Category: 4098-06-0

Lin, Cin-Hao; Wen, Hsin-Chuan; Chiang, Cheng-Chin; Huang, Jen-Sheng; Chen, Yunching; Wang, Sheng-Kai published the artcile< Polyproline tri-helix macrocycles as nanosized scaffolds to control ligand patterns for selective protein oligomer interactions>, Electric Literature of 4098-06-0, the main research area is conformation polyproline helix macrocycle synthesis nanosized scaffold cell recognition; protein oligomer interaction glycoprotein cell surface nanomedicine; asialoglycoprotein receptor oligomer human hepatoma cell galactose pattern selectivity; solid phase peptide synthesis Click chem azide alkyne cycloaddition; peptide cyclization macrocycle conjugation glycan galactose mannose; asialoglycoprotein receptors; carbohydrate-protein interactions; molecular architecture; molecular patterns; polyproline.

Multivalent ligand-receptor interactions play essential roles in biol. recognition and signaling. As the receptor arrangement on the cell surface can alter the outcome of cell signaling and also provide spatial specificity for ligand binding, controlling the presentation of ligands has become a promising strategy to manipulate or selectively target protein receptors. The lack of adjustable universal tools to control ligand positions at the size of a few nanometers has prompted the development of polyproline tri-helix macrocycles as scaffolds to present ligands in designated patterns. Model lectin Helix pomatia agglutinin has shown selectivity toward the matching GalNAc ligand pattern matching its binding sites arrangement. The GalNAc pattern selectivity is also observed on intact asialoglycoprotein receptor oligomer on human hepatoma cells showing the pattern-selective interaction can be achieved not only on isolated protein oligomers but also the receptors arranged on the cell surface. As the scaffold design allows convenient creation of versatile ligand patterns, it can be expected as a promising tool to probe the arrangement of receptors on the cell surface and as nanomedicine to manipulate signaling or cell recognition.

Small published new progress about Agglutinins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Electric Literature of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bhardwaj, Monika; Rasool, Faheem; Tatina, Madhu Babu; Mukherjee, Debaraj published the artcile< Construction of Fused Oxabicyclic Scaffolds from Glycals and Styrenes via One-Pot Domino Transformations>, COA of Formula: C12H16O7, the main research area is arylcyclopentenofuran arylnaphthopyran diastereoselective nonracemic preparation; triflic acid catalyst ring opening cyclocondensation glycosylation styrene glycal; stereoselective tandem ring opening cyclocondensation styrene glycal dichloromethane solvent; tandem Ferrier glycosylation Friedel Crafts reaction styrene glycal arene; mechanism kinetic isotope effect cyclocondensation styrene glucal benzene.

Glycals underwent diastereoselective cascade ring opening and cyclocondensation reactions with styrenes in the presence of TfOH in CH2Cl2 to yield arylcyclopentenofurans such as I. When either benzene or toluene was used as solvent, glycals underwent diastereoselective cascade Ferrier C-glycosylation and double Friedel-Crafts reactions with styrenes in the presence of TfOH to yield arylnaphthopyrans (oxadecalins) such as II. The mechanism of the reaction of triacetoxy-D-glucal with styrene in benzene was studied by isolation of intermediates and by determination of the deuterium kinetic isotope effect which provided evidence for the C-glycosylation as the slow step in the reaction. A mechanism for the reactions is proposed.

Organic Letters published new progress about Cyclic ethers Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, COA of Formula: C12H16O7.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Si-Xian; Tsai, Yun-Tzu; Lin, Yu-Tung; Li, Jia-Yue; Chang, Che-Chien published the artcile< Design and synthesis of trivalent Tn glycoconjugate polymers by nitroxide-mediated polymerization>, Formula: C12H16O7, the main research area is synthesis trivalent Tn glycoconjugate polymer nitroxide mediated polymerization.

A new synthetic method for preparing Tn glycoconjugate polymers, containing tumor-associated carbohydrate antigens, by controlled living radical polymerization is reported. To mimic the authentic structures of Tn glycopeptide antigens and to explore the controlled living radical polymerization, three tumor-associated carbohydrate antigens (GalNAc, GalNAcα1-O-Ser, and GalNAcα1-O-Thr) were attached to a styrene-type monomer through a diethylene glycol spacer. Under nitroxide-mediated polymerization, controlled living radical polymerization proceeded to afford defined glycopeptide polymers with different Tn densities and compositions The polydispersity index (PDI) and mol. weights were increased and conversions were decreased upon increasing the concentration of Tn glycoconjugate monomers. The resulting Tn glycoconjugate polymers were characterized by NMR and IR. The spectral data indicate that the Tn glycoconjugate moiety did attach to the polymer chain and Tn glycoconjugate d. could be adjusted through the nitroxide-mediated polymerization conditions. The number of Tn units containing in the polymer chains could be estimated by NMR integration. This synthetic approach provides a new and efficient tool for constructing novel Tn glycoconjugate polymers.

Tetrahedron published new progress about Tumor antigens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Formula: C12H16O7.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Madumo, Gilbert K.; Moshapo, Paseka T.; Kinfe, Henok H. published the artcile< Effects of lipophilicity, protecting group and stereochemistry on the antimalarial activity of carbohydrate-derived thiochromans>, Quality Control of 4098-06-0, the main research area is carbohydrate thiochroman synthesis lipophilicity antimalarial Plasmodium falciparum.

A series of novel carbohydrate-derived thiochromans has been successfully synthesized in order to investigate the influence of alkyl substituents on the aromatic ring of the thiophenol moiety in addition to the effect of protecting groups and stereochem. on the sugar component of the target mols. Results from the evaluation of the thiochromans for their antimalarial activity against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum suggest that the presence of short chain alkyl substituents, a benzyl ether protecting group and equatorial orientation of the C-4 substituent on the sugar moiety are crucial structural features that impart high antimalarial activity.

Medicinal Chemistry Research published new progress about Antimalarials. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Quality Control of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Re, Rebecca N.; Proessdorf, Johanna C.; La Clair, James J.; Subileau, Maeva; Burkart, Michael D. published the artcile< Tailoring chemoenzymic oxidation via in situ peracids>, Synthetic Route of 4098-06-0, the main research area is chemoenzymic oxidation peracid olefin lipid epoxidation.

Epoxidation chem. often suffers from the challenging handling of peracids and thus requires in situ preparation Here, we describe a two-phase enzymic system that allows the effective generation of peracids and directly translate their activity to the epoxidation of olefins. We demonstrate the approach by application to lipid and olefin epoxidation as well as sulfide oxidation These methods offer useful applications to synthetic modifications and scalable green processes.

Organic & Biomolecular Chemistry published new progress about Alkenes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Synthetic Route of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ul Lah, Hafiz; Mir, Shabir Ahmad; Hussain, Gulzar; Wani, Rafiq Ahmad; Yousuf, Syed Khalid published the artcile< Facile NBS/DMSO mediated dibromination of olefins including selected natural products and glycals>, SDS of cas: 4098-06-0, the main research area is alkene bromosuccinimide chemoselective diastereoselective dibromination; organodibromide preparation.

A highly chemo- and diastereoselective vic-dibromination of olefins was developed. The process employed a readily available N-Bromosuccinimide (NBS)/DMSO reagent system as a bromine source. High substrate scope, simple reaction conditions, application to natural products and glycals makes the process very attractive.

Journal of Chemical Sciences (Berlin, Germany) published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, SDS of cas: 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Postigo, Al published the artcile< Propagation chains in photocatalyzed radical nucleophilic substitutions of thiolates with perfluoroalkyl groups>, Synthetic Route of 4098-06-0, the main research area is thiol perfluorobutyl iodide perfluoroalkylation mecahnism quantum yield fluorescence quenching.

Quantum yields and radical chain lengths were investigated in photocatalyzed radical nucleophilic perfluorobutyl group substitution reactions of 2-mercaptothiolate anion under three different photocatalytic systems operating in reductive and quenching manners. Important propagation chain lengths were uncovered with photocatalysts under both scenarios, reductive and oxidative. The different overall quantum yields and chain lengths observed demonstrated the balance between the efficiency of the photoinitiation events, propagation and termination steps. Theor. calculations provide a better understanding and throw light into whether a closed or an open catalytic cycle is operating in photoinitiated perfluoroalkyl group-thiolate coupling reaction.

Chemical Physics Letters published new progress about Chemical chains. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Synthetic Route of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Darbem, Mariana P.; Esteves, Henrique A.; de Oliveira, Isadora M.; Pimenta, Daniel C.; Stefani, Helio A. published the artcile< Palladium-Catalyzed Thio- and Selenocarbonylation of 2-Iodoglycals>, Synthetic Route of 4098-06-0, the main research area is glycoside thioester selenoester catalytic thiocarbonylation coupling monosaccharide; thiol iodoglycal cross coupling molybdenum hexacarbonyl carbon monoxide disaccharide.

The carbonylative cross-coupling reactions of 2-iodoglycals with thiols and selenols in the presence of molybdenum hexacarbonyl as a solid source of carbon monoxide is described. This methodol. permitted the synthesis of 29 C2-glycosides bearing thioester and selenoester functionalities in moderate to excellent yields and high functional group tolerance. Moreover, this communication describes the first catalytic carbonylative coupling reaction of selenols with a carbon electrophile.

ChemCatChem published new progress about Carbonylation. 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Synthetic Route of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rasool, Faheem; Ahmed, Ajaz; Hussain, Nazar; Yousuf, Syed Khalid; Mukherjee, Debaraj published the artcile< One-Pot Regioselective and Stereoselective Synthesis of C-Glycosyl Amides from Glycals Using Vinyl Azides as Glycosyl Acceptors>, Recommanded Product: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, the main research area is C glycosyl amide regioselective stereoselective synthesis glycal vinyl azide.

The reaction of glycals containing good leaving groups with aromatic vinyl azides to give α-C-glycosyl amides in good yields is described. Various vinyl azides with different groups undergo the reaction smoothly. In these reactions, an iminodiazonium intermediate is generated by the attack of the vinyl azide onto the glycal under Lewis acid conditions. This undergoes Schmidt-type denitrogenative 1,2-migration to form a nitrilium ion, which, upon hydrolysis, gives the desired C-glycosyl amide.

Organic Letters published new progress about Azides Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl vinyl). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Recommanded Product: (2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Palo-Nieto, Carlos; Sau, Abhijit; Jeanneret, Robin; Payard, Pierre-Adrien; Salame, Aude; Martins-Teixeira, Maristela Braga; Carvalho, Ivone; Grimaud, Laurence; Galan, M. Carmen published the artcile< Copper Reactivity Can Be Tuned to Catalyze the Stereoselective Synthesis of 2-Deoxyglycosides from Glycals>, Computed Properties of 4098-06-0, the main research area is glycal deoxy glycoside copper catalyst stereoselective glycosylation disaccharide.

We demonstrate that tuning the reactivity of Cu by the choice of oxidation state and counterion leads to the activation of both “”armed”” and “”disarmed”” type glycals toward direct glycosylation leading to the α-stereoselective synthesis of deoxy-glycosides in good to excellent yields. Mechanistic studies show that CuI is essential for effective catalysis and stereocontrol and that the reaction proceeds through dual activation of both the enol ether as well as the OH nucleophile.

Organic Letters published new progress about Disaccharides Role: SPN (Synthetic Preparation), PREP (Preparation). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, Computed Properties of 4098-06-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics