Category: 415918-91-1

Category: esters-buliding-blocks. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, is researched, Molecular C36H30NO2P, CAS is 415918-91-1, about Desymmetrization of difluoromethylene groups by C-F bond activation. Author is Butcher, Trevor W.; Yang, Jonathan L.; Amberg, Willi M.; Watkins, Nicholas B.; Wilkinson, Natalie D.; Hartwig, John F..

Tertiary stereogenic centers containing one fluorine atom are valuable for medicinal chem. because they mimic common tertiary stereogenic centers containing one hydrogen atom, but they possess distinct charge distribution, lipophilicity, conformation and metabolic stability1-3. Although tertiary stereogenic centers containing one hydrogen atom are often set by enantioselective desymmetrization reactions at one of the two carbon-hydrogen (C-H) bonds of a methylene group, tertiary stereocenters containing fluorine have not yet been constructed by the analogous desymmetrization reaction at one of the two carbon-fluorine (C-F) bonds of a difluoromethylene group3. Fluorine atoms are similar in size to hydrogen atoms but have distinct electronic properties, causing C-F bonds to be exceptionally strong and geminal C-F bonds to strengthen one another4. Thus, exhaustive defluorination typically dominates over the selective replacement of a single C-F bond, hindering the development of the enantioselective substitution of one fluorine atom to form a stereogenic center5,6. Here the authors report the catalytic, enantioselective activation of a single C-F bond in an allylic difluoromethylene group to provide a broad range of products containing a monofluorinated tertiary stereogenic center. By combining a tailored chiral iridium phosphoramidite catalyst, which controls regioselectivity, chemoselectivity and enantioselectivity, with a fluorophilic activator, which assists the oxidative addition of the C-F bond, these reactions occur in high yield and selectivity. The design principles proposed in this work extend to palladium-catalyzed benzylic substitution, demonstrating the generality of the approach.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Category: esters-buliding-blocks. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, is researched, Molecular C36H30NO2P, CAS is 415918-91-1, about Methyl-monofluorination of ibuprofen selectively increases its inhibitory activity toward cyclooxygenase-1 leading to enhanced analgesic activity and reduced gastric damage in vivo. Author is Su, Hong; Xie, Yuli; Liu, Wen-Bo; You, Shu-Li.

Newly developed monofluoromethylation reaction provided access to various bioactive mols. with an interesting monofluoromethyl unit. An iridium-catalyzed asym. version was employed for large-scale methyl-monofluorination of widely used nonsteroidal anti-inflammatory drug ibuprofen (the active S isoform). The methyl-monofluorinated ibuprofen was found to selectively inhibit cyclooxygenase-1 over cyclooxygenase-2 and surprisingly, the compound, with almost equal pharmacokinetic profile, was shown to increase analgesic activity and diminish gastric damage in animal models comparing to the parent drug ibuprofen. Therefore, methyl-monofluorination could be a useful strategy for improving efficacy and safety profile of drugs from the ‘profen’ family.

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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, is researched, Molecular C36H30NO2P, CAS is 415918-91-1, about Regio- and Enantioselective N-Allylations of Imidazole, Benzimidazole, and Purine Heterocycles Catalyzed by Single-Component Metallacyclic Iridium Complexes. Author is Stanley, Levi M.; Hartwig, John F..

Highly regio- and enantioselective iridium-catalyzed N-allylations of benzimidazoles, imidazoles, and purines were developed. N-Allylated benzimidazoles and imidazoles were isolated in high yields (up to 97%) with high branched-to-linear selectivity (up to 99:1) and enantioselectivity (up to 98% ee) from the reactions of benzimidazole and imidazole nucleophiles with unsym. allylic carbonates in the presence of single component, ethylene-bound, metallacyclic iridium catalysts. N-Allylated purines were also obtained in high yields (up to 91%) with high N9/N7 selectivity (up to 96:4), high branched-to-linear selectivity (98:2), and high enantioselectivity (up to 98% ee) under similar conditions. Competition experiments between common amine nucleophiles and the heterocyclic nitrogen nucleophiles illustrated the effect of nucleophile pKa on the rate of the iridium-catalyzed N-allylation reactions. Kinetic studies on the allylation of benzimidazole catalyzed by metallacyclic iridium-phosphoramidite complexes, in combination with studies on the deactivation of these catalysts in the presence of heterocyclic nucleophiles, provided insight into the effects of the structures of the phosphoramidite ligands on the stability of the metallacyclic catalysts.

From this literature《Regio- and Enantioselective N-Allylations of Imidazole, Benzimidazole, and Purine Heterocycles Catalyzed by Single-Component Metallacyclic Iridium Complexes》,we know some information about this compound(415918-91-1)Recommanded Product: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, but this is not all information, there are many literatures related to this compound(415918-91-1).

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, is researched, Molecular C36H30NO2P, CAS is 415918-91-1, about Stereoselective synthesis of 2,6-disubstituted piperidines using the iridium-catalyzed allylic cyclization as configurational switch: asymmetric total synthesis of (+)-241 D and related piperidine alkaloids. Author is Gnamm, Christian; Krauter, Caroline M.; Broedner, Kerstin; Helmchen, Guenter.

Pressing the configurational switch: Use of enantiomeric Ir catalysts allows the vinylpiperidine building blocks I (R = CH:CH2, R1 = H; R = H, R1 = CH:CH2) to be synthesized with high selectivity. Total syntheses of the dendrobate alkaloid (+)-241 D, its C6-epimer, and spruce alkaloid I (R = H, R1 = n-Pr) are presented as applications.

From this literature《Stereoselective synthesis of 2,6-disubstituted piperidines using the iridium-catalyzed allylic cyclization as configurational switch: asymmetric total synthesis of (+)-241 D and related piperidine alkaloids》,we know some information about this compound(415918-91-1)Reference of (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, but this is not all information, there are many literatures related to this compound(415918-91-1).

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Axial-to-Central Chirality Transfer for Construction of Quaternary Stereocenters via Dearomatization of BINOLs, published in 2019-11-15, which mentions a compound: 415918-91-1, mainly applied to spiro benzochromene naphthalenone asym synthesis; binaphthol dearomatization axial chirality transfer propargyl carbonate enantioselective spirocyclization, Computed Properties of C36H30NO2P.

Herein, an axial-to-central chirality transfer strategy for the synthesis of chiral quaternary stereocenters via dearomatization of (S)-BINOLs is disclosed. The reaction of (S)-BINOL with a wide range of propargyl carbonates I (R = Me, cyclopropyl, Ph, 4-ClC6H4, 1-naphthyl, 2-benzothienyl, etc.) proceeded smoothly to afford chiral spiro compounds II in high yields with excellent enantioselectivities. In addition, the strategy was extended to kinetic resolution of rac-BINOLs albeit with moderate s value.

There is still a lot of research devoted to this compound(SMILES：C[C@@H](N(P1OC2=CC=C3C=CC=CC3=C2C4=C5C=CC=CC5=CC=C4O1)[C@@H](C6=CC=CC=C6)C)C7=CC=CC=C7)Computed Properties of C36H30NO2P, and with the development of science, more effects of this compound(415918-91-1) can be discovered.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quality Control of (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, is researched, Molecular C36H30NO2P, CAS is 415918-91-1, about Influence of copper salts, solvents, and ligands on the structures of precatalytic phosphoramidite copper complexes for conjugate addition reactions. Author is Zhang, Hongxia; Gschwind, Ruth M..

For Cu-catalyzed enantioselective conjugate addition reactions of organozinc reagents, the available knowledge about the mechanism and the structures involved is still insufficient to understand in detail the strong influences of solvent, salt, and ligand size, or to enable a rational control of this reaction. Screening with three phosphoramidite ligands and four Cu(I) salts using NMR spectroscopy revealed a binuclear Cu complex with mixed trigonal/tetrahedral stereochem. as the basic structural motif of the ground state of precatalysts with highly stereoselective ligands. Ligands with smaller amine moieties allow higher coordination numbers and higher aggregation levels, leading to reduced ee values. Since the ESI mass spectra of several precatalytic Cu halide complexes show a striking correlation with the structures observed in solution, ESI-MS may be used as a fast tool to determine the maximum number of phosphoramidite ligands attached to Cu.

There is still a lot of research devoted to this compound(SMILES：C[C@@H](N(P1OC2=CC=C3C=CC=CC3=C2C4=C5C=CC=CC5=CC=C4O1)[C@@H](C6=CC=CC=C6)C)C7=CC=CC=C7)Quality Control of (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, and with the development of science, more effects of this compound(415918-91-1) can be discovered.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 415918-91-1, is researched, SMILESS is C[C@@H](N(P1OC2=CC=C3C=CC=CC3=C2C4=C5C=CC=CC5=CC=C4O1)[C@@H](C6=CC=CC=C6)C)C7=CC=CC=C7, Molecular C36H30NO2PJournal, Article, Organic & Biomolecular Chemistry called Application of iridium catalyzed allylic substitution reactions in the synthesis of branched tryptamines and homologues via tandem hydroformylation-Fischer indole synthesis, Author is Bondzic, Bojan P.; Farwick, Andreas; Liebich, Jens; Eilbracht, Peter, the main research direction is tryptamine preparation allylic substitution iridium catalyst; hydroformylation Fischer indole synthesis iridium allylic substitution.Synthetic Route of C36H30NO2P.

Combination of enantioselective allylation reactions with a tandem hydroformylation-Fischer indole synthesis sequence as a highly diversity-oriented strategy for the synthesis of tryptamines and homologues was explored. This modular approach allows the substituents at C3 of the indole core, the type of the amine moiety, and the distance of the amine moiety to the indole core in the final synthetic step to be defined. The starting materials required for the hydroformylation step were synthesized via iridium catalyzed enantioselective allylic substitution reactions in high yields and excellent enantioselectivities. The Rh catalyzed hydroformylation step in the presence of Ph hydrazine, allows the in situ formed aldehyde to be trapped as the hydrazone. Subsequent acid catalyzed indolization furnishes the desired indole structures, e.g. I, in moderate to good yields.

There is still a lot of research devoted to this compound(SMILES：C[C@@H](N(P1OC2=CC=C3C=CC=CC3=C2C4=C5C=CC=CC5=CC=C4O1)[C@@H](C6=CC=CC=C6)C)C7=CC=CC=C7)Synthetic Route of C36H30NO2P, and with the development of science, more effects of this compound(415918-91-1) can be discovered.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine(SMILESS: C[C@@H](N(P1OC2=CC=C3C=CC=CC3=C2C4=C5C=CC=CC5=CC=C4O1)[C@@H](C6=CC=CC=C6)C)C7=CC=CC=C7,cas:415918-91-1) is researched.Related Products of 610-09-3. The article 《Hydrovinylation of Norbornene. Ligand-Dependent Selectivity and Asymmetric Variations》 in relation to this compound, is published in Organic Letters. Let’s take a look at the latest research on this compound (cas:415918-91-1).

Norbornene undergoes Ni-catalyzed (1-2 mol% allylnickel bromide/phosphine/NaBARF, sodium tetrakis[3,5-bis(trifluormethyl)phenyl]borate or AgSbF6, 1 bar ethylene, -50 °C) hydrovinylation (>97% yield), giving either a 1:1 or a 2:1 (norbornene/ethylene) adduct depending on the size of the phosphine. Use of binaphthol-derived phosphoramidite ligand results in up to 80% ee for the 1:1 adduct. The course of the reaction is highly dependent on the ligand (size and configuration of the appendages) and the counteranion present.

There is still a lot of research devoted to this compound(SMILES：C[C@@H](N(P1OC2=CC=C3C=CC=CC3=C2C4=C5C=CC=CC5=CC=C4O1)[C@@H](C6=CC=CC=C6)C)C7=CC=CC=C7)Product Details of 415918-91-1, and with the development of science, more effects of this compound(415918-91-1) can be discovered.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, is researched, Molecular C36H30NO2P, CAS is 415918-91-1, about Asymmetric allylation of aryl aldehydes: studies on the scope and mechanism of the palladium catalyzed diethylzinc mediated umpolung using phosphoramidite ligands, the main research direction is asym allylation aryl aldehyde palladium diethylzinc phosphoramidite ligand.Safety of (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine.

Using modular, monodentate phosphoramidite ligands, enantioselective palladium catalyzed diethylzinc mediated allylation of aldehydes was achieved. The scope of the asym. C-C bond formation was investigated with respect to nucleophilic and electrophilic components and an alternative reaction mechanism is proposed based on our findings.

From this literature《Asymmetric allylation of aryl aldehydes: studies on the scope and mechanism of the palladium catalyzed diethylzinc mediated umpolung using phosphoramidite ligands》,we know some information about this compound(415918-91-1)Safety of (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, but this is not all information, there are many literatures related to this compound(415918-91-1).

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chu, Wen-Dao; Guo, Fangfang; Yu, Lefei; Hong, Junting; Liu, Qianyi; Mo, Fanyang; Zhang, Yan; Wang, Jianbo published an article about the compound: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine( cas:415918-91-1,SMILESS:C[C@@H](N(P1OC2=CC=C3C=CC=CC3=C2C4=C5C=CC=CC5=CC=C4O1)[C@@H](C6=CC=CC=C6)C)C7=CC=CC=C7 ).Quality Control of (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:415918-91-1) through the article.

The first catalytic enantioselective C(sp)-C(sp) cross-coupling reaction between N-tosylhydrazones and trialkylsilylethynes in the presence of Cu(I) salts and chiral phosphoramidite ligands was developed. A series of synthetically interesting, functionalized alkynes were obtained with moderate to good enantioselectivities (up to 83% ee). Cu(II) carbene migratory insertion is proposed to be the enantio-determining step.

From this literature《Cu(I)-Catalyzed Asymmetric Cross-Coupling of N-Tosylhydrazones and Trialkylsilylethynes: Enantioselective Construction of C(sp)-C(sp3) Bonds》,we know some information about this compound(415918-91-1)Quality Control of (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, but this is not all information, there are many literatures related to this compound(415918-91-1).

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics