Category: 2253-73-8

Organocatalysis for the Asymmetric Michael Addition of Aldehydes and α,β-Unsaturated Nitroalkenes was written by Shim, Jae Ho;Cheun, Seok Hyun;Kim, Hyeon Soo;Ha, Deok-Chan. And the article was included in Catalysts in 2022.Safety of Isopropylisothiocyanate The following contents are mentioned in the article:

A mirror image of an aldehyde and α,β-unsaturated nitroalkene were reacted in the presence of (R,R)-1,2-diphenylethylenediamine (DPEN). Thiourea were introduced as an organic catalyst and a selective Michael addition reaction were carried out. The primary amine moiety of DPEN reacts with aldehydes to form enamines, which was activated by the hydrogen bond formation between the nitro groups of α,β-unsaturated nitroalkenes and thiourea. Obtained an asym. Michael product by adding 1,4-enamine to an alkene to form a new carbon-carbon bond. As a result, the primary amine of the chiral diamine were converted to an enamine. The reaction proceeded with a relatively high degree of enantioselectivity, which were achieved using double activation via hydrogen bonding of the nitro group and thiourea. Michael products with a high degree of enantioselectivity (97-99% syn ee) and diastereoselectivity (syn/anti = 9/1) were obtained in yields ranging from 94-99% depending on the aldehydes. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Safety of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Safety of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Experimental and Computational Study of the 1,5-O → N Carbamoyl Snieckus-Fries-Type Rearrangement was written by Feberero, Claudia;Sedano, Carlos;Suarez-Pantiga, Samuel;Lopez, Carlos Silva;Sanz, Roberto. And the article was included in Journal of Organic Chemistry in 2020.Name: Isopropylisothiocyanate The following contents are mentioned in the article:

The reactions of o-lithiated O-aryl N,N-diethylcarbamates with different C-N multiple bond electrophiles have been thoroughly studied. A 1,5-O → N carbamoyl shift, a new variation of the anionic Fries-type rearrangement, takes place when nitriles, imines, or alkylcarbodiimides are employed. In these cases, the carbamoyl group plays a dual role as a directing group, building up a variety of functional groups through the 1,5-O → N carbamoyl migration. On the other hand, the use of iso(thio)cyanates and arylcarbodiimides led to non-rearranged o-functionalized O-arylcarbamates. This reactivity was further computationally explored, and the governing factor could be traced back to the relative basicity of the alternative products (migrated vs nonmigrated substrates). This exploration also provided interesting insights about the degree of complexation of the lithium cations onto these substrates. A new access to useful 2-hydroxybenzophenone derivatives has also been developed. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Name: Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Name: Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Experimental and Computational Study of the 1,5-O → N Carbamoyl Snieckus-Fries-Type Rearrangement was written by Feberero, Claudia;Sedano, Carlos;Suarez-Pantiga, Samuel;Lopez, Carlos Silva;Sanz, Roberto. And the article was included in Journal of Organic Chemistry in 2020.Safety of Isopropylisothiocyanate The following contents are mentioned in the article:

The reactions of o-lithiated O-aryl N,N-diethylcarbamates with different C-N multiple bond electrophiles have been thoroughly studied. A 1,5-O → N carbamoyl shift, a new variation of the anionic Fries-type rearrangement, takes place when nitriles, imines, or alkylcarbodiimides are employed. In these cases, the carbamoyl group plays a dual role as a directing group, building up a variety of functional groups through the 1,5-O → N carbamoyl migration. On the other hand, the use of iso(thio)cyanates and arylcarbodiimides led to non-rearranged o-functionalized O-arylcarbamates. This reactivity was further computationally explored, and the governing factor could be traced back to the relative basicity of the alternative products (migrated vs nonmigrated substrates). This exploration also provided interesting insights about the degree of complexation of the lithium cations onto these substrates. A new access to useful 2-hydroxybenzophenone derivatives has also been developed. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Safety of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Safety of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Surfactant based nanoreactor micellar assembly: An innovative route for synthesis of 2-thioxo-2,3-dihydroquinazolin-4(1H)-ones was written by Patil, Mayuri V.;Mhaldar, Pradeep M.;Tayade, Shivaji N.;Rashinkar, Gajanan S.;Pore, Dattaprasad M.. And the article was included in Journal of Molecular Liquids in 2022.Product Details of 2253-73-8 The following contents are mentioned in the article:

An innovative route for synthesis of 2-thioxo-2,3-dihydroquinazolin-4(1H)-ones using isatoic anhydride and Ph isothiocyanate via in-situ formation of anthranilic acid was described. The reaction was performed in the nano-micellar assembly of surfactant, 4-(dimethylamino)-1-hexadecylpyridinium hydroxide [DAHP]⁺[OH]^– as a nano-reactor. The micelle concentration of surfactant is found to be 0.002 mol.dm^-3 using the conductivity data. The micellar particle dimensions were demonstrated from small-angle X-ray scattering (SAXS) anal. viz. micelle diameter and the interspacing between two micelles which were found to be 14.8 nm and 2.6 nm, resp. From the TGA anal., the surfactant is thermally stable up to 250°C with 76.01% weight loss. The practical simplicity, atom economy, good to high yields, ease of product isolation and purification, water as eco-benign solvent and catalyst recyclability were the remarkable aspects of the present methodol. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Product Details of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Product Details of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Surfactant based nanoreactor micellar assembly: An innovative route for synthesis of 2-thioxo-2,3-dihydroquinazolin-4(1H)-ones was written by Patil, Mayuri V.;Mhaldar, Pradeep M.;Tayade, Shivaji N.;Rashinkar, Gajanan S.;Pore, Dattaprasad M.. And the article was included in Journal of Molecular Liquids in 2022.Synthetic Route of C4H7NS The following contents are mentioned in the article:

An innovative route for synthesis of 2-thioxo-2,3-dihydroquinazolin-4(1H)-ones using isatoic anhydride and Ph isothiocyanate via in-situ formation of anthranilic acid was described. The reaction was performed in the nano-micellar assembly of surfactant, 4-(dimethylamino)-1-hexadecylpyridinium hydroxide [DAHP]⁺[OH]^– as a nano-reactor. The micelle concentration of surfactant is found to be 0.002 mol.dm^-3 using the conductivity data. The micellar particle dimensions were demonstrated from small-angle X-ray scattering (SAXS) anal. viz. micelle diameter and the interspacing between two micelles which were found to be 14.8 nm and 2.6 nm, resp. From the TGA anal., the surfactant is thermally stable up to 250°C with 76.01% weight loss. The practical simplicity, atom economy, good to high yields, ease of product isolation and purification, water as eco-benign solvent and catalyst recyclability were the remarkable aspects of the present methodol. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Synthetic Route of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In silico and ADMET evaluation of bioactive drug compounds of Turbinaria ornata against fungal enzyme Candidapepsin (Secreted Aspartic Protease) was written by Biswal, R. Abhishek;Pazhamalai, Vivek. And the article was included in Research Journal of Chemistry and Environment in 2020.Application of 2253-73-8 The following contents are mentioned in the article:

The mol. docking anal. of bioactive compounds of Turbinaria ornata against the fungal disease candida pepsin was done. This study mainly reveals the inhibition potential of each drug mol. against targeted enzyme by interacting with the amino acids. The targeted enzymes were studies and retrieved from PDB by removing heteroatoms and water mols. The organic bioactive compounds were screened by using Lipinski rule of five and ADMET properties for knowing drug likeliness. The mol. docking anal. was done against virulent protein by using Autodock software 4.2.6. The visualization of docked confirmation was visualized by using Discovery studio 3.1. The organic bioactive compound namely Benzo(k)fluoranthene, Tetramethrin-1 and Kresoxim Me have better inhibition potential with binding energy -6.44 Kcal/mol, -5.91 Kcal/mol and -5.51 Kcal/mol resp. This study mainly focuses on computational perspectives of structure based protein ligand docking for the development of novel drug therapy. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Application of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In silico and ADMET evaluation of bioactive drug compounds of Turbinaria ornata against fungal enzyme Candidapepsin (Secreted Aspartic Protease) was written by Biswal, R. Abhishek;Pazhamalai, Vivek. And the article was included in Research Journal of Chemistry and Environment in 2020.Application of 2253-73-8 The following contents are mentioned in the article:

The mol. docking anal. of bioactive compounds of Turbinaria ornata against the fungal disease candida pepsin was done. This study mainly reveals the inhibition potential of each drug mol. against targeted enzyme by interacting with the amino acids. The targeted enzymes were studies and retrieved from PDB by removing heteroatoms and water mols. The organic bioactive compounds were screened by using Lipinski rule of five and ADMET properties for knowing drug likeliness. The mol. docking anal. was done against virulent protein by using Autodock software 4.2.6. The visualization of docked confirmation was visualized by using Discovery studio 3.1. The organic bioactive compound namely Benzo(k)fluoranthene, Tetramethrin-1 and Kresoxim Me have better inhibition potential with binding energy -6.44 Kcal/mol, -5.91 Kcal/mol and -5.51 Kcal/mol resp. This study mainly focuses on computational perspectives of structure based protein ligand docking for the development of novel drug therapy. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Application of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1 was written by Benchekroun, Mohamed;Ermolenko, Ludmila;Tran, Minh Quan;Vagneux, Agathe;Nedev, Hristo;Delehouze, Claire;Souab, Mohamed;Baratte, Blandine;Josselin, Beatrice;Iorga, Bogdan I.;Ruchaud, Sandrine;Bach, Stephane;Al-Mourabit, Ali. And the article was included in European Journal of Medicinal Chemistry in 2020.Recommanded Product: 2253-73-8 The following contents are mentioned in the article:

With the aim to develop new chem. tools based on simplified natural metabolites to help deciphering the mol. mechanism of necroptosis, simplified benzazole fragments including 2-aminobenzimidazole and the 2-aminobenzothiazole analogs were prepared during the synthesis of the marine benzosceptrin B. Compounds inhibiting the RIPK1 protein kinase were discovered. A library of 54 synthetic analogs were prepared and evaluated through a phenotypic screen using the inhibition of the necrotic cell death induced by TNF-α in human Jurkat T cells deficient for the FADD protein. This article reports the design, synthesis and biol. evaluation of a series of 2-aminobenzazoles on the necroptotic cell death through the inhibition of RIPK1 protein kinase. The 2-aminobenzimidazole and 2-aminobenzothiazole platforms presented herein can serve as novel chem. tools to study the mol. regulation of necroptosis and further develop lead drug candidates for chronic pathologies involving necroptosis. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Recommanded Product: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1 was written by Benchekroun, Mohamed;Ermolenko, Ludmila;Tran, Minh Quan;Vagneux, Agathe;Nedev, Hristo;Delehouze, Claire;Souab, Mohamed;Baratte, Blandine;Josselin, Beatrice;Iorga, Bogdan I.;Ruchaud, Sandrine;Bach, Stephane;Al-Mourabit, Ali. And the article was included in European Journal of Medicinal Chemistry in 2020.Formula: C4H7NS The following contents are mentioned in the article:

With the aim to develop new chem. tools based on simplified natural metabolites to help deciphering the mol. mechanism of necroptosis, simplified benzazole fragments including 2-aminobenzimidazole and the 2-aminobenzothiazole analogs were prepared during the synthesis of the marine benzosceptrin B. Compounds inhibiting the RIPK1 protein kinase were discovered. A library of 54 synthetic analogs were prepared and evaluated through a phenotypic screen using the inhibition of the necrotic cell death induced by TNF-α in human Jurkat T cells deficient for the FADD protein. This article reports the design, synthesis and biol. evaluation of a series of 2-aminobenzazoles on the necroptotic cell death through the inhibition of RIPK1 protein kinase. The 2-aminobenzimidazole and 2-aminobenzothiazole platforms presented herein can serve as novel chem. tools to study the mol. regulation of necroptosis and further develop lead drug candidates for chronic pathologies involving necroptosis. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Metabolic Changes during Storage of Brassica napus Seeds under Moist Conditions and the Consequences for the Sensory Quality of the Resulting Virgin Oil was written by Bonte, Anja;Schweiger, Rabea;Pons, Caroline;Wagner, Claudia;Bruehl, Ludger;Matthaeus, Bertrand;Mueller, Caroline. And the article was included in Journal of Agricultural and Food Chemistry in 2017.Safety of Isopropylisothiocyanate The following contents are mentioned in the article:

Virgin rapeseed (Brassica napus) oil is a valuable niche product, if delivered with a high quality. In this study, the effects of moist storage of B. napus seeds for 1 to 4 days on the seed metabolome and the chemo-sensory properties of the produced oils were determined The concentrations of several primary metabolites, including monosaccharides and amino acids, rapidly increased in the seeds, probably indicating the breakdown of storage compounds to support seed germination. Seed concentrations of indole glucosinolates increased with a slight time offset suggesting that amino acids may be used to modify secondary metabolism The volatile profiles of the oils were pronouncedly influenced by moist seed storage, with the sensory quality of the oils decreasing. This study provides a direct time-resolved link between seed metabolism under moist conditions and the quality of the resulting oils, thereby emphasizing the crucial role of dry seed storage in ensuring high oil quality. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Safety of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Safety of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics