Category: 4248-19-5

In 2019,Organic Letters included an article by Shao, Xiaoqing; Zheng, Yue; Tian, Lifang; Martin-Torres, Inmaculada; Echavarren, Antonio M.; Wang, Yahui. Application In Synthesis of tert-Butyl carbamate. The article was titled 《Decarboxylative Csp3-N Bond Formation by Electrochemical Oxidation of Amino Acids》. The information in the text is summarized as follows:

Decarboxylative Csp3-N coupling reactions have been developed through electrochem. oxidation of amino acids. The reaction proceeds via anodic oxidative decarboxylation of carboxylic acids to form stabilized carbocations, which are trapped by azoles or amides to construct C-N bonds. This method avoids the preactivation of carboxylic acids and the use of expensive transition-metals and external chem. oxidants. In addition to this study using tert-Butyl carbamate, there are many other studies that have used tert-Butyl carbamate(cas: 4248-19-5Application In Synthesis of tert-Butyl carbamate) was used in this study.

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Application In Synthesis of tert-Butyl carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Worayuthakarn, Rattana; Suddee, Nattanit; Nealmongkol, Prattya; Ruchirawat, Somsak; Thasana, Nopporn published an article in 2022. The article was titled 《Copper-Mediated C-O/C-N Bond Formation: A Facile Synthesis of 3-Amidocoumarin, 3-Amidoazacoumarin, and N -Aroylindole Derivatives》, and you may find the article in Synlett.Safety of tert-Butyl carbamate The information in the text is summarized as follows:

Three different heterocyclic systems such as 3-amidocoumarins, 3-amidoazacoumarins I [R1 = H, OMe; R2 = H, OMe; R1 = R2 = H, OMe; X = CH, N; Y = CH, N; Ar = Ph, furan-3-yl, thiophene-2-yl, etc.; Z = N, O] and N-benzoylindol-2-carboxamides II [R = H, 6-OMe, 5-OMe, etc.] were synthesized via of copper-mediated C-O/C-N bond formation from azlactones under various heating conditions. The stereochem. of the double bond dictated the nature of the products. Microwave irradiation played an important role in the isomerization of the trisubstituted olefin leading to the formation of 3-amidocoumarins and 3-amidoazacoumarins. Three products showed promising-to-good cytotoxic activities against a panel of cancer cell lines, including HepG2 (hepatoblastoma) and MOLT-3 (T-lymphoblast acute lymphoblastic leukemia). In the experiment, the researchers used many compounds, for example, tert-Butyl carbamate(cas: 4248-19-5Safety of tert-Butyl carbamate)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Safety of tert-Butyl carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Name: tert-Butyl carbamateIn 2022 ,《Fluorine-induced diastereodivergence discovered in an equally rare enantioselective syn-aza-Henry reaction》 was published in Chemical Science. The article was written by Bing, Jade A.; Schley, Nathan D.; Johnston, Jeffrey N.. The article contains the following contents:

In attention to the aza-Henry reaction, particularly over the past two decades, a wide range of effective catalysts has been resulted for the enantio- and diastereoselective versions, driven by the versatility of the β-amino nitroalkane products RCH(R1)NO2 (R = H, F; R1 = Ph, 2-phenylethyl) as precursors to secondary amines anti/syn- RC(NO2)R1CH(R2)NH(C(O)2C(CH3)3) (R2 = 2,2-dimethylpropyl, CH2=CH(CH2)2, Ph, 4-chlorophenyl) and vic-diamines. Despite this broad effort, syn-diastereoselective variants are exceedingly rare. A subset of α-fluoro nitroalkane additions that are characterized by an unusual crossover in diastereoselection, often delivering the products with high selectivities is discovered. A rigorous comparative anal. of non-fluorinated and α-fluoro nitroalkanes in their additions to azomethines have been reported here. Both homogeneous and heterogeneous catalysis were applied to probe the possibility that this phenomenon might be more widely operative in the enantioselective additions of fluorine-substituted carbon nucleophiles. A complete correlation within four categories is described that a clear trend is uncovered, while revealing a dramatic and distinct reversal of diastereoselection that would normally go undetected. In the experiment, the researchers used tert-Butyl carbamate(cas: 4248-19-5Name: tert-Butyl carbamate)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Name: tert-Butyl carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Organic Letters included an article by Yasumoto, Kento; Kano, Taichi; Maruoka, Keiji. SDS of cas: 4248-19-5. The article was titled 《One-Pot Synthesis of Less Accessible N-Boc-Propargylic Amines through BF3-Catalyzed Alkynylation and Allylation Using Boronic Esters》. The information in the text is summarized as follows:

Alkynyl and alkenyl N-Boc propargylamines such as I (R = Ph, 4-MeOC6H4, 4-BrC6H4, 4-MeO2CC6H4, Bu, cyclohexyl, Me3Si) were prepared by alkynylation or allylation of N-Boc alkynyl aldimines (generated in situ from alkynals and BocNH2 or from N,N’-di-Boc aminals) with alkynyl or allyl diisopropylborates in the presence of BF3·Et2O at ambient temperature in CH2Cl2. The method allows N-Boc-propargylic amines to be obtained that are difficult to prepare by other methods. In the experimental materials used by the author, we found tert-Butyl carbamate(cas: 4248-19-5SDS of cas: 4248-19-5)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.SDS of cas: 4248-19-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Organic Letters included an article by Feng, Fang-Fang; Li, Shen; Cheung, Chi Wai; Ma, Jun-An. Application In Synthesis of tert-Butyl carbamate. The article was titled 《Chiral β-Keto Propargylamine Synthesis via Enantioselective Mannich Reaction of Enamides with C-Alkynyl N-Boc N,O-Acetals》. The information in the text is summarized as follows:

Propargylamines are an important class of compounds in organic synthesis and drug discovery, yet the synthesis of chiral β-keto propargylamines remains underdeveloped. Herein, the authors describe a streamlined and general enantioselective Mannich reaction of enamides with C-alkynyl N-Boc N,O-acetals, which serve as readily available C-alkynyl imine precursors, to access a broad range of chiral β-keto N-Boc-propargylamines bearing single stereogenic centers in high yields (up to 98%) and in high enantioselectivities (up to 95% ee). The experimental process involved the reaction of tert-Butyl carbamate(cas: 4248-19-5Application In Synthesis of tert-Butyl carbamate)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Application In Synthesis of tert-Butyl carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《A facile synthesis of ligands for the von Hippel-Lindau E3 ligase》 was written by Steinebach, Christian; Voell, Sabine Anna; Vu, Lan Phuong; Bricelj, Alesa; Sosic, Izidor; Schnakenburg, Gregor; Guetschow, Michael. SDS of cas: 4248-19-5 And the article was included in Synthesis in 2020. The article conveys some information:

The proteolysis-targeting chimeras (PROTACs) have become an integral part of different stages of drug discovery. This growing field, therefore, benefits from advancements in all segments of the design of these compounds Herein, an efficient and optimized synthetic protocol to various von Hippel-Lindau (VHL) ligands is presented, which enables easy access to multigram quantities of these essential PROTAC building blocks. Moreover, the elaborated synthesis represents a straightforward approach to further explore the chem. space of VHL ligands. The experimental process involved the reaction of tert-Butyl carbamate(cas: 4248-19-5SDS of cas: 4248-19-5)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.SDS of cas: 4248-19-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Iridium-catalyzed asymmetric trans-selective hydrogenation of 1,3-disubstituted isoquinolines》 was written by Kim, Alexia N.; Ngamnithiporn, Aurapat; Bartberger, Michael D.; Stoltz, Brian M.. Reference of tert-Butyl carbamateThis research focused ontrans tetrahydroisoquinoline preparation enantioselective; isoquinoline hydrogenation iridium catalyst. The article conveys some information:

The development of the first asym. trans-selective hydrogenation of 1,3-disubstituted isoquinolines is reported. Utilizing [Ir(cod)Cl]2 and a com. available chiral Josiphos ligand, a variety of differentially substituted isoquinolines are hydrogenated to produce enantioenriched trans-tetrahydroisoquinolines in good yield with high levels of enantioselectivity. Directing group studies demonstrate that the hydroxymethyl functionality at the C1 position is critical for hydrogenation to favor the trans-diastereomer. Preliminary mechanistic studies reveal that non-coordinating chlorinated solvents and halide additives are crucial to enable trans-selectivity. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl carbamate(cas: 4248-19-5Reference of tert-Butyl carbamate)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Reference of tert-Butyl carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Ground Triplet Spirobiradical: 2,2′,7,7′-Tetra(tert-butyl)-9,9′(10H,10’H)-spirobiacridine-10,10′-dioxyl》 were Kanetomo, Takuya; Ichihashi, Kana; Enomoto, Masaya; Ishida, Takayuki. And the article was published in Organic Letters in 2019. COA of Formula: C5H11NO2 The author mentioned the following in the article:

A new spirobiradical, 2,2′,7,7′-tetra(tert-butyl)-9,9′(10H,10’H)-spirobiacridine-10,10′-dioxyl, was prepared The crystallog. anal. clarified the D2d mol. structure, suggesting the degeneracy of SOMOs. The magnetic study revealed that intramol. ferromagnetic coupling was operative with 2J/kB = +23(1) K. To the best of our knowledge, the ferromagnetic coupling parameter is the largest ever reported for a paramagnetic spiro compound The experimental process involved the reaction of tert-Butyl carbamate(cas: 4248-19-5COA of Formula: C5H11NO2)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.COA of Formula: C5H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Rekha; Sharma, Sonam; Singh, Gurdeep; Vijaya Anand, Ramasamy published an article in ACS Organic & Inorganic Au. The title of the article was 《Tropylium Salt-Promoted Vinylogous Aza-Michael Addition of Carbamates to para-Quinone Methides: Elaboration to Diastereomerically Pure α,α’-Diarylmethyl Carbamates》.Formula: C5H11NO2 The author mentioned the following in the article:

A tropylium cation-promoted vinylogous aza-Michael addition of carbamates to para-quinone methides (QMs) to access a wide range of unsym. α,α’-diarylmethyl carbamates I [R1 = Ph, 2-naphthyl, 2-thienyl, etc.; R2 = Et, i-Pr, t-Bu] was reported. This mild protocol was effective for the vinylogous conjugate addition of (-)-menthyl carbamate to p-QMs, and the resp. diastereomerically pure α,α’-diarylmethyl carbamate derivatives II [R3 = Ph, 4-MeOC6H4, 3-O2NC6H4, etc.] could be obtained in excellent yields and diastereoselectivities (up to >20:1 de).tert-Butyl carbamate(cas: 4248-19-5Formula: C5H11NO2) was used in this study.

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Formula: C5H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rossolini, Thomas; Das, Ashis; Nicolai, Stefano; Waser, Jerome published an article in 2022. The article was titled 《Pd(II)-Catalyzed Aminoacetoxylation of Alkenes via Tether Formationã€? and you may find the article in Organic Letters.Quality Control of tert-Butyl carbamate The information in the text is summarized as follows:

A Pd-catalyzed method based on the use of a mol. tether was described for olefin difunctionalization to yield oxazolidines I [R = H, Ph, 3-tolyl, etc.; PG = Boc, Ts, Cbz]. Enabled by an easily introduced trifluoroacetaldehyde-derived tether, simultaneous introduction of oxygen and nitrogen heteroatoms across unsaturated carbon-carbon bonds was achieved under oxidative conditions, most probably via high valent Pd intermediates. Good yields and high diastereoselectivity were obtained with aryl-substituted alkenes, whereas nonterminal alkyl-substituted olefins gave aza-Heck products. Tether cleavage under mild conditions provided fast access to functionalized β-amino alcs. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl carbamate(cas: 4248-19-5Quality Control of tert-Butyl carbamate)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Quality Control of tert-Butyl carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics