Category: 4755-77-5

In 2022,Xu, Wengang; Zhang, Yangyang; Wu, Yongdi; Wang, Jian; Lu, Xuelian; Zhou, Yirong; Zhang, Fang-Lin published an article in Journal of Organic Chemistry. The title of the article was 《Direct Assembly of Diverse Unsymmetrical Tertiary 9-Fluorenols via Transient Directing Group-Enabled Palladium-Catalyzed Dual C-H Bond Activation of α-Ketoesters》.Formula: C4H5ClO3 The author mentioned the following in the article:

An expeditious construction of an unsym. tertiary 9-fluorenol skeleton, e.g., I was accomplished starting from readily available α-keto esters and aryl iodides. An inexpensive, com. available, substituted aniline was utilized as a potent monodentate transient directing group (TDG) to assist palladium-catalyzed direct ortho-C-H arylation and tandem dual C-H activation of α-ketoesters to form two carbon-carbon bonds. To demonstrate practical applications, the reaction was enlarged to the gram scale, and subsequent one-step derivatization allowed facile access to structurally diversified useful derivatives A series of control experiments was carried out to shed light on the possible catalytic mechanism. In addition to this study using Ethyl oxalyl monochloride, there are many other studies that have used Ethyl oxalyl monochloride(cas: 4755-77-5Formula: C4H5ClO3) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Formula: C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,ACS Chemical Neuroscience included an article by Pallesen, Jakob; Moellerud, Stine; Frydenvang, Karla; Pickering, Darryl S.; Bornholdt, Jan; Nielsen, Birgitte; Pasini, Diletta; Han, Liwei; Marconi, Laura; Kastrup, Jette Sandholm; Johansen, Tommy N.. Electric Literature of C4H5ClO3. The article was titled 《N1-substituted quinoxaline-2,3-diones as kainate receptor antagonists: x-ray crystallography, structure-affinity relationships, and in vitro pharmacology》. The information in the text is summarized as follows:

Among the ionotropic glutamate receptors, the physiol. role of kainate receptors is less well understood. Although ligands with selectivity toward the kainate receptor subtype GluK1 are available, tool compounds with selectivity at the remaining kainate receptor subtypes are sparse. Here, we have synthesized a series of quinoxaline-2,3-diones with substitutions in the N1-, 6-, and 7-position to investigate the structure-activity relationship (SAR) at GluK1-3 and GluK5. Pharmacol. characterization at native and recombinant kainate and AMPA receptors revealed that I had a GluK3-binding affinity (Ki) of 0.142 μM and 8-fold preference for GluK3 over GluK1. Despite lower binding affinity of II at GluK3 (Ki = 2.91 μM), its preference for GluK3 over GluK1 and GluK2 was >30-fold. I was crystallized with the GluK1 ligand-binding domain to understand the SAR. The X-ray structure showed that I stabilized the protein in an open conformation, consistent with an antagonist binding mode. In the experimental materials used by the author, we found Ethyl oxalyl monochloride(cas: 4755-77-5Electric Literature of C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Electric Literature of C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quality Control of Ethyl oxalyl monochlorideIn 2020 ,《Transition-metal free direct C-H functionalization of quinoxalin-2(1H)-ones with oxamic acids leading to 3-carbamoyl quinoxalin-2(1H)-ones》 appeared in Organic Chemistry Frontiers. The author of the article were Yuan, Jin-Wei; Zhu, Jun-Liang; Zhu, Hu-Lin; Peng, Fang; Yang, Liang-Yu; Mao, Pu; Zhang, Shou-Ren; Li, Yan-Chun; Qu, Ling-Bo. The article conveys some information:

A practical transition-metal free decarboxylative coupling reaction of oxamic acids with quinoxalin-2(1H)-ones was developed under mild conditions. This transformation provided an efficient approach for the preparation of 3-carbamoyl quinoxalin-2(1H)-ones, which are important subunits in biol. active natural products and medicinal chem. This protocol features broad substrate scope, good yields and mild reaction conditions. In the experiment, the researchers used Ethyl oxalyl monochloride(cas: 4755-77-5Quality Control of Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Quality Control of Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 4755-77-5In 2019 ,《A newfangled synthesis of integrase inhibitor drug substance raltegravir potassium》 appeared in Asian Journal of Chemistry. The author of the article were Rao, S. Venkat; Potluri, Vamsi Krishna; Potluri, Ramesh Babu. The article conveys some information:

Raltegravir sodium synthesis was achieved from its one of the key starting materials with retro synthetic approach, in which without using its critical starting material chem. known as 5-methyl-1,3,4-oxadiazole-2-carbonyl chloride and which is more unstable during the synthesis of raltegravir potassium. Almost all the existed literatures commonly using this starting material in its synthesis even it is having a stability issue and hence to achieve a stable and economically viable synthesis. The current research describes a new route of synthesis by constructing an oxadiazole ring in a retro synthetic manner.Ethyl oxalyl monochloride(cas: 4755-77-5Product Details of 4755-77-5) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Product Details of 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Dongjie; Xu, Xu; Zhang, Jingyu; Zhao, Yingsheng published their research in Journal of Organic Chemistry in 2021. The article was titled 《Ligand Promoted Olefination of Anilides for Indirectly Introducing Fluorinated Functional Groups via Palladium Catalyst》.Reference of Ethyl oxalyl monochloride The article contains the following contents:

A palladium-catalyzed, ligand promoted, C-H fluorine-containing olefination of anilides with 4-bromo-3,3,4,4-tetrafluorobutene as the fluorinated reagent, which was a potential transformation into other compounds due to its -CF2CF2Br functional group. -CF2CF2H was obtained by using the mild reducing agent sodium borohydride. Bioactive compounds such as aminoglutethimide derivative and propham were well-tolerated in this reaction, both of which highlighted the synthetic importance of this method. In addition to this study using Ethyl oxalyl monochloride, there are many other studies that have used Ethyl oxalyl monochloride(cas: 4755-77-5Reference of Ethyl oxalyl monochloride) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Reference of Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kaur, Ravneet; Singh, Dipak; Singh, Ravi P. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Stereoselective Synthesis of Dihydrocoumarins via [1,2]-Phospha-Brook Rearrangement in Three-Component Coupling Reaction of α-Ketoesters, o-Quinone Methides, and Dialkyl Phosphites》.Product Details of 4755-77-5 The article contains the following contents:

A highly regio- and diastereoselective approach for the synthesis of phosphate substituted dihydrocoumarins I (R1 = 4-methoxyphenyl, 2-(4-methylphenyl)ethenyl, 2-phenylethenyl, etc.; R2 = Ph, 3-bromophenyl, 2-thienyl, etc.; R3 = i-Pr, Et, Ph) via Bronsted base catalyzed [1,2]-phospha-Brook rearrangement is reported. The two-step, one-pot Michael addition of α-phosphonyloxy enolates proceeds by coupling of dialkyl phosphite HP(=O)(OR3)2 and α-ketoesters R2C(O)C(O)OEt to o-quinone methides II, followed by an intramol. cyclization, providing 3,4-dihydrocoumarin frameworks I. The results came from multiple reactions, including the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5Product Details of 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Product Details of 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: 4755-77-5In 2021 ,《Quinazoline-containing hydrazydes of dicarboxylic acids and products of their structural modification: a novel class of anti-inflammatory agents》 appeared in Acta Chimica Slovenica. The author of the article were Krasovska, Nataliia; Stavytskyi, Viktor; Nosulenko, Inna; Karpenko, Oleksandr; Voskoboinik, Oleksii; Kovalenko, Serhii. The article conveys some information:

The synthesis of hydrazides formed by quinazolin-4(3H)-ylidenehydrazine and dicarboxylic acids, as well as their further modification are described in the present manuscript. It was shown that above-mentioned hydrazides may be obtained via acylation of initial quinazolin-4(3H)-ylidenehydrazine by corresponding acylhalides, cyclic anhydrides and imidazolides of dicarboxylic acids monoesters. Obtained hydrazides were converted into [1,2,4]triazolo[1,5-c]quinazolines that were used as initial compounds for chem. modification aimed to the introduction of amide fragment to the mol. The IR, 1H NMR and chromato-mass spectral data of obtained compounds were studied and discussed. Obtained substances were studied for anti-inflammatory activity using carrageenan-induced paw inflammation model. Amides of ([1,2,4]triazolo[1,5-c]quinazoline-2-yl)alkyl carboxylic acids were detected as promising class of anti-inflammatory agents for further purposeful synthesis and profound study of anti-inflammatory activity. In the experimental materials used by the author, we found Ethyl oxalyl monochloride(cas: 4755-77-5HPLC of Formula: 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.HPLC of Formula: 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Tandem Phospha-Michael Addition/N-Acylation/ Intramolecular Wittig Reaction of aza-o-Quinone Methides: Approaches to 2,3-Disubstituted Indoles》 was written by Hua, Ting-Bi; Chao, Fei; Wang, Long; Yan, Chen-Yang; Xiao, Cong; Yang, Qing-Qing; Xiao, Wen-Jing. Recommanded Product: Ethyl oxalyl monochloride And the article was included in Advanced Synthesis & Catalysis in 2020. The article conveys some information:

A tandem phospha-Michael addition/N-acylation/intramol. Wittig reaction of in situ formed aza-o-QMs is disclosed. This approach features high functional group tolerance and provides a convenient and practical access to biol. significant indole derivatives (37 examples, up to 91% yield) under mild reaction conditions. In the part of experimental materials, we found many familiar compounds, such as Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Recommanded Product: Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Category: esters-buliding-blocksIn 2022 ,《Investigation of solid state architectures in tetrazolyl tryptophol stabilized by crucial aromatic interactions and hydrogen bonding: Experimental and theoretical analysis》 was published in Journal of Molecular Structure. The article was written by Ibrar, Aliya; Zaib, Sumera; Hokelek, Tuncer; Simpson, Jim; McAdam, Christopher John; El Azab, Islam H.; Mersal, Gaber A. M.; Ibrahim, Mohamed M.; Frontera, Antonio; Khan, Imtiaz. The article contains the following contents:

The present study reports the synthesis of a new nitrogen rich hybrid compound namely tetrazolyl tryptophol 6 achieved through a multistep synthetic approach. The structure of the target tetrazole-indole hybrid was established using FTIR, 1H- and 13C NMR, HRMS, and X-ray diffraction data. Investigation of solid state architectures in tetrazolyl tryptophol revealed that an intramol. N5-H5N…N4 hydrogen bond links the 5-membered ring of the indole to the tetrazole ring. The O1-H1O… N3 and N1-H1N…O1 hydrogen bonds and π…π contacts also emerged as crucial contributors in the formation of supramol. topol. of tetrazole-indole hybrid. Numerous centroid to centroid contacts involving the aromatic rings of both the indole ring system and the tetrazole ring link adjacent mols. in an obverse face-to-face fashion. Hirshfeld surface anal. further revealed the prevailing significance of π…π and H-bonding contacts. The mech. stability of the crystal packing through crystal voids anal. and intermol. interaction energies were also calculated Finally, DFT calculations were performed to evaluate the hydrogen bonding and π…π stacking contacts with their rationalization and characterization using MEP surfaces, QTAIM and NCIPlot anal.Ethyl oxalyl monochloride(cas: 4755-77-5Category: esters-buliding-blocks) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Journal of Medicinal Chemistry included an article by Liu, Mingming; Liang, Yuru; Zhu, Zhongzhen; Wang, Jin; Cheng, Xingxing; Cheng, Jiayi; Xu, Binpeng; Li, Rong; Liu, Xinhua; Wang, Yang. Application of 4755-77-5. The article was titled 《Discovery of Novel Aryl Carboxamide Derivatives as Hypoxia-Inducible Factor 1α Signaling Inhibitors with Potent Activities of Anticancer Metastasis》. The information in the text is summarized as follows:

In order to discover novel hypoxia-inducible factor 1 (HIF-1) inhibitors for the cancer metastasis treatment, 68 new aryl carboxamide compounds were synthesized and evaluated for their inhibitory effect by dual luciferase-reporter assay. Based on five rounds of investigation on structure-activity relationships step by step, compound I was discovered as the most active inhibitor (IC50 = 0.32 μM) with no obvious cytotoxicity (CC50 > 50 μM). It effectively attenuated hypoxia-induced HIF-1α protein accumulation and reduced transcription of vascular epidermal growth factor in a dose-dependent manner, which was further demonstrated by its inhibitory potency on capillary-like tube formation, angiogenesis of zebrafish as well as cellular migration and invasion. Importantly, compound I exhibited antimetastatic potency in breast cancer lung metastasis in the mice model, indicating its promising therapeutic potential for prevention and treatment of tumor metastasis. These results definitely merit attention for further rational design of more efficient HIF-1 inhibitors in the future. The results came from multiple reactions, including the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5Application of 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application of 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics