Category: 3052-61-7

Otsu, Takayuki published the artcilePolymer design by iniferter technique in radical polymerization: synthesis of AB and ABA block copolymers containing random and alternating copolymer sequences, Synthetic Route of 3052-61-7, the publication is Polymer Journal (Tokyo, Japan) (1985), 17(1), 97-104, database is CAplus.

The iniferter (initiator-transfer agent-terminator) technique was applied to the synthesis of the AB and ABA block copolymers containing various random and alternating copolymer sequences. Monomeric photoiniferters used were of general formula Ar[CH₂SC(:S)NEt₂]_x [Ar = Ph, x = 1, (I) [3052-61-7]; Ar = 1,4-C₆H₄, x = 2, (II) [89964-93-2]; and Ar = 1,2,4,5-C₆H₂, x = 4, (III) [92687-20-2]]. Polymeric photoiniferters were prepared by photolysis of I, II, and III. The photopolymerizations with I and II proceeded via a living radical mechanism III and gave soluble mono- and bifunctional polymers, resp. However, III induced living radical polymerization of styrene with gelation. When various polymers and copolymers obtained by I and II were used as polymeric photoiniferters, the AB and ABA block copolymers containing random copolymer sequences were obtained in high yields. Similarly, the alternating copolymerization of iso-Bu vinyl ether with maleic anhydride in the presence of alternating copolymers (e.g., styrene and di-iso-Pr fumarate), which were obtained with I and II, as polymeric photoiniferters gave the AB and ABA block copolymers consisting of alternating copolymer sequences. III and the polymers and copolymers obtained by III could also act as an excellent crosslinking agent.

Polymer Journal (Tokyo, Japan) published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Synthetic Route of 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Otsu, Takayuki published the artcileLiving mono- and biradical polymerizations in homogeneous system synthesis of AB and ABA type block copolymers, Product Details of C12H17NS2, the publication is Polymer Bulletin (Berlin, Germany) (1984), 11(2), 135-42, database is CAplus.

To design the structure of the block copolymers by radical polymerization benzyl N,N-diethyldithiocarbamate (I) [3052-61-7] and P-xylylene N,N-diethyldithiocarbamate (II) [89964-93-2] were used as mono- and bifunctional photo-iniferters, resp., for the polymerizations of styrene and Me methacrylate. These polymerizations proceeded via a living radical mechanism. When the ratio of the concentration of the diethyldithiocarbamate group to that of a photo-iniferter mol. was kept constant, the yields of the polymers obtained by both I and II were identical, and their mol. weights(M) by II were 2 times as high as those by I. This observation strongly suggested that the polymerizations by I and II were performed by living mono- and biradical mechanisms, resp. By using the polymers obtained by I and II as polymeric photo-iniferters of the polymerization of second monomers, the AB and ABA-type block copolymers [25034-86-0] were obtained, resp.

Polymer Bulletin (Berlin, Germany) published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Product Details of C12H17NS2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wu, Zhiyong published the artcileAn Efficient Synthesis of Benzyl Dithiocarbamates by Base-Promoted Cross-Coupling Reactions of Benzyl Chlorides with Tetraalkylthiuram Disulfides at Room Temperature, Recommanded Product: Benzyl diethylcarbamodithioate, the publication is European Journal of Organic Chemistry (2018), 2018(48), 7033-7036, database is CAplus.

A straightforward, mild and efficient protocol for the synthesis of benzyl dithiocarbamates from benzyl chlorides and tetraalkylthiuram disulfides is presented. This protocol is compatible with a wide variety of electron-donating and -withdrawing substituents and enables construction of various dithiocarbamate derivatives from readily available starting materials.

European Journal of Organic Chemistry published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C38H24F4O4P2, Recommanded Product: Benzyl diethylcarbamodithioate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Des Azevedo, Sonia published the artcileMolecularly Imprinted Polymer-Hybrid Electrochemical Sensor for the Detection of β-Estradiol, Category: esters-buliding-blocks, the publication is Industrial & Engineering Chemistry Research (2013), 52(39), 13917-13923, database is CAplus.

This paper discusses the construction of a novel electrochem. sensor for 17β-estradiol (E2) based on a molecularly imprinted polymer (MIP)-conducting polymer modified hybrid electrode. A bifunctional monomer, N-phenylethylene diamine methacrylamide (NPEDMA), was used for the construction of the electrochem. sensor. Conducting films were prepared on the surface of a gold electrode by electropolymerization of the aniline moiety of NPEDMA. A layer of MIP was photochem. grafted over the polyaniline, via N,N-diethyldithiocarbamic acid benzyl ester (iniferter) activation of the methacrylamide groups. Computational modeling was used to select the most suitable monomer for preparation of MIPs for E2. Exptl. parameters such as deposition time, cyclic voltammetric (CV) scan cycles, and conditions for polymer accumulation were optimized. The detection limit of the resulting sensor, determined by CV, was 6.86 × 10^-7 M. Furthermore, the hybrid electrode was successfully used to analyze E2 in water without complex sample pretreatment. These results reveal that the MIP hybrid sensor has potential to be an effective technique for the electrochem. determination of E2 in real-time in complicated matrixes.

Industrial & Engineering Chemistry Research published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Pathak, Purnendu Kumar published the artcileA novel electrocatalytic nanocomposite of reduced graphene oxide/silver nanocube hybrid decorated imprinted polymer for ultra-trace sensing of temozolomide, Safety of Benzyl diethylcarbamodithioate, the publication is New Journal of Chemistry (2018), 42(16), 13486-13496, database is CAplus.

A new nanocomposite of reduced graphene oxide/silver nanocube hybrid decorated molecularly imprinted polymer at the surface of a screen-printed carbon electrode was developed for the electroanal. of an anticancerous drug, temozolomide, at the ultra-trace level. For this, a hybrid of reduced graphene oxide/silver nanocubes was successfully obtained through the simultaneous reduction of Ag⁺ and graphene oxide via simple one-pot green synthesis. Among the various shapes of nanomaterials used in imprinted polymer synthesis, silver nanocubes, as evident from SEM, TEM and, X-ray diffraction methods, have been found to render high surface to volume ratios and a higher electrocatalytic activity. Herein, the synergistic electrocatalytic effect of reduced graphene oxide and silver nanocubes was utilized for decreasing the analyte oxidation overpotential, without any interfacial barrier in between the imprinted film and the electrode surface, owing to the porous texture of the coating. Consequently, approx. 3-fold differential pulse anodic stripping current and ∼5-fold electron transfer rate kinetics were obtained on the reduced graphene oxide/silver nanocube hybrid compared with the simple graphene oxide decorated sensor. The covalent Ag-S links, in between the imprinted film and the silver nanocube decorated screen-printed carbon electrode, were crucial for imparting higher stability to the coating of the film. A perfect linearity in the current-concentration profile was observed, in the range 1.09-144.21 ng mL^-1, with the detection limits of 0.16 (aqueous), 0.24 (blood plasma), 0.31 (pharmaceutics), and 0.42 (urine) ng mL^-1 (S/N = 3). The proposed sensor was found to be useful in aqueous and real samples (human blood plasma, human urine, and pharmaceutics), without any matrix effect, cross-reactivity, or false-positives.

New Journal of Chemistry published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Safety of Benzyl diethylcarbamodithioate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Prasad, Bhim Bali published the artcileSol-gel derived multiwalled carbon nanotubes ceramic electrode modified with molecularly imprinted polymer for ultra trace sensing of dopamine in real samples, HPLC of Formula: 3052-61-7, the publication is Electrochimica Acta (2011), 56(20), 7202-7211, database is CAplus.

A new class of composite electrodes made of sol-gel derived ceramic-multiwalled C nanotubes was used for the growth of a nanometer thin film adopting surface grafting-from approach. For this the multiwalled C nanotubes-ceramic electrode surface is 1st modified with an iniferter (benzyl N,N-diethyldithiocarbamate) and then dopamine imprinted polymer, under UV irradiation, for differential pulse anodic stripping voltammetric sensing of dopamine in aqueous, blood serum, cerebrospinal fluid, and pharmaceutical samples (detection limit 0.143-0.154 ng mL^-1, 3σ), without any cross reactivity, interferences and false-pos. contributions. Such composite electrodes offer higher stability, electron kinetics, and renewable porous surface of larger electroactive area (with insignificant capacitance) than C ceramic electrodes. Addnl. cyclic voltammetry (stripping mode) and chronocoulometry experiments were performed to explore electrodics and kinetics of electrooxidation of dopamine.

Electrochimica Acta published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, HPLC of Formula: 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Brahemi, Ghali published the artcileExploring the Structural Requirements for Inhibition of the Ubiquitin E3 Ligase Breast Cancer Associated Protein 2 (BCA2) as a Treatment for Breast Cancer, Computed Properties of 3052-61-7, the publication is Journal of Medicinal Chemistry (2010), 53(7), 2757-2765, database is CAplus and MEDLINE.

The zinc-ejecting aldehyde dehydrogenase (ALDH) inhibitory drug disulfiram (DSF) was a breast cancer-associated protein 2 (BCA2) inhibitor with potent antitumor activity. We herein describe our work in the synthesis and evaluation of new series of zinc-affinic mols. to explore the structural requirements for selective BCA2-inhibitory antitumor activity. An N(C=S)S-S motif was required, based on selective activity in BCA2-expressing breast cancer cell lines and against recombinant BCA2 protein. Notably, the DSF analogs (3a and 3c) and dithio(peroxo)thioate compounds (5d and 5f) were found to have potent activity (submicromolar IC₅₀) in BCA2 pos. MCF-7 and T47D cells but were inactive (IC₅₀ > 10 μM) in BCA2 neg. MDA-MB-231 breast cancer cells and the normal breast epithelial cell line MCF10A. Testing in the isogenic BCA2 +ve MDA-MB-231/ER cell line restored antitumor activity for compounds that were inactive in the BCA2 -ve MDA-MB-231 cell line. In contrast, structurally related dithiocarbamates and benzisothiazolones (lacking the disulfide bond) were all inactive. Compounds 5d and 5f were addnl. found to lack ALDH-inhibitory activity, suggestive of selective E3 ligase-inhibitory activity and worthy of further development.

Journal of Medicinal Chemistry published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Computed Properties of 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tripathi, Rama Pathi published the artcileSyntheses and spermicidal activities of dithiocarbamates, Quality Control of 3052-61-7, the publication is Acta Pharmaceutica (Zagreb) (1996), 46(3), 169-176, database is CAplus.

Dithiocarbamates R¹C(:S)S^–Na⁺ [I; R¹ = Et₂N, 1-piperidinyl, 4-morpholinyl, 4-methyl-1-piperazinyl, 4-(phenylmethyl)-1-piperazinyl] and several different esters of N,N-diethyldithiocarbamic acid were synthesized, and some of them evaluated as spermicides. The compounds I as well as Et₂NC(:S)SMe and Et₂NC(:S)SCH₂CO₂H showed 100% spermicidal activity at 0.5% or 0.1% concentration

Acta Pharmaceutica (Zagreb) published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C8H8BFO2, Quality Control of 3052-61-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ishizu, Koji published the artcileControlled radical polymerization of 2-hydroxyethyl methacrylate initiated by photofunctional 2-(N,N-diethyldithiocarbamyl)isobutyric acid, Formula: C12H17NS2, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2003), 42(1), 76-82, database is CAplus.

We demonstrated that d. functional theory calculations provide a reliable and quant. prediction of the trends in C-S bond dissociation energies using several model compounds as photoinitiator. On the basis of this information, we designed a possible photofunctional initiator for the polymerization of hydrophilic vinyl monomers. Photopolymerization of 2-hydroxyethyl methacrylate (HEMA) was carried out in ethanol initiated by 2-(diethyldithiocarbamoyl)isobutyric acid under UV irradiation We obtained first-order time-conversion plots in this polymerization system, and the straight line in the semilogarithmic coordinates indicated first order in monomer. The mol. weight of the prepared poly(2-hydroxyethyl methacrylate) (PHEMA) increased with increasing conversion. The mol. weight distribution (M_w/M_n) of the PHEMA was about 1.5. Me methacrylate could also be polymerized in a living fashion with such a PHEMA precursor as a macroinitiator because PHEMA exhibited a dithiocarbamate group at its terminal end. This system could be applied to the architecture of amphiphilic block copolymers. It was concluded that these polymerization systems proceeded with a controlled radical mechanism.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Formula: C12H17NS2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Watanabe, Junji published the artcileBioconjugate polymer by photo-iniferter approach: Hydrophilic random or block copolymer-coated surface, Application of Benzyl diethylcarbamodithioate, the publication is Materials Science & Engineering, C: Materials for Biological Applications (2009), 29(7), 2287-2293, database is CAplus.

The fabrication of a high-performance polymer material is important, since it would have the potential of being utilized as a highly effective platform for bioconjugation. In the present study, hydrophilic random or block polymers were designed by a photo-iniferter approach. As typical monomers, Bu methacrylate (BMA) and acrylic acid (AA) were selected to prepare a surface modifier on a substrate. As surface modifiers, the monomers were copolymerized in block and random sequences, and the resulting polymer-coated surfaces were compared in terms of surface wettability and the bioconjugation of the fluorescence-labeled protein. The most favorable characteristic of the resulting polymers was that they offered a dual function: the stability of the adsorbed polymer layer and bioconjugation via functional groups. In the present study, the authors focused on the phys. properties of the polymer-coated surface. Bioconjugation and cell viability were also evaluated.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C8H6BrF3S, Application of Benzyl diethylcarbamodithioate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics