Category: 30095-98-8

Bunce, Richard A.; Herron, Derrick M.; Ackerman, Matthew L. published the artcile< Aryl-fused nitrogen heterocycles by a tandem reduction-Michael addition reaction>, Name: Methyl 2-(2-nitrophenyl)acetate, the main research area is nitrogen heterocycle aryl fused preparation; quinolineacetate tetrahydro preparation; benzoxazineacetate dihydro preparation; quinoxalineacetate tetrahydro preparation; nitrophenylpentenoate preparation tandem reduction Michael addition; nitrophenoxybutenoate preparation tandem reduction Michael addition; nitroanilinobutenoate preparation tandem reduction Michael addition.

The tetrahydroquinolines, benzoxazines, and quinoxalines I (X = CH2, O, NH; R = H, Me) were prepared from the nitrobenzenes II by tandem iron/HOAc reduction-Michael addition reactions.

Journal of Organic Chemistry published new progress about Heterocyclic compounds, nitrogen Role: SPN (Synthetic Preparation), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Name: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Choudary, B. M.; Reddy, G. Vidya Sagar; Rao, K. Koteswara published the artcile< Vanadium-catalyzed novel oxidation of arylacetic esters for the synthesis of arylglyoxylic esters>, Electric Literature of 30095-98-8, the main research area is arylacetate oxidation vanadium montmorillonite catalyst; arylglyoxylate; glyoxylate aryl.

Direct synthesis of arylglyoxylic esters RC6H4COCO2Me (R = H, 2-, 4-OMe, 4-Me, 4-NH2, 4-NO2, 2-, 4-Cl) in excellent yields (24-88%) from inexpensive arylacetic esters RC6H4CH2CO2Me is realized for the first time by the oxidation of activated methylene using vanadium pillared clay as the catalyst and tert-Bu hydroperoxide as an oxidant.

Journal of the Chemical Society, Chemical Communications published new progress about Oxidation. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Electric Literature of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kumar, Amit; Sharma, Gaurav; Shukla, Sanjeev K.; Panda, Gautam published the artcile< A Tandem Semipinacol Rearrangement/aldehyde Arylation or Alkylation of Trisubstituted 2,3-Epoxy Alcohols with Grignard reagents for Functionalized 1,3-diols>, Quality Control of 30095-98-8, the main research area is anti diol preparation diastereoselective DFT; epoxy alc Grignard reagent tandem semipinacol rearrangement arylation alkylation.

A tandem semipinacol rearrangement/aldehyde arylation or alkylation reaction leading to formation of functionalized 1,3-diols bearing three consecutive tertiary stereocenters anti-R1CH(OH)R2CHR3C(OH) (R1 = Ph, 2-methoxyphenyl, 6-bromo-2-methoxyquinolin-3-yl, etc.; R2 = Ph, naphth-1-yl; R3 = iso-Pr, Ph, thiophen-2-yl, etc.) is identified from the reaction of various new trisubstituted 2,3-epoxy alcs. I with numerous Grignard reagents R3MgX. This reaction is useful for stereoselective construction of three consecutive tertiary stereocenters. The observed 1,3-diols exist in anti-configuration which is confirmed by the 2D-NOESY, crystal structure of acetonide of one of the 1,3-diol analog 3ai and further DFT studies.

Journal of Organic Chemistry published new progress about Alcohols, epoxy Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Quality Control of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cheng, Kai; Li, Shiyu; Lv, Xiao; Tian, Yongbin; Kong, Haiyan; Huang, Xufeng; Duan, Yajun; Han, Jihong; Xie, Zhouling; Liao, Chenzhong published the artcile< Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure>, HPLC of Formula: 30095-98-8, the main research area is isatin monoamine oxidase B; Fragment-based drug design; Isatin; Isoform selectivity; Structure activity relationship; hMAO-B.

Herein we report our efforts of developing reversible selective hMAO-B inhibitors based on isatin, a fragment in an X-ray crystal structure. Five different scaffolds were designed and many compounds were synthesized. Among them, compound A3(I) demonstrated very high potency and isoform selectivity against hMAO-B, 11 and 13 times more potent (IC50 = 3 nM) and 23.64 and 6.8 times more selective than the marked drugs, selegiline and safinamide. However, the endeavors to modify the polar 3-one group of isatin, that is in a hydrophobic environment in the binding site of hMAO-B, to small nonpolar hydrophobic groups did not bring about improved hMAO-B inhibitors, which may challenge our understanding of mol. interactions and mol. recognition in biol. systems.

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, HPLC of Formula: 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Felpin, Francois-Xavier; Ibarguren, Oier; Nassar-Hardy, Luma; Fouquet, Eric published the artcile< Synthesis of Oxindoles by Tandem Heck-Reduction-Cyclization (HRC) from a Single Bifunctional, in Situ Generated Pd/C Catalyst>, Reference of 30095-98-8, the main research area is methyl nitroaryl acetate formaldehyde methylenation; nitroaryl acrylate preparation aromatic diazonium salt hydrogen reusable palladium; Heck reduction cyclization arylmethyl oxindole preparation; catalyst Heck reduction cyclization reusable palladium.

A tandem sequence involving palladium-catalyzed sequential Heck-reduction-cyclization transformations in mild conditions has been developed for the synthesis of oxindoles, e.g., I. The protocol involves inexpensive reagents and does not require any additives such as base or ligands.

Journal of Organic Chemistry published new progress about Carboxylic esters Role: RCT (Reactant), RACT (Reactant or Reagent) (nitroaralkyl). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Reference of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Sangku; Lim, Hee-Jong; Cha, Kobpurn Lulu; Sulikowski, Gary A. published the artcile< Asymmetric approaches to 1,2-disubstituted mitosenes based on the intramolecular cyclization of diazoesters>, Related Products of 30095-98-8, the main research area is mitosene antitumor antibiotic asym synthesis; intramol cyclization diazoester chiral copper catalyst; mitomycin ring system asym synthesis.

A strategy for the asym. synthesis of 1,2-disubstituted mitosenes is described. The key reaction is the decomposition of a meso diazoester in the presence of chiral copper(I) catalysts. Cyclization of diazoesters derived from (1R,2S,5R)-menthol and (R)-pantolactone provide optically pure 1,2-disubstituted mitosenes, e.g. I (R = α-, β-CO2Me; R1 = α-, β-H) following oxidation and purification by flash chromatog.

Tetrahedron published new progress about Antitumor antibiotics. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Related Products of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Praveen, Aletti S.; Yathirajan, Hemminge S.; Narayana, Badiadka; Sarojini, Balladka K. published the artcile< Synthesis and spectroscopic characterization of some novel Schiff bases of benzylidene derivatives>, Formula: C9H9NO4, the main research area is benzylidene Schiff base preparation.

A series of Schiff bases I (R1 = 3-Me, 4-Me, 4-MeO, 4-EtO, 2-O2N; R2 = H, 4-CN, 4-F, 4-MeO) have been synthesized by treatment of 2-(substituted phenyl)acetohydrazides with few benzaldehyde derivatives

Pharma Chemica published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Formula: C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Motoyama, Yukihiro; Kamo, Kazuyuki; Nagashima, Hideo published the artcile< Catalysis in Polysiloxane Gels: Platinum-Catalyzed Hydrosilylation of Polymethylhydrosiloxane Leading to Reusable Catalysts for Reduction of Nitroarenes>, Related Products of 30095-98-8, the main research area is nitroarene chemoselective reduction platinum encapsulated polysiloxane gel; aniline preparation.

Novel polysiloxane gels with encapsulated platinum species were prepared by treatment of polymethylhydrosiloxane with alkenes in the presence of Karstedt’s catalyst. These gels act as reusable catalysts in the reduction of functionalized nitroarenes with H2 to the corresponding substituted anilines without leaking the catalyst species.

Organic Letters published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Related Products of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Surakanti, Ramu; Sanivarapu, Sumalatha; Thulluri, Chiranjeevi; Iyer, Pravin S.; Tangirala, Raghuram S.; Gundla, Rambabu; Addepally, Uma; Murthy, Y. L. N.; Velide, Lakshmi; Sen, Subhabrata published the artcile< Synthesis of privileged scaffolds by using diversity-oriented synthesis>, Name: Methyl 2-(2-nitrophenyl)acetate, the main research area is pyrrolidine indoline cyclotryptamine preparation anticancer antibacterial; spiro indoline preparation anticancer antibacterial.

An elegant reagent-controlled strategy has been developed for the generation of a diverse range of biol. active scaffolds from a chiral bicyclic lactam. Reduction of the chiral lactam with LAH or alkylation with LHMDS to trigger different cyclization reactions have been shown to generate privileged scaffolds, such as pyrrolidines, indolines, and cyclotryptamines. Their amenability to substitution allows us to create various compound libraries by using these scaffolds. In silico studies were used to estimate the drug-like properties of these compounds Selected compounds were subjected to anticancer screening by using three different cell lines. In addition, all these compounds were subjected to antibacterial screening to gauge the spectrum of biol. activity that was conferred by our DOS methodol. Gratifyingly, with no addnl. iterative cycles, our method directly generated anticancer compounds with potency at low nanomolar concentrations, as represented by spiroindoline I.

Chemistry – An Asian Journal published new progress about Antibacterial agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Name: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Jie S.; Son, Jung-Ho; Teuthorn, Andrew P.; Haddadin, Makhluf J.; Kurth, Mark J.; Tantillo, Dean J. published the artcile< Diverting Reactive Intermediates Toward Unusual Chemistry: Unexpected Anthranil Products from Davis-Beirut Reaction>, Formula: C9H9NO4, the main research area is interrupted Davis Beirut reaction anthranil preparation.

The discovery of a new variation on the Davis-Beirut reaction is described in which an atypical heterocyclic framework (the anthranil or benzo[c]isoxazole framework) is formed as the result of diversion of a key reactive intermediate away from its expected reactivity – a potentially general approach to reaction design and development. Exptl. and computational support for the proposed mechanism and origins of altered reactivity are described.

Journal of Organic Chemistry published new progress about Aromatic nitro compounds Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Formula: C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics