Category: 5003-48-5

Analysis of benorilate metabolites in in rabbit plasma by using capillary electrophoresis-chemiluminescence was written by Gan, Tingting;Chen, Hua;Xia, Zhining;Jiang, Xuemei;Zhang, Rong;Xin, Longtao;Yu, Yanlin. And the article was included in Fenxi Ceshi Xuebao in 2006.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

An anal. method based on online coupling of capillary electrophoresis with chemiluminescence detection was established to monitor the active metabolites of benorilate in rabbit plasma. The optimized conditions in electrophoresis were determined after evaluating various controlling factors, which were running buffer containing 5 mmol/L β-cyclodextrin and 5 mmol/L luminol of 12 mmol/L borax-4 mmol/L sodium hydroxide and 13 kV running voltage, and the sample solution was injected 3 s with electronic mode. Under the optimized conditions, the concentrations of paracetamol in rabbit plasma in different time were determined The linear range of paracetamol in rabbit plasma was about 0.1-5.0 mg/L, with the determination limit of 3.81 × 10^-2 mg/L (signal-to-noise ratio is 3). The average recoveries and RSD (n = 4) for peak area were 90-115% and 2.1-2.9%, resp. The characteristics of this method are high speed, simply and sensitive, and it is suitable for the anal. of biol. samples to determine the drug’s concentration in plasma. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate

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GC-MS rapid screening of eight non-steroidal anti-inflammatory drugs in health foods and traditional Chinese medicines was written by Zhu, Xiao-hong;Li, Tao;Ma, Peng-fei;Zhu, Jian-rong;Yan, Yu;Liu, Hai-jing. And the article was included in Yaowu Fenxi Zazhi in 2012.Reference of 5003-48-5 The following contents are mentioned in the article:

A GC-MS method for detection of non-steroidal anti-inflammatory drugs that illegally added in health foods and traditional Chinese medicines was established. Samples were extracted and enriched by using solvent extraction or liquid-liquid extraction method. Qual. detection was carried out by GC-MS and Scan mode. In addition, quant. anal. was performed using Selected ion monitoring (SIM) mode. The anal. capillary column was DP-5 ms (30 m×0.25 mm×0.25 μm). The oven temperature was set at 120°C (1 min) initially, it was programmed to rise to 230°C at 10°C·min^-1, and then rise to 270°C at 15°C·min^-1 20 min). The EI ion source was selected and the solvent was delayed by 2.5 min. The MS scanning was set at the range of 40-350 amu. Under the selected chromatog. conditions, 8 kinds of chem. drugs could get a better separation within 30 min. Then paracetamol and diclofenac sodium were detected in two batches of samples. This method was rapid, accurate, and selective, which was suitable for fast qual. detection of drugs added illegally. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Reference of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Reference of 5003-48-5

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Ester – Wikipedia,
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Structure-Based Classification of Antibacterial Activity was written by Cronin, Mark T. D.;Aptula, Aynur O.;Dearden, John C.;Duffy, Judith C.;Netzeva, Tatiana I.;Patel, Hiren;Rowe, Philip H.;Schultz, T. Wayne;Worth, Andrew P.;Voutzoulidis, Konstantinos;Schueuermann, Gerrit. And the article was included in Journal of Chemical Information and Computer Sciences in 2002.Safety of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

The aim of this study was to develop a simple quant. structure-activity relation (QSAR) for the classification and prediction of antibacterial activity, to enable in silico screening. To this end a database of 661 compounds, classified according to whether they had antibacterial activity, and for which a total of 167 physicochem. and structural descriptors were calculated, was analyzed. To identify descriptors that allowed separation of the two classes (i.e. those compounds with and without antibacterial activity), anal. of variance was utilized and models were developed using linear discriminant and binary logistic regression analyses. Model predictivity was assessed and validated by the random removal of 30% of the compounds to form a test set, for which predictions were made from the model. The results of the analyses indicated that six descriptors, accounting for hydrophobicity and inter- and intramol. hydrogen bonding, provided excellent separation of the data. Logistic regression anal. was shown to model the data slightly more accurately than discriminant anal. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Safety of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Safety of 4-Acetamidophenyl 2-acetoxybenzoate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Use of NMR for quantitative analysis of pharmaceuticals was written by Kwakye, J. K.. And the article was included in Talanta in 1985.Related Products of 5003-48-5 The following contents are mentioned in the article:

An NMR method for anal. of pharmaceuticals involves the addition of an internal standard to a sample and subsequent extraction with a solvent, integrating the appropriate peaks and calculating the weight (W_t) of a component in the sample from the equation, W_t = E_T × I_TW_s/E_s/E_sI_s where E_T and E_s are the NMR equivalent weights of sample and the standard, I_T and I_s are the integrals of the selected sample and standard peaks and W_s is the weight of the standard used. Various tablets, capsules, and suspensions were analyzed by this method. Maleic acid, 3,4-dimethoxybenzoic acid, 3-acetobenzothiophene and vanillin were used as the internal standards The NMR method was simpler than the official methods and the time required for anal. was 40 min. The average recovery was 97.1-110.4%. However the method was less precise than the official methods. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Related Products of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Related Products of 5003-48-5

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Highly sensitive determination of benorilate using silver nanoparticles/polyindole/reduced graphene oxide nanocomposite modified electrode was written by Li, Rong-Fang;Zhang, Sheng-Feng;Kong, Fen-Ying;Wang, Zhong-Xia;Fang, Hai-Lin;Wang, Wei. And the article was included in Journal of Electroanalytical Chemistry in 2021.SDS of cas: 5003-48-5 The following contents are mentioned in the article:

It is known that excessive intake of drugs can cause harmful side effects to the human body. Monitoring of drugs in tablets is important to control levels below allowable limits. Herein a novel electrochem. sensor for sensitive detection of benorilate was developed using silver nanoparticles-polyindole-reduced graphene oxide (AgNPs-PIn-rGO) nanocomposite. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used to investigate the electrochem. behavior of benorilate. The AgNPs-PIn-rGO nanocomposite exhibited outstanding electrocatalytic activity toward benorilate. In addition, the effects of scaning rate, pH and accumulation time on the performance of the electrochem. sensor were also studied. Under the optimal condition, the designed sensor showed an appreciable linear response range (0.06μM-80μM) and a low detection limit (6 nM). Meanwhile, the sensor also displayed excellent selectivity and good storage stability. More importantly, the established method was successfully applied for benorilate determination in pharmaceutical tablets and the result was satisfactory. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5SDS of cas: 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Are all aspirins really alike? A comparison of gastric ulcerogenicity with bioefficacy in rats was written by Rainsford, K. D.;Whitehouse, M. W.. And the article was included in Pharmacological Research Communications in 1980.COA of Formula: C17H15NO5 The following contents are mentioned in the article:

Fifteen aspirin [50-78-2] formulations (including 11 com. types) and various other salicylate preparations were compared primarily for intrinsic gastric ulcerogenicity in cold stressed rats. Several buffered aspirins were notably just as ulcerogenic as aspirin suspensions. High Na⁺-containing aspirin formulations were the least ulcerogenic of those examined but also exhibited the shortest duration of action as antipyretics when assayed against yeast-induced fever in rats. Incorporation of D-glucose [50-99-7] with certain metabolizable bases (citrate, acetate) markedly reduced the ulcerogenic activity of aspirin. Aspirin impurities, benorylate [5003-48-5], several non-acetylated salicylates (e.g. diflunisal [22494-42-4], diplosal [552-94-3]) were compared for antiinflammatory potency, antipyretic activity and gastric ulcerogenic. For non-analgesic use, salts of salicylic acid, diflunisal and diplosal would seem preferable to aspirin, conferring the same potential benefit (as antiinflammatory-antipyretic drugs) but with lower gastric ulcerogenicity. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5COA of Formula: C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.COA of Formula: C17H15NO5

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effects of phenacetin, paracetamol, and caffeine on the erosive activity of acetylsalicyclic acid in the rat stomach: dose-response relationships, time course of erosion development, and effects on acid secretion was written by Seegers, A. J. M.;Jager, L. P.;Van Noordwijk, J.. And the article was included in Journal of Pharmacy and Pharmacology in 1979.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Adult male and female rats were equally susceptible to acetylsalicylic acid (I) [50-78-2]-induced gastric injury. Simultaneous administration of caffeine [58-08-2] or paracetamol (II) [103-90-2] resp. increased or decreased the degree of gastric lesion; phenacetin [62-44-2] administration had no effect. The effects of caffeine and II were dose-dependent and developed after 3-4 h. II or phenacetin pretreatment 1 h before I administration was ineffective. Benorylate [5003-48-5] administration caused no more erosions than equivalent mixtures of I and II. Histamine-stimulated gastric acid output was rapidly diminished during perfusion with I; II and caffeine had no initial effect on this but after 30 min the latter increased secretion to levels observed with caffeine alone. Thus, caffeine potentiates I-induced gastric erosions by stimulating acid secretion, but II inhibits them by preventing their development. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Prediction and screening of biologically active compounds in honeysuckle (Lonicera japonica) by biopartitioning micellar chromatography was written by Gan, Yuan;Liang, Yan;Chen, Han;Xue, Jin-Tao;Yan, Xin-Yu;Xiong, Dong-Mei;Chen, Cong;Ye, Li-Ming;Xu, Ting;Chen, Yu. And the article was included in Asian Journal of Chemistry in 2014.Category: esters-buliding-blocks The following contents are mentioned in the article:

A new in vitro method, based on the retention data in biopartitioning micellar chromatog., is validated for prediction and screening of bioactive components of honeysuckle (Lonicera japonica). Relationships between the capacity factors of honeysuckle extracts and chem. drugs with related curative effects are studied. Finally, statistical anal. and predictive model were obtained. The results reveal that anti-inflammatory, antipyretic and analgesic effects are the main efficacy of honeysuckle, antibiotic and antiviral effects take second place, effect of lowering blood pressure, high blood fat and blood sugar is the weakest. Besides, with further relevant Matlab programming function, the probability of the components associated with different effects can be obtained by calculating the honeysuckle capacity factors, so as to identify which peak represents the active ingredient in the chromatogram and which is the main pharmacol. action. The use of biopartitioning micellar chromatog. is simple, reproducible and can provide key information for predicting and screening bioactive constituents of honeysuckle extracts This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Category: esters-buliding-blocks).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effects of benorylate and impacina on the metabolism of cultured hepatocytes was written by Castell, J. V. M.;Montoya, A.;Larrauri, A.;Lopez, P.;Gomez-L., J.. And the article was included in Xenobiotica in 1985.HPLC of Formula: 5003-48-5 The following contents are mentioned in the article:

The effects of benorylate (I) [5003-48-5] and impacina (II) [99040-04-7] on liver metabolism was evaluated by adapting the use of cultured adult rat hepatocytes as a biol. model. Cells were exposed to subtoxic levels of the xenobiotic which was incorporated into the culture media. This was followed by the evaluation in treated cultures of some biochem. functions typical of the liver, namely, gluconeogenesis, glycogen  [9005-79-2] metabolism, synthesis of plasma proteins and ureogenesis, and a comparison was made with nontreated controls. I impaired glucose  [50-99-7] release by hepatocytes to the medium and net accumulation of glycogen was detected. Urea  [57-13-6] production also diminished (20%) in I-treated cells. II significantly increased the synthesis of albumin and transferrin when added at therapeutic levels into the culture medium and did not alter other biochem. functions of the hepatocytes. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5HPLC of Formula: 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.HPLC of Formula: 5003-48-5

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Structure-activity relationships in antiinflammatory drugs and predictability was written by Mager, Peter P.;Metzner, J.;Paintz, M.;Wenzel, U.. And the article was included in Scientia Pharmaceutica in 1980.Formula: C17H15NO5 The following contents are mentioned in the article:

The antiinflammatory activity of salicylic acid and pyrazolone derivatives was regressed against Hammett’s electronic constant, Hansch’s lipophilic substitution constant, and Mager’s relative surface tension. There is a sufficient recognition (comparison between exptl. obtained and theor. calculated values) and predictability (comparison between forecasts and exptl. proof after synthesis). This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Formula: C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics