Category: 5003-48-5

Prodrugs to Codrugs was written by Gangrade, Deepali;Karande, Ravindra. And the article was included in Current Drug Therapy in 2017.Product Details of 5003-48-5 The following contents are mentioned in the article:

A review. Background: The Carrier linked prodrug as per literature is known to be a pharmacol. inactive chem. derivative and could be used to change the physicochem. properties of compounds Codrugs is a type of carrier linked prodrug, and consist of two usually synergistic drugs or moieties attached to each other. Objective: synthesis of codrug consists of two pharmacol. active compounds coupled together where one drug is the carrier for the other and vice versa. Result: It is a very beneficial area of research and its admittance in human therapy has given successful results clin. as well as therapeutically. Conclusion: The emphasis is carried on Benorylate, the Codrug of aspirin and paracetamol for improved anti-inflammatory and analgesic activity. The article also takes a review of the various applications of Codrugs and the development in this field during the last few decades. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Product Details of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Product Details of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

LC-MS/MS screening for 36 chemical components in health food and Chinese traditional patent medicine was written by Li, Dan;Wen, Hongmei;Cui, Fuchun;Huang, Ya;Guo, Chun;Sun, Xiarong;Yang, Jingping. And the article was included in Yaowu Fenxi Zazhi in 2010.Safety of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

A liquid chromatog.-tandem mass chromatog. (LC-MS/MS) method for the simultaneous screening 36 chem. components in health food and Chinese Traditional Patent Medicine was established. This method involves liquid chromatog.-tandem mass spectrometry, the separation was conducted by Sunfire C₁₈ (2.1 mm × 100 mm, 5.0 μm). The mobile phase consisted of 0.1% formic acid and methanol (25:75). The target compounds were analyzed with LC-MS/MS-ESI. Multiple-reaction monitoring (MRM) was used to screen 36 chem. components in health food and Chinese Traditional Patent Medicine. A fast and sensitive liquid chromatog. mass spectrometric (LC/MS) method for the simultaneous screening of 36 chem. components was described. The LOD of these substances were below 20 ng. The method was sufficiently selective and sensitive to detect chem. components in health food and Chinese Traditional Patent Medicine. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Safety of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Safety of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Study on relation of dissolution of benorilate tablets with drug concentration in human plasma was written by Chen, Zongdai;Du, Kairong;Zeng, Jingze;Zhang, Da;Deng, Fu. And the article was included in Yaowu Fenxi Zazhi in 2002.Reference of 5003-48-5 The following contents are mentioned in the article:

The relation between dissolution of benorilate tablets and benorilate concentration in human plasma was analyzed. Sodium lauryl sulfate (1%) solution was used as the medium, and paddles method was used with sampling after 45 min. UV spectrophotometry was adapted for the determination of dissolution of benorilate tablets. The concentration of benorilate in human plasma was estimated by using a HPLC method which was developed to determine the hydrolytic products of benorilate paracetamol and salicylic acid. p-Dimethylaminobenzaldehyde was used as the internal standard The relationship between dissolution and concentration of benorilate in human plasma was treated statistically. A good relationship existed between the dissolution and pharmacokinetic parameters AUC, C_max [r=0.968; 0.985 (n=5), r_0.01,3=0.959]. The method could control the sample quality effectively. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Reference of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Reference of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qualitative organic analysis. I. Identification of drugs by principal components analysis of standardized thin-layer chromatographic data in four eluent systems was written by Musumarra, Giuseppe;Scarlata, Giuseppe;Cirma, Giuseppe;Romano, Guido;Palazzo, Silvana;Clementi, Sergio;Giulietti, Gianfranco. And the article was included in Journal of Chromatography in 1985.Related Products of 5003-48-5 The following contents are mentioned in the article:

Identification of drugs by principal component anal. of standardized retention factor (R_F) values in 4 eluent systems, [EtOAc [141-78-6]-MeOH [67-56-1]-30% NH₄OH (85:10:15), cyclohexane  [110-82-7]-PhMe [108-88-3]-Et₂NH [109-89-7] (65:25:10), EtOAc-CHCl₃  [67-66-3] (50:50), and Me₂CO [67-64-1] with the plate dipped in KOH solution] provided a 2-component model which accounts for 73% of the total variance. The scores plot allowed the restriction of the range of inquiry to a few candidates. This result is of great practical significance in anal. toxicol., especially when account is taken of the cost, the time, the anal. instrumentation and the simplicity of the calculations required by the method. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Related Products of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Related Products of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ultraviolet spectrophotometry in drug control. XXVIII. New pharmaceuticals with chromophores of benzene rings in the molecules. 3. Effect of substitution and solvents was written by Kracmar, J.;Kracmarova, J.. And the article was included in Cesko-Slovenska Farmacie in 1982.Application of 5003-48-5 The following contents are mentioned in the article:

UV spectra of 10 drugs with a benzene chromophore, baclofen  [1134-47-0], lorcainide  [59729-31-6], DL-ibuprofen  [15687-27-1], DL-mexiletine  [31828-71-4], clonidine  [4205-90-7], ketoconazole  [65277-42-1], terbutaline  [23031-25-6], propafenone  [54063-53-5], xipamide  [14293-44-8], and benorilate  [5003-48-5] were described. Solvent effects on absorption shifts, absorption maximum of characteristic bands, and Beer’s law were discussed and specific absorbances calculated Use of these spectra for characterization and determination are discussed. Concentration ranges for determination in μg amounts are given. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Application of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Enzyme-inducing effects of salicylate derivatives was written by Goudonnet, Herve;Mounie, Jacques;Bereksi-Reguig, K.;Truchot, Roger. And the article was included in Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales in 1982.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Of the salicylate derivatives examined, salicylic acid  [69-72-7] itself, Me salicylate  [119-36-8], salicylazosulfapyridine  [599-79-1], 4-iodosalicylic acid  [16870-28-3], and acetylsalicylic acid  [50-78-2] appeared not to induce liver microsomal enzymes in rats, while salicylamide (I) [65-45-2] and benorylate (II) [5003-48-5] caused significant induction, and 3,5-diiodosalicylic acid (III) [133-91-5] was an extremely potent inducer. After 3 daily oral 125-mg/kg doses of III, for example, liver microsomal cytochrome P 450 activity was doubled. Structure-activity relations are briefly discussed. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

High-pressure liquid chromatographic evaluation of cyclic paracetamol-acetylsalicylate and its active metabolites with results of a comparative pharmacokinetic investigation in the rat was written by Marzo, A.;Quadro, G.;Treffner, E.;Ripamonti, M.;Meroni, G.;Lucarelli, C.. And the article was included in Arzneimittel-Forschung in 1990.Application In Synthesis of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Like benorilate, its correlated open ester, MR 897 (I), a cyclic ester between acetylsalicylic acid and paracetamol, gives rise to acetylsalicylic acid, salicylic acid and paracetamol by enzymic hydrolysis. An anal. method was developed, which detects parent drugs and active metabolites, in order to compare the pharmacokinetic and metabolic behavior of the 2 products. The method was specifically validated for quant. anal. of salicylic acid and paracetamol, which are the main systemic metabolites of both MR 897 and benorilate. Extraction from rat plasma or tissue homogenate was carried out in 2 steps with Et₂O and Et acetate. Recovery of the anal. substances ranged from 82.7% for paracetamol to 98.5% for salicylic acid. The results of a comparative pharmacokinetic investigation of MR 897 and benorilate in the rat confirm higher bioavailability and a more favorable plasma level profile with MR 897. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Application In Synthesis of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application In Synthesis of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Formulation and bioavailability of benorilate tablets was written by Chen, J.;Tu, X. D.. And the article was included in Yaoxue Xuebao in 1994.Name: 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

A new formulation tablet B was developed and compared with tablet A with the purpose of improving the bioavailability of benorilate by reducing its particle size. The dissolution rate in vitro was determined by paddle method and using surfactant solution medium. The plasma concentrations of hydrolyzates which are salicylic acid and paracetamol from benorilate in vivo were measured by HPLC. The dissolution rates of ground and unground drug are 0.0337 min^-1 and 0.0152 min^-1, resp. Compared with tablet A, the cumulative dissolution percentage of B is higher. The mean dissolution time of B and A are 15.77 min and 42.25 min, resp. The study in vivo showed that the C_max, T_p and AUC of salicylic acid for these two formulations have no significant difference. The relative bioavailability of B to A is 125.59%. Their in vivo process fits one-compartment model and first order elimination. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Name: 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Name: 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Analgesic and antiinflammatory properties of some new salicylic acid derivatives, including QSAR was written by Langner, A.;Hagen, V.;Labes, D.;Krause, E.. And the article was included in Agents and Actions Supplements in 1982.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Results from analgesic (hot-plate and radiant-heat methods) and antiinflammatory (carrageenin rat paw edema) activity screening in 21 salicylates showed that only 4 compounds [acetylsalicylic acid piperidide, pyrrolidide (I), p-hydroxyanilide [19065-81-7], and 2-pyrimidylamide [71924-69-1] derivatives] had analgesic activity comparable to that of acetylsalicylic acid and only 4 (I and the acetylsalicylic acid p-nitranilide  [25671-41-4], α-pyridylamide, and 2-nitro-4-methoxyanilide [36930-83-3] derivatives) had antiinflammatory activity comparable to that of salicylamide. The remaining substances were either weakly active or inactive. Hansch anal. was performed on a selected number of the substances and the results are discussed in relation to structural requirements for activity. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pharmacological studies of 1-(p-chlorophenyl)propanol and 2-(1-hydroxy-3-butenyl)phenol: two new non-narcotic analgesics designed by molecular connectivity was written by Garcia-March, F. J.;Garcia-Domenech, R.;Galvez, J.;Anton-Fos, G. M.;de Julian-Ortiz, J. V.;Giner-Pons, R.;Recio-Iglesias, M. C.. And the article was included in Journal of Pharmacy and Pharmacology in 1997.Application of 5003-48-5 The following contents are mentioned in the article:

Mol. topol. has been applied to the design of new analgesic drugs. Linear discriminant anal. and connectivity functions were used to design two potentially suitable drugs which were synthesized and tested for analgesic properties by the acetic acid-induced abdominal constriction test in mice and the tail-flick test in rats. In mice, the compound 1-(p-chlorophenyl)propanol showed higher analgesic activity, both i.p. and orally, then acetylsalicylic acid. 2-(1-Hydroxy-3-butenyl)phenol exhibited a lesser protective effect (70% of that shown by acetylsalicylic acid). In rats, acetylsalicylic acid gave the greatest protection against pain when administered i.p., while 1-(p-chlorophenyl)propanol was the most active orally. The 2-(1-hydroxy-3-butenyl)phenol, both i.p. and orally, showed the least protective effect. These results demonstrated the peripheral analgesic properties of the selected compounds, thus confirming the validity of the mol. design method. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Application of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics