The objective of this paper was to establish a HPLC method for determining benorilate tablets. A C₁₈ column was used. The mobile phase consisted of methanol and water (56:44, adjusted to pH 3.5 with phosphoric acid). The UV detector was set at 240 nm. The calibration curve showed good linearity over the range of 0.52-6.24 μg (r = 0.9999), and the average recovery rate was 101.1%. The new method could be used to determine the content of benorilate in benorilate tablets. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Computed Properties of C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Computed Properties of C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Topological Approach to Analgesia was written by Galvez, J.;Garcia-Domenech, R.;De Julian-Ortiz, V.;Soler, R.. And the article was included in Journal of Chemical Information and Computer Sciences in 1994.Computed Properties of C17H15NO5 The following contents are mentioned in the article:

In this study the authors show that by making use of the mol. connectivity indexes, including a new index, which the authors denominate “σ_t” and which is obtained from a linear combination of the indexes, as well as from an “E” form index, it is possible to discriminate minor (nonnarcotic) analgesic character with great efficiency, as well as foreseeing the analgesic potency of the analyzed compounds, which represents, without a doubt, a powerful tool for the rational design of new analgesic drugs. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Computed Properties of C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qualitative organic analysis. Part 3. Identification of drugs and their metabolites by PCA of standardized TLC data was written by Romano, Guido;Caruso, Giuseppe;Musumarra, Giuseppe;Pavone, Didier;Cruciani, Gabriele. And the article was included in Journal of Planar Chromatography–Modern TLC in 1994.Related Products of 5003-48-5 The following contents are mentioned in the article:

Principal components anal. (PCA) of standardized R_F values of 443 drugs and their metabolites present in urine and blood samples chromatographed with four sheet systems provided a two-component model accounting for 70.8% of the total variance. The “scores” plot enabled either identification, or restriction of the range of inquiry to few candidates. This simple, cheap and fast anal. method is of vital importance in the identification of an unknown drug in cases of overdose intoxication or poisoning. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Related Products of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Related Products of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics