Category: 4248-19-5

Adamek, Jakub; Zielezny, Paulina; Erfurt, Karol published an article in 2021. The article was titled 《Synthesis of N-Protected 1-Aminoalkylphosphonium Salts from Amides, Carbamates, Lactams, or Imides》, and you may find the article in Journal of Organic Chemistry.Electric Literature of C5H11NO2 The information in the text is summarized as follows:

This report describes the development and optimization of the one-pot method for the synthesis of N-protected 1-aminoalkylphosphonium salts [R1CONR2CHR3P+Ar3]X based on the three-component coupling of aldehydes R3CHO and either amides, carbamates, lactams, imides, or ureas R1CONHR2 in the presence of triarylphosphonium salts [Ar3PH]X. The proposed strategy is very efficient and easy to carry out even on a larger scale (20 g) in any typical laboratory Most reactions occur at temperatures between 50 and 100° in a short time (1-2 h) without requiring any catalyst, and simple workup procedures afford good to excellent yields. The exceptions are condensations with imides, which require much higher temperatures (150-170°) and longer reaction times (even 30 h). The possibility of carrying out the synthesis under solvent-free conditions (neat reactions) is also demonstrated. Finally, we prove the developed one-pot methodol. can be successfully applied for the synthesis of structurally diverse N-protected 1-aminoalkylphosphonium salts. Mechanistic studies showed the intermediate products of described couplings are 1-hydroxyalkylphosphonium salts, not N-hydroxyalkylamides, -imides, etc., as initially expected. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl carbamate(cas: 4248-19-5Electric Literature of C5H11NO2)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Electric Literature of C5H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ni, Hangcheng; Li, Chaoming; Shi, Xingzi; Hu, Xianyue; Mao, Hui published an article in 2022. The article was titled 《Visible-Light-Promoted Fe(III)-Catalyzed N-H Alkylation of Amides and N-Heterocycles》, and you may find the article in Journal of Organic Chemistry.Application of 4248-19-5 The information in the text is summarized as follows:

A wide variety of amides RNH2 (R = benzoyl, 2-phenylacetyl, N-benzoylcarbamoyl, etc.) and nitrogen-containing heterocycles e.g., 1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione was tolerated in this protocol to give N-alkylated products I (R1 = H, Me; X = O, S) and e.g., II resp. The applicability of this protocol was further demonstrated by late-stage alkylation of N-H-containing pharmaceuticals. Moreover, N-H-alkylated α-amino tetrahydrofurans could be transformed into versatile ring-opened amino alcs. RNH(CH2)4OH under reducing conditions. A mechanistic study revealed that hydrogen atom transfer by a tert-butoxyl radical and a chlorine radical was responsible for the activation of C(sp3)-H precursors. The experimental process involved the reaction of tert-Butyl carbamate(cas: 4248-19-5Application of 4248-19-5)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Application of 4248-19-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: tert-Butyl carbamateIn 2021 ,《Copper(I)-catalyzed regioselective Ullmann-type coupling of primary carbamates and 5-substituted-1,2,3-triiodobenzenes: facile synthesis of 2,3-diiodinated N-aryl carbamates》 appeared in New Journal of Chemistry. The author of the article were Al-Zoubi, Raed M.; Al-Jammal, Walid K.; Al-Zoubi, Mazhar S.; McDonald, Robert; Zarour, Ahmad; Yassin, Aksam; Al-Ansari, Abdulla. The article conveys some information:

An efficient and unprecedented synthesis of 2,3-dihalo-N-phenylcarbamates through highly regioselective Ullmann-type C-N arylation reactions of 5-substituted-1,2,3-trihalobenzenes and primary carbamates was described. Remarkably, the amination reactions proceeded exclusively at the terminal positions the less sterically hindered, and the most regioactive positions. The highest yields were isolated from a combination between electron poor 1,2,3-triiodobenzenes and Et carbamates. The optimized conditions were found to be suitable for many functional groups. The first and unprecedented method to make 2,3-dihalo-N-phenylcarbamates that is efficient, general in scope, highly regioselective and gave truly remarkable precursors for other transformations.tert-Butyl carbamate(cas: 4248-19-5Recommanded Product: tert-Butyl carbamate) was used in this study.

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Recommanded Product: tert-Butyl carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Xu, Wen-Ke; Guo, Jia-Ming; Liu, Chang-Hong; Sun, Jian-Ting; Lv, Min; Wei, Bang-Guo published an article in Organic & Biomolecular Chemistry. The title of the article was 《AgNTf2 catalyzed cycloaddition of N-acyliminium ions with alkynes for the synthesis of the 3,4-dihydro-1,3-oxazin-2-one skeleton》.Formula: C5H11NO2 The author mentioned the following in the article:

A catalyzed process for the synthesis of 4,6-substituted 3,4-dihydro-1,3-oxazin-2-one I [R = cyclopropyl, Ph, thiophen-2-yl, etc.; R1 = Ph, 4-ethynylphenyl, thiophen-3-yl, etc.] skeleton has been developed through cycloaddition of in situ generated acyliminium intermediates with alkynes R1CCH. A range of chain N,O-acetals (CH3)3COC(O)NHCH(OCH3)(R) and terminal alkynes was amenable for this mild transformation. As a result, a series of desired cycloaddition products I were obtained in moderate to good yields. The results came from multiple reactions, including the reaction of tert-Butyl carbamate(cas: 4248-19-5Formula: C5H11NO2)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Formula: C5H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: 4248-19-5In 2020 ,《Diastereoselective Syntheses of Spiro[indoline-3,4′-pyridin]-2-yl Carbamates via AgOTf/Ph3P-Catalyzed Tandem Cyclizations of Tryptamine-Ynesulfonamides》 was published in Journal of Organic Chemistry. The article was written by Liang, Guoduan; Pang, Yadong; Ji, Yanjun; Zhuang, Kaitong; Li, Linji; Xie, Fukai; Yang, Lu; Cheng, Maosheng; Lin, Bin; Liu, Yongxiang. The article contains the following contents:

Spiro[indoline-3,4′-piperidine] is a significant structural scaffold in numerous polycyclic indole alkaloids with a variety of bioactivities. In this study, a synthetic strategy was developed to access spiro[indoline-3,4′-pyridin]-2-yl carbamate via an AgOTf/PPh3-catalyzed tandem cyclization of tryptamine-ynesulfonamides. The unique feature of this strategy is the efficient intermol. capturing of the in situ generated spiroindoleninium intermediates with carbamates, leading to the diastereoselective syntheses of spiro[indoline-3,4′-pyridin]-2-yl carbamate derivatives A broad scope of this cyclization was demonstrated by a variety of tryptamine-ynesulfonamide substrates and several carbamates. A plausible mechanism of this reaction was proposed. In the experiment, the researchers used tert-Butyl carbamate(cas: 4248-19-5HPLC of Formula: 4248-19-5)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.HPLC of Formula: 4248-19-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Serusi, Lorenzo; Palombi, Laura; Pierri, Giovanni; Mola, Antonia Di; Massa, Antonio published an article in Journal of Organic Chemistry. The title of the article was 《Asymmetric Cascade Aza-Henry/Lactamization Reaction in the Highly Enantioselective Organocatalytic Synthesis of 3-(Nitromethyl)isoindolin-1-ones from α-Amido Sulfones》.SDS of cas: 4248-19-5 The author mentioned the following in the article:

The asym. synthesis of novel 3-substituted isoindolinones, e.g., I was herein reported. A new cascade reaction was developed that consisted of the asym. nitro-Mannich reaction of suitable α-amido sulfones designed from 2-formyl benzoates, followed by the in situ cyclization of the adducts. Very high enantioselectivities, up to 98% ee, and very good yields were obtained in the presence of the readily available neutral bifunctional organocatalyst derived from trans-1,2-diaminocyclohexane, which was known as Takemoto’s catalyst. The investigation of the reactivity of the obtained products allowed either the selective Boc-deprotection or reduction of the nitro group, leading to further functionalized 3-substituted isoindolinones without affecting the enantiomeric purity. The results came from multiple reactions, including the reaction of tert-Butyl carbamate(cas: 4248-19-5SDS of cas: 4248-19-5)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.SDS of cas: 4248-19-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Encoding BRAF inhibitor functions in protein degraders》 was written by Miller, Daniel S. J.; Voell, Sabine A.; Sosic, Izidor; Proj, Matic; Rossanese, Olivia W.; Schnakenburg, Gregor; Gutschow, Michael; Collins, Ian; Steinebach, Christian. Quality Control of tert-Butyl carbamateThis research focused onVemurafenib derivative BRAF kinase inhibitor antitumor activity. The article conveys some information:

Various BRAF kinase inhibitors were developed to treat cancers carrying the BRAFV600E mutation. First-generation BRAF inhibitors could lead to paradoxical activation of the MAPK pathway, limiting their clin. usefulness. Here, we show the development of two series of BRAFV600E-targeting PROTACs and demonstrate that the exchange of the inhibitor scaffold from vemurafenib to paradox-breaker ligands resulted in BRAFV600E degraders that did not cause paradoxical ERK activation. In the experimental materials used by the author, we found tert-Butyl carbamate(cas: 4248-19-5Quality Control of tert-Butyl carbamate)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Quality Control of tert-Butyl carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Dong, Xiaonan; Liang, Qiren; Pan, Yun-Zu; Wang, Xiaoyu; Kuo, Yi-Chun; Chiang, Wei-Chung; Zhang, Xuewu; Williams, Noelle S.; Rizo, Josep; Levine, Beth; De Brabander, Jef K. published an article in ACS Medicinal Chemistry Letters. The title of the article was 《Novel Bcl-2 Inhibitors Selectively Disrupt the Autophagy-Specific Bcl-2-Beclin 1 Protein-Protein Interaction》.Electric Literature of C5H11NO2 The author mentioned the following in the article:

Autophagy plays essential roles in a wide variety of physiol. processes, such as cellular homeostasis, metabolism, development, differentiation, and immunity. Selective pharmacol. modulation of autophagy is considered a valuable potential therapeutic approach to treat diverse human diseases. However, development of such therapies has been greatly impeded by the lack of specific small mol. autophagy modulators. Herein, authors performed structure-activity relationship studies on a previously discovered weak Bcl-2 inhibitor SW076956, and developed a panel of small mol. compounds that selectively released Bcl-2-mediated inhibition of autophagy-related Beclin 1 compared to apoptosis-related Bax at nanomolar concentration NMR anal. showed that compound I directly binds Bcl-2 and specifically inhibits the interaction between the Bcl-2 and Beclin 1 BH3 domains without disruption of the Bcl-2-Bax BH3 interaction. More broadly, this proof-of-concept study demonstrates that targeting protein-protein interactions of the intrinsic autophagy regulatory network can serve as a valuable strategy for the development of autophagy-based therapeutics. After reading the article, we found that the author used tert-Butyl carbamate(cas: 4248-19-5Electric Literature of C5H11NO2)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Electric Literature of C5H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Asymmetric Organocatalyzed Friedel-Crafts Reaction of Trihaloacetaldehydes and Phenols》 was written by Svestka, David; Otevrel, Jan; Bobal, Pavel. Category: esters-buliding-blocksThis research focused ontrihalohydroxyalkylphenol preparation enantioselective regioselective; phenol trihaloacetaldehyde Friedel Crafts reaction organocatalyst. The article conveys some information:

Herein, the asym. organocatalyzed method for the Friedel-Crafts reaction between activated phenols and trihaloacetaldehydes was reported. A three-phase screening including 41 compounds was employed to identify a catalyst structure based on 3,5-dinitrobenzamide of 9-amino-epi-cinchonidine as the lead catalytic mol. Under the optimized reaction conditions, the above catalyst offered trihalohydroxyalkylated adducts, e.g., I in yields ranging from 26 to 92% and enantiomeric ratios within 69:31-99:1. The reaction scope was determined on 29 entries and several follow-up transformations of the enantioenriched products were accomplished. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl carbamate(cas: 4248-19-5Category: esters-buliding-blocks)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Enantioselective synthesis of chiral α-alkynylated thiazolidones by tandem S-addition/acetalization of alkynyl imines》 was published in Organic & Biomolecular Chemistry in 2020. These research results belong to Wang, Mei-Xin; Liu, Juan; Liu, Zhen; Wang, Yingcheng; Yang, Qi-Qiong; Shan, Wenyu; Deng, Yu-Hua; Shao, Zhihui. Reference of tert-Butyl carbamate The article mentions the following:

A SPINOL-derived chiral phosphoric acid catalyzed asym. formal [2+3]-annulation of in-situ generated alkynyl imines and 1,4-dithiane-2,5-diol was developed to afford enantiopure α-alkynylated thiazolidones with up to 72% yield and 98.5 : 1.5 er. This tandem annulation involved a tandem S-addition of alkynyl imines/intramol. acetalization, followed by PDC-mediated oxidation The α-alkynylated thiazolidones facilely afforded the corresponding chiral α-alkynylated or α-alkenylated cyclic sulfoxides via further elaboration. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl carbamate(cas: 4248-19-5Reference of tert-Butyl carbamate)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Reference of tert-Butyl carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics