Category: 30095-98-8

Wagnieres, Olivier; Xu, Zhengren; Wang, Qian; Zhu, Jieping published the artcile< Unified Strategy to Monoterpene Indole Alkaloids: Total Syntheses of (±)-Goniomitine, (±)-1,2-Dehydroaspidospermidine, (±)-Aspidospermidine, (±)-Vincadifformine, and (±)-Kopsihainanine A>, Product Details of C9H9NO4, the main research area is stereoselective synthesis monoterpene indole alkaloid; goniomitine stereoselective synthesis; dehydroaspidospermidine stereoselective synthesis; aspidospermidine vincadifformine kopsihainanine stereoselective synthesis; decarboxylative vinylation palladium catalyst monoterpene indole alkaloid synthesis; oxidation reduction cyclization integrated stereoselective synthesis monoterpene indole alkaloid.

Total syntheses of (±)-goniomitine, (±)-1,2-dehydroaspidospermidine, (±)-aspidospermidine, (±)-vincadifformine, and (±)-kopsihainanine A were achieved featuring two common key steps: (1) a palladium-catalyzed decarboxylative vinylation that provides quick access to cyclopentene intermediates containing all of the carbons present in the natural products and (2) an integrated oxidation/reduction/cyclization (iORC) sequence for skeletal reorganization that converts the cyclopentenes to the pentacyclic structures of the natural products. By incorporation of a geometric constraint to iORC substrates, both the chemoselectivity (C7 vs. N1 cyclization) and the stereoselectivity (trans- vs. cis-fused ring system) of the cyclization process can be controlled.

Journal of the American Chemical Society published new progress about Cyclization. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Product Details of C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

RajanBabu, T. V.; Reddy, G. S.; Fukunaga, Tadamichi published the artcile< Nucleophilic addition of silyl enol ethers to aromatic nitro compounds: scope and mechanism of reaction>, Name: Methyl 2-(2-nitrophenyl)acetate, the main research area is organosilicon alkylation nitro compound; silicon organic nitro alkylation; aromatic nitro organosilicon alkylation; heteroaromatic nitro organosilicon alkylation; benzene nitro organosilicon alkylation; anthracene nitro organosilicon alkylation; naphthalene nitro organosilicon alkylation; isoquinoline nitro organosilicon alkylation; benzothiadiazole nitro organosilicon alkylation.

In contrast to alkali metal enolates, silyl enol ethers and ketene silyl acetals added to aromatic nitro compounds in the presence of a fluoride ion source to give intermediate dihydroarom. nitronates, which could be observed by NMR. In situ oxidation of the intermediate with Br or DDQ gave α-nitroaryl carbonyl compounds in moderate to high yields. The reaction was applicable to alkyl-, alkoxy-, and halogen-substituted nitrobenzenes as well as to heterocyclic and condensed nitroarom. compounds While substitution ortho to the nitro group predominated with sterically undemanding silyl reagents, para-substitution products were exclusively obtained with bulky reagents. However, by blocking the para position with an appropriate group such as chlorine, the addition could be directed to the ortho position. Halogen atoms of halogenated nitro aromatics and p-nitrocumenyl chloride were not displaced in the reaction, suggesting the absence of radical ion intermediates. Dihydroarom. nitro derivatives could be isolated in some cases, such as anthracene and naphthalene systems, which are less prone to rearomatize.

Journal of the American Chemical Society published new progress about Alkylation. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Name: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xia, Yi; Yang, Zheng-Yu; Xia, Peng; Bastow, Kenneth F.; Nakanishi, Yuka; Nampoothiri, Priya; Hamel, Ernest; Brossi, Arnold; Lee, Kuo-Hsiung published the artcile< Antitumor agents. Part 226: Synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters>, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate, the main research area is phenylquinoloneacetic acid preparation antitumor agent cytotoxicity.

2-Phenyl-4-quinolone acetic acids and their esters were synthesized and evaluated for interaction with tubulin and for cytotoxicity against a panel of human tumor cell lines. 2-Phenyl- and 2-(2′-fluorophenyl)-4-quinolone-8-acetic acids displayed potent cytotoxicity with ED50 values at nanomolar concentrations, but had minimal activity against tubulin polymerization 2-(2′-Fluorophenyl)-4-quinolone-6-acetic acid and 2-(2′-fluorophenyl)-4-quinolone-8-acetic acid Me ester moderately inhibited tubulin polymerization

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shi, Weihua; Jiang, Zhigan; He, Haiying; Xiao, Fubiao; Lin, Fusen; Sun, Ya; Hou, Lijuan; Shen, Liang; Han, Lixia; Zeng, Minggao; Lai, Kunmin; Gu, Zhengxian; Chen, Xinsheng; Zhao, Tao; Guo, Li; Yang, Chun; Li, Jian; Chen, Shuhui published the artcile< Correction to ""The Discovery of 3,3′-Spiro[azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection"" [Erratum to document cited in CA168:169484]>, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate, the main research area is spiro azetidine indoline fusion inhibitor respiratory syncytial virus erratum.

In the original publication, there are errors in two references and a typog. error within the table of contents; the corrections are provided here.

ACS Medicinal Chemistry Letters published new progress about Antiviral agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sudta, Pichit; Kirk, Nicholas; Bezos, Anna; Gurlica, Anthony; Mitchell, Rhys; Weber, Thomas; Willis, Anthony C.; Prabpai, Samran; Kongsaeree, Palangpon; Parish, Christopher R.; Suksamrarn, Sunit; Kelso, Michael J. published the artcile< Synthesis, Structural Characterisation, and Preliminary Evaluation of Non-Indolin-2-one-based Angiogenesis Inhibitors Related to Sunitinib (Sutent)>, Electric Literature of 30095-98-8, the main research area is sunitinib analog preparation angiogenesis inhibitor SAR.

The indolin-2-one fused-ring system and the 2,4-dimethylpyrrole unit represent key structural motifs in the anticancer drug sunitinib (Sutent) and predecessor angiogenesis inhibitors that have undergone anticancer clin. trials (e.g. semaxanib, SU5416). In pursuit of novel anti-angiogenic scaffolds, we were interested in identifying whether the indolin-2-one group in these structures could be modified without losing activity. This paper describes novel condensation chem. used to prepare a test series of (E)- and (Z)-alkenes related to SU5416 that retain the 2,4-dimethylpyrrole unit while incorporating ring-opened indolin-2-ones. Unique structural characteristics were identified in the compounds, such as intramol. hydrogen bonds in the (Z)-alkenes, and several examples were shown to possess significant anti-angiogenic activity in a rat aorta in vitro model of angiogenesis. The work demonstrates that the indolin-2-one moiety is not an absolute requirement for angiogenesis inhibition in the sunitinib/SU5416 class.

Australian Journal of Chemistry published new progress about Antiangiogenic agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Electric Literature of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sojak, L.; Perjessy, A.; Kubinec, R.; Giumanini, A. G. published the artcile< CGC-FTIR characterization of mononitro and dinitro isomers from nitration mixtures of methyl arylacetates>, HPLC of Formula: 30095-98-8, the main research area is GC FTIR nitration mixture methyl arylacetate; gas chromatog FTIR arylacetate nitration mixture.

Twenty-one isomeric compounds from nitration of Me phenyl-, diphenyl-, and (hydroxy)diphenylacetates and the parent compounds were separated by capillary gas chromatog. with apolar stationary phase HP-5 and detected by FID and FTIRD. The measured retention indexes and IR spectral data of C=O and NO2 groups were correlated with mol. structure of analytes. The regularities in GC retention as well as in the FTIR data of isomeric aromatic nitro compounds were formulated. The obtained results can be useful for GC-FTIR identification of ring positional isomers of nitration products of other Me arylacetates.

Chemical Papers published new progress about Capillary gas chromatography. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, HPLC of Formula: 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Numao, Naganori; Hamada, Tatsuo; Yonemitsu, Osamu published the artcile< A mechanistic study of the photoreaction of dimethylaniline and methyl chloroacetate. Role of acid-base properties in both the ground state and the excited state>, Product Details of C9H9NO4, the main research area is fluorescence quenching alkylation dimethylaniline; methoxycarbonylmethylation aniline photochem mechanism; exciplex dimethylaniline photochem methoxycarbonylmethylation; kinetics photochem methoxycarbonylmethylation methylaniline.

Quantum yields for fluorescence quenching and disappearance of PhNMe2 (I) were determined for the photochem. alkylation of I with ClCH2CO2Me, in both acidic and basic solutions, to give o- and p-MeO2CCH2C6H4NMe2. Under acidic conditions the reaction occurs via an exciplex, and under basic conditions an exciplex and a charge-transfer complex are involved.

Tetrahedron published new progress about 30095-98-8. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Product Details of C9H9NO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Suzuki, Hitomi; Takeuchi, Toyomi; Mori, Tadashi published the artcile< Ozone-Mediated Nitration of Phenylalkyl Ethers, Phenylacetic Esters, and Related Compounds with Nitrogen Dioxide. The Highest Ortho Substitution Observed in the Electrophilic Nitration of Arenes>, Quality Control of 30095-98-8, the main research area is ozone nitration phenylalkyl ether phenylacetate; aryl ether nitration Kyodai regiochem; regioselective substitution Kyodi nitration phenyl ether; Kyodai nitration phenylalkyl ether benzeneacetate; electrophilic nitration nitrogen dioxide.

By the combined action of ozonized oxygen and nitrogen dioxide (the Kyodai nitration), the title compounds were smoothly nitrated in dichloromethane at subzero degrees with high ortho positional selectivity. Although the conventional nitration of phenylacetic acid and esters mainly produces m- and p-nitro derivatives, the present nitration offers a simple high-yield synthesis of o-nitro derivatives which are important as precursor in organic synthesis. The proportions of the ortho isomer in the nitration products from Me 2-phenylethyl ether and Me phenylacetate were 71 and 88%, resp., the latter value being the highest ortho isomer proportion so far observed in the electrophilic aromatic nitration. The observed high ortho selectivity has been rationalized in terms of radical cation intermediate and six-membered cyclic transition state.

Journal of Organic Chemistry published new progress about Alkyl aryl ethers Role: RCT (Reactant), RACT (Reactant or Reagent). 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Quality Control of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Musso, Loana; Cincinelli, Raffaella; Zuco, Valentina; De Cesare, Michelandrea; Zunino, Franco; Fallacara, Anna Lucia; Botta, Maurizio; Dallavalle, Sabrina published the artcile< 3-Arylidene-N-hydroxyoxindoles: A New Class of Compounds Endowed with Antitumor Activity>, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate, the main research area is arylidene hydroxyoxindole synthesis antitumor p53 apoptosis; N-hydroxyoxindole; antiproliferative activity; antitumor agents; apoptosis; p53.

A series of compounds containing the N-hydroxyoxindole scaffold were synthesized and evaluated for antitumor activity. The compounds showed potent antiproliferative activity against the wild-type p53 IGROV-1 ovarian carcinoma cell line and considerably lower efficacy against the mutant IGROV-1/Pt1 subline that lacks p53 function. The differential response of ovarian carcinoma cells depending on p53 status was also reflected in the varied susceptibility to apoptosis of the treated cell lines. These results support a role for the p53 transcription factor as a determinant of cytotoxicity. The therapeutic potential of the most promising compound of the series was evaluated in the treatment of an IGROV-1 xenograft growing as ascitic tumor in mice. Using i.p. administration, daily treatment with the compound for four weeks produced a significant delay in the onset of ascites.

ChemMedChem published new progress about Antitumor agents. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Recommanded Product: Methyl 2-(2-nitrophenyl)acetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Strazzolini, Paolo; Giumanini, Angelo G.; Runcio, Antonio; Scuccato, Massimo published the artcile< Experiments on the Chaperon Effect on the Nitration of Aromatics>, Synthetic Route of 30095-98-8, the main research area is nitration alkylbenzene substituent effect.

A nitro group may be effectively delivered to the ortho position of alkylbenzenes, provided that a suitable chaperon function is located in α-position and a dilute solution of HNO3 in CH2Cl2 is used. The carbonyl function of an aldehyde or ketone is the best choice, but a carboxyl, alkoxycarbonyl, and amide group all work well. The ether function showed a less pronounced ortho orientation effect, whereas the hydroxyl group was too prone to oxidation Side reactions were minimal under the conditions employed. A para chaperon effect was seemingly at work in the CH2Cl2 nitration of benzenepropanenitrile. All the results were compared with the corresponding classical nitration in H2SO4.

Journal of Organic Chemistry published new progress about Nitration. 30095-98-8 belongs to class esters-buliding-blocks, and the molecular formula is C9H9NO4, Synthetic Route of 30095-98-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics