Category: 4755-77-5

Koehling, Jonas; Kalinovich, Nataliya; Pajkert, Romana; Tverdomed, Sergey N.; Lork, Enno; Wagner, Veit; Roeschenthaler, Gerd-Volker published an article in 2021. The article was titled 《Oxamates as 1,2-Diketone Equivalents: The Effect of Fluorine》, and you may find the article in ChemistrySelect.Quality Control of Ethyl oxalyl monochloride The information in the text is summarized as follows:

In this paper, new fluorinated derivatives were presented, which were synthesized from selected fluorinated primary amines RFNH2 (RF=CH2CF3, CH2CHF2, CH2CF2CH3, CH(CF3)2, CH(CH3)CF3) or their hydrochlorides and Et oxalylchloride. Since oxamates was considered as 1,2 diketones, their properties, geometries, effective charges at oxygen and nitrogen and the pKa values for the N-H grouping were investigated . In two cases, the mol. structures was measured by XRD, observing almost planar arrangement of C2-N1-C3-C4 atoms. The effect of fluorine was discussed and compared with non-fluorinated oxamates. The effective charges were controlled by various alkyl substituents at nitrogen (branched or straight, fluorinated or non-fluorinated) and can open a new field, especially when fluorinated, for multiple applications in material sciences (surfaces) and biochem. systems (enzymes). In the experiment, the researchers used many compounds, for example, Ethyl oxalyl monochloride(cas: 4755-77-5Quality Control of Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Quality Control of Ethyl oxalyl monochloride

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The author of 《Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor》 were Zhang, Cunyu; Creech, Katrina L.; Zuercher, William J.; Willson, Timothy M.. And the article was published in Scientific Reports in 2019. Recommanded Product: Ethyl oxalyl monochloride The author mentioned the following in the article:

Development of an efficient and scalable synthesis of 6-formylindolo[3,2-b]carbazole (FICZ), a naturally-occurring aryl hydrocarbon receptor (AhR) ligand, allowed its biol. and phys. properties to be studied. FICZ was shown to be the most potent among a series of 6-substituted indolo[3,2-b]carbazoles I (R = H, CHO, CH2OH, C(O)OEt, C(O)OH) for activation of AhR in cells. Photostability studies of FICZ revealed a non-enzymic mechanism for its conversion to a biol. active quinone. These results further support the hypothesis that FICZ is a light-dependent hormone that links sun exposure to regulation of biol. pathways in peripheral tissues. In addition to this study using Ethyl oxalyl monochloride, there are many other studies that have used Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: Ethyl oxalyl monochloride) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Recommanded Product: Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Ang; Forte, Jeremy; Li, Yanling; Journaux, Yves; Lisnard, Laurent published an article in 2021. The article was titled 《Synthesis, structure and magnetic properties of an oxamate-based 1D coordination polymer built on pentametallic links》, and you may find the article in Inorganica Chimica Acta.Recommanded Product: Ethyl oxalyl monochloride The information in the text is summarized as follows:

The solvothermal reaction of the hexadentate 2-(oxamato)benzoic acid ligand (oaba) with copper(II) and cobalt(II) ions has yielded the [Cu4Co3(oaba)4(OH)2(DMF)6]·2(DMF)·1H2O (1) 1D coordination polymer. The single-crystal x-ray diffraction study reveals the formation of a neutral chain built from pentametallic complexes where each multi-polydentate ligand bridges four metal centers. The atypical morphol. observed here for an oxamate-based 1D polymer arises from the use of a ligand bearing extra coordination sites. Magnetometry indicates strong dominating antiferromagnetic interactions within the polymer resulting in a non-zero ferrimagnetic state at low temperature The results came from multiple reactions, including the reaction of Ethyl oxalyl monochloride(cas: 4755-77-5Recommanded Product: Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Recommanded Product: Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Category: esters-buliding-blocksIn 2019 ,《Slow magnetic relaxation in mononuclear gadolinium(III) and dysprosium(III) oxamate complexes》 appeared in Polyhedron. The author of the article were da Cunha, Tamyris T.; Barbosa, Vitor M. M.; Oliveira, Willian X. C.; Pinheiro, Carlos B.; Pedroso, Emerson F.; Nunes, Wallace C.; Pereira, Cynthia L. M.. The article conveys some information:

A series of lanthanide(III) oxamate complexes of formula Na[Eu(4-HOpa)4(H2O)]•2H2O (1), Na[Gd(4-HOpa)4(H2O)]•2H2O (2), Na[Dy(4-HOpa)4(H2O)]•2H2O (3), and Na[Ho(4-HOpa)4(H2O)]•2H2O (4) (4-HOpa = N-4-hydroxyphenyloxamate) were synthesized and characterized. The crystal structures of complexes 1-4, as well as the oxamate ligand in the Et ester acid form (Et[4-HOpa]), were elucidated by single crystal X-ray diffraction. 1-4 are isostructural, and they crystallize in the P21/n space group of the monoclinic system. The crystal structures of 1-4 consist of mononuclear lanthanide(III) complex anions, [Ln(4-HOpa)4(H2O)]- (Ln = Eu3+, Gd3+, Dy3+, and Ho3+), coordinated sodium countercations, and crystallization water mols., resulting in a 2D NaILnIII supramol. coordination network. The coordination sphere of Ln3+ ions consists of square-face capped square antiprism (SAPRS-9). Magnetic properties were investigated for 1-4 in the 2-300 K temperature range using polycrystalline samples. Complex 2 exhibits an unusual and rare slow-relaxation of the magnetization for Gd3+ ions under DC applied field of 1.0 kOe, behaving as a field-induced single-ion magnet as occurs for the Dy3+ complex 3. The Eu3+ complex 1 has a nonmagnetic ground state, while the Ho3+ compound 4 behave as a paramagnet, and do not exhibit relaxation of the magnetization with or without an applied field. In the part of experimental materials, we found many familiar compounds, such as Ethyl oxalyl monochloride(cas: 4755-77-5Category: esters-buliding-blocks)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm−1.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Ti(IV) Complexes with Bidentate O-Chelating N-Heterocyclic Carbenes for Use in the Homopolymerization of Ethylene and Its Copolymerization with Cyclic Olefins》 were van der Ende, Melita; Hauser, Philipp M.; Lienert, Christina; Wang, Dongren; Frey, Wolfgang; Buchmeiser, Michael R.. And the article was published in ChemCatChem in 2019. Computed Properties of C4H5ClO3 The author mentioned the following in the article:

The synthesis of titanium (IV) complexes bearing bidentate O-chelating N-heterocyclic carbenes (NHCs) is reported. Double deprotonation of the resp. NHC precursor ligand and further reaction with one equivalent of TiCl4·THF2 leads to the formation of complexes Ti1-3 of the general formula TiCl3(NHC-R-O)(THF); (NHC-R-O = 1-(2,6-diisopropylphenyl)-3-(2-O-phenyl)-4,5-dihydroimidazol-2-ylidene, 1-(mesityl)-3-(2-O-phenyl)-4,5-dihydroimidazol-2-ylidene, 1-(2,6-dimethylphenyl)-3-(2-O-phenyl)-4,5-dihydroimidazol-2-ylidene). Furthermore, these Ti-(NHC-R-O) trichloride complexes can be reacted with the bulky aryloxo ligands 2,6-ditBu-4-methylphenolate and 2,2′,4,4′,6,6′-hexa-iPr-terphenoxide, resp., to form the mixed titanium (aryloxo)(NHC-R-O) dichloride pre-catalysts Ti4-6. Single-crystal X-ray structures of complexes Ti1, Ti5 and Ti6 are presented. Depending on the aryloxo ligand used, the complexes possess either a trigonal bipyramidal or square pyramidal ligand sphere. The propensity of Ti1, Ti4-6 to homopolymerize ethylene and to copolymerize ethylene with norborn-2-ene (NBE) and cyclopentene (CPE), resp., was investigated and access to high-mol. weight (co-)polymers with such complexes is disclosed. In addition to this study using Ethyl oxalyl monochloride, there are many other studies that have used Ethyl oxalyl monochloride(cas: 4755-77-5Computed Properties of C4H5ClO3) was used in this study.

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Computed Properties of C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Two Octanuclear {Cu4Ln4} (Ln = Dy or Tb) Complexes with a Butterfly-Shaped Unit Exhibiting Zero-Field Single-Molecule Magnet Behavior》 was published in Inorganic Chemistry in 2020. These research results belong to Zhao, Xiaoxi; Li, Ge; Ma, Jingjing; Liu, Weisheng. Category: esters-buliding-blocks The article mentions the following:

One-pot reaction of an asym. acylhydrazone ligand H3L with Ln(ClO4)3 and CuCl2 in MeOH and MeCN solvents resulted in two novel octanuclear complexes, [Cu4Dy4L4Cl6(MeOH)8(H2O)4]·Cl2(MeOH)9(H2O)3 (1) and [Cu4Tb4L4Cl6(MeOH)2(H2O)10]·Cl2(H2O)x (2). Single-crystal x-ray diffraction studies revealed that these two complexes are isostructural and can be viewed as being built from two {Cu2Ln2L2} (Ln = Dy or Tb) butterfly-shaped units. D.c. magnetic susceptibilities and field-dependent magnetization measurements demonstrated the presence of strong ferromagnetic interaction between CuII and LnIII and magnetic anisotropy. Also, a.c. (a.c.) magnetic measurements illustrate that these two complexes show temperature- and frequency-dependent signals in the out-of-phase a.c. susceptibility under zero applied field, which are typical features of the slow relaxation of the magnetization for 1 and 2. The effective energy barrier (Ueff) for 1 was 54 K, which is one of the highest Ueff values yet reported for CuII/LnIII single-mol. magnets. An asym. acylhydrazone ligand H3L with two coordination pockets was synthesized to construct two novel 3d-4f octanuclear {Cu4Ln4L4} [Ln = Dy 1 or Tb 2 ] complexes with a butterfly-shaped unit. Meanwhile, 1 and 2 exhibited temperature- and frequency-dependent signals in the out-of-phase a.c. susceptibility under zero applied field, which indicated they exhibited typical single-mol. magnet behavior, resulting in an energy barrier (Ueff) for 1 of 54 K. In the part of experimental materials, we found many familiar compounds, such as Ethyl oxalyl monochloride(cas: 4755-77-5Category: esters-buliding-blocks)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ngo, Quoc Anh; Thi, Thuy Hang Nguyen; Pham, Minh Quan; Delfino, Domenico; Do, Thi Thao published their research in Molecular Diversity in 2021. The article was titled 《Antiproliferative and antiinflammatory coxib-combretastatin hybrids suppress cell cycle progression and induce apoptosis of MCF7 breast cancer cellsã€?Reference of Ethyl oxalyl monochloride The article contains the following contents:

In our study, some newly synthesized aryl-substituted pyrazole derivatives mimicking cis-diphenylethylene scaffold of two apoptotic inducing agents celecoxib and combretastatin A-4 were found to have strong antiproliferative as well as antiinflammatory activities. Among these coxib-combretastatin hybrids, two lead compounds 8 and 6c simultaneously inhibited prostaglandin E2 (PGE2) production in LPS-activated murine macrophage RAW 264.7 cells and suppressed cell cycle progression of MCF7 cells at G2/M or G0/G1 phases, but only compound 8 induced apoptosis via caspase-3 activation. Both the lead compounds showed good docking energies with both protein targets COX-2 and tubulin in the mol. interaction modeling. The cis-diphenylethylene scaffold of celecoxib or combretastatin A-4 as well as functional groups such as the Et ester group and the sulfonamide could be considered as potential key features for the dual activity of studied compounds meanwhile the trimethoxybenzene remained the crucial characterization of the newly derived compounds of combretastatins. The experimental part of the paper was very detailed, including the reaction process of Ethyl oxalyl monochloride(cas: 4755-77-5Reference of Ethyl oxalyl monochloride)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Reference of Ethyl oxalyl monochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 4755-77-5In 2021 ,《Isomerization-Induced Multiple Reaction Pathways in Platinum-Catalyzed C-H Acylation Reaction of 2-Aryloxypyridinesã€?appeared in Organometallics. The author of the article were Barham, Alexander; Neu, Justin; Canter, Cathleen L.; Pike, Robert D.; Li, Yumin; Huo, Shouquan. The article conveys some information:

In Pt-catalyzed C-H acylation of 2-(2-methylphenoxy)pyridine (L1) with Et chlorooxoacetate to produce Et 2-(3-methyl-2-(pyridin-2-yloxy))phenyl-2-oxoacetate (L2), possible reaction steps involved in the catalytic cycle were studied, which include the ligand exchange of precatalysts cis- and trans-Pt(PhCN)2Cl2 with L1, the intramol. C-H activation (cyclometalation) of cis- and trans-Pt(L1)2Cl2 (1), and the acylation of the trans-cyclometalated Pt complex (trans-2) formed from the C-H activation reaction. The cis coordination compounds including the intermediate Pt complexes showed much higher reactivity toward the ligand exchange and the C-H activation than their trans isomers. Consequently, the cis isomers exhibit higher catalytic activity in the C-H acylation reaction. Although the C-H activation of cis- and trans-Pt(L1)2Cl2 produces trans-2, the cis isomer (cis-2) is very likely formed in the C-H activation of cis-Pt(L1)2Cl2 but undergoes isomerization to the more stable trans-2. Probably the fast reaction pathway via all cis-Pt complexes may be responsible for the efficient catalytic reaction, but isomerization of cis-2 to trans-2 could be highly competitive. The acylation of the trans-cycloplatinated complex produces both cis- and trans-Pt complexes Pt(L1)(L2)Cl2. The regaining of the cis-Pt complex revives the catalytic cycle. After reading the article, we found that the author used Ethyl oxalyl monochloride(cas: 4755-77-5Product Details of 4755-77-5)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. Lacking the ability to form hydrogen bonds, acyl chlorides have lower boiling and melting points than similar carboxylic acids. For example, acetic acid boils at 118 °C, whereas acetyl chloride boils at 51 °C. Like most carbonyl compounds, infrared spectroscopy reveals a band near 1750 cm�.Product Details of 4755-77-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Total Synthesis of Fontanesine B and Its Isomer: Their Antiproliferative Activity against Human Colorectal Cancer Cellsã€?were Abe, Takumi; Itoh, Tomoki; Terasaki, Masaru. And the article was published in Helvetica Chimica Acta in 2019. Computed Properties of C4H5ClO3 The author mentioned the following in the article:

A concise synthesis of pyrano[3,2-e]indole alkaloid fontanesine B (I) by a Fischer indolization is described. This key Fischer indolization starts with the pyran-ring and alkene intact, facilitating potential synthetic applications. Furthermore, fontanesine B and its isomer were evaluated for in vitro antiproliferative activity against human colorectal cancer cells. The isomer of fontanesine B (II) showed higher antiproliferative activity than the natural product, fontanesine B (2). The experimental part of the paper was very detailed, including the reaction process of Ethyl oxalyl monochloride(cas: 4755-77-5Computed Properties of C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Computed Properties of C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Anti-influenza virus activity of benzo[d]thiazoles that target heat shock protein 90ã€?was published in Bioorganic Chemistry in 2020. These research results belong to Lamut, Andraz; Gjorgjieva, Marina; Naesens, Lieve; Liekens, Sandra; Lillsunde, Katja-Emilia; Tammela, Paivi; Kikelj, Danijel; Tomasic, Tihomir. Electric Literature of C4H5ClO3 The article mentions the following:

Seasonal or pandemic influenza virus infections are a worldwide health problem requiring antiviral therapy. Since virus resistance to the established neuraminidase inhibitors and novel polymerase inhibitors is growing, new drug targets are needed. Heat shock protein 90 (Hsp90) is associated with several aspects of the influenza virus life cycle, and is considered a relevant host cell target. We report here on a series of benzo[d]thiazole and 4,5,6,7-tetrahydrobenzo[d]thiazole derivatives with robust and selective activities against influenza A (H1N1, H3N2) and influenza B viruses. Two compounds, 1 and 4, have low micromolar EC50 values and show high binding affinities for Hsp90, which suggests that inhibition of Hsp90 is the mechanism underlying their antiviral effects. These compounds represent suitable scaffolds for designing novel Hsp90 inhibitors with favorable activities against influenza virus. In the part of experimental materials, we found many familiar compounds, such as Ethyl oxalyl monochloride(cas: 4755-77-5Electric Literature of C4H5ClO3)

Ethyl oxalyl monochloride(cas: 4755-77-5) belongs to acyl chlorides. In the laboratory, acyl chlorides are generally prepared by treating carboxylic acids with thionyl chloride (SOCl2). The reaction is catalyzed by dimethylformamide and other additives.Electric Literature of C4H5ClO3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics