Category: 2253-73-8

Anatomical structure of venom gland and venom composition analysis of Sirex noctilio was written by Wang, Zhengtong;Yang, Huawei;Li, Biying;Ren, Lili;Shi, Juan. And the article was included in Dongbei Linye Daxue Xuebao in 2021.Computed Properties of C4H7NS The following contents are mentioned in the article:

With Sirex noctilio collected from infected areas in Heilongjiang and Inner Mongolia, the anatomical locations of the venom gland and venom reservoir were observed by dissecting the abdomen of female adult S. noctilio and their structural characteristics were observed under a microscope. The temperature was set at 50°C and the venom composition was analyzed at 5°C/min to 200°C with Thermo Scientific GC-MS. The venom gland and venom reservoir were located at the base of S. noctilio ovipositor. The venom reservoir was translucent crystalline tissue with the size of green beans, and its structural features is beneficial for S. noctilio to store as many venoms as possible. Venoms, among which fatty acids account for the major proportion, contain alkaloids, sugars and glycosides, fatty acids and proteins. The fatty acids include palmitic acid, palmitoleic acid, stearic acid and stearic acid, and the proteins in the venom component may be the active substances that cause damage to the host trees. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Computed Properties of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Anatomical structure of venom gland and venom composition analysis of Sirex noctilio was written by Wang, Zhengtong;Yang, Huawei;Li, Biying;Ren, Lili;Shi, Juan. And the article was included in Dongbei Linye Daxue Xuebao in 2021.Application In Synthesis of Isopropylisothiocyanate The following contents are mentioned in the article:

With Sirex noctilio collected from infected areas in Heilongjiang and Inner Mongolia, the anatomical locations of the venom gland and venom reservoir were observed by dissecting the abdomen of female adult S. noctilio and their structural characteristics were observed under a microscope. The temperature was set at 50°C and the venom composition was analyzed at 5°C/min to 200°C with Thermo Scientific GC-MS. The venom gland and venom reservoir were located at the base of S. noctilio ovipositor. The venom reservoir was translucent crystalline tissue with the size of green beans, and its structural features is beneficial for S. noctilio to store as many venoms as possible. Venoms, among which fatty acids account for the major proportion, contain alkaloids, sugars and glycosides, fatty acids and proteins. The fatty acids include palmitic acid, palmitoleic acid, stearic acid and stearic acid, and the proteins in the venom component may be the active substances that cause damage to the host trees. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Application In Synthesis of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application In Synthesis of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tideglusib and Its Analogues As Inhibitors of Staphylococcus aureus SrtA was written by Yang, Teng;Zhang, Tao;Guan, Xiang-Na;Dong, Ze;Lan, Lefu;Yang, Song;Yang, Cai-Guang. And the article was included in Journal of Medicinal Chemistry in 2020.SDS of cas: 2253-73-8 The following contents are mentioned in the article:

Sortase A (SrtA) anchors surface proteins to the cell wall envelope, and it has attracted increasing interesting as a potential antivirulence target. Several small-mol. inhibitors for SrtA have been developed, but target validation remains largely underexplored. Herein, we report a new class of SrtA inhibitors that supports antivirulence therapy through small-mol. targeting of SrtA. Tideglusib (TD), a drug candidate for myotonic dystrophy, was outstanding in high-throughput screening. A concise synthetic route quickly provided TD analogs, and the structure-activity relationships for SrtA inhibition have been established from those analogs. Several compounds largely retained the in vitro potency and exhibited a better solubility than TD. Addnl., TD attenuated virulence-related phenotypes in vitro and protected mice against lethal S. aureus USA300 bacteremia. Our study indicates that TD and its analogs could be new candidates as SrtA inhibitors with potential in the development of new antivirulence agents. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8SDS of cas: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.SDS of cas: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tideglusib and Its Analogues As Inhibitors of Staphylococcus aureus SrtA was written by Yang, Teng;Zhang, Tao;Guan, Xiang-Na;Dong, Ze;Lan, Lefu;Yang, Song;Yang, Cai-Guang. And the article was included in Journal of Medicinal Chemistry in 2020.Product Details of 2253-73-8 The following contents are mentioned in the article:

Sortase A (SrtA) anchors surface proteins to the cell wall envelope, and it has attracted increasing interesting as a potential antivirulence target. Several small-mol. inhibitors for SrtA have been developed, but target validation remains largely underexplored. Herein, we report a new class of SrtA inhibitors that supports antivirulence therapy through small-mol. targeting of SrtA. Tideglusib (TD), a drug candidate for myotonic dystrophy, was outstanding in high-throughput screening. A concise synthetic route quickly provided TD analogs, and the structure-activity relationships for SrtA inhibition have been established from those analogs. Several compounds largely retained the in vitro potency and exhibited a better solubility than TD. Addnl., TD attenuated virulence-related phenotypes in vitro and protected mice against lethal S. aureus USA300 bacteremia. Our study indicates that TD and its analogs could be new candidates as SrtA inhibitors with potential in the development of new antivirulence agents. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Product Details of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and biological evaluation of Vinpocetine derivatives was written by Pan, Bo-Wen;Shi, Yang;Li, Wen-Chao;Wang, Qing;Pan, Meng;Wu, Qiong;Fu, Hong-Zheng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Electric Literature of C4H7NS The following contents are mentioned in the article:

A new series of Vinpocetine derivatives were synthesized and evaluated for their inhibitory activity on PDE1A in vitro. Seven compounds with higher inhibitory activity were selected for surface plasmon resonance (SPR) binding experiments Compared with Vinpocetine, these high potency compounds presented a higher binding affinity with PDE1A, which was consistent with inhibitory activity. After further screening, four compounds and Vinpocetine were selected to examine the vasorelaxant effects on endothelium-intact rat thoracic aortic rings. The study suggested that the effects of compounds I (R¹ = 4-fluorophenyl) and I (R¹ = 3-fluorophenyl) were the most significant with the maximum value of 93.46 ± 0.77% and 92.90 ± 0.78% (n = 5) at a concentration of 100μM resp. Based on these studies, compounds I (R¹ = 4-fluorophenyl) and I (R¹ = 3-fluorophenyl) were considered for further development as hit compounds This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Electric Literature of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Electric Literature of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and biological evaluation of Vinpocetine derivatives was written by Pan, Bo-Wen;Shi, Yang;Li, Wen-Chao;Wang, Qing;Pan, Meng;Wu, Qiong;Fu, Hong-Zheng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.COA of Formula: C4H7NS The following contents are mentioned in the article:

A new series of Vinpocetine derivatives were synthesized and evaluated for their inhibitory activity on PDE1A in vitro. Seven compounds with higher inhibitory activity were selected for surface plasmon resonance (SPR) binding experiments Compared with Vinpocetine, these high potency compounds presented a higher binding affinity with PDE1A, which was consistent with inhibitory activity. After further screening, four compounds and Vinpocetine were selected to examine the vasorelaxant effects on endothelium-intact rat thoracic aortic rings. The study suggested that the effects of compounds I (R¹ = 4-fluorophenyl) and I (R¹ = 3-fluorophenyl) were the most significant with the maximum value of 93.46 ± 0.77% and 92.90 ± 0.78% (n = 5) at a concentration of 100μM resp. Based on these studies, compounds I (R¹ = 4-fluorophenyl) and I (R¹ = 3-fluorophenyl) were considered for further development as hit compounds This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8COA of Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.COA of Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of pyrrole-ferrocene ensembles and their rearrangement into 2-(ferrocenylmethyl)-1,2-dihydro-3H-pyrrol-3-ones was written by Tarasova, Ol’ga A.;Nedolya, Nina A.;Albanov, Alexander I.;Bagryanskaya, Irina Yu.;Trofimov, Boris A.. And the article was included in Journal of Organometallic Chemistry in 2021.Formula: C4H7NS The following contents are mentioned in the article:

Rearrangement of ferrocenylmethoxypyrroles 3-(FcCH₂O)-2-SR²-1-R¹C₄H₂N afforded ferrocenylmethyl 3(2H)-pyrrolones 1-R¹-2-SR²-2-CH₂Fc-3-O-C₄H₂N as a result of formal C[1,3]-shift. The lithiation of (ferrocenylmethoxy)allene followed by sequential reaction with isothiocyanate and S-alkylation of the adduct gives the corresponding alkyl buta-2,3-dienimidothioate (1-aza-1,3,4-triene), which in the presence of CuI or CuBr cyclizes into (ferrocenylmethoxy)/sulfanyl-substituted pyrrole ring. The process is carried out in one or two preparative steps depending on an alkylating agent. A novel unexpected rearrangement of the synthesized 3-(ferrocenylmethoxy)-2-sulfanyl-1H-pyrroles into 2-(ferrocenylmethyl)-2-sulfanyl-1,2-dihydro-3H-pyrrol-3-ones, proceeding in CDCl₃ at room temperature or in toluene under heating, is discovered. The transformation of the 3-(ferrocenylmethoxy)-1H-pyrroles into 1,2-dihydro-3H-pyrrol-3-ones is most likely the result of the formal [1,3]-O-to-C-rearrangements (acid-induced or thermal, resp.). This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of pyrrole-ferrocene ensembles and their rearrangement into 2-(ferrocenylmethyl)-1,2-dihydro-3H-pyrrol-3-ones was written by Tarasova, Ol’ga A.;Nedolya, Nina A.;Albanov, Alexander I.;Bagryanskaya, Irina Yu.;Trofimov, Boris A.. And the article was included in Journal of Organometallic Chemistry in 2021.HPLC of Formula: 2253-73-8 The following contents are mentioned in the article:

Rearrangement of ferrocenylmethoxypyrroles 3-(FcCH₂O)-2-SR²-1-R¹C₄H₂N afforded ferrocenylmethyl 3(2H)-pyrrolones 1-R¹-2-SR²-2-CH₂Fc-3-O-C₄H₂N as a result of formal C[1,3]-shift. The lithiation of (ferrocenylmethoxy)allene followed by sequential reaction with isothiocyanate and S-alkylation of the adduct gives the corresponding alkyl buta-2,3-dienimidothioate (1-aza-1,3,4-triene), which in the presence of CuI or CuBr cyclizes into (ferrocenylmethoxy)/sulfanyl-substituted pyrrole ring. The process is carried out in one or two preparative steps depending on an alkylating agent. A novel unexpected rearrangement of the synthesized 3-(ferrocenylmethoxy)-2-sulfanyl-1H-pyrroles into 2-(ferrocenylmethyl)-2-sulfanyl-1,2-dihydro-3H-pyrrol-3-ones, proceeding in CDCl₃ at room temperature or in toluene under heating, is discovered. The transformation of the 3-(ferrocenylmethoxy)-1H-pyrroles into 1,2-dihydro-3H-pyrrol-3-ones is most likely the result of the formal [1,3]-O-to-C-rearrangements (acid-induced or thermal, resp.). This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8HPLC of Formula: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Insights into the mode of action of 2-(4-methoxyphenyl)ethyl isothiocyanate on Aspergillus niger was written by Wu, Tian-Lin;Hu, Yong-Mei;Sun, Yu;Zhang, Zhi-Jun;Wu, Zheng-Rong;Zhao, Wen-Bin;Tang, Chen;Du, Sha-Sha;He, Ying-Hui;Ma, Yue;Yang, Cheng-Jie;Liu, Ying-Qian. And the article was included in Food Control in 2022.Related Products of 2253-73-8 The following contents are mentioned in the article:

Isothiocyanates had attracted attention for many years due to their antimicrobial properties. In this study, the antifungal efficiency of eighteen isothiocyanate compounds were evaluated against six plant pathogenic fungi and two molds in vitro. Among them, 2-(4-methoxyphenyl)ethyl isothiocyanate displayed the highest antifungal activity against Aspergillus niger (EC50 = 4.19μg/mL). The further studies of its mode of action showed that it may damage the cell morphol. and membrane integrity in a dose dependent manner by morphol. observation, Pr iodide staining and the release of cellular contents. On the other hand, the decrease of related enzyme activities in tricarboxylic acid cycle suggested that 2-(4-methoxyphenyl)ethyl isothiocyanate may effected energy metabolism Besides, reactive oxygen species, the content of malondialdehyde, the total antioxidant capacity, the content of glutathione and the kinase of oxidative reactive were changed in fungi treated with 2-(4-methoxyphenyl)ethyl isothiocyanate, compared with those in untreated fungi, which all indicated that 2-(4-methoxyphenyl)ethyl isothiocyanate exhibited antifungal activity against A.niger by inducing oxidative stress. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Related Products of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Related Products of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Insights into the mode of action of 2-(4-methoxyphenyl)ethyl isothiocyanate on Aspergillus niger was written by Wu, Tian-Lin;Hu, Yong-Mei;Sun, Yu;Zhang, Zhi-Jun;Wu, Zheng-Rong;Zhao, Wen-Bin;Tang, Chen;Du, Sha-Sha;He, Ying-Hui;Ma, Yue;Yang, Cheng-Jie;Liu, Ying-Qian. And the article was included in Food Control in 2022.Safety of Isopropylisothiocyanate The following contents are mentioned in the article:

Isothiocyanates had attracted attention for many years due to their antimicrobial properties. In this study, the antifungal efficiency of eighteen isothiocyanate compounds were evaluated against six plant pathogenic fungi and two molds in vitro. Among them, 2-(4-methoxyphenyl)ethyl isothiocyanate displayed the highest antifungal activity against Aspergillus niger (EC50 = 4.19μg/mL). The further studies of its mode of action showed that it may damage the cell morphol. and membrane integrity in a dose dependent manner by morphol. observation, Pr iodide staining and the release of cellular contents. On the other hand, the decrease of related enzyme activities in tricarboxylic acid cycle suggested that 2-(4-methoxyphenyl)ethyl isothiocyanate may effected energy metabolism Besides, reactive oxygen species, the content of malondialdehyde, the total antioxidant capacity, the content of glutathione and the kinase of oxidative reactive were changed in fungi treated with 2-(4-methoxyphenyl)ethyl isothiocyanate, compared with those in untreated fungi, which all indicated that 2-(4-methoxyphenyl)ethyl isothiocyanate exhibited antifungal activity against A.niger by inducing oxidative stress. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Safety of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Safety of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics