Category: 403-33-8

Gu, Yuanyun; Zhang, Zhen; Wang, Yan-En; Dai, Ziteng; Yuan, Yaqi; Xiong, Dan; Li, Jie; Walsh, Patrick J.; Mao, Jianyou published an article in 2022. The article was titled 《Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe3)2/Cs+ System》, and you may find the article in Journal of Organic Chemistry.Electric Literature of C8H7FO2 The information in the text is summarized as follows:

Chemoselective deprotonative functionalization of benzylic C-H bonds is challenging, because the arene ring contains multiple aromatic C(sp2)-H bonds, which can be competitively deprotonated and lead to selectivity issues. Recently it was found that bimetallic [MN(SiMe3)2 M = Li, Na]/Cs+ combinations exhibit excellent benzylic selectivity. Herein, is reported the first deprotonative addition of toluenes to Weinreb amides mediated by LiN(SiMe3)2/CsF for the synthesis of a diverse array of 2-arylacetophenones. Surprisingly, simple Me benzoates also react with toluenes under similar conditions to form 2-arylacetophenones without double addition to give tertiary alc. products. This finding greatly increases the practicality and impact of this chem. Some challenging substrates with respect to benzylic deprotonations, such as fluoro and methoxy substituted toluenes, are selectively transformed to 2-aryl acetophenones. The value of benzylic deprotonation of 3-fluorotoluene is demonstrated by the synthesis of a key intermediate in the preparation of Polmacoxib. After reading the article, we found that the author used Methyl 4-fluorobenzoate(cas: 403-33-8Electric Literature of C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Electric Literature of C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Facile amidation of esters with aromatic amines promoted by lanthanide tris (amide) complexes》 was written by Li, Zhao; Guo, Chenjun; Chen, Jue; Yao, Yingming; Luo, Yunjie. Name: Methyl 4-fluorobenzoate And the article was included in Applied Organometallic Chemistry in 2020. The article conveys some information:

The development of catalysts capable of catalyzing amidation of esters with amines to construct amides under mild conditions is of great importance. Compared to aliphatic amines, the direct catalytic amidation of esters with less nucleophilic aromatic amines was rather difficult. Employing simple lanthanide tris (amide) complexes Ln[N (SiMe3)2]3(μ-Cl)Li (THF)3 as the catalysts, it was found a broad range of aromatic amines and esters were efficiently converted into various amides in good yields under mild conditions. A plausible mechanism for this transformation was exptl. supported as starting from an amide exchange reaction between the lanthanide tris (amide) complex and the substrate amine. The experimental part of the paper was very detailed, including the reaction process of Methyl 4-fluorobenzoate(cas: 403-33-8Name: Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Name: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Palladium-Catalyzed, Copper(I)-Promoted Methoxycarbonylation of Arylboronic Acids with O-Methyl S-Aryl Thiocarbonates》 was written by Cao, Ya-Fang; Li, Ling-Jun; Liu, Min; Xu, Hui; Dai, Hui-Xiong. SDS of cas: 403-33-8 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

Here, we report O-Me S-aryl thiocarbonates as a versatile esterification reagent for palladium-catalyzed methoxycarbonylation of arylboronic acid in the presence of copper(I) thiophene-2-carboxylate (CuTC). The reaction condition is mild, and a variety of substituents including sensitive -Cl, -Br, and free -NH2 could be tolerated. Further applications in the late-stage esterification of some pharmaceutical drugs demonstrate the broad utility of this method. After reading the article, we found that the author used Methyl 4-fluorobenzoate(cas: 403-33-8SDS of cas: 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.SDS of cas: 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sang, Dayong; Yue, Huaxin; Fu, Yang; Tian, Juan published their research in Journal of Organic Chemistry in 2021. The article was titled 《Cleavage of Carboxylic Esters by Aluminum and Iodine》.Recommanded Product: 403-33-8 The article contains the following contents:

A one-pot procedure for deprotecting carboxylic esters such as ArC(O)OR [Ar = Ph, 2-HOC6H4, 4-BrC6H4, etc.; R = Me, Bn, iPr, t-But] using aluminum and iodine under nonhydrolytic conditions was described. Cleavage of lactones afforded the corresponding ω-iodoalkylcarboxylic acids ICH2(CH2)nC(O)OH [n = 2, 4, 12]. Aryl acetylates undergo deacetylation with the participation of the neighboring group. This method enabled the selective cleavage of alkyl carboxylic esters in the presence of aryl esters. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Recommanded Product: 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Recommanded Product: 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Xiaofang; Zhou, Lei; Li, Fangshao; Xiao, Jing published an article in 2021. The article was titled 《PCl3-mediated transesterification and aminolysis of tert-butyl esters via acid chloride formation》, and you may find the article in Journal of Chemical Research.Product Details of 403-33-8 The information in the text is summarized as follows:

A PCl3-mediated conversion of tert-Bu esters into esters R1C(O)OR2 [R1 = Ph, 4-MeC6H4, 4-ClC6H4, etc.; R2 = Me, Et, i-Pr, etc.] and amides R1C(O)NR2R3 [R1 = Ph, n-Bu, CH2Bn, etc.; R2 = Ph, n-Bu, Bn, etc.; R3 = H, Me, Ph] in one-pot under air was developed. This novel protocol highlighted by the synthesis of skeletons of bioactive mols. and gram-scale reactions. Mechanistic studies revealed that this transformation involved the formation of an acid chloride in situ, which was followed by reactions with alcs. or amines to afford the desired products. In the part of experimental materials, we found many familiar compounds, such as Methyl 4-fluorobenzoate(cas: 403-33-8Product Details of 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Product Details of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

SDS of cas: 403-33-8In 2021 ,《I2-Promoted [3+2] Cyclization of 1,3-Diketones with Potassium Thiocyanate: a Route to Thiazol-2(3H)-One Derivatives》 was published in Advanced Synthesis & Catalysis. The article was written by An, Zhenyu; Liu, Yafeng; Zhao, Pengbo; Yan, Rulong. The article contains the following contents:

An I2-promoted strategy has been developed for the synthesis of thiazol-2(3H)-one derivatives from 1,3-diketones with potassium thiocyanate. This [3+2] cyclization reaction involves C-S and C-N bond formation and exhibits good functional group tolerance. A series of thiazol-2(3H)-one derivatives are obtained in moderate to good yields. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8SDS of cas: 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.SDS of cas: 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Joly, Nicolas; Bettoni, Leo; Gaillard, Sylvain; Poater, Albert; Renaud, Jean-Luc published their research in Journal of Organic Chemistry in 2021. The article was titled 《Phosphine-Free Ruthenium Complex-Catalyzed Synthesis of Mono- or Dialkylated Aryl Hydrazides via the Borrowing Hydrogen Strategy》.Quality Control of Methyl 4-fluorobenzoate The article contains the following contents:

A diaminocyclopentadienone ruthenium tricarbonyl complex-catalyzed synthesis of mono- or dialkylated aryl hydrazides from N-unsubstituted aryl hydrazides and various substituted primary and secondary alcs. as alkylating reagents using the borrowing hydrogen strategy has been developed. Deuterium labeling experiments confirmed that the alcs. are the hydride source in this cascade process. D. functional theory (DFT) calculations unveiled the origin and the threshold between the mono- and dialkylation. The experimental process involved the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8Quality Control of Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Quality Control of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kondrashov, Mikhail; Svensson, Samuel P. S.; Stroem, Peter; Westermark, Andreas; Jacobson-Ingemyr, Hanna; Takano, Akihiro; Tari, Lenke; Toth, Miklos; Cai, Minying; Hruby, Victor J.; Schou, Magnus published their research in Bioconjugate Chemistry in 2021. The article was titled 《Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma》.HPLC of Formula: 403-33-8 The article contains the following contents:

A new fluorescent biarsenical peptide labeling probe was synthesized and labeled with the radioactive isotopes 11C and 18F. The utility of this probe was demonstrated by installing each of these isotopes into a melanocortin 1 receptor (MC1R) binding peptide, which targets melanoma tumors. Its applicability was further showcased by subsequent in vitro imaging in cells as well as in vivo imaging in melanoma xenograft mice by fluorescence and positron emission tomog. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8HPLC of Formula: 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.HPLC of Formula: 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Chun; Zhang, Chao; Tang, Jie; Ye, Shengqing; Ma, Mingliang; Wu, Jie published an article in 2021. The article was titled 《Synthesis of γ-Keto Sulfones through a Three-Component Reaction of Cyclopropanols, DABCO·(SO2)2 and Alkyl Halides》, and you may find the article in Advanced Synthesis & Catalysis.Recommanded Product: Methyl 4-fluorobenzoate The information in the text is summarized as follows:

A route to γ-keto sulfones RC(O)(CH2)2SO2R1 [R = 4-FC6H4, Bn, 2-naphthyl, etc.; R1 = Me, Bn, 4-BrC6H4CH2, etc.] through a metal-free reaction of cyclopropanols, DABCO·(SO2)2 and alkyl halides was described. This reaction occurs under mild conditions in the absence of any catalysts, additives, or oxidants. Various functional groups including as ester, amino, methoxy, bromo, trifluoromethyl, nitro and carbonyl were tolerated well in this transformation and the corresponding γ-keto sulfones were afforded in 35% to 95% yields. The proposed mechanism implies that this reaction proceeded through γ-keto sulfinate intermediate generated in situ, which further undergoes nucleophilic substitution with alkyl halides leading to γ-keto sulfones. In the experiment, the researchers used Methyl 4-fluorobenzoate(cas: 403-33-8Recommanded Product: Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Recommanded Product: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《C-F bond arylation of fluoroarenes catalyzed by Pd0 phosphine complexes: theoretical insight into regioselectivity, reactivity, and prediction of ligands》 was written by Zhong, Rong-Lin. Recommanded Product: Methyl 4-fluorobenzoate And the article was included in Organic Chemistry Frontiers in 2020. The article conveys some information:

Palladium-catalyzed C-F bond arylation of pentafluorobenzene was theor. investigated as an example of aryl-F bond functionalization. DFT computations show that C3-regioselective arylation of pentafluorobenzene occurs more favorably than C1 and C2-ones as reported exptl., through oxidative addition of the C-F bond to Pd0 species, transmetalation and reductive elimination of the C-C bond. Oxidative addition of the C-F bond is the rate-determining and regioselectivity-determining step. The lower energy transition state of the oxidative addition of the C3-F bond (TS-C3) arises from a larger stabilization energy between Pd0(BrettPhos) and distorted pentafluorobenzene moieties in TS-C3 than those in TS-C1 and TS-C2. The larger stabilization energy is a result of a lower σ* orbital energy of the distorted C3-F bond than those of C1-F and C2-F bonds, which leads to a larger charge transfer from the Pd dπ orbital to the σ* orbital of the C3-F bond. The results suggest that both σ* orbital energy and bond dissociation energy are important factors for determining the reactivity of the C-F bond. Also, the activation barriers of the C-F bond with different substitution groups follow the order: NO2 < COOMe < CN ~CF3 < F, which is approx. consistent with the order of electron-withdrawing ability of these groups. It is theor. predicted here that NMe2-substituted BrettPhos is better for C-F bond cleavage than BrettPhos, where three NMe2 groups are introduced to BrettPhos instead of the iso-Pr groups. The experimental part of the paper was very detailed, including the reaction process of Methyl 4-fluorobenzoate(cas: 403-33-8Recommanded Product: Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Recommanded Product: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics