Category: 2253-73-8

Design, synthesis, and biological evaluation of N-arylpiperazine derivatives as interferon inducers was written by Chu, Yeonjeong;Raja Sekhara Reddy, B.;Pratap Reddy Gajulapalli, V.;Sudhakar Babu, K.;Kim, Eunha;Lee, Sanghee. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Recommanded Product: Isopropylisothiocyanate The following contents are mentioned in the article:

Type I Interferon (IFN) signaling plays an important role in the immune defense system against virus infection and in the innate immune response, thus IFNs are widely used as anti-viral agents and treatment for immune disorder or cancer. However, there is a growing demand for novel small-mol. IFN inducer due to tolerance, toxicity, or short duration of action following direct administration of IFNs. The authors assessed arylpiperazine (ARP) as a new core skeleton of IFN inducer. To study structure-activity relation, the authors designed and synthesized a series of ARP analogs and evaluated the ability to stimulate IFN response in THP-1 human monocyte cells. Compound 1-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-(3,4,5-trimethoxyphenyl)ethenone was identified as a potent type I IFN inducer as it significantly increased cytokine secretion and increased expression of various IFN-stimulating genes which are representative biomarkers of type I IFN pathway. The authors’ results suggested a beneficial therapeutic potential of 1-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-(3,4,5-trimethoxyphenyl)ethenone as an anti-viral agent. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Recommanded Product: Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Design, synthesis, and biological evaluation of N-arylpiperazine derivatives as interferon inducers was written by Chu, Yeonjeong;Raja Sekhara Reddy, B.;Pratap Reddy Gajulapalli, V.;Sudhakar Babu, K.;Kim, Eunha;Lee, Sanghee. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.SDS of cas: 2253-73-8 The following contents are mentioned in the article:

Type I Interferon (IFN) signaling plays an important role in the immune defense system against virus infection and in the innate immune response, thus IFNs are widely used as anti-viral agents and treatment for immune disorder or cancer. However, there is a growing demand for novel small-mol. IFN inducer due to tolerance, toxicity, or short duration of action following direct administration of IFNs. The authors assessed arylpiperazine (ARP) as a new core skeleton of IFN inducer. To study structure-activity relation, the authors designed and synthesized a series of ARP analogs and evaluated the ability to stimulate IFN response in THP-1 human monocyte cells. Compound 1-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-(3,4,5-trimethoxyphenyl)ethenone was identified as a potent type I IFN inducer as it significantly increased cytokine secretion and increased expression of various IFN-stimulating genes which are representative biomarkers of type I IFN pathway. The authors’ results suggested a beneficial therapeutic potential of 1-(4-(2,3-dichlorophenyl)piperazin-1-yl)-2-(3,4,5-trimethoxyphenyl)ethenone as an anti-viral agent. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8SDS of cas: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X was written by Fonovic, Ursa Pecar;Knez, Damijan;Hrast, Martina;Zidar, Nace;Proj, Matic;Gobec, Stanislav;Kos, Janko. And the article was included in European Journal of Medicinal Chemistry in 2020.Product Details of 2253-73-8 The following contents are mentioned in the article:

Cathepsin X is a cysteine carboxypeptidase that is involved in various physiol. and pathol. processes. In particular, highly elevated expression and activity of cathepsin X has been observed in cancers and neurodegenerative diseases. Previously, we identified compound Z9 (1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-((4-isopropyl-4H-1,2,4-triazol-3-yl)thio)ethan-1-one) as a potent and specific reversible cathepsin X inhibitor. Here, we have explored the effects of chem. variations to Z9 of either benzodioxine or triazol moieties, and the importance of the central ketomethylenethio linker. The ketomethylenethio linker was crucial for cathepsin X inhibition, whereas changes of the triazole heterocycle did not alter the inhibitory potencies to a greater extent. Replacement of benzodioxine moiety with substituted benzenes reduced cathepsin X inhibition. Overall, several synthesized compounds showed similar or improved inhibitory potencies against cathepsin X compared to Z9, with IC₅₀ values of 7.1μM-13.6μM. Addnl., 25 inhibited prostate cancer cell migration by 21%, which is under the control of cathepsin X. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Product Details of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X was written by Fonovic, Ursa Pecar;Knez, Damijan;Hrast, Martina;Zidar, Nace;Proj, Matic;Gobec, Stanislav;Kos, Janko. And the article was included in European Journal of Medicinal Chemistry in 2020.Product Details of 2253-73-8 The following contents are mentioned in the article:

Cathepsin X is a cysteine carboxypeptidase that is involved in various physiol. and pathol. processes. In particular, highly elevated expression and activity of cathepsin X has been observed in cancers and neurodegenerative diseases. Previously, we identified compound Z9 (1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-((4-isopropyl-4H-1,2,4-triazol-3-yl)thio)ethan-1-one) as a potent and specific reversible cathepsin X inhibitor. Here, we have explored the effects of chem. variations to Z9 of either benzodioxine or triazol moieties, and the importance of the central ketomethylenethio linker. The ketomethylenethio linker was crucial for cathepsin X inhibition, whereas changes of the triazole heterocycle did not alter the inhibitory potencies to a greater extent. Replacement of benzodioxine moiety with substituted benzenes reduced cathepsin X inhibition. Overall, several synthesized compounds showed similar or improved inhibitory potencies against cathepsin X compared to Z9, with IC₅₀ values of 7.1μM-13.6μM. Addnl., 25 inhibited prostate cancer cell migration by 21%, which is under the control of cathepsin X. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Product Details of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Three-component bis-heterocyclization for synthesis of 2-aminobenzo[4,5]thieno[3,2-d]thiazoles was written by Huang, Huawen;Qu, Zhonghua;Ji, Xiaochen;Deng, Guo-Jun. And the article was included in Organic Chemistry Frontiers in 2019.Application of 2253-73-8 The following contents are mentioned in the article:

A cooperative base system has been developed for the novel three component bis-heterocyclization of methylketoxime acetates. The present protocol provides an effective entry to 2-aminobenzo[4,5]thieno[3,2-d]thiazoles, e.g., I. Mechanistically, the formation of trisulfur radical anion [S₃] ̇^– and Willgerodt-Kindler-type sulfuration would be the key for this transformation. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Application of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Microwave-Assisted Rapid Regioselective One-Pot Synthesis of Novel 2-Oxothiazolidine Dicarboxylate was written by Bangade, Vikas Madhukar;Mali, Prakash Rambhau;Shirsat, Prashishkumar Kishan;Meshram, Harshadas Mitaram. And the article was included in ChemistrySelect in 2019.Quality Control of Isopropylisothiocyanate The following contents are mentioned in the article:

A regioselective synthesis of 2-oxothiazolidine dicarboxylate (OTDC) under microwave irradiations is reported. Methoxylation, demethylation and double reductive cyclization occurs in single step by three component one pot reaction under microwave irradiations. The microwave irradiations, planar arrangement of intermediate imino(sp²)-thio-maleate and in situ demethylation considered as driving forces for regioselective cyclization. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Quality Control of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

One-Pot Synthesis of Unsymmetrical Bis-Heterocycles: Benzimidazole-, Benzoxazole-, and Benzothiazole-Linked Thiazolidines was written by Lu, Hsueh-Yuan;Barve, Indrajeet J.;Selvaraju, Manikandan;Sun, Chung-Ming. And the article was included in ACS Combinatorial Science in 2020.Recommanded Product: Isopropylisothiocyanate The following contents are mentioned in the article:

A one-pot, three-component synthesis of benzimidazole-linked thiazolidines from 2-cyanomethyl benzimidazole, iso-, isothio-, or isoselenocyanates and 1,2-dichloroethane is reported. Isolation of the key intermediate formed during the course of the reaction validates its mechanistic pathway. Under the same reaction conditions, benzimidazole-linked/fused thiazinanes were obtained when 1,3-dichloropropane or diiodomethane was used. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Recommanded Product: Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

One-Pot Synthesis of Unsymmetrical Bis-Heterocycles: Benzimidazole-, Benzoxazole-, and Benzothiazole-Linked Thiazolidines was written by Lu, Hsueh-Yuan;Barve, Indrajeet J.;Selvaraju, Manikandan;Sun, Chung-Ming. And the article was included in ACS Combinatorial Science in 2020.COA of Formula: C4H7NS The following contents are mentioned in the article:

A one-pot, three-component synthesis of benzimidazole-linked thiazolidines from 2-cyanomethyl benzimidazole, iso-, isothio-, or isoselenocyanates and 1,2-dichloroethane is reported. Isolation of the key intermediate formed during the course of the reaction validates its mechanistic pathway. Under the same reaction conditions, benzimidazole-linked/fused thiazinanes were obtained when 1,3-dichloropropane or diiodomethane was used. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8COA of Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.COA of Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Transition-metal-free visible light-promoted photoredox oxidative dehydrogenative cyclization: expeditious approach to 1,2,4-thiadiazoles was written by Xiong, Zhiqiang;Zhong, Qihao;Sheng, Shouri;Chen, Junmin. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2021.Formula: C4H7NS The following contents are mentioned in the article:

A novel visible-light-catalyzed oxidative N-S bond formation for the synthesis of 3,5-disubstituted 1,2,4-thiadiazoles I (R¹ = Me, Ph, cyclopropyl, etc.; R² = i-Pr, Ph, 3-chlorophenyl, etc.) has been developed. This protocol features a metal-free approach, green oxidant, room temperature process, broad substrate scope, good functional group tolerance, excellent yields and a one-pot reaction without the isolation of the intermediates. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Transition-metal-free visible light-promoted photoredox oxidative dehydrogenative cyclization: expeditious approach to 1,2,4-thiadiazoles was written by Xiong, Zhiqiang;Zhong, Qihao;Sheng, Shouri;Chen, Junmin. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2021.Reference of 2253-73-8 The following contents are mentioned in the article:

A novel visible-light-catalyzed oxidative N-S bond formation for the synthesis of 3,5-disubstituted 1,2,4-thiadiazoles I (R¹ = Me, Ph, cyclopropyl, etc.; R² = i-Pr, Ph, 3-chlorophenyl, etc.) has been developed. This protocol features a metal-free approach, green oxidant, room temperature process, broad substrate scope, good functional group tolerance, excellent yields and a one-pot reaction without the isolation of the intermediates. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Reference of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Reference of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics