Category: 30095-98-8

Xing, Bo; Ni, Chuanfa; Hu, Jinbo published the artcile< Hypervalent Iodine(III) Catalyzed Balz-Schiemann Fluorination under Mild Conditions>, Reference of 30095-98-8, the main research area is arenediazonium tetrafluoroborate Balz Schiemann fluorination hypervalent iodine catalyst; fluoride aryl preparation; Balz-Schiemann reaction; aryl fluorides; diazonium salts; fluorination; iodine.

An unprecedented hypervalent iodine(III)-catalyzed Balz-Schiemann reaction was described. In the presence of a hypervalent iodine compound, the fluorination reaction proceeded under mild conditions (25-60 °C), and featured a wide substrate scope and good functional-group compatibility.

Angewandte Chemie, International Edition published new progress about Aryl fluorides Role: SPN (Synthetic Preparation), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Reference of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nawghare, Beena R.; Lokhande, Pradeep D. published the artcile< First iodine-catalyzed deallylation of reactive allyl methylene esters>, HPLC of Formula: 30095-98-8, the main research area is allyl methylene ester iodine catalyzed deallylation lactonization.

A C-allyl cleavage was developed using inexpensive and mild I2 in DMSO. A variety of compounds with active methylene groups were C-deallylated using this reagent. This method is efficient and operationally simple in comparison to the methods using transition-metal complexes.

Synthetic Communications published new progress about Active methylene compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, HPLC of Formula: 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Delayre, Bastien; Piemontesi, Cyril; Wang, Qian; Zhu, Jieping published the artcile< TiCl3-Mediated Synthesis of 2,3,3-Trisubstituted Indolenines: Total Synthesis of (+)-1,2-Dehydroaspidospermidine, (+)-Condyfoline, and (-)-Tubifoline>, Reference of 30095-98-8, the main research area is titanium chloride mediated synthesis indolenine; dehydroaspidospermidine total synthesis; condyfoline total synthesis; tubifoline total synthesis; 1,2-rearrangements; indole alkaloids; natural products; titanium trichloride; total synthesis.

2,3,3-Trisubstituted indolenine constitutes an integral part of many biol. important monoterpene indole alkaloids. We report herein an unprecedented access to this skeleton by a TiCl3-mediated reductive cyclization of tetrasubstituted alkenes bearing a 2-nitrophenyl substituent. The proof of concept is demonstrated firstly by accomplishing a concise total synthesis of (+)-1,2-dehydroaspidospermidine (I) featuring a late-stage application of this key transformation. A sequence of reduction of nitroarene to nitrosoarene followed by 6π-electron-5-atom electrocyclization and a 1,2-alkyl shift of the resulting nitrone intermediate was proposed to account for the reaction outcome. A subsequent total synthesis of (+)-condyfoline (II) not only illustrates the generality of the reaction, but also provides a mechanistic insight into the nature of the 1,2-alkyl shift. The exclusive formation of (+)-condyfoline indicates that the 1,2-alkyl migration follows a concerted Wagner-Meerwein pathway, rather than a stepwise retro-Mannich/Mannich reaction sequence. Conditions for almost quant. conversion of (+)-condyfoline to (-)-tubifoline (III) by way of a retro-Mannich/1,3-prototropy/transannular cyclization cascade are also documented.

Angewandte Chemie, International Edition published new progress about Biomimetic synthesis. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Reference of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gualtierotti, Jean-Baptiste; Pasche, Delphine; Wang, Qian; Zhu, Jieping published the artcile< Phosphoric acid catalyzed desymmetrization of bicyclic bislactones bearing an all-carbon stereogenic center: Total syntheses of (-)-rhazinilam and (-)-leucomidine B>, HPLC of Formula: 30095-98-8, the main research area is bicyclic bislactone alc desymmetrization ring opening phosphate catalyst; rhazinilam asym total synthesis; leucomidine B asym total synthesis; alkaloids; natural products; organocatalysis; synthetic methods; total synthesis.

In the presence of a catalytic amount of an imidodiphosphoric acid, enantioselective desymmetrization of bicyclic bislactones by reaction with alcs. took place smoothly to afford enantiomerically enriched monoacids having an all-C stereogenic center. Concise catalytic enantioselective syntheses of both (-)-rhazinilam and (-)-leucomidine B were subsequently developed using Me (S)-4-ethyl-4-formylpimelate monoacid as a common starting material.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, HPLC of Formula: 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Manna, Kartic; Ganguly, Tanusree; Baitalik, Sujoy; Jana, Ranjan published the artcile< Visible-Light- and PPh3-Mediated Direct C-N Coupling of Nitroarenes and Boronic Acids at Ambient Temperature>, Electric Literature of 30095-98-8, the main research area is secondary amine photochem preparation triphenylphosphine mediator; nitroarene boronic acid intermol reductive amination.

Herein a metal-free, visible-light- and triphenylphosphine-mediated intermol., reductive amination between nitroarenes and boronic acids at ambient temperature without any photocatalyst is presented. Mechanistically, a slow reduction of nitroarenes to a nitroso and, finally, a nitrene intermediate occurs that leads to the amination product with concomitant 1,2-aryl/-alkyl migration from a boronate complex. A wide range of nitroarenes underwent C-N coupling with aryl-/alkylboronic acids providing high yields.

Organic Letters published new progress about Amination catalysts (photochem). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Electric Literature of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Guihua; Cao, Jian; Wang, Qian; Zhu, Jieping published the artcile< Desymmetrization of Prochiral Cyclopentenes Enabled by Enantioselective Palladium-Catalyzed Oxidative Heck Reaction>, HPLC of Formula: 30095-98-8, the main research area is desymmetrization cyclopentene enantioselective oxidative Heck palladium catalyst; oxidative Heck arylboronic acid cyclopentene palladium catalyst diastereoselective enantioselective.

In the presence of a catalytic amount of Pd(TFA)2 and a chiral Pyox ligand under oxygen atm., oxidative Heck reaction between arylboronic acids and 4-substituted or 4,4-disubstituted cyclopent-1-enes afforded the chiral arylated products with concurrent creation of two stereocenters in good yields with excellent diastereo- and enantioselectivities.

Organic Letters published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, HPLC of Formula: 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Strazzolini, Paolo; Verardo, Giancarlo; Gorassini, Fausto; Giumanini, Angelo G. published the artcile< Orientation effect of side chain substituents in aromatic substitution. Induced ortho nitration>, Application In Synthesis of 30095-98-8, the main research area is ortho nitration toluene derivative regiochem; benzeneacetic acid ortho nitration.

The presence of a free carboxyl or ester function on the α-carbon of toluene induces the nitration of the Ph ring in the ortho position at or above the statistical value (chaperon effect), when pure HNO3 is used in CH2Cl2 solution This is at variance with the results of classical nitration in H2SO4, where p-nitration predominates by far and m-nitration occurs to a remarkable extent. The new finding is explained in terms of precomplex formation.

Bulletin of the Chemical Society of Japan published new progress about Nitration. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Application In Synthesis of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Guihua; Cao, Jian; Wang, Qian; Zhu, Jieping published the artcile< Desymmetrization of Prochiral Cyclopentenes Enabled by Enantioselective Palladium-Catalyzed Oxidative Heck Reaction>, HPLC of Formula: 30095-98-8, the main research area is desymmetrization cyclopentene enantioselective oxidative Heck palladium catalyst; oxidative Heck arylboronic acid cyclopentene palladium catalyst diastereoselective enantioselective.

In the presence of a catalytic amount of Pd(TFA)2 and a chiral Pyox ligand under oxygen atm., oxidative Heck reaction between arylboronic acids and 4-substituted or 4,4-disubstituted cyclopent-1-enes afforded the chiral arylated products with concurrent creation of two stereocenters in good yields with excellent diastereo- and enantioselectivities.

Organic Letters published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, HPLC of Formula: 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Strazzolini, Paolo; Verardo, Giancarlo; Gorassini, Fausto; Giumanini, Angelo G. published the artcile< Orientation effect of side chain substituents in aromatic substitution. Induced ortho nitration>, Application In Synthesis of 30095-98-8, the main research area is ortho nitration toluene derivative regiochem; benzeneacetic acid ortho nitration.

The presence of a free carboxyl or ester function on the α-carbon of toluene induces the nitration of the Ph ring in the ortho position at or above the statistical value (chaperon effect), when pure HNO3 is used in CH2Cl2 solution This is at variance with the results of classical nitration in H2SO4, where p-nitration predominates by far and m-nitration occurs to a remarkable extent. The new finding is explained in terms of precomplex formation.

Bulletin of the Chemical Society of Japan published new progress about Nitration. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Application In Synthesis of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rodenko, Boris; Toebes, Mireille; Hadrup, Sine Reker; van Esch, Wim J. E.; Molenaar, Annemieke M.; Schumacher, Ton N. M.; Ovaa, Huib published the artcile< Generation of peptide-MHC class I complexes through UV-mediated ligand exchange>, Computed Properties of 30095-98-8, the main research area is peptide complex MHC class I UV exchange.

Major histocompatibility complex (MHC) class I mols. present peptide ligands on the cell surface for recognition by appropriate cytotoxic T cells. MHC-bound peptides are critical for the stability of the MHC complex, and standard strategies for the production of recombinant MHC complexes are based on in vitro refolding reactions with specific peptides. This strategy is not amenable to high-throughput production of vast collections of MHC mols. The authors have developed conditional MHC ligands that form stable complexes with MHC mols. but can be cleaved upon UV irradiation The resulting empty, peptide-receptive MHC mols. can be charged with epitopes of choice under native conditions. Here the authors describe in-depth procedures for the high-throughput production of peptide-MHC (pMHC) complexes by MHC exchange, the anal. of peptide exchange efficiency by ELISA and the parallel production of MHC tetramers for T-cell detection. The production of the conditional pMHC complex by an in vitro refolding reaction can be achieved within 2 wk, and the actual high-throughput MHC peptide exchange and subsequent MHC tetramer formation require less than a day.

Nature Protocols published new progress about CD8-positive T cell. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Computed Properties of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics