Category: 2253-73-8

A New Facet of Azatriene Reactivity: A Short Cut to 5-Amino-3-methyl-4-(1H-pyrrol-1-yl)thiophene-2-carboxylates and 5-Amino-3-methyl-4-(1H-pyrrol-1-yl)thiophene-2-carbonitriles was written by Nedolya, Nina A.;Tarasova, Olga A.;Albanov, Alexander I.;Trofimov, Boris A.. And the article was included in European Journal of Organic Chemistry in 2018.HPLC of Formula: 2253-73-8 The following contents are mentioned in the article:

An simple and expedient approach to highly functionalized tetrasubstituted thiophenes from readily accessible starting materials [(1H-pyrrol-1-yl)allene, isothiocyanates, and alkyl 2-bromoacetates or 2-bromoacetonitrile] has been developed. The method is based on the one-pot synthesis and fast in-situ cyclization of alkyl 2-{[2-(1H-pyrrol-1-yl)buta-2,3-dienimidoyl]sulfanyl}acetates or cyanomethyl 2-(1H-pyrrol-1-yl)buta-2,3-dienimidothioates (1-aza-1,3,4-trienes) to give previously unknown thiophene-2-carboxylates and thiophene-2-carbonitriles, resp., both bearing pyrrole substituents. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8HPLC of Formula: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.HPLC of Formula: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ag(I)-Catalyzed rapid access to 2-amino-4-methylenethiazolines with potential applications in bioconjugation chemistry was written by Xiang, Lingling;Wu, Haiting;Liang, Yunshi;Deng, Huiying;He, Yiting;Xu, Qin;Zhang, Jing. And the article was included in Organic & Biomolecular Chemistry in 2021.COA of Formula: C4H7NS The following contents are mentioned in the article:

An Ag(I)-catalyzed tandem addition-cyclization of isothiocyanate RNCS (R = Ph, cyclohexyl, i-Pr, etc.) and propargylamine was successfully applied to the synthesis of 2-amino-4-methylenethiazolines I. This route features an unprecedented fast reaction rate with full conversion reached within 10 min at room temperature for aromatic isothiocyanates and excellent chemoselectivity for exocyclic products. The application of this strategy is further highlighted by the accelerated bioconjugation of propargylamine with fluorescein isothiocyanate (FITC) under Ag(I)-catalysis. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8COA of Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.COA of Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ag(I)-Catalyzed rapid access to 2-amino-4-methylenethiazolines with potential applications in bioconjugation chemistry was written by Xiang, Lingling;Wu, Haiting;Liang, Yunshi;Deng, Huiying;He, Yiting;Xu, Qin;Zhang, Jing. And the article was included in Organic & Biomolecular Chemistry in 2021.Application of 2253-73-8 The following contents are mentioned in the article:

An Ag(I)-catalyzed tandem addition-cyclization of isothiocyanate RNCS (R = Ph, cyclohexyl, i-Pr, etc.) and propargylamine was successfully applied to the synthesis of 2-amino-4-methylenethiazolines I. This route features an unprecedented fast reaction rate with full conversion reached within 10 min at room temperature for aromatic isothiocyanates and excellent chemoselectivity for exocyclic products. The application of this strategy is further highlighted by the accelerated bioconjugation of propargylamine with fluorescein isothiocyanate (FITC) under Ag(I)-catalysis. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Application of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

(Propargylsulfanyl)-2-aza-1,3,5-trienes as a direct source for novel family of highly functionalized 4,5-dihydro-1,3-thiazoles was written by Nedolya, Nina A.;Tarasova, Ol’ga A.;Albanov, Alexander I.;Klyba, Lyudmila V.;Trofimov, Boris A.. And the article was included in Tetrahedron in 2017.Related Products of 2253-73-8 The following contents are mentioned in the article:

A novel, simple approach to 2-(1-alkoxyprop-1-enyl)-5-ethenylidene-4,5-dihydro-1,3-thiazoles was disclosed through the reaction of (propargylthio)-2-aza-1,3,5-trienes (readily available from alkoxyallenes, isothiocyanates, and propargyl bromide) with potassium or sodium tert-butoxide (1.1-1.4 equiv) under mild conditions [DMSO/THF (∼1:4-5), ∼-30°, 15-30 min]. The process proceeds through deprotonation of an activated SCH₂ group, followed by intramol. [1,5]-ring-closure. Unlike alkyl-, benzyl-, and allylthio-analogs, the exclusive or competitive formation of seven-membered azaheterocycles was not observed This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Related Products of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of fused 3-amino-1,2,4-triazoles via sequential addition of aryl hydrazines to isothiocyanates and I₂-mediated cyclodesulfurization was written by Jiao, Shufeng;Wang, Zhen;Zhao, Qiongli;Yu, Wenquan;Chang, Junbiao. And the article was included in Tetrahedron in 2018.Name: Isopropylisothiocyanate The following contents are mentioned in the article:

A variety of fused 3-amino-1,2,4-triazole derivatives I (X= CH, N; R¹ = 7-Me, 5-Me, 8-Cl, etc.; R² = Ph, 4-MeC₆H₄, 4-FC₆H₄, 2-MeC₆H₄, etc.) were synthesized via addition of aryl hydrazines to isothiocyanates followed by I₂-mediated oxidative cyclodesulfurization. This transition-metal-free synthetic process provides facile access to 1,2,4-triazolo[4,3-a]pyridines and related heterocyclic frameworks bearing a 3-amino substituent from readily accessible substrates in an efficient and scalable fashion. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Name: Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gram Scalable Method to Synthesize Biscarbodiimides and Asymmetric Monocarbodiimides: A Platform to Access an Array of Phosphaguanidines, Amidines, and Guanidines was written by Camelio, Andrew M.;Krasovskiy, Arkady;Bailey, Brad;Davis, Anna. And the article was included in Journal of Organic Chemistry in 2022.Quality Control of Isopropylisothiocyanate The following contents are mentioned in the article:

A mild, broadly functional group tolerant methodol. has been developed to access a variety of mono- and bis-carbodiimides RN=C=NR¹ (R = i-Pr, cyclohexyl, adamantan-1-yl, etc.; R¹ = Bn, cyclohexyl) and RN=C=N(CH₂)₅N=C=NR in good yield and high purity on multigram scale. Direct addition into these versatile motifs facilitated the rapid synthesis of a library of novel amidinines, guanidines, and phosphaguanidines RNHC(R²)=NR¹ (R² = diphenylphosphanyl, 9H-carbazol-9-yl, diethylaminyl, etc.) and RN=C(R²)NH(CH₂)_nNHC(R²)=NR (n = 4, 5). This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Quality Control of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gram Scalable Method to Synthesize Biscarbodiimides and Asymmetric Monocarbodiimides: A Platform to Access an Array of Phosphaguanidines, Amidines, and Guanidines was written by Camelio, Andrew M.;Krasovskiy, Arkady;Bailey, Brad;Davis, Anna. And the article was included in Journal of Organic Chemistry in 2022.Safety of Isopropylisothiocyanate The following contents are mentioned in the article:

A mild, broadly functional group tolerant methodol. has been developed to access a variety of mono- and bis-carbodiimides RN=C=NR¹ (R = i-Pr, cyclohexyl, adamantan-1-yl, etc.; R¹ = Bn, cyclohexyl) and RN=C=N(CH₂)₅N=C=NR in good yield and high purity on multigram scale. Direct addition into these versatile motifs facilitated the rapid synthesis of a library of novel amidinines, guanidines, and phosphaguanidines RNHC(R²)=NR¹ (R² = diphenylphosphanyl, 9H-carbazol-9-yl, diethylaminyl, etc.) and RN=C(R²)NH(CH₂)_nNHC(R²)=NR (n = 4, 5). This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Safety of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Safety of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Access to 3-Amino-[1,2,4]-triazolo Pyridines and Related Heterocycles via Electrochemically Induced Desulfurative Cyclization was written by Hu, Yunfei;Chen, Li;Zou, Canlin;He, Jiangtao;Feng, Luanqi;Wu, Jia-Qiang;Chen, Wen-Hua;Hu, Jinhui. And the article was included in Organic Letters in 2022.Reference of 2253-73-8 The following contents are mentioned in the article:

An efficient, one-pot approach was established for synthesizing a wide range of 3-amino-[1,2,4]-triazolo pyridines and related heterocycles from the electrochem. induced desulfurative cyclization of 2-hydrazinopyridines with isothiocyanates. The protocol allowed for the formation of C-N bonds under simple conditions without transition metals or external oxidants. The practicability of this strategy was demonstrated by its broad substrate scope, good functional group compatibility, and gram-scale synthesis. The late-stage modification of 3-amino-[1,2,4]-triazolo pyridines enabled to obtain several mols. with potent anticancer activity. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Reference of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Access to 3-Amino-[1,2,4]-triazolo Pyridines and Related Heterocycles via Electrochemically Induced Desulfurative Cyclization was written by Hu, Yunfei;Chen, Li;Zou, Canlin;He, Jiangtao;Feng, Luanqi;Wu, Jia-Qiang;Chen, Wen-Hua;Hu, Jinhui. And the article was included in Organic Letters in 2022.Product Details of 2253-73-8 The following contents are mentioned in the article:

An efficient, one-pot approach was established for synthesizing a wide range of 3-amino-[1,2,4]-triazolo pyridines and related heterocycles from the electrochem. induced desulfurative cyclization of 2-hydrazinopyridines with isothiocyanates. The protocol allowed for the formation of C-N bonds under simple conditions without transition metals or external oxidants. The practicability of this strategy was demonstrated by its broad substrate scope, good functional group compatibility, and gram-scale synthesis. The late-stage modification of 3-amino-[1,2,4]-triazolo pyridines enabled to obtain several mols. with potent anticancer activity. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Product Details of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

4-(N-Boc-amino)-1H-1,2,3-triazolecarbothioamides in the synthesis of a new heterocyclic [1,2,3]triazolo[4,5-e][1,4]thiazepine system was written by Syrota, Natalia A.;Kemskiy, Sergiy V.;Bol’but, Andriy V.;Chernobaev, Igor I.;Liavinets, Oleksandr S.;Vovk, Mykhailo V.. And the article was included in Chemistry of Heterocyclic Compounds in 2021.Reference of 2253-73-8 The following contents are mentioned in the article:

4-(N-Boc-amino)-1H-1,2,3-triazolecarbothioamides I [R¹ = Me, Ph, 2-MeOC₆H₄, H₂CH₂CPh; R² = Et, i-Pr, t-Bu, cyclohexyl] , obtained by a sequential treatment of 4-(N-Boc-amino)-1H-1,2,3-triazoles with n-BuLi and alkyl isothiocyanates at -78 and -60°C, reacted with Et bromoacetate, forming the resp. 4-(N-Boc-amino)-5-thioimidates II , which underwent intramol. cyclocondensation upon treatment in saturated HCl solution in dioxane, producing 8-(alkylimino)-4,8-dihydro-1H-[1,2,3]triazolo[4,5-e][1,4]thiazepin-5(6H)-ones III. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Reference of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics