Category: 2253-73-8

Access to Metal-Bridged Osmathiazine Derivatives by a Formal [4+2] Cyclization was written by Li, Jinhua;Lin, Yu-Mei;Zhang, Hong;Chen, Yuan;Lin, Zhenyang;Xia, Haiping. And the article was included in Chemistry – A European Journal in 2019.SDS of cas: 2253-73-8 The following contents are mentioned in the article:

Treatment of osmacyclopentadiene derivatives 1 with Ph or iso-Pr isothiocyanate gave the fused five and six-membered osmacycles 2–5 by a formal [4+2] cyclization. The facile protonation of the newly generated exocyclic imine in complexes 2–5 afforded conjugation-extended osmacycle derivatives 6–9. Compounds 2–9 each contain two main-group heteroatoms (N and S) in the fused six-membered ring located at the ortho (for S) and para (for N) positions relative to the osmium center; these species can be regarded as rare osma-1,3-thiazine derivatives and represent the first fused metallathiazine derivatives In contrast to the non-planar organic 6H-1,3-thiazine, nearly coplanar metallathiazines 8 and 9 can be achieved by tuning the groups on the two nitrogen atoms. These unique metal-bridged osma-1,3-thiazine derivatives exhibit remarkable stabilities, broad spectral absorptions spanning the visible spectra, and considerable photothermal properties, which suggests their potential applications in material science. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8SDS of cas: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.SDS of cas: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

[1,2,3]Triazolo[4,5-d]pyrimidine derivatives incorporating (thio)urea moiety as a novel scaffold for LSD1 inhibitors was written by Li, Zhong-Hua;Ma, Jin-Lian;Liu, Gai-Zhi;Zhang, Xin-Hui;Qin, Ting-Ting;Ren, Wei-Hong;Zhao, Tao-Qian;Chen, Xiao-Hui;Zhang, Zhen-Qiang. And the article was included in European Journal of Medicinal Chemistry in 2020.Formula: C4H7NS The following contents are mentioned in the article:

Lysine specific demethylase 1 (LSD1) plays an essential role in maintaining a balanced methylation status at histone tails. Overexpression of LSD1 has been involved in the development of a variety of human diseases, including cancers. Herein, on the basis of our previously developed LSD1 inhibitors, two series of new [1,2,3]triazolo[4,5-d]pyrimidine derivatives incorporating (thio)urea moiety were designed and evaluated for their LSD1 inhibitory abilities, leading to a novel chem. class of LSD1 inhibitors. Among them, compound 31 was found to moderately inhibit LSD1 activity, as well as increase the expression of H3K4me2 at the cellular level. This compound also showed good selectivity against MAO-A/-B, and a panel of kinases such as CDK and BTK. Besides, the MTT assay suggested that the selected compounds could inhibit the proliferation of LSD1-overexpressed cancer cells. Although this class of compounds only showed moderate anti-LSD1 activity in the micromolar range, this work presents a novel chemotype of LSD1 inhibitors with good enzyme selectivity as well as cellular LSD1 inhibitory activity, and could provide a useful template for the development of more potent LSD1 inhibitors for cancer treatment. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

[1,2,3]Triazolo[4,5-d]pyrimidine derivatives incorporating (thio)urea moiety as a novel scaffold for LSD1 inhibitors was written by Li, Zhong-Hua;Ma, Jin-Lian;Liu, Gai-Zhi;Zhang, Xin-Hui;Qin, Ting-Ting;Ren, Wei-Hong;Zhao, Tao-Qian;Chen, Xiao-Hui;Zhang, Zhen-Qiang. And the article was included in European Journal of Medicinal Chemistry in 2020.Recommanded Product: Isopropylisothiocyanate The following contents are mentioned in the article:

Lysine specific demethylase 1 (LSD1) plays an essential role in maintaining a balanced methylation status at histone tails. Overexpression of LSD1 has been involved in the development of a variety of human diseases, including cancers. Herein, on the basis of our previously developed LSD1 inhibitors, two series of new [1,2,3]triazolo[4,5-d]pyrimidine derivatives incorporating (thio)urea moiety were designed and evaluated for their LSD1 inhibitory abilities, leading to a novel chem. class of LSD1 inhibitors. Among them, compound 31 was found to moderately inhibit LSD1 activity, as well as increase the expression of H3K4me2 at the cellular level. This compound also showed good selectivity against MAO-A/-B, and a panel of kinases such as CDK and BTK. Besides, the MTT assay suggested that the selected compounds could inhibit the proliferation of LSD1-overexpressed cancer cells. Although this class of compounds only showed moderate anti-LSD1 activity in the micromolar range, this work presents a novel chemotype of LSD1 inhibitors with good enzyme selectivity as well as cellular LSD1 inhibitory activity, and could provide a useful template for the development of more potent LSD1 inhibitors for cancer treatment. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Recommanded Product: Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Catalyst-free Hydrophosphinylation of Isocyanates and Isothiocyanates under Low-Added-Solvent Conditions was written by Huke, Cameron D.;Taylor, Laurence J.;Argent, Stephen P.;Kays, Deborah L.. And the article was included in ACS Sustainable Chemistry & Engineering in 2021.Recommanded Product: Isopropylisothiocyanate The following contents are mentioned in the article:

Phosphinecarboxamides R¹R²P(O)CXNHR³ (R¹, R² = Ph, ⁱPr, OEt, OMe; R³ = aryl, ⁱPr, ^tBu, n-Pr, C₆H₁₃, PhCH₂, Cy, 2-furyl; X = O, S) were prepared by green, catalyst-free, low-solvent hydrophosphination of isocyanates R³N:C:X with secondary phosphine oxides and dialkyl phosphites R¹R²P(O)H. A range of phosphorus nucleophiles including secondary phosphine oxides HP(O)R₂ (R = Ph, ⁱPr), phosphites HP(O)(OR)₂ (R = Me, Et), and Me phenylphosphinate were tested. The procedure tolerated isocyanates and isothiocyanates featuring a wide range of substituents, and with use of 4 equiv of 2-methyltetrahydrofuran (2-MeTHF), solid substrates can be utilized. Twenty-five compounds were prepared, with improved functional group tolerance compared to previous methods allowing access to new compounds (16 are novel). Facile scale up and simple reaction conditions make this a straightforward and practical methodol. for obtaining phosphorus analogs of ureas and thioureas, which are challenging to synthesize by other methods. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Recommanded Product: Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Catalyst-free Hydrophosphinylation of Isocyanates and Isothiocyanates under Low-Added-Solvent Conditions was written by Huke, Cameron D.;Taylor, Laurence J.;Argent, Stephen P.;Kays, Deborah L.. And the article was included in ACS Sustainable Chemistry & Engineering in 2021.Synthetic Route of C4H7NS The following contents are mentioned in the article:

Phosphinecarboxamides R¹R²P(O)CXNHR³ (R¹, R² = Ph, ⁱPr, OEt, OMe; R³ = aryl, ⁱPr, ^tBu, n-Pr, C₆H₁₃, PhCH₂, Cy, 2-furyl; X = O, S) were prepared by green, catalyst-free, low-solvent hydrophosphination of isocyanates R³N:C:X with secondary phosphine oxides and dialkyl phosphites R¹R²P(O)H. A range of phosphorus nucleophiles including secondary phosphine oxides HP(O)R₂ (R = Ph, ⁱPr), phosphites HP(O)(OR)₂ (R = Me, Et), and Me phenylphosphinate were tested. The procedure tolerated isocyanates and isothiocyanates featuring a wide range of substituents, and with use of 4 equiv of 2-methyltetrahydrofuran (2-MeTHF), solid substrates can be utilized. Twenty-five compounds were prepared, with improved functional group tolerance compared to previous methods allowing access to new compounds (16 are novel). Facile scale up and simple reaction conditions make this a straightforward and practical methodol. for obtaining phosphorus analogs of ureas and thioureas, which are challenging to synthesize by other methods. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Synthetic Route of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Synthetic Route of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Design and synthesis of novel C₁₄-urea-tetrandrine derivatives with potent anti-cancer activity was written by Lan, Junjie;Huang, Lan;Lou, Huayong;Chen, Chao;Liu, Tangjingjun;Hu, Shengcao;Yao, Yao;Song, Junrong;Luo, Jun;Liu, Yazhou;Xia, Bin;Xia, Lei;Zeng, Xueyi;Ben-David, Yaacov;Pan, Weidong. And the article was included in European Journal of Medicinal Chemistry in 2018.HPLC of Formula: 2253-73-8 The following contents are mentioned in the article:

Tetrandrine is a dibenzyltetrahydroisoquinoline alkaloid, isolated from traditional Chinese medicinal plant Stephania tetrandra, with antitumor activity. Our previous study identified several derivatives of tetrandrine showing better activities than parental compound against human hepatocellular carcinoma cells. To increase diversity and cytotoxic activities of the original compound, a series of novel 14-urea-tetrandrine derivatives were synthesized through structural modification of tetrandrine. These derivatives demonstrated a moderate to strong anti-proliferative activities against human cell lines HEL and K562 (Leukemia), prostate (PC3), breast (MDA-MB-231) and melanoma (WM9). Compound I showed strongest cytotoxic effect against PC3 cells with IC₅₀ value of 0.64 μM, which was 12-fold, 31-fold and 26-fold lower than the parental tetrandrine, 5-fluorouracil and cisplatin, resp. Preliminary structure-activity relationship study indicated that urea substitution was the key pharmacophore for the enhancement of their antitumor activities. Induction of apoptosis by I was associated with the activation of pro-apoptotic protein BAX and inhibition of antiapoptosis proteins survivin as well as Bcl-2. Moreover, activation of caspases led to increase cleavage of PARP, which further accelerates apoptotic cell death. These results reveal that the compound I may be used as a potential anticancer drug candidate. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8HPLC of Formula: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.HPLC of Formula: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effects of Maerua subcordata (Gilg) DeWolf on electrophile-responsive element (EpRE)-mediated gene expression in vitro was written by Gebrelibanos Hiben, Mebrahtom;de Haan, Laura;Spenkelink, Bert;Wesseling, Sebas;Louisse, Jochem;Vervoort, Jacques;Rietjens, Ivonne M. C. M.. And the article was included in PLoS One in 2019.Application of 2253-73-8 The following contents are mentioned in the article:

This study tested the EpRE induction ability of Maerua subcordata (fruit, leaf, root, seed) methanol extracts and selected candidate constituents thereof, identified by liquid chromatog. coupled with multistage mass spectroscopy, employing an EpRE luciferase reporter gene assay using hepa-1c1c7 mouse hepatoma cells. A parallel Cytotox CALUX assay using human osteosarcoma U2OS cells was used to monitor any non-specific changes in luciferase activity or cytotoxicity. Results showed that fruit, root, and seed extracts were non-cytotoxic but leaf exhibited some cytotoxicity and that the leaf, fruit, and seed extracts showed strong induction of EpRE mediated gene expression. Selected candidates included glucosinolates, isothiocyanates, and some biogenic amines. Subsequent studies showed that methyl-, ethyl-, isopropyl-, isobutyl- isothiocyanates, and sec-Bu thiocyanate as well as glucobrassicin induced concn dependent EpRE-mediated gene expression while the biogenic amines stachydrine and trigonelline acted as inhibitors of EpRE-mediated gene expression at 100μM. The identification of glucolepidiin, glucobrassicin, glucocapparin, stachydrine, and trigonelline in all extracts was confirmed using standards and based on multiple reaction monitoring. In conclusion, this study provided a first report on EpRE mediated gene expression effects of M. subcordata; and despite detection of different glucosinolates in all extracts, those containing glucobrassicin particularly displayed high EpRE induction. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Application of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effects of Maerua subcordata (Gilg) DeWolf on electrophile-responsive element (EpRE)-mediated gene expression in vitro was written by Gebrelibanos Hiben, Mebrahtom;de Haan, Laura;Spenkelink, Bert;Wesseling, Sebas;Louisse, Jochem;Vervoort, Jacques;Rietjens, Ivonne M. C. M.. And the article was included in PLoS One in 2019.Recommanded Product: Isopropylisothiocyanate The following contents are mentioned in the article:

This study tested the EpRE induction ability of Maerua subcordata (fruit, leaf, root, seed) methanol extracts and selected candidate constituents thereof, identified by liquid chromatog. coupled with multistage mass spectroscopy, employing an EpRE luciferase reporter gene assay using hepa-1c1c7 mouse hepatoma cells. A parallel Cytotox CALUX assay using human osteosarcoma U2OS cells was used to monitor any non-specific changes in luciferase activity or cytotoxicity. Results showed that fruit, root, and seed extracts were non-cytotoxic but leaf exhibited some cytotoxicity and that the leaf, fruit, and seed extracts showed strong induction of EpRE mediated gene expression. Selected candidates included glucosinolates, isothiocyanates, and some biogenic amines. Subsequent studies showed that methyl-, ethyl-, isopropyl-, isobutyl- isothiocyanates, and sec-Bu thiocyanate as well as glucobrassicin induced concn dependent EpRE-mediated gene expression while the biogenic amines stachydrine and trigonelline acted as inhibitors of EpRE-mediated gene expression at 100μM. The identification of glucolepidiin, glucobrassicin, glucocapparin, stachydrine, and trigonelline in all extracts was confirmed using standards and based on multiple reaction monitoring. In conclusion, this study provided a first report on EpRE mediated gene expression effects of M. subcordata; and despite detection of different glucosinolates in all extracts, those containing glucobrassicin particularly displayed high EpRE induction. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Recommanded Product: Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alternating Chain Growth Copolymerization of Isothiocyanates and Epoxides was written by Song, Lidao;Liu, Mingqi;You, Donglei;Wei, Wei;Xiong, Huiming. And the article was included in Macromolecules (Washington, DC, United States) in 2021.Application In Synthesis of Isopropylisothiocyanate The following contents are mentioned in the article:

A class of heteroatom polymers through anionic chain growth copolymerization of epoxides and isothiocyanates has been successfully obtained under mild conditions via initiation by a simple salt of lithium alkoxide. The resulting polymers have characteristics of controlled mol. weights and low dispersity with a well-defined backbone of carbonimidothioate repeat units (-OC(=N)S-) at 100% alternating degree, which have been confirmed in the ¹H-¹³C heteronuclear multiple bond correlation NMR spectrum and mass spectrum. Side reactions have been greatly suppressed in the copolymerization, and no more than 5% cyclic small mol. byproducts have been produced. We have revealed the special role of lithium bonds in regulating the alternating copolymerization of these two types of monomers, which are involved in activating isothiocyanates as well as binding the incoming monomers to the growing chain ends due to the especial coordination capability of lithium ions to multiple nucleophilic sites. The proposed mechanism of the alternating copolymerization process is supported by d. functional theory calculations Moreover, the copolymerization exhibits first-order kinetics with respect to the monomers and a quasi-living feature. Our strategy is expected to shed light on the incorporation of different types of cumulated double bonds as comonomers into polymer backbones, and the high availability of epoxides and isothiocyanates of various substitutions will forge the development of such kinds of heteropolymers. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Application In Synthesis of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alternating Chain Growth Copolymerization of Isothiocyanates and Epoxides was written by Song, Lidao;Liu, Mingqi;You, Donglei;Wei, Wei;Xiong, Huiming. And the article was included in Macromolecules (Washington, DC, United States) in 2021.Name: Isopropylisothiocyanate The following contents are mentioned in the article:

A class of heteroatom polymers through anionic chain growth copolymerization of epoxides and isothiocyanates has been successfully obtained under mild conditions via initiation by a simple salt of lithium alkoxide. The resulting polymers have characteristics of controlled mol. weights and low dispersity with a well-defined backbone of carbonimidothioate repeat units (-OC(=N)S-) at 100% alternating degree, which have been confirmed in the ¹H-¹³C heteronuclear multiple bond correlation NMR spectrum and mass spectrum. Side reactions have been greatly suppressed in the copolymerization, and no more than 5% cyclic small mol. byproducts have been produced. We have revealed the special role of lithium bonds in regulating the alternating copolymerization of these two types of monomers, which are involved in activating isothiocyanates as well as binding the incoming monomers to the growing chain ends due to the especial coordination capability of lithium ions to multiple nucleophilic sites. The proposed mechanism of the alternating copolymerization process is supported by d. functional theory calculations Moreover, the copolymerization exhibits first-order kinetics with respect to the monomers and a quasi-living feature. Our strategy is expected to shed light on the incorporation of different types of cumulated double bonds as comonomers into polymer backbones, and the high availability of epoxides and isothiocyanates of various substitutions will forge the development of such kinds of heteropolymers. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Name: Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Name: Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics