Category: 5003-48-5

Molecular spectroscopic study on site-selective binding of benorilate to bovine serum albumin was written by Zhang, Yan-zheng;Chen, Fang;Wang, Ya-dan;Zhang, Yin-tang;Huang, Ju;Chen, Yan;Ye, Bao-xian;Xu, Mao-tian. And the article was included in Faguang Xuebao in 2012.Application In Synthesis of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

The interaction between benorilate (BEN) and bovine serum albumin (BSA) was investigated under physiol. condition by mol. spectroscopic techniques, including fluorescence spectroscopy, UV-visible spectroscopy, synchronous fluorescence spectroscopy and three-dimensional fluorescence spectroscopy. The intrinsic fluorescence of tryptophan in BSA was significantly quenched by BEN via dynamic quenching. The hydrophobic interaction did favor the interaction of BSA with BEN. The apparent binding constants and binding sites number at the tryptophan site were 1 050 L · mol^-1 and 0.88, resp. Thermodn. parameters such as enthalpy change (ΔH), entropy change (ΔS) and free energy change (ΔG) were also obtained. The conformation changes of BSA in the presence of BEN were proved by the evidences of synchronous fluorescence spectroscopy and three-dimensional fluorescence spectroscopy. Two site-specific fluorescence probes, dansylamide (DA) and dansyl-L-proline (DP), were employed in competitive binding experiments to monitor the BEN binding sites of BSA. The apparent binding constants at site I and II were 4 300 and 21 200 L · mol^-1, resp. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Application In Synthesis of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of 4-Acetamidophenyl 2-acetoxybenzoate

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Analysis of analgesic formulations by high-pressure liquid chromatography was written by Doadrio Villarejo, A.;Doadrio, A.;Lastres, J. L.;Cadorniga, R.. And the article was included in Anales de la Real Academia de Farmacia in 1984.Recommanded Product: 5003-48-5 The following contents are mentioned in the article:

Acetylsalicylic acid  [50-78-2], lysine acetylsalicylic acid  [37933-78-1], and benorilate  [5003-48-5] were determined by reversed-phase ion-pair HPLC in a variety of analgesic formulations containing codeine  [76-57-3], phenacetin  [62-44-2], caffeine  [58-08-2], dextropropoxyphene  [469-62-5], ascorbic acid  [50-81-7], thiamine  [59-43-8], pyridoxol  [65-23-6], cyanocobalamine  [68-19-9], phenylephrine  [59-42-7], chlorpheniramine maleate  [113-92-8], and lidocaine  [137-58-6]. The stationary phase was LiChrosorb RP18 or RP8. In addition salicylic acid  [69-72-7] was determined in the same formulations and results were compared to USP and British Pharmacopeia methods. The lower detection limit was 1 μg/mL. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Recommanded Product: 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 5003-48-5

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Parameterization of an empirical model for the prediction of n-octanol, alkane and cyclohexane/water as well as brain/blood partition coefficients was written by Zerara, Mohamed;Brickmann, Juergen;Kretschmer, Robert;Exner, Thomas E.. And the article was included in Journal of Computer-Aided Molecular Design in 2009.SDS of cas: 5003-48-5 The following contents are mentioned in the article:

Quant. information of solvation and transfer free energies is often needed for the understanding of many physicochem. processes, e.g the mol. recognition phenomena, the transport and diffusion processes through biol. membranes and the tertiary structure of proteins. Recently, a concept for the localization and quantification of hydrophobicity has been introduced (Jaeger et al., J Chem Inf Comput Sci 43:237-247, 2003). This model is based on the assumptions that the overall hydrophobicity can be obtained as a superposition of fragment contributions. To date, all predictive models for the logP have been parameterized for n-octanol/water (logP _oct) solvent while very few models with poor predictive abilities are available for other solvents. We propose a parameterization of an empirical model for n-octanol/water, alkane/water (logP _alk) and cyclohexane/water (logP _cyc) systems. Comparison of both logP _alk and logP _cyc with the logarithms of brain/blood ratios (logBB) for a set of structurally diverse compounds revealed a high correlation showing their superiority over the logP_oct measure in this context. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5SDS of cas: 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 5003-48-5

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LC-MS-MS Simultaneous Determination of Paracetamol, Pseudoephedrine and Chlorpheniramine in Human Plasma: Application to a Pharmacokinetic Study was written by Liao, Qiongfeng;Xie, Zhiyong;Pan, Biyan;Zhu, Chenchen;Yao, Meicun;Xu, Xinjun;Wan, Jinzhi. And the article was included in Chromatographia in 2008.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

A liquid chromatog.-tandem mass spectrometry (LC-MS-MS) method was developed for the simultaneous determination of paracetamol, pseudoephedrine and chlorpheniramine in human plasma. Diphenhydramine was used as the internal standard Analytes were extracted from alkalized human plasma by liquid-liquid extraction (LLE) using Et acetate. After electrospray ionization pos. ion fragments were detected in the selected reaction monitoring (SRM) mode with a triple quadrupole tandem mass spectrometer. The method was linear in the concentration range of 20.0-10000.0 ng mL^-1 for paracetamol, 1.0-500.0 ng mL^-1 for pseudoephedrine and 0.1-50.0 ng mL^-1 for chlorpheniramine. The intra- and inter-day precisions were below 14.5% and the bias was between -7.3 and +2.8% for all analytes. The validated LC-MS-MS method was applied to a pharmacokinetic study in which each healthy Chinese volunteer received a tablet containing 300 mg benorylate, 30 mg pseudoephedrine hydrochloride and 2 mg chlorpheniramine maleate. This is the first assay method described for the simultaneous determination of paracetamol, pseudoephedrine and chlorpheniramine in human plasma samples. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

[Rapid identification 15 effective components of anti common cold medicine with MRM by LC-MS/MS]. was written by Jiang, Jian-Guo;Zhang, Xi-Ru;Zhang, Yi-Hua;Song, Geng-Shen. And the article was included in Yao xue xue bao = Acta pharmaceutica Sinica in 2013.Safety of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

This paper reports the establishment of a method for rapid identification 15 effective components of anti common cold medicine (paracetamol, aminophenazone, pseudoephedrine hydrochloride, methylephedrine hydrochloride, caffeine, amantadine hydrochloride, phenazone, guaifenesin, chlorphenamine maleate, dextromethorphen hydrobromide, diphenhydramine hydrochloride, promethazine hydrochloride, propyphenazone, benorilate and diclofenac sodium) with MRM by LC-MS/MS. The samples were extracted by methanol and were separated from a Altantis T3 column within 15 min with a gradient of acetonitrile-ammonium acetate (containing 0.25% glacial acetic acid), a tandem quadrupole mass spectrometer equipped with electrospray ionization source (ESI) was used in positive ion mode, and multiple reaction monitoring (MRM) was performed for qualitative analysis of these compounds. The minimum detectable quantity were 0.33-2.5 microg x kg(-1) of the 15 compounds. The method is simple, accurate and with good reproducibility for rapid identification many components in the same chromatographic condition, and provides a reference for qualitative analysis illegally added chemicals in anti common cold medicine. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Safety of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Safety of 4-Acetamidophenyl 2-acetoxybenzoate

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Ester – Wikipedia,
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Validation results and analysis of microorganism limit test method for 14 kinds of chemical drugs was written by Li, Hui-e;Zhang, Dan;You, Ya-ning;Zhou, Zhi-yun;Cui, Yu-jin. And the article was included in Xibei Yaoxue Zazhi in 2007.Formula: C17H15NO5 The following contents are mentioned in the article:

The objective is to establish the determination method for the microbial limit of 14 chem. agents. The recovery rate is tested by artificial pollution by 4 exptl. strains to verify whether the bacteriostatic effect is presented. The results show that the recovery rate of the 3 test sample of Letosteine granule (25.50 mg/pack) and nimodipine tablet (group I) are all higher than 70%, and without bacteriostatic effect; the Lufenweima slow release tablet, loratadine orally disintegrating tablets, Letosteine capsule (25.50 mg/capsule) 4 test samples (group II) has certain bacteriostatic effect; while Lexapro tablet, Nifedipine slow release capsule, culvfensuan tablet, famotidine orally disintegrating tablets, Zolpidem Tartrate orally disintegrating tablets (5.10 mg/tablet) and Benorilate tablet, these 7 test samples (group III) has strong bacteriostatic effect. Determination of the microbial limit of test samples in group I is conducted by routine method. Determination of the microbial limit of test samples in group II is conducted by media dilution method (0.2 mL/plate, which is 1 mL for 5 plates). Determination of the microbial limit of test samples in group III is conducted by the membrane filtration with centrifugation method. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Formula: C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Formula: C17H15NO5

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reduction by acetylsalicylic acid of paracetamol-induced hepatic glutathione depletion in rats treated with 4,4′-dichlorobiphenyl, phenobarbitone and pregnenolone-16α-carbonitrile was written by Van Bree, L.;Groot, E. J.;De Vries, J.. And the article was included in Journal of Pharmacy and Pharmacology in 1989.Category: esters-buliding-blocks The following contents are mentioned in the article:

The role of enzyme induction in the reduction by acetylsalicylic acid (ASA) of paracetamol-induced hepatic glutathione (GSH) depletion was studied in rats. Administration of an overdose of paracetamol to control rats resulted in an appreciable decrease of GSH concentration Pretreatment with the enzyme inducers phenobarbitone, 3-methylcholanthrene (3-MC), pregnenolone-16α-carbonitrile and 4,4′-dichlorobiphenyl potentiated the paracetamol-induced depletion of GSH. Simultaneous administration of an equimolar dose of ASA reduced the paracetamol-induced depletion of GSH in all instances except for those rats that were not pretreated and those given 3-MC. Benzorylate, the ASA ester of paracetamol, depressed rat liver GSH to levels comparable to those produced by the combination of paracetamol and ASA. ASA itself caused only minor changes in liver GSH concentrations ASA diminishes paracetamol-induced GSH depletion in rats with a phenobarbitone type of enzyme induction. Inhibition of the formation of the reactive metabolite of paracetamol or reduction of the absorption rate of paracetamol seems to be unlikely as a mechanism underlying the ASA-induced effect. An ASA-mediated effect via changes of the hepatic SH status is proposed. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Category: esters-buliding-blocks).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pharmaceutical compounds in aquatic environment in China: locally screening and environmental risk assessment was written by Chen, Yongshan;Xi, Xiuping;Yu, Gang;Cao, Qiming;Wang, Bin;Vince, Francois;Hong, Youwei. And the article was included in Frontiers of Environmental Science & Engineering in 2015.Recommanded Product: 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

An environmental risk assessment was performed for pharmaceutical compounds present in the aquatic environment of China. Predicted environmental concentration (PEC) of the compounds were calculated according to European Medicines Evaluation Agency (EMEA) guidelines. Available ecotoxicol. data compromised by applying a very conservative assessment factor (AF) were employed to calculate the predicted noeffect concentration (PNEC). The screening principle and the risk assessment were based on risk quotient (RQ), which derived from the PEC and related PNEC values. PEC results indicated that all the compounds except sulfadimethoxine and levocarnitine, should carry out phase II risk assessment in EMEA guideline. RQ values suggested that more than 36 pharmaceuticals may be imposed health threats to the aquatic environment; especially the antibiotic therapeutic class including amoxicillin, sulfasalazine, trimethoprim, oxytetracycline and erythromycin showed high RQ values. These substances with high RQ value (RQ≥1) were regarded as toppriority pharmaceuticals for control in the aquatic environment of China. However, the antibiotic substances which had low risk quotient (RQ <1), should be reassessed by its potentially induced resistance under low concentration in future. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Recommanded Product: 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

LC-MS detection of valuable or toxic ingredients and 48 chemical drugs added into Dahuoluo pills and Tongren Dahuoluo pills was written by Hu, Qing;Zhong, Jiqiang;Mao, Xiuhong;Wang, Ke;Ji, Shen. And the article was included in Yaowu Fenxi Zazhi in 2010.Name: 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Sep. specific methods by LC/MSⁿ for the identification of 3 valuable or toxic ingredients and 48 analgesic and anti-inflammatory chem. drugs added illegally into Dahuoluo pills and Tongren Dahuoluo pills were established. The detection of 48 compounds was performed by Agilent 1100 HPLC/MSD trap using Agilent ZORBAX SB-C₁₈ (2.1 mm × 150 mm, 5 μm) column as stationary phase and 0.5% formic acid solution-methanol system as mobile phase. The gradient elution was done with as flow rate of 0.3 mL/min^-1. The detection of 3 valuable and toxic ingredients was performed by the same instrument and stationary phase, using water acetonitrile system in gradient elution as mobile phase. Pos. and neg. ionization switch autoscan mode was adopt using ESI source. Samples were extracted by Ultrasonic with methanol. Comparing with retention time and spectra of references in library set up by ourselves, the target compounds in sample are screened and identified. There were ephedrine detected in 229 samples, hyodeoxycholic acid detected in 41 samples, and loureirin B detected in 71 samples. The methods were accurate, fast and sensitive. It was the first time in China to report the LC/MS method, which could evaluate the quality of samples objectively. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Name: 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Name: 4-Acetamidophenyl 2-acetoxybenzoate

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An integrated virtual screening and drug repurposing strategy for the discovery of new antimalarial drugs against Plasmodium falciparum phosphatidylinositol 3-kinase was written by Verma, Kanika;Lahariya, Ayush K.;Dubey, Shivangee;Verma, Anil K.;Das, Aparup;Schneider, Kristan A.;Bharti, Praveen K.. And the article was included in Journal of Cellular Biochemistry in 2021.Electric Literature of C17H15NO5 The following contents are mentioned in the article:

The emergence and spread of drug resistance in Plasmodium falciparum, the parasite causing the most severe form of human malaria, is a major threat to malaria control and elimination programs around the globe. With P. falciparum having evolved widespread resistance against a number of previously widely used drugs, currently, artemisinin (ART) and its derivatives are the cornerstones of first-line treatments of uncomplicated malaria. However, growing incidences of ART failure reflect the spread of ART-resistant P. falciparum strains. Despite current efforts to understand the primary cause of ART resistance due to mutations in the Kelch 13 gene (PfK13), the mechanism underlying ART resistance is still not completely unclear and no feasible strategies to counteract the causes and thereby restoring the efficiency of ART have been developed. We use a polypharmacol. approach to identify potential drugs that can be used for the novel purpose (target). Of note, we have designed a multimodal stratagem to identify approved drugs with a potential antimalarial activity using computational drug reprofiling. Our investigations suggest that oxetacaine, simvastatin, repaglinide, aclidinium, propafenone, and lovastatin could be repurposed for malaria control and prevention. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Electric Literature of C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Electric Literature of C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics