Category: 30414-53-0

Kalhapure, Vijay; Magar, Dhananjay; Kothalkar, Nishant; Khaladkar, Tushar; Roychowdhury, Abhijit published their research in Current Organic Synthesis on February 29 ,2020. The article was titled 《Synthesis of Substituted imidazo[1,5-a]pyrimidine-2-(1H)-one Core Structure》.Name: Methyl 3-oxovalerate The article contains the following contents:

Simple transformation starting from amino acetonitrile hydrochloride led to the synthesis of two different regio-isomers of imidazopyrimidinones I [R = H Ph; R1 = Me, Et, Ph; X = CH, N; Y = CH, N]. In addition to this study using Methyl 3-oxovalerate, there are many other studies that have used Methyl 3-oxovalerate(cas: 30414-53-0Name: Methyl 3-oxovalerate) was used in this study.

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Name: Methyl 3-oxovalerate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gupta, Aniket; Saha, Anusuya; Rahaman, Ajijur; Kumar, Jogendra; Suresh, Eringathodi; Ganguly, Bishwajit; Bhadra, Sukalyan published their research in Journal of Organic Chemistry on August 5 ,2022. The article was titled 《Cooperativity between the Substrate and Ligand in Palladium-Catalyzed Allylic Alkylation Using 1-Aryl-1-propynes》.Safety of Methyl 3-oxovalerate The article contains the following contents:

A monoprotected amino acid Bz-Gly-OH assists in the allylic alkylation of a variety of ketones, β-keto esters, aldehydes, etc., during enamine-palladium catalysis to gave alkylated products such as R1C(O)CHR2CH2CH=CHAr [R1 = Me, Et, n-Pr; R2 = Et, C(O)OMe, C(O)OEt, C(O)OBn, etc.; R1R2 = (CH2)3, (CH2)4, (CH2)5, etc.]. D. functional theory calculations revealed that Bz-Gly-OH assisted in the formation of an enamine that attacks the π-allylpalladium complex via an outer sphere mechanism. The preliminary result pointed to an asym. allylic alkylation under a new mode of bifunctional catalysis. The experimental process involved the reaction of Methyl 3-oxovalerate(cas: 30414-53-0Safety of Methyl 3-oxovalerate)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Safety of Methyl 3-oxovalerate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Radiosynthesis of a carbon-11 labeled PDE5 inhibitor [11C]TPN171 as a new potential PET heart imaging agent》 was written by Xu, Zhidong; Jia, Limeng; Liu, Wenqing; Li, Wei; Song, Ying; Zheng, Qi-Huang. Application In Synthesis of Methyl 3-oxovalerate And the article was included in Applied Radiation and Isotopes on August 31 ,2020. The article conveys some information:

To develop PET tracers for imaging of heart disease, a new carbon-11 labeled potent and selective PDE5 inhibitor [11C]TPN171 ([11C]9) has been synthesized. The reference standard TPN171 (9) and its corresponding precursor desmethyl-TPN171 (11) were synthesized from Me 3-oxovalerate and 2-hydroxybenzonitrile in 9 and 10 steps with 31% and 25% overall chem. yield, resp. The radiotracer [11C]TPN171 was prepared from desmethyl-TPN171 with [11C]CH3OTf through N-11C-methylation and isolated by HPLC purification followed by SPE formulation in 45-55% radiochem. yield, based on [11C]CO2 and decay corrected to EOB. The radiochem. purity was >99%, and the molar activity (Am) at EOB was in a range of 370-740 GBq/μmol.Methyl 3-oxovalerate(cas: 30414-53-0Application In Synthesis of Methyl 3-oxovalerate) was used in this study.

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Application In Synthesis of Methyl 3-oxovalerate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Optimization of hydrothermal co-liquefaction of seaweeds with lignocellulosic biomass: Merging 2nd and 3rd generation feedstocks for enhanced bio-oil production》 was written by Yuan, Chuan; Wang, Shuang; Cao, Bin; Hu, Yamin; Abomohra, Abd El-Fatah; Wang, Qian; Qian, Lili; Liu, Lu; Liu, Xinlin; He, Zhixia; Sun, Chaoqun; Feng, Yongqiang; Zhang, Bo. Synthetic Route of C6H10O3 And the article was included in Energy (Oxford, United Kingdom) on April 15 ,2019. The article conveys some information:

The present work aimed to explore the optimized conditions of hydrothermal co-liquefaction (co-HTL) of the green seaweed “”Enteromorpha clathrata (EN)”” and the lignocellulosic agricultural waste “”rice husk (RH)””. Sep. hydrothermal liquefaction (HTL) of EN and RH showed bio-oil yields of 26.0% and 45.6%, resp. However, co-HTL under optimized conditions showed significant increase in the bio-oil yield by 71.7% over that of EN, and insignificant difference with that of RH. Nevertheless, the conversion ratio of co-HTL showed 10.6% significant increase over that of RH. GC-MS results showed that main compounds of EN and RH bio-oil lump into the C15-C20 and C5-C12 regions, mainly representing carbon range of diesel and gasoline, resp. Short-chain (C5-C12) and long-chain (C14-C20) compounds in the bio-oil obtained by co-HTL represented 72% and 28%, resp. In addition, the ratio of aromatic compounds in the bio-oil of RH was reduced by 9.3% as a result of co-HTL. In conclusion, results suggested 50% ethanol as a co-solvent, 300°C and 45 min as optimum conditions for co-HTL of EN:RH (1:1 weight/weight). The present study demonstrated an efficient route for co-HTL of 3rd generation feedstocks with 2nd generation feedstocks which will have a significant impact on large-scale applications. The results came from multiple reactions, including the reaction of Methyl 3-oxovalerate(cas: 30414-53-0Synthetic Route of C6H10O3)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Synthetic Route of C6H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Safety of Methyl 3-oxovalerateOn May 7, 2020 ,《Synthesis of (±)-rupestines B and C by intramolecular Mizoroki-Heck cyclization》 appeared in Tetrahedron Letters. The author of the article were Starchman, Evangeline S.; Marshall, Mari S.; Vyvyan, James R.. The article conveys some information:

The total synthesis of rupestines B and C, I (R = α-Me, β-Me, resp.), two guaipyridine sesquiterpene alkaloids, is reported. These compounds are isolated from Artemisia rupestris L. and have structural similarities to that of cananodine, a guaipyridine alkaloid with activity against two liver cancer cell lines. The synthesis of rupestines B and C was accomplished in six steps using an intramol. Mizoroki-Heck cyclization as the key-step to form the seven-membered carbocycle of the targets. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-oxovalerate(cas: 30414-53-0Safety of Methyl 3-oxovalerate)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Safety of Methyl 3-oxovalerate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis of Polysubstituted Pyrroles through Electro-Oxidative Annulation of 1,3-Dicarbonyl Compounds and Primary Amines》 was written by Xiong, Mingteng; Liang, Xiao; Zhou, Yifeng; Pan, Yuanjiang. SDS of cas: 30414-53-0 And the article was included in Journal of Organic Chemistry on April 2 ,2021. The article conveys some information:

Synthetic method of polysubstituted pyrroles I [R1 = H, 2-Me, 2-MeO, etc.; R2 = Me, Et; R3 = Me, Et, i-Pr] from easily available materials, 1,3-dicarbonyl compounds and primary amines, via electro-oxidative intermol. annulation was reported. Under similar conditions, enamines were also converted smoothly into desired products I, indicating that in situ formed enamines were crucial intermediates for the first transformation. Neither transition-metal salts nor harsh conditions were required to facilitate the dehydrocyclization process. In the experiment, the researchers used many compounds, for example, Methyl 3-oxovalerate(cas: 30414-53-0SDS of cas: 30414-53-0)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.SDS of cas: 30414-53-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《A simple route towards the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles from primary amines and 1,3-dicarbonyl compounds under metal-free conditions》 was published in Organic & Biomolecular Chemistry in 2019. These research results belong to Guo, Ningxin; Liu, Xiufen; Xu, Hongyan; Zhou, Xi; Zhao, Huaiqing. Synthetic Route of C6H10O3 The article mentions the following:

An acetic acid-promoted approach that enabled the synthesis of 1,4,5-trisubstituted 1,2,3-triazole derivatives were achieved. This transformation employed readily available primary amines, 1,3-dicarbonyls and tosyl azide as the starting materials via a cycloaddition reaction under metal-free conditions. The reaction provideed a simple access to fully substituted 1,2,3-triazoles from com. substrates in moderate to excellent yields. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-oxovalerate(cas: 30414-53-0Synthetic Route of C6H10O3)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Synthetic Route of C6H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Xiang-Jin; Zhang, Jie; Xu, Yu-Ning; Li, Yi-Ming; Chi, Man; Yan, Yu; Wu, Rui-Xue; Zhang, Hui-Ru; Zhu, Yan-Ping published their research in Journal of Organic Chemistry on December 3 ,2021. The article was titled 《Cascade Wolff Rearrangement/Acylation: A Metal-Free and Eco-Friendly Approach for 4-Hydroxy-pyrazolo[3,4-b]pyridin-6-ones and N-Pyrazole Amides Synthesis from 5-Aminopyrazoles and α-Diazoketones》.Application of 30414-53-0 The article contains the following contents:

A highly chemoselective cascade Wolff rearrangement/acylation reaction between 5-aminopyrazoles and diazo compounds has been developed. The protocol can facilitate the switchable synthesis of 4-hydroxy-pyrazolo[3,4-b]pyridin-6-ones I (R1 = Me, Et, Ph, etc.; R2 = Ph, t-Bu, 2-naphthyl, etc.; R3 = Ph, 4-MeOC6H4, 3-thienyl, etc.) and N-pyrazole amides II (R1 = Me, t-Bu, Ph; R2 = Ph, 4-FC6H4, 2-naphthyl, etc.; R3 = Me, c-hexyl, Ph, etc.; R4 = Me, Et) with the merits of a broad substrate scope, high functional group compatibility, and green and sustainable performance manner. All reactions proceeded efficiently without any catalyst and additives (acid and base) and resulted in the release of benign N2, wherein di-Et carbonate served as a green benign solvent. In the experiment, the researchers used Methyl 3-oxovalerate(cas: 30414-53-0Application of 30414-53-0)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Application of 30414-53-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2021,Organic & Biomolecular Chemistry included an article by Wang, Wenxing; Zhang, Shuo; Shi, Guang; Chen, Zhiwei. Related Products of 30414-53-0. The article was titled 《Electrochemical synthesis of 1,2,4,5-tetrasubstituted imidazoles from enamines and benzylamines》. The information in the text is summarized as follows:

An electrochem. method for synthesizing 1,2,4,5-tetrasubstituted imidazoles I (R = Me, Et, Ph, i-Pr; R1 = n-Bu, Bn, cyclohexyl, 4-chlorophenyl, naphthalen-1-yl, etc.; R2 = Me, OMe, OEt, Ot-Bu; R3 = Ph, 2,3-dichlorophenyl, thiophen-2-yl, etc.) was developed under undivided electrolytic conditions. This synthesis was specifically realized based on electrochem. C(sp3)-H amination via enamines (Z)-RC(NHR1)=C(O)R2 and amines R3NH2. Readily available starting materials were used, avoiding the use of both transition metals and oxidants. The practicability of the method lies in its broad substrate adaptability and in its ability to provide a simple green pathway for synthesizing GABAA receptor analogs I (R = Me; R1 = 2,4-dichlorophenyl; R2 = OEt; R3 = 4-bromophenyl). In the experimental materials used by the author, we found Methyl 3-oxovalerate(cas: 30414-53-0Related Products of 30414-53-0)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Related Products of 30414-53-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qian, Xing-Kai; Zhang, Jing; Song, Pei-Fang; Zhao, Yi-Su; Ma, Hong-Ying; Jin, Qiang; Wang, Dan-Dan; Guan, Xiao-Qing; Li, Shi-Yang; Bao, XiaoZe; Zou, Li-Wei published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Discovery of pyrazolones as novel carboxylesterase 2 inhibitors that potently inhibit the adipogenesis in cells》.Safety of Methyl 3-oxovalerate The author mentioned the following in the article:

Carboxylesterase 2 (CES2) is one of the most important Phase I drug metabolizing enzymes in the carboxylesterase family. It plays crucial roles in the bioavailability of oral ester prodrugs and the therapeutic effect of some anticancer drugs such as irinotecan (CPT11) and capecitabine. In addition to the well-known roles of CES2 in xenobiotic metabolism, the enzyme also participates in endogenous metabolism and the production of lipids. In this study, we synthesized a series of pyrazolones and assayed their inhibitory effects against CES2 in vitro. Structure-activity relationship anal. of these pyrazolones (I) reveals that the introduction of 4-methylphenyl unit (R1), 4-methylbenzyl (R2) and cyclohexyl (R3) moieties are beneficial for CES2 inhibition. Guided by these SARs results, 1-cyclohexyl-4-(4-methylbenzyl)-3-p-tolyl-1H-pyrazol-5(4H)-one (27, II) was designed and synthesized. Further investigations demonstrated that the compound 27 exhibited stronger CES2 inhibition activity with a lower IC50 value (0.13μM). The inhibition kinetic study demonstrated that compound 27 inhibited the hydrolysis of CES2-fluorescein diacetate (FD) through non-competitive inhibition. In addition, the mol. docking showed that the core of pyrazolone, the cyclohexane moiety, 4-methylbenzyl and 4-methylphenyl groups in compound 27 all played important roles with the amino acid residues of CSE2. Also, compound 27 could inhibit adipocyte adipogenesis induced by mouse preadipocytes. In brief, we designed and synthesized a novel pyrazolone compound with a strong inhibitory ability on CES2 and could inhibit the adipogenesis induced by mouse preadipocytes, which can be served as a promising lead compound for the development of more potent pyrazolone-type CES2 inhibitors, and also used as a potential tool for exploring the biol. functions of CES2 in human being. In the experimental materials used by the author, we found Methyl 3-oxovalerate(cas: 30414-53-0Safety of Methyl 3-oxovalerate)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Safety of Methyl 3-oxovalerate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics