Category: 31566-31-1

Formulation and evaluation of hydrophobic polymer based matrix sustained release tablets of captopril was written by Mishra, Shreyash;Upadhyay, Pranav Kumar. And the article was included in European Journal of Biomedical and Pharmaceutical Sciences in 2022.Electric Literature of C21H44O5 The following contents are mentioned in the article:

A review. The purpose of the present study was to prepare oral sustained release matrix tablets of highly water soluble drug, Captopril using a hydrophobic polymer compritol (glyceryl behenate) and to evaluate the effect of hydrophobic polymer and effect of methods of preparation on the release of the drug The tablets were prepared by direct compression, wet granulation techniques. The matrix tablets were evaluated for various parameters as phys. appearance, dimensions, hardness, weight variation, friability, drug content, in vitro dissolution studies. Also the matrix tablets prepared by hot melt granulation showed more effective retarded release rate than tablets prepared by direct compression and wet granulation techniques. Compritol 888 ATO can be used as a matrix former to sustain the release of water soluble drugs. Tizanidine hydrochloride tablets were prepared by melt direct compression technique using xanthum gum, glyceryl behenate, glyceryl monostearate and stearic acid in different proportion. Formulated sustend release tablets were evaluated for appearance, dimensions (diameter and thickness), weight varation, hardness, friability, drug content and in-vitro release of Tizanidine hydrochloride. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Electric Literature of C21H44O5).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Electric Literature of C21H44O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rabies virus glycoprotein- and transferrin-functionalized liposomes to elevate epigallocatechin gallate and FK506 activity and mediate MAPK against neuronal apoptosis in Parkinson′s disease was written by Kuo, Yung-Chih;Feng, Kuo-Chen;Rajesh, Rajendiran. And the article was included in Journal of the Taiwan Institute of Chemical Engineers in 2022.Reference of 31566-31-1 The following contents are mentioned in the article:

The difficulty of drugs to cross the blood-brain barrier (BBB) to reach specific sites and target multiple factors responsible for neurovegetative diseases necessitates the development of an effective drug delivery system. Rabies virus glycoprotein (RVG)- and transferrin (Tf)-grafted liposomes were constructed to deliver epigallocatechin gallate (EGCG) and FK506 to BBB against neurodegeneration for Parkinson′s disease (PD) treatment. Surface RVG and Tf revealed substantial improvement in BBB permeability of EGCG and FK506, and incorporation of phosphatidy-l-serine (PS) in RVG-Tf-EGCG-FK506-liposomes ameliorated α-synuclein docking. EGCG and FK506-encapsulated liposomes decreased cytotoxicity to 1-methyl-4-phenylpyridinium-impacted neurons. Immunofluorescence and western blot studies demonstrated better activity of RVG-Tf-EGCG-FK506-PS-liposomes in suppressing Bax, α-synuclein, caspase-3, p-tau protein, p-p38, p-ERK1/2 and p-cJNK expressions, and in increasing Bcl-2, tyrosine hydroxylase, dopamine transporter, p-CREB and p-ERK5 expressions. Multi-targeted RVG-Tf-PS-liposomes advantaged BBB permeation and contributed to neuroprotective effect to promote the efficiency of EGCG and FK506 in PD management. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Reference of 31566-31-1).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 31566-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Experimental study on expended energy on structural degradation of lubricating greases was written by Ahme, Leif;Kuhn, Erik;Delgado Canto, Miguel Angel. And the article was included in Tribology Letters in 2022.Name: Glyceryl monostearate The following contents are mentioned in the article:

One of the keystones of tribol. studies is the energetical approach to the lubrication process. In the particular case of lubricating greases, part of the lubrication process energy dissipates due to a shear-induced structural rearrangement of the 3D network of the thickening agent dispersed in the base oil. This fact confers them a particular consistency, mech. stability, rheol., and tribol. behavior. In this research work, we investigate the mech. structural degradation induced by shear stress applied in rheol. tests (rotational and oscillation mode) and the influence of thickener (type and composition) and base oil on both the degradation process and the expended mech. energies. For this purpose, lithium, calcium and polyurea-based greases of NLGI grade 2 were used. These greases have been manufactured with a different base oil (mineral, synthetic and vegetable oils) and kinematic viscosity of 48 or 240 mm²/s. Some biogenic greases were also included in this research. The optical microscopy anal. revealed thickener particles-based agglomerates with different shapes and sizes that reduced notably, if not almost completely destroyed, after stress. Due to the thickener particles-based agglomerates distribution, significant differences in the shear-induced frictional energy inside the bulk grease during the shear process were detected. The size of agglomerates depended on both the thickener content and the base oil viscosity and not the type of base oil. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Name: Glyceryl monostearate).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Name: Glyceryl monostearate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Molecular networking based dereplication of AChE inhibitory compounds from the medicinal plant Vincetoxicum funebre (Boiss. & Kotschy) was written by Abbas-Mohammadi, Mahdi;Moridi Farimani, Mahdi;Salehi, Peyman;Ebrahimi, Samad Nejad;Sonboli, Ali;Kelso, Celine;Skropeta, Danielle. And the article was included in Journal of Biomolecular Structure and Dynamics in 2022.Electric Literature of C21H44O5 The following contents are mentioned in the article:

Alzheimer′s disease (AD) is a devastating neurodegenerative disease affecting 47 million people worldwide. While acetylcholinesterase (AChE) inhibitors such as donepezil and galantamine are leading drugs in the symptomatic treatment of AD, new AChE inhibitors continue to be explored for improved potency and selectivity. Herein, a mol. networking approach using high resolution (HR-MS) and tandem mass spectrometry (MS²) has been used for rapid chem. profiling of an extract of the medicinal plant Vincetoxicum funebre Boiss. & Kotschy (Apocynaceae family) that was active against AChE. A total of 44 compounds were identified by combining the MN with traditional natural product methods, including the isolation and identification of five known compounds (13, 41-44) and a novel C₁₃-norisoprenoid (40). In addition, the potential inhibitory activity of all 44 compounds was evaluated against the AChE enzyme via mol. docking to provide further support to the proposed structures. The glycosylated flavonoid querciturone (31) exhibited the highest affinity with a docking score value of -13.43 kJ/mol. Another five compounds showed stronger docking scores against AChE than the clin. used donepezil including the most active isolated compound daucosterol (44), with a binding affinity of -10.11 kJ/mol towards AChE. These findings broaden our understanding of Vincetoxicum metabolites and highlight the potential of glycosylated flavonoids as AChE inhibitors. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Electric Literature of C21H44O5).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Electric Literature of C21H44O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Polystyrene microplastics inhibit the neurodevelopmental toxicity of mercury in zebrafish (Danio rerio) larvae with size-dependent effects was written by Wang, Jing;Wu, Jin;Cheng, Haodong;Wang, Yudi;Fang, Yanjun;Wang, Lei;Duan, Zhenghua. And the article was included in Environmental Pollution (Oxford, United Kingdom) in 2022.Recommanded Product: Glyceryl monostearate The following contents are mentioned in the article:

Insufficient evidence exists regarding the effects of microplastics (MPs) on the neuronal toxicity of heavy metals in the early stages of organisms. Herein, the effects of micro-polystyrene (μ-PS; 157 μm) and nano-polystyrene (n-PS; 100 nm) particles on the neurodevelopmental toxicity of mercury (Hg) in zebrafish embryos were compared. Zebrafish embryos exposed to Hg at the concentration of 0.1 mg L^-1 revealed blood disorders, delayed hatching, and malformations such as pericardial edema and tail deformity. The length of the larval head was significantly reduced (P < 0.01) and in vivo expression of atoh1a in the cerebellum of neuron-specific transgenic zebrafish Tg(atoh1a:dTomato) larvae was inhibited by 29.46% under the Hg treatment. Most of the toxic effects were inhibited by the combined exposure to μ-PS or n-PS with Hg, and n-PS decreased the neurodevelopmental toxicity of Hg more significantly than μ-PS. Metabolomic anal. revealed that in addition to inhibiting the amino acid metabolism pathway as in the μ-PS+Hg treatment, the n-PS+Hg treatment inhibited unsaturated fatty acid metabolism in zebrafish larvae, likely because of a greater reduction in Hg bioavailability, thus reducing the oxidative damage caused by Hg in the larvae. The combined effects of MPs and heavy metals differ greatly among different species and their targeted effects. We conclude that the combined toxicity mechanisms of MPs and heavy metals require further clarification. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Recommanded Product: Glyceryl monostearate).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Recommanded Product: Glyceryl monostearate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Multifunctional gluten/guar gum copolymer with self-adhesion, self-healing, and remolding properties as smart strain sensor and self-powered device was written by Ounkaew, Artjima;Kasemsiri, Pornnapa;Srichiangsa, Natnaree;Jetsrisuparb, Kaewta;Knijnenburg, Jesper T. N.;Okhawilai, Manunya;Hiziroglu, Salim;Theerakulpisut, Somnuk. And the article was included in eXPRESS Polymer Letters in 2022.Quality Control of Glyceryl monostearate The following contents are mentioned in the article:

In this research, a multifunctional strain sensor based on gluten/guar gum (GG) copolymer was developed. The effects of gluten/GG blended ratios on the mech. and elec. properties, self-adhesion, self-healing, remolding, self-powered and long-term stability of the strain sensors were studied. Among tested substrates, the gluten/GG blend indicated a strong adhesion to wood and paper substrates and showed a maximum adhesive strength at 1.5 wt% of GG in the copolymer (gluten/GG-1.5%). The adhesive strength of gluten/GG-1.5% decreased in the acceptable range when it was applied in 10 repeated adhesion cycles. The gluten/GG-1.5% exhibited a high elec. conductivity of 0.12 S/m and stretchability of 465%. The gluten/GG-based sensor containing glycerol showed long-term stability of self-healing, remolding, and self-powered ability when stored for 7 days, whereas the self-adhesive ability decreased with increasing storage time. The self-adhesive gluten/GG-1.5% was used to monitor human limb movements, which showed remarkable sensitivity during the storage time of 3 days. Such properties suggested a potential use of smart strain sensors with multifunctional capabilities for applications in wearable electronic devices. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Quality Control of Glyceryl monostearate).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Quality Control of Glyceryl monostearate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Barrier Dispersion-Based Coatings Containing Natural and Paraffin Waxes was written by Woch, Julia;Malachowska, Edyta;Korasiak, Kamil;Lipkiewicz, Aneta;Dubowik, Marcin;Chrobak, Justyna;Ilowska, Jolanta;Przybysz, Piotr. And the article was included in Molecules in 2022.Recommanded Product: Glyceryl monostearate The following contents are mentioned in the article:

Petroleum, synthetic, and natural waxes have been used as hydrophobic bases for dispersions intended for use as barrier coatings for packaging paper. Oil-in-water dispersions with alk. pH were prepared by a two-step homogenization procedure containing paraffin wax, with various characteristics, the Fischer-Tropsch synthesis product or beeswax. The size of the dispersed particles determined by dynamic light scattering depended on the type of hydrophobic base used and was in the range of 350-440 nm. The ability of dispersion particles in aggregation driven by electrostatic attraction, evaluated by zeta potential anal. by electrophoretic light scattering, was from -26 to -50 mV. Static multiply light scattering was used for 30 days of stability assessment and helped to select the dispersion with a Sarawax SX70 wax base as the most stable. Dispersions were further used for coating the backing of kraft paper by the Meyer rod method. Coated paper with an applied coating of 6 g/m² had very good hydrophobic properties (Cobb60 < 4 g/m²), sufficient strength properties, and air permeation, which enabled its application as a packaging material. The dispersions based on Sarawax SX70 wax were evaluated as the best coating for Mondi ProVantage Kraftliner 125 g/m² backing paper. Good hydrophobic properties and strength properties indicate the possibility of using the SX70-based wax dispersion coating as a replacement for PFAS coatings in some applications. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Recommanded Product: Glyceryl monostearate).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: Glyceryl monostearate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Determining the protective effects of Ma-Mu-Ran Antidiarrheal Capsules against acute DSS-induced enteritis using 16S rRNA gene sequencing and fecal metabolomics was written by Zheng, Si-Li;Zhang, Dong-Ning;Duan, Yan-Fen;Huang, Fang;Han, Lin-Tao;Mo, Guo-Yan. And the article was included in Chinese Journal of Natural Medicines in 2022.Electric Literature of C21H44O5 The following contents are mentioned in the article:

Ma-Mu-Ran Antidiarrheal Capsules (MMRAC) is traditional Chinese medicine that has been used to treat diarrhea caused by acute enteritis (AE) and bacillary dysentery in Xinjiang (China) for many years. However, the potential therapeutic mechanism of MMRAC for AE and its regulatory mechanism on host metabolism is unclear. This study used fecal metabolomics profiling with GC/MS and 16S rRNA gene sequencing anal. to explore the potential regulatory mechanisms of MMRAC on a dextran sulfate sodium salt (DSS)-induced mouse model of AE. Fecal metabolomics-based analyses were performed to detect the differentially expressed metabolites and metabolic pathways. The 16S rRNA gene sequencing anal. was used to assess the altered gut microbes at the genus level and for functional prediction. Moreover, Pearson correlation anal. was used to integrate differentially expressed metabolites and altered bacterial genera. The results revealed that six intestinal bacteria and seven metabolites mediated metabolic disorders (i.e., metabolism of amino acid, carbohydrate, cofactors and vitamins, and lipid) in AE mice. Besides, ten altered microbes mediated the differential expression of eight metabolites and regulated these metabolisms after MMRAC administration. Overall, these findings demonstrate that AE is associated with metabolic disorders and microbial dysbiosis. Further, we present that MMRAC exerts protective effects against AE by improving host metabolism through the intestinal flora. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Electric Literature of C21H44O5).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Electric Literature of C21H44O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Optimization of pomelo (Citrus grandis L. Osbeck) juice foam composition: Effect of foam composition on foam quality was written by Warepam, Sophia Chanu;Jena, Sujata. And the article was included in Journal of Food Processing and Preservation in 2022.Quality Control of Glyceryl monostearate The following contents are mentioned in the article:

In this study, the effect of pomelo juice foam composition on the foam properties was investigated for the production of foam mat-dried pomelo juice powder. The pomelo juice foam was prepared using maltodextrin (MD), glycerol monostearate (GMS), and CM-cellulose (CMC) at various concentrations in the range of 2-8%, 0.5-2%, and 5-10%, resp. A face-centered central composite design was followed. The optimum quality of stable pomelo juice foam was evaluated in terms of min. foam d., min. foam collapse, maximum foam stability, and maximum foam capacity. The optimum concentration of the foaming agents as obtained through numerical optimization using design expert 10.0 was 6.027% MD, 1.217% CMC, and 8% GMS with a desirability of 0.777. The foam quality at optimum conditions was as follows: 0.769 g/cc foam d., 92% foam stability, 12.66% foam collapse, and 91.74% foam capacity. Feasibility or incorporation of the developed pomelo juice powder in bakery products, ice cream, yogurt, etc., could be tested for wide applicability. Novelty impact statement : The present study aims at optimizing pomelo juice foam composition to produce good quality stable foam so as to convert it into foam mat-dried powder. Foam mat-dried pomelo juice powder has very good reconstitution property and the reconstituted juice is a rich source of vitamin C and other minerals. The findings of the present study would facilitate the production of foam mat-dried pomelo juice powder which has good potential for diet conscious persons. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Quality Control of Glyceryl monostearate).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Quality Control of Glyceryl monostearate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Development of a Novel MR Colonography via Iron-Based Solid Lipid Nanoparticles was written by Wang, Huiyang;Wang, Siqi;Zhu, Xisong;Ding, Wenxiu;Shen, Tianlun;Fan, Hongjie;Zhang, Yanhua;Peng, Lijun;Yuan, Hong;Liu, Xiangrui;Ling, Jun;Sun, Jihong. And the article was included in International Journal of Nanomedicine in 2022.Electric Literature of C21H44O5 The following contents are mentioned in the article:

To develop an iron-based solid lipid nanoparticle (SLN) absorbable by the intestinal wall and assess the differential diagnostic value of intestinal lesions in magnetic resonance imaging (MRI). SLNs were prepared with the simultaneous loading of trivalent Fe ions (Fe³⁺), levodopa Me ester (DM), and fluorescein isothiocyanate (FITC). We evaluated the particle size, loading rate, encapsulation efficiency, and cytotoxicity of SLNs. The T1 contrast effects of the FeDM-FITC-SLNs and gadolinium-based contrast agent (GBCA) were compared in different mouse models: acute ulcerative colitis (AUC), chronic ulcerative colitis (CUC), colon adenocarcinoma (COAD), and normal control. MRI was performed in the same mouse with i.v. injection of GBCA on day 1 and enema of FeDM-FITC-SLNs on day 2. The signal-to-noise ratios (SNRs) were compared using one-way anal. of variance. Tissues were then collected for histol. The average particle size of FeDM-FITC-SLN was 220 nm. The mean FeDM loading rate was 94.3%, and the encapsulation efficiency was 60.3%. The relaxivity was 4.02 mM^-1·s^-1. After enema with FeDM-FITC-SLNs, MRI showed the following contrast enhancement duration: AUC = COAD > normal > CUC. Confocal fluorescence microscopy confirmed that FeDM-FITC-SLNs were mainly distributed in the intestinal mucosa and tumor capsule. Iron-based SLNs are promising alternatives for contrast enhancement at T1-weighted MRI and will help in the differential diagnosis of intestinal bowel diseases (IBDs). This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Electric Literature of C21H44O5).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C21H44O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics