Category: 2253-73-8

Sidearm effect in (thio)urea/alkoxide-mediated ring-opening polymerization of cyclic esters was written by Zhu, Ningning;Behzadi, Shabnam;Si, Guifu;Tan, Chen. And the article was included in Polymer International in 2021.Electric Literature of C4H7NS The following contents are mentioned in the article:

Thiourea and urea catalysts have received much attention in the field of ring-opening polymerization In the (thio)urea/alkoxide catalytic system, sidearm groups can influence the catalytic performance of the organocatalyst moiety. In this work, a series of (thio)ureas bearing 2-, 3- and 4-pyridyl moieties were designed and synthesized. The (thio)ureas bearing a 2-pyridyl group exhibited much higher catalytic activities than the (thio)ureas bearing 3- or 4-pyridyl groups, suggesting a sidearm effect. Both crystal data and computational studies indicated that 2-pyridyl can form an intramol. hydrogen bond with the NH moiety, resulting in a Broensted base/Lewis acid bifunctional catalytic system. Furthermore, the catalyst was stimuli-responsive in Lewis acid/base-modulated ring-opening polymerization Coordination between the Lewis acid BEt₃ and the catalyst was found to terminate the polymerization Subsequently, the coordinated species was cleaved using the Lewis base bicyclo[2.2.2]-1,4-diazaoctane, resulting in the reactivation of the catalyst. 2020 Society of Chem. Industry. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Electric Literature of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sidearm effect in (thio)urea/alkoxide-mediated ring-opening polymerization of cyclic esters was written by Zhu, Ningning;Behzadi, Shabnam;Si, Guifu;Tan, Chen. And the article was included in Polymer International in 2021.Recommanded Product: Isopropylisothiocyanate The following contents are mentioned in the article:

Thiourea and urea catalysts have received much attention in the field of ring-opening polymerization In the (thio)urea/alkoxide catalytic system, sidearm groups can influence the catalytic performance of the organocatalyst moiety. In this work, a series of (thio)ureas bearing 2-, 3- and 4-pyridyl moieties were designed and synthesized. The (thio)ureas bearing a 2-pyridyl group exhibited much higher catalytic activities than the (thio)ureas bearing 3- or 4-pyridyl groups, suggesting a sidearm effect. Both crystal data and computational studies indicated that 2-pyridyl can form an intramol. hydrogen bond with the NH moiety, resulting in a Broensted base/Lewis acid bifunctional catalytic system. Furthermore, the catalyst was stimuli-responsive in Lewis acid/base-modulated ring-opening polymerization Coordination between the Lewis acid BEt₃ and the catalyst was found to terminate the polymerization Subsequently, the coordinated species was cleaved using the Lewis base bicyclo[2.2.2]-1,4-diazaoctane, resulting in the reactivation of the catalyst. 2020 Society of Chem. Industry. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Recommanded Product: Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Use of Dithiasuccinoyl-Caged Amines Enables COS/H₂S Release Lacking Electrophilic Byproducts was written by Cerda, Matthew M.;Mancuso, Jenna L.;Mullen, Emma J.;Hendon, Christopher H.;Pluth, Michael D.. And the article was included in Chemistry – A European Journal in 2020.Computed Properties of C4H7NS The following contents are mentioned in the article:

The enzymic conversion of carbonyl sulfide (COS) to hydrogen sulfide (H₂S) by carbonic anhydrase has been used to develop self-immolating thiocarbamates as COS-based H₂S donors to further elucidate the impact of reactive sulfur species in biol. The high modularity of this approach has provided a library of COS-based H₂S donors that can be activated by specific stimuli. A common limitation, however, is that many such donors result in the formation of an electrophilic quinone methide byproduct during donor activation. As a mild alternative, we demonstrate here that dithiasuccinoyl groups can function as COS/H₂S donor motifs, and that these groups release two equivalent of COS/H₂S and uncage an amine payload under physiol. relevant conditions. Addnl., we demonstrate that COS/H₂S release from this donor motif can be altered by electronic modulation and alkyl substitution. These insights are further supported by DFT investigations, which reveal that aryl and alkyl thiocarbamates release COS with significantly different activation energies. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Computed Properties of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Computed Properties of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Design, Synthesis, and Biological Evaluation of New Peripheral 5HT_2A Antagonists for Nonalcoholic Fatty Liver Disease was written by Kim, Minhee;Hwang, Inseon;Pagire, Haushabhau S.;Pagire, Suvarna H.;Choi, Wonsuk;Choi, Won Gun;Yoon, Jihyeon;Lee, Won Mi;Song, Jin Sook;Yoo, Eun Kyung;Lee, Seung Mi;Kim, Mi-jin;Bae, Myung Ae;Kim, Dooseop;Lee, Heejong;Lee, Eun-Young;Jeon, Jae-Han;Lee, In-Kyu;Kim, Hail;Ahn, Jin Hee. And the article was included in Journal of Medicinal Chemistry in 2020.Formula: C4H7NS The following contents are mentioned in the article:

Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent worldwide, causing serious liver complications, including nonalcoholic steatohepatitis. Recent findings suggest that peripheral serotonin (5-hydroxytryptamine, 5HT) regulates energy homeostasis, including hepatic lipid metabolism More specifically, liver-specific 5HT_2A knockout mice exhibit alleviated hepatic lipid accumulation and hepatic steatosis. Here, structural modifications of pimavanserin (CNS drug), a 5HT_2A antagonist approved for Parkinson’s disease, led us to synthesize new peripherally acting 5HT_2A antagonists. Among the synthesized compounds, compound 14a showed good in vitro activity, good liver microsomal stability, 5HT subtype selectivity, and no significant inhibition of CYP and hERG. The in vitro and in vivo blood-brain barrier permeability study proved that 14a acts peripherally. Compound 14a decreased the liver weight and hepatic lipid accumulation in high-fat-diet-induced obesity mice. Our study suggests new therapeutic possibilities for peripheral 5HT_2A antagonists in NAFLD. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Design, Synthesis, and Biological Evaluation of New Peripheral 5HT_2A Antagonists for Nonalcoholic Fatty Liver Disease was written by Kim, Minhee;Hwang, Inseon;Pagire, Haushabhau S.;Pagire, Suvarna H.;Choi, Wonsuk;Choi, Won Gun;Yoon, Jihyeon;Lee, Won Mi;Song, Jin Sook;Yoo, Eun Kyung;Lee, Seung Mi;Kim, Mi-jin;Bae, Myung Ae;Kim, Dooseop;Lee, Heejong;Lee, Eun-Young;Jeon, Jae-Han;Lee, In-Kyu;Kim, Hail;Ahn, Jin Hee. And the article was included in Journal of Medicinal Chemistry in 2020.HPLC of Formula: 2253-73-8 The following contents are mentioned in the article:

Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent worldwide, causing serious liver complications, including nonalcoholic steatohepatitis. Recent findings suggest that peripheral serotonin (5-hydroxytryptamine, 5HT) regulates energy homeostasis, including hepatic lipid metabolism More specifically, liver-specific 5HT_2A knockout mice exhibit alleviated hepatic lipid accumulation and hepatic steatosis. Here, structural modifications of pimavanserin (CNS drug), a 5HT_2A antagonist approved for Parkinson’s disease, led us to synthesize new peripherally acting 5HT_2A antagonists. Among the synthesized compounds, compound 14a showed good in vitro activity, good liver microsomal stability, 5HT subtype selectivity, and no significant inhibition of CYP and hERG. The in vitro and in vivo blood-brain barrier permeability study proved that 14a acts peripherally. Compound 14a decreased the liver weight and hepatic lipid accumulation in high-fat-diet-induced obesity mice. Our study suggests new therapeutic possibilities for peripheral 5HT_2A antagonists in NAFLD. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8HPLC of Formula: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Design, Synthesis, Biological Evaluation and SARs of Novel Anthranilic Diamide Derivatives Containing Amide, Carbamate, Urea, and Thiourea Moieties was written by Liu, Jingbo;Li, Yuxin;Zhang, Xiulan;Cheng, Dandan;Wei, Wei;Wu, Changchun;Xie, Yongtao;Xiong, Lixia;Li, Zhengming. And the article was included in Chinese Journal of Chemistry in 2017.Quality Control of Isopropylisothiocyanate The following contents are mentioned in the article:

In order to discover potential ryanodine receptor insecticides, 21 novel anthranilic diamide analogs containing amide, carbamate, urea, and thiourea moieties were designed and synthesized based on bioisosteric approach. The biol. assays against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella) indicated that these compounds displayed moderate to excellent activities. Especially, compound I showed 100% larvicidal activities against oriental armyworm at 1.0 mg·L^-1, equivalent to the standard chlorantraniliprole (100%, 1.0 mg·L^-1). Moreover, the larvicidal activity of I against diamondback moth was 100% at 0.1 mg·L^-1, more effective than that of chlorantraniliprole (90%, 0.1 mg·L^-1). Therefore, I can be used as a new lead structure for the development of insecticidal agents. The preliminary structure-activity relationship showed that the introduction of carbamate groups into 4-position on the benzene ring of the N-phenylpyrazole moiety has a pos. effect on the larvicidal activities. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Quality Control of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Quality Control of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and evaluation of the pharmacological activity of open analogues of cromakalim carrying urea and thiourea moieties was written by Mechouche, N.;Bouhedja, M.;Habila, T.;Stiti, MZ.;Faury, G.;Pirotte, B.;Khelili, S.. And the article was included in International Journal of Research in Pharmacy and Chemistry in 2022.Product Details of 2253-73-8 The following contents are mentioned in the article:

Some new ring-opened analogs of cromakalim I [R¹ = Me, Et, Bn; R² = H, Me; R³ = i-Pr, t-Bu, Ph, etc.; X = H, OMe, Br; Y = O, S] bearing urea and thiourea moieties were synthesized and tested as vasodilators rat trachea and aorta of resp., and as stimulators of elastin synthesis from isolated humain vascular smooth muscle cells. Cromakalim, pinacidil, diazoxide, and verapamil were used as refrences compounds in the vasodilating experiments while diazoxide was used as a reference in the elastin experiments Furthur investigations were undertaken to determine the mechanism of action of the vasodilator activity. The pharmacol. results on rat aorta rings revealed that the most active vasodilator compound was I [R¹ = Et, R² = Me, R³ = 4-CNC₆H₅, X = Br, Y = S] and was almost 15-fold more active than diazoxide, but was 4-fold and 11 folds less active than pinacidil and cromakalim resp. FInvestigations on elastin synthesis showed that diazoxide significantly elevated elastin quantity by 34%. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Product Details of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and evaluation of the pharmacological activity of open analogues of cromakalim carrying urea and thiourea moieties was written by Mechouche, N.;Bouhedja, M.;Habila, T.;Stiti, MZ.;Faury, G.;Pirotte, B.;Khelili, S.. And the article was included in International Journal of Research in Pharmacy and Chemistry in 2022.Recommanded Product: 2253-73-8 The following contents are mentioned in the article:

Some new ring-opened analogs of cromakalim I [R¹ = Me, Et, Bn; R² = H, Me; R³ = i-Pr, t-Bu, Ph, etc.; X = H, OMe, Br; Y = O, S] bearing urea and thiourea moieties were synthesized and tested as vasodilators rat trachea and aorta of resp., and as stimulators of elastin synthesis from isolated humain vascular smooth muscle cells. Cromakalim, pinacidil, diazoxide, and verapamil were used as refrences compounds in the vasodilating experiments while diazoxide was used as a reference in the elastin experiments Furthur investigations were undertaken to determine the mechanism of action of the vasodilator activity. The pharmacol. results on rat aorta rings revealed that the most active vasodilator compound was I [R¹ = Et, R² = Me, R³ = 4-CNC₆H₅, X = Br, Y = S] and was almost 15-fold more active than diazoxide, but was 4-fold and 11 folds less active than pinacidil and cromakalim resp. FInvestigations on elastin synthesis showed that diazoxide significantly elevated elastin quantity by 34%. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Recommanded Product: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Use of Dithiasuccinoyl-Caged Amines Enables COS/H₂S Release Lacking Electrophilic Byproducts was written by Cerda, Matthew M.;Mancuso, Jenna L.;Mullen, Emma J.;Hendon, Christopher H.;Pluth, Michael D.. And the article was included in Chemistry – A European Journal in 2020.Product Details of 2253-73-8 The following contents are mentioned in the article:

The enzymic conversion of carbonyl sulfide (COS) to hydrogen sulfide (H₂S) by carbonic anhydrase has been used to develop self-immolating thiocarbamates as COS-based H₂S donors to further elucidate the impact of reactive sulfur species in biol. The high modularity of this approach has provided a library of COS-based H₂S donors that can be activated by specific stimuli. A common limitation, however, is that many such donors result in the formation of an electrophilic quinone methide byproduct during donor activation. As a mild alternative, we demonstrate here that dithiasuccinoyl groups can function as COS/H₂S donor motifs, and that these groups release two equivalent of COS/H₂S and uncage an amine payload under physiol. relevant conditions. Addnl., we demonstrate that COS/H₂S release from this donor motif can be altered by electronic modulation and alkyl substitution. These insights are further supported by DFT investigations, which reveal that aryl and alkyl thiocarbamates release COS with significantly different activation energies. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Product Details of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wasabia koreana Nakai: a preliminary study on nutrients and chemical compounds that may impact sensory properties was written by Kim, Da-Som;Kim, Hoe Sung;Lee, Jookyeong;Pan, Jeong Hoon;Kim, Young Jun;Kim, Jae Kyeom;Woo, Seongmin;Shin, Eui-Cheol. And the article was included in Molecules in 2018.Product Details of 2253-73-8 The following contents are mentioned in the article:

In this study, the nutritional, functional, and chem. measurements of sensory attributes of different parts of wasabi, namely, leaf, petiole, and rhizome, were investigated. Proximate composition anal. showed the presence of high amounts of carbohydrates in the rhizome and amino acid composition anal. confirmed high proportions of glutamic acid and aspartic acid in all three parts. While proximate composition showed low lipid content in wasabi, ω-3 fatty acids accounted for a high proportion (>44%) of the total lipids. Wasabi leaves had high vitamin C and total phenolic contents, and thus demonstrated antioxidant capacity. Allyl isothiocyanate, which gives wasabi its characteristic pungent taste, was identified by gas chromatog./mass spectrometry and an electronic nose. On an electronic tongue, wasabi leaves showed compounds associated with sourness and saltiness while the petiole had high content of compounds associated with sweetness and bitterness. This study provides basic data for the utilization of wasabi parts as food materials based on their nutritional, functional, and chem. measure of sensory attributes. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Product Details of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics