Category: 4755-77-5

《A Discrete 3d-4f Metallacage as an Efficient Catalytic Nanoreactor for a Three-Component Aza-Darzens Reaction》 was written by Zhou, Shengbin; Zhang, Zhichao; Bai, Dongjie; Li, Jingzhe; Cui, Xiang; Xu, Zhichuan J.; Tang, Yu; Tang, Xiaoliang; Liu, Weisheng. Recommanded Product: 4755-77-5This research focused onzinc europium metallacage preparation nanoreactor Darzens reaction catalysis; crystal structure europium zinc metallacage quadruple helicate. The article conveys some information:

The exploration and development of coordination nanocages can provide an approach to control chem. reactions beyond the bounds of the flask, which has aroused great interest due to their significant applications in the field of mol. recognition, supramol. catalysis, and mol. self-assembly. Herein, the authors employ a semirigid and nonsym. bridging ligand (H5L) with rich metal-chelating sites to construct an unusual and discrete 3d-4f metallacage, [Zn2Er4(H2L)4(NO3)Cl2(H2O)]·NO3·xCH3OH·yH2O (Zn2Er4). The 3d-4f Zn2Er4 cage possesses a quadruple-stranded structure, and all of the ligands wrap around an open spherical cavity within the core. The self-assembly of the unique cage not only ensures the structural stability of the Zn2Er4 cage as a nanoreactor in solution but also makes the bimetallic lanthanide cluster units active sites that are exposed in the medium-sized cavity. It is important to note that the Zn2Er4 cage as a homogeneous catalyst was successfully applied to catalyze three-component aza-Darzens reactions of formaldehyde, anilines, and α-diazo esters without another additive under mild conditions, displaying better catalytic activity, higher specificity, short reaction time, and low catalyst loadings. A possible mechanism for this three-component aza-Darzens reaction catalyzed by the Zn2Er4 cage is proposed. These exptl. results demonstrated the great potential of the discrete 3d-4f metallacage as a host nanoreactor for the development of supramol. or mol. catalysis. In the part of experimental materials, we found many familiar compounds, such as Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Recommanded Product: 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Metal-, Photocatalyst-, and Light-Free Direct C-H Acylation and Carbamoylation of Heterocycles》 were Westwood, Matthew T.; Lamb, Claire J. C.; Sutherland, Daniel R.; Lee, Ai-Lan. And the article was published in Organic Letters in 2019. Reference of Ethyl oxalyl monochloride The author mentioned the following in the article:

Direct C-H acylation and carbamoylation of heterocycles can be readily achieved without requiring any conventional metal, photocatalyst, electrocatalysis, or light activation, thus significantly improving on sustainability, costs, toxicity, waste, and simplicity of the operational procedure. These mild conditions are also suitable for gram-scale reactions and late-stage functionalizations of complex mols., including pharmaceuticals, N,N-ligands, and light-sensitive mols. In the experiment, the researchers used Ethyl oxalyl monochloride(cas: 4755-77-5Reference of Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Reference of Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Hyaluronic acid-coated polymeric micelles with hydrogen peroxide scavenging to encapsulate statins for alleviating atherosclerosis》 was written by Mu, Dan; Li, Jianhui; Qi, Yu; Sun, Xuan; Liu, Yihai; Shen, Song; Li, Yuyu; Xu, Biao; Zhang, Bing. COA of Formula: C4H5ClO3 And the article was included in Journal of Nanobiotechnology in 2020. The article conveys some information:

Inflammation and oxidative stress are two major factors that are involved in the pathogenesis of atherosclerosis. A smart drug delivery system that responds to the oxidative microenvironment of atherosclerotic plaques was constructed in the present study. Simvastatin (SIM)-loaded biodegradable polymeric micelles were constructed from hyaluronic acid (HA)-coated poly(ethylene glycol)-poly(tyrosine-Et oxalyl) (PEG-Ptyr-EO) for the purpose of simultaneously inhibiting macrophages and decreasing the level of reactive oxygen species (ROS) to treat atherosclerosis. HA coating endows the micelle system the ability of targeting CD44-pos. inflammatory macrophages. Owing to the ROS-responsive nature of PEG-Ptyr-EO, the micelles can not only be degraded by enzymes, but also consumes ROS by itself at the pathol. sites, upon which the accumulation of pro-inflammatory macrophages is effectively suppressed and oxidative stress is alleviated. Consequently, the cellular uptake experiment demonstrated that SIM-loaded HA-coated micelles can be effectively internalized by LPS-induced RAW264.7 cells and showed high cytotoxicity against the cells, but low cytotoxicity against LO2 cells. In mouse models of atherosclerosis, i.v. SIM-loaded HA-coated micelles can effectively reduce plaque content of cholesterol, resulting in remarkable therapeutic effects. In conclusion, the SIM-loaded micelle system provides a promising and innovative option against atherosclerosis. The experimental part of the paper was very detailed, including the reaction process of Ethyl oxalyl monochloride(cas: 4755-77-5COA of Formula: C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.COA of Formula: C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Ferrocenylethenyl-substituted oxadiazoles with phenolic and nitro anchors as sensitizers in dye sensitized solar cells》 were Singh, Amita; Kociok-Kohn, Gabriele; Trivedi, Manoj; Chauhan, Ratna; Kumar, Abhinav; Gosavi, Suresh W.; Terashima, Chiaki; Fujishima, Akira. And the article was published in New Journal of Chemistry in 2019. Name: Ethyl oxalyl monochloride The author mentioned the following in the article:

Three new ferrocenyl oxadiazoles, viz. (E)-2-(4-hydroxyphenyl)-5-(2-ferrocenyl-ethen-1-yl)-1,3,4-oxadiazole (D2), (E)-2-(4-nitrophenyl)-5-(2-ferrocenyl-ethen-1-yl)-1,3,4-oxadiazole (D3) and (E)-3-(4-nitrophenyl)-5-[5-(2-ferroceneylethen-1-yl)-1,3,4-oxadiazol-2-yl]-1,2,4-oxadiazole (D4) derived from (E)-3-ferrocenylacrylic acid (D1) having phenolic or nitro anchors, were synthesized and characterized using microanalyses and relevant spectroscopic techniques. UV-visible spectroscopic studies indicate that with respect to ferrocene, the electronic absorption bands of the new compounds are bathochromically shifted up to 600 nm with a concomitant enhancement in their intensities. All four compounds were used as photosensitizers in TiO2-based dye-sensitized solar cells (DSSCs). The photovoltaic performances and charge transport properties (EIS spectra) of these compounds were studied to appraise their dye performance. All four compounds displayed good photovoltaic performances. However, compounds D2 and D4 displayed superior performance, which might be due to the better electronic communication between the ferrocenyl moiety and the six membered aromatic ring with their -OH/NO2 anchors having five membered oxadiazole spacers, as well as the high dye loading of these compounds on the TiO2 surface, which suppresses charge recombination, prolongs electron lifetime, and decreases the total resistance of DSSCs. The assembly fabricated using D4 performed better with an overall conversion efficiency η of 4.70%, Jsc of 10.33 mA cm-2 and Voc of -0.712 V. In the experiment, the researchers used many compounds, for example, Ethyl oxalyl monochloride(cas: 4755-77-5Name: Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Name: Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Metabolite Responsive Nanoparticle-Protein Complex》 were Fruehauf, Krista R.; Kim, Tae Il; Nelson, Edward L.; Patterson, Joseph P.; Wang, Szu-Wen; Shea, Kenneth J.. And the article was published in Biomacromolecules in 2019. Formula: C4H5ClO3 The author mentioned the following in the article:

Stimuli-responsive polymers are an efficient means of targeted therapy. Compared to conventional agents, they increase bioavailability and efficacy. In particular, polymer hydrogel nanoparticles (NPs) can be designed to respond when exposed to a specific environmental stimulus such as pH or temperature However, targeting a specific metabolite as the trigger for stimuli response could further elevate selectivity and create a new class of bioresponsive materials. In this work we describe an N-isopropylacrylamide (NIPAm) NP that responds to a specific metabolite, characteristic of a hypoxic environment found in cancerous tumors. NIPAm NPs were synthesized by copolymerization with an oxamate derivative, a known inhibitor of lactate dehydrogenase (LDH). The oxamate-functionalized NPs (OxNP) efficiently sequestered LDH to produce an OxNP-protein complex. When exposed to elevated concentrations of lactic acid, a substrate of LDH and a metabolite characteristic of hypoxic tumor microenvironments, OxNP-LDH complexes swelled (65%). The OxNP-LDH complexes were not responsive to structurally related small mols. This work demonstrates a proof of concept for tuning NP responsiveness by conjugation with a key protein to target a specific metabolite of disease. The results came from multiple reactions, including the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5Formula: C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Formula: C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《A luminescent inorganic-organic hybrid, [Cd(C16H10N2O8S)(H2O)], for the selective and recyclable detection of chromates and dichromates in aqueous solution》 were Kundu, Tanaya; Manna, Krishna; Jana, Ajay K.; Natarajan, Srinivasan. And the article was published in New Journal of Chemistry in 2019. Recommanded Product: 4755-77-5 The author mentioned the following in the article:

A new inorganic-organic hybrid compound [Cd(H2L)(H2O)], 1, {where, H2L2- = 4,4′-sulfonylbis(phenylene)bis(oxamate)} was prepared under solvothermal conditions. The compound has a three-dimensional structure. The compound exhibits strong luminescence behavior, and was used for the detection of chromate and dichromate anions in aqueous media at low concentrations The compound exhibited high selectivity and recyclability for the detection of low concentrations (ppm levels) of chromate and dichromate ions. Compound 1 also is an effective catalyst for the Knoevenagel condensation involving aromatic aldehyde and malononitrile under green solvent-free conditions with high yield and recyclability. The experimental part of the paper was very detailed, including the reaction process of Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Recommanded Product: 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Zhou, Yin; Gao, Cheng-Feng; Ma, Hai; Nie, Jing; Ma, Jun-An; Zhang, Fa-Guang published an article in Chemistry – An Asian Journal. The title of the article was 《Quadruple Functionalized Pyrazole Pharmacophores by One-pot Regioselective [3+2] Cycloaddition of Fluorinated Nitrile Imines and Dicyanoalkenes》.Formula: C4H5ClO3 The author mentioned the following in the article:

A quadruple functionalization approach for the modular construction of fully substituted N1-aryl 3-di/trifluoro-methyl-4/5-cyanopyrazole pharmacophores from readily available hydrazonyl chlorides and dicyanoalkenes was presented. The realization of this [3+2] cycloaddition reaction hinges upon the employment of N-aryl di/trifluoromethyl nitrile imines as the 1,3-dipoles to bypass external synthetic steps and dicyanoalkenes as the dipolarophiles to tune the regioselectivity. This one-pot strategy offered access to a divergent library of cyano analogs of prevalent 3-di/trifluoromethyl pyrazole pharmacophores, among which several compounds have shown potent inhibitory activity towards cyclooxygenase 2 (COX-2) compared with marketed drug Celecoxib. The experimental process involved the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5Formula: C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Formula: C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Inorganic Chemistry included an article by Kalinke, Lucas H. G.; Cangussu, Danielle; Mon, Marta; Bruno, Rosaria; Tiburcio, Estefania; Lloret, Francesc; Armentano, Donatella; Pardo, Emilio; Ferrando-Soria, Jesus. Recommanded Product: 4755-77-5. The article was titled 《Metal-Organic Frameworks as Playgrounds for Reticulate Single-Molecule Magnets》. The information in the text is summarized as follows:

Achieving fine control on the structure of metal-organic frameworks (MOFs) is mandatory to obtain target phys. properties. Herein, the authors present how the combination of a metalloligand approach and a postsynthetic method is a suitable and highly useful synthetic strategy to success on this extremely difficult task. First, a novel oxamato-based tetranuclear Co(III) compound with a tetrahedron-shaped geometry was used, for the 1st time, as the metalloligand toward Ca(II) metal ions to lead to a diamagnetic CaII-CoIII three-dimensional (3D) MOF {Ca6(H2O)24[CoIII4(tpatox)4]}·44H2O (1), tpatox6- = N,N’,N”-tris(4-phenyl)aminetris(oxamate). In a 2nd stage single-crystal-to-single-crystal manner, the Ca(II) ions are replaced by Tb(III), Dy(III), Ho(III), and Er(III) to yield isostructural LnIII-CoIII [Ln = Tb 2, Dy 3, Ho 4, and Er 5] 3-dimensional MOFs. Direct-current magnetic properties for 2-5 show typical performances for the ground-state terms of the lanthanoid cations [7F6 (TbIII), 6H15/2 (DyIII), 5I8 (HoIII), and 4I15/2 (ErIII)]. Anal. of the χMT data indicates that the ground state is the lowest MJ value, i.e., MJ = 0 (2 and 4) and ±1/2 (3 and 5). Kramers’ ions (3 and 5) exhibit field-induced emergent frequency-dependent alternating-current magnetic susceptibility signals, which is indicative of the presence of slow magnetic relaxation typical of single-mol. magnets. The authors report the combined use of the metalloligand design strategy and postsynthetic methodologies to build up a family of isostructural metal-organic frameworks as playgrounds toward the controlled spatial organization of single-mol. magnets. The experimental process involved the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Recommanded Product: 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chattopadhyay, Samir; Ghatak, Arnab; Ro, Youngju; Guillot, Regis; Halime, Zakaria; Aukauloo, Ally; Dey, Abhishek published their research in Inorganic Chemistry in 2021. The article was titled 《Ligand Radical Mediated Water Oxidation by a Family of Copper o-Phenylene Bis-oxamidate Complexes》.Application of 4755-77-5 The article contains the following contents:

Understanding the reactivity landscape for the activation of water until the formation of the O-O bond and O2 release in mol. chem. is a decisive step in guiding the elaboration of cost-effective catalysts for the oxygen-evolving reaction (OER). Copper(II) complexes have recently caught the attention of chemists as catalysts for the 4e-/4H+ water oxidation process. While a copper(IV) intermediate has been proposed as the reactive intermediate species, no spectroscopic signature has been reported so far. Copper(III) ligand radical species have also been formulated and supported by theor. studies. We found, herein, that the reactivity sequence for the water oxidation with a family of Copper(II) o-phenylene bis-oxamidate complexes is a function of the substitution pattern on the periphery of the aromatic ring. In-situ EPR, FTIR, and rR spectroelectrochem. studies helped to sequence the elementary electrochem. and chem. events leading toward the O2 formation selectively at the copper center. EPR and FTIR spectroelectrochem. suggests that ligand-centered oxidations are preferred over metal-centered oxidations rR spectroelectrochem. study revealed the accumulation of a bis-imine bound copper(II) superoxide species, as the reactive intermediate, under catalytic turnover, which provides the evidence for the O-O bond formation during OER. The experimental process involved the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5Application of 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Application of 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Ma, Yu-Hong; He, Xiao-Yu; Wang, Long; Yang, Qing-Qing published an article in Journal of Organic Chemistry. The title of the article was 《PPh3-Triggered Tandem Synthesis of 2,3-Disubstituted Benzofuran Derivatives from o-Quinone Methides with Acyl Chlorides》.COA of Formula: C4H5ClO3 The author mentioned the following in the article:

A PPh3-triggered tandem strategy for the efficient synthesis of valuable 2,3-disubstituted benzofuran derivatives in generally good to high yields from aryl or alkyl acyl chlorides and o-quinone methides has been developed. This method features mild reaction conditions, simple operation, and a broad substrate scope.Ethyl oxalyl monochloride(cas: 4755-77-5COA of Formula: C4H5ClO3) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.COA of Formula: C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics