Category: 30414-53-0

《Oxidant-Controlled Divergent Syntheses of Pyrazoles and Pyrroles by Copper(I)-Catalyzed Oxidative Coupling of β-Enamino Esters》 was published in Asian Journal of Organic Chemistry in 2019. These research results belong to Jang, Su San; Chang, Jun Yeong; Kang, Gil Yeong; Youn, So Won. Related Products of 30414-53-0 The article mentions the following:

Copper(I)-catalyzed oxidative annulations of β-enamino esters with oxidant dependence were disclosed. These reactions offered divergent syntheses of fully substituted pyrazoles and pyrroles from a common enamine substrate through sequential C-C and N-N or C-N bond-forming reactions in the presence of nitriles as reagent or co-solvent. A mechanism involving radical intermediates generated by single-electron transfer (SET) was proposed for both processes.Methyl 3-oxovalerate(cas: 30414-53-0Related Products of 30414-53-0) was used in this study.

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Related Products of 30414-53-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Chiral Spirocyclic Phosphoric Acid-Catalyzed Synthesis of 4-Alkyl-3,4-dihydropyrimidin-2(1H)-one Derivatives by Asymmetric Biginelli Reactions》 was written by Guo, Yongbiao; Gao, Zhenhua; Wang, Kang; Li, Junchen; Bi, Xiaojing; Guo, Lei; Liu, Haibo; Shi, Enxue; Xiao, Junhua. Application of 30414-53-0 And the article was included in Asian Journal of Organic Chemistry on April 30 ,2020. The article conveys some information:

A chiral spirocyclic phosphoric acid-catalyzed asym. Biginelli reaction based on aliphatic aldehydes was realized for the synthesis of biol. important and synthetically useful 4-alkyl-3,4-dihydropyrimidin-2-(1H)-one (4-alkyl-DHPM) skeletons I [R = Et, n-Bu, n-heptyl, etc.; R1 = Me, Et, t-Bu, etc.; R2 = Me, Et] in good yield and with high levels of enantioinduction. The utility of this transformation was further demonstrated by direct thionation and C-C/C-N bond construction to provide a series of 4-alkyl-DHPMs derivatives I without any loss of optical activity, providing streamlined access to the formal synthesis of Batzelladine A. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-oxovalerate(cas: 30414-53-0Application of 30414-53-0)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Application of 30414-53-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gao, Xin; Turek-Herman, Joshua R.; Choi, Young Joo; Cohen, Ryan D.; Hyster, Todd K. published their research in Journal of the American Chemical Society on December 1 ,2021. The article was titled 《Photoenzymatic Synthesis of α-Tertiary Amines by Engineered Flavin-Dependent “”Ene””-Reductases》.Recommanded Product: 30414-53-0 The article contains the following contents:

α-Tertiary amines are a common motif in pharmaceutically important mols. but are challenging to prepare using asym. catalysis. Here, author demonstrate engineered flavin-dependent ‘ene’-reductases (EREDs) can catalyze radical additions into oximes to prepare this motif. Two different EREDs were evolved into competent catalysts for this transformation with high levels of stereoselectivity. Mechanistic studies indicate that the oxime contributes to the enzyme templated charge-transfer complex formed between the substrate and cofactor. These products can be further derivatized to prepare a variety of motifs, highlighting the versatility of ERED photoenzymic catalysis for organic synthesis. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-oxovalerate(cas: 30414-53-0Recommanded Product: 30414-53-0)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Recommanded Product: 30414-53-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

COA of Formula: C6H10O3On September 5, 2021 ,《Rational design, synthesis, biological evaluation and molecular docking studies of chromone-pyrimidine derivatives as potent anti-cancer agents》 was published in Journal of Molecular Structure. The article was written by Kantankar, Abhijit; Jayaprakash Rao, Y.; Mallikarjun, G.; Hemasri, Y.; Kethiri, Raghava Reddy. The article contains the following contents:

A series of pyrimidine based chromone hybrids I [R = Me, methoxymethyl, 4-fluorophenyl, etc.; R1 = H, methoxycarbonyl, ethoxycarbonyl, etc.] were synthesized from 7-methoxy-8-formyl-chromone using facile multi-component modified Biginelli reaction. All the synthesized compounds I were characterized and evaluated for their in-vitro anti-cancer activity against three cancer cell lines, human cervical (HeLa), lung (A549), myelogenous leukemia (K562) cancer cell lines and on a normal cell line(HEK-293) for the selectivity reference Among them, compounds I [R = 4-fluorophenyl, 2-fluorophenyl, 4-methoxyphenyl, 4-(trifluoromethoxy)phenyl; R1 = H] and I [R = methoxymethyl, methyl; R1 = methoxycarbonyl, ethoxycarbonyl] exhibited potent anti-cancer activities against A549, HeLa and K562 cell lines with IC50 values in micro molar range. The compounds I were displayed selective anti-cancer activity against K562 cell line compared to on other cancer cell lines. All the compounds I showed relative non-toxicity against normal cell line. The selectivity of the compounds against K562 cell line has been substantiated by mol. docking in BCR-ABL Tyrosine kinase using genetic algorithm program (GOLD 3.0.1). These results indicated that the chromones I were promised as the anti-cancer agents for the effective treatment of different types of cancers. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-oxovalerate(cas: 30414-53-0COA of Formula: C6H10O3)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.COA of Formula: C6H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quality Control of Methyl 3-oxovalerateOn September 21, 2021 ,《Rhodium-Catalyzed [4+2] Annulation of N-Aryl Pyrazolones with Diazo Compounds To Access Pyrazolone-Fused Cinnolines》 was published in European Journal of Organic Chemistry. The article was written by Lin, Chih-Yu; Huang, Wan-Wen; Huang, Ying-Ti; Dhole, Sandip; Sun, Chung-Ming. The article contains the following contents:

An efficient synthesis of novel dinitrogen-fused heterocycles such as pyrazolo[1,2-a]cinnoline derivatives have been accomplished by the rhodium(III)-catalyzed reaction of N-arylpyrazol-5-ones with α-diazo compounds This reaction proceeds through a cascade C-H activation/intramol. cyclization with a broad substrate scope. Furthermore, this protocol is successfully extended to the unusual phosphorus-containing α-diazo compounds and cyclic diazo compounds as the cross-coupling partners to deliver the two new kinds of pyrazolo[1,2-a]cinnolinones. The control experiments were performed to reveal insight into the mechanism of this reaction, involving reversible C-H activation, migratory insertion of the diazo compound, and cascade cyclization as the key steps of the transformation. Moreover, gram-scale synthesis and further transformation of the target product demonstrate the synthetic utility of the present protocol. In addition to this study using Methyl 3-oxovalerate, there are many other studies that have used Methyl 3-oxovalerate(cas: 30414-53-0Quality Control of Methyl 3-oxovalerate) was used in this study.

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Quality Control of Methyl 3-oxovalerate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Divergent Synthesis of Multisubstituted Unsymmetric Pyrroles and Pyrrolin-4-ones from Enamino Esters via Copper-Catalyzed Aerobic Dimerization》 was published in European Journal of Organic Chemistry in 2019. These research results belong to Chen, Zhi-Wei; Zheng, Lei; Liu, Jin. Computed Properties of C6H10O3 The article mentions the following:

A facile synthetic method to access multisubstituted unsym. pyrrole and pyrrolin-4-one derivatives is disclosed. In the presence of Cu(OAc)2 and KOAc, substituted pyrrole derivatives are produced in good yields (up to 93 %) through oxidative cyclization of enamino esters. Meanwhile, using CuCl2 and TFA (trifluoroacetic acid), pyrrolin-4-one derivatives are obtained in excellent yields (up to 94 %) through 1,2-aryl migration. A wide range of functional groups have been tolerated, and a reliable method for the synthesis of valuable multisubstituted pyrroles and pyrrolin-4-ones has been developed. In the experiment, the researchers used many compounds, for example, Methyl 3-oxovalerate(cas: 30414-53-0Computed Properties of C6H10O3)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Computed Properties of C6H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

El-Hefnawy, Mohamed E.; Alhayyani, Sultan; El-Sherbiny, Mohsen M.; Abomohra, Abd El-Fatah; Al-Harbi, Mamdouh published an article in Journal of Cleaner Production. The title of the article was 《Endogenous bioethanol production by solid-state prefermentation for enhanced crude bio-oil recovery through integrated hydrothermal liquefaction of seaweeds》.Synthetic Route of C6H10O3 The author mentioned the following in the article:

The present study evaluated the action of endogenous bioethanol produced during solid-state fermentation of Ulva spp. on subsequent hydrothermal liquefaction (HTL). HTL of raw biomass (RB) was compared with HTL of the fermented biomass after bioethanol separation (F-Aqua) and HTL of the whole fermentation broth containing the bioethanol (F-Eth). Optimization of fermentation conditions increased the ethanol yield efficiency (Yeff) and specific ethanol yield (SEY) from 23.55% and 0.120 g g-1 sugar consumed to 43.97% and 0.224 g g-1 sugar consumed, resp. TGA and FTIR anal. confirmed noticeable changes in the thermal profile and functional groups of the fermented residue with increased volatiles and lower ash content. Among different HTL treatments, F-Eth showed the highest bio-oil yield of 24.96% at 250°C, which was 37.7% and 39.0% higher than that of RB and F-Aqua, resp. In addition, hydrocarbons and esters in the bio-oil represented the dominant compounds in F-Aqua and F-Eth, altogether 28.28% and 68.58%, resp., compared to 17.96% in RB. Economic anal. for a proposed 100 ton year-1 plant confirmed that HTL of the whole fermentation broth containing endogenous bioethanol enhanced the gross energy output to 8.152 GJ ton-1, which represented 4.2-time, 51.1%, and 23.3% higher than individual bioethanol production, individual bio-oil production, and sequential bioethanol/bio-oil recovery, with the highest net annual profit of 29553 US$ compared to 23391 US$ for the sequential production In the part of experimental materials, we found many familiar compounds, such as Methyl 3-oxovalerate(cas: 30414-53-0Synthetic Route of C6H10O3)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Synthetic Route of C6H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ye, Chen-Xi; Chen, Shuming; Han, Feng; Xie, Xiulan; Ivlev, Sergei; Houk, K. N.; Meggers, Eric published an article in Angewandte Chemie, International Edition. The title of the article was 《Atroposelective Synthesis of Axially Chiral N-Arylpyrroles by Chiral-at-Rhodium Catalysis》.Application In Synthesis of Methyl 3-oxovalerate The author mentioned the following in the article:

A transformation of fluxional into configurationally stable axially chiral N-arylpyrroles was achieved with a highly atroposelective electrophilic aromatic substitution catalyzed by a chiral-at-metal rhodium Lewis acid. Specifically, N-arylpyrroles were alkylated with N-acryloyl-1H-pyrazole electrophiles in up to 93% yield and with up to >99.5% ee, and follow-up conversions reveal the synthetic utility of this new method [e.g., I + N-acryloyl-1H-pyrazole → II (up to 93% yield, 92% isolated, 99% ee)]. DFT calculations elucidate the origins of the observed excellent atroposelectivity. In addition to this study using Methyl 3-oxovalerate, there are many other studies that have used Methyl 3-oxovalerate(cas: 30414-53-0Application In Synthesis of Methyl 3-oxovalerate) was used in this study.

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Application In Synthesis of Methyl 3-oxovalerate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 30414-53-0On May 12, 2021 ,《Rapid broad spectrum detection of carbapenemases with a dual fluorogenic-colorimetric probe》 appeared in Journal of the American Chemical Society. The author of the article were Ma, Chi-Wang; Ng, Kenneth King-Hei; Yam, Bill Hin-Cheung; Ho, Pak-Leung; Kao, Richard Yi-Tsun; Yang, Dan. The article conveys some information:

Carbapenems stand as one of the last-resort antibiotics; however, their efficacy is threatened by the rising number and rapid spread of carbapenemases. Effective antimicrobial stewardship thus calls for rapid tests for these enzymes to aid appropriate prescription and infection control. Herein, we report the first effective pan-carbapenemase reporter CARBA-H with a broad scope covering all three Ambler classes. Using a chem. biol. approach, we demonstrated that the absence of the 1β-substituent in the carbapenem core is key to pan-carbapenemase recognition, which led to our rational design and probe development. CARBA-H provides a dual colorimetric-fluorogenic response upon carbapenemase-mediated hydrolysis. A clear visual readout can be obtained within 15 min when tested against a panel of carbapenemase-producing Enterobacteriaceae (CPE) clin. isolates that notably includes OXA-48 and OXA-181-producing strains. Furthermore, CARBA-H can be applied to the detection of carbapemenase activity in CPE-spiked urine samples. The results came from multiple reactions, including the reaction of Methyl 3-oxovalerate(cas: 30414-53-0Application of 30414-53-0)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Application of 30414-53-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quality Control of Methyl 3-oxovalerateOn October 18, 2021 ,《Ru-NHC-Catalyzed Asymmetric Hydrogenation of 2-Quinolones to Chiral 3,4-Dihydro-2-Quinolones》 was published in Angewandte Chemie, International Edition. The article was written by Hu, Tianjiao; Lueckemeier, Lukas; Daniliuc, Constantin; Glorius, Frank. The article contains the following contents:

The Ru(II)-NHC-catalyzed asym. hydrogenation of 2-quinolones under mild reaction conditions was developed. Alkyl-, aryl- and halogen-substituted optically active dihydro-2-quinolones I [R = H, Me; R1 = Me, Bn; R2 = H, Me, Et, i-Pr, Ph; R3 = H; R4 = H, Me, Ph, etc.; R5 = H, OMe, F, etc.; R6 = H, Me; R1R3 = (CH2)3] were obtained in high yields with moderate to excellent enantioselectivities. The reaction provided an efficient and atom-economic pathway to construct simple chiral 3,4-dihydro-2-quinolones. The desired products could be further reduced to tetrahydroquinolines and octahydroquinolones. The experimental process involved the reaction of Methyl 3-oxovalerate(cas: 30414-53-0Quality Control of Methyl 3-oxovalerate)

Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.Quality Control of Methyl 3-oxovalerate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics