Category: 2253-73-8

Synthesis of N-trifluoromethyl amides from carboxylic acids was written by Liu, Jianbo;Parker, Matthew F. L.;Wang, Sinan;Flavell, Robert R.;Toste, F. Dean;Wilson, David M.. And the article was included in Chem in 2021.Application In Synthesis of Isopropylisothiocyanate The following contents are mentioned in the article:

Here, the synthesis of N-trifluoromethyl amides R¹C(O)NCF₃(R²) [R¹ = Et, cyclohexyl, CH₂CH₂Ph, etc.; R² = Me, allyl, CH₂CH₂Ph, etc.] from carboxylic acid halides and esters under mild conditions via isothiocyanates in the presence of silver fluoride at room temperature was reported. Through this strategy, isothiocyanates were desulfurized with AgF, and then the formed derivative was acylated to afford N-trifluoromethyl amides, including previously inaccessible structures. This method showed broad scope, provides a platform for rapidly generating N-trifluoromethyl amides by virtue of the diversity and availability of both reaction partners and should find application in the modification of advanced intermediates. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Application In Synthesis of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application In Synthesis of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of N-trifluoromethyl amides from carboxylic acids was written by Liu, Jianbo;Parker, Matthew F. L.;Wang, Sinan;Flavell, Robert R.;Toste, F. Dean;Wilson, David M.. And the article was included in Chem in 2021.Computed Properties of C4H7NS The following contents are mentioned in the article:

Here, the synthesis of N-trifluoromethyl amides R¹C(O)NCF₃(R²) [R¹ = Et, cyclohexyl, CH₂CH₂Ph, etc.; R² = Me, allyl, CH₂CH₂Ph, etc.] from carboxylic acid halides and esters under mild conditions via isothiocyanates in the presence of silver fluoride at room temperature was reported. Through this strategy, isothiocyanates were desulfurized with AgF, and then the formed derivative was acylated to afford N-trifluoromethyl amides, including previously inaccessible structures. This method showed broad scope, provides a platform for rapidly generating N-trifluoromethyl amides by virtue of the diversity and availability of both reaction partners and should find application in the modification of advanced intermediates. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Computed Properties of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of 2-[(5-Amino-1H-pyrrol-2-yl)sulfanyl]acetic Acid Esters: One-Pot Assembly from Propargyl Amines, Isothiocyanates, and Alkyl 2-Bromoacetates was written by Tarasova, Olga A.;Nedolya, Nina A.;Albanov, Alexander I.;Trofimov, Boris A.. And the article was included in Synthesis in 2019.HPLC of Formula: 2253-73-8 The following contents are mentioned in the article:

The compounds 2-[(5-Amino-1 H-pyrrol-2-yl)sulfanyl]acetic acid esters I (R = R¹ = Me, Et, Pr; RR¹ = -(CH₂)₄-, -(CH₂)₅-, -(CH₂)₂O(CH₂)₂-; R² = Me, Et, i-Pr, n-Bu, CH₂CH₂OCH=CH₂; R³ = Me, Et, i-Pr, t-Bu, Bn) have been synthesized in up to 77% yield by the one-pot reaction of lithiated propargylamines RR¹NCH₂CCH with isothiocyanates R²N=C=S followed by sequential treatment with t-BuOK-DMSO and alkyl 2-bromoacetates BrCH₂CO₂R³. The process occurs through the initial formation of the thiophene core, followed by its recyclization into the pyrrole nucleus at a higher temperature (ca. 45-60 °C). This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8HPLC of Formula: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of 2-[(5-Amino-1H-pyrrol-2-yl)sulfanyl]acetic Acid Esters: One-Pot Assembly from Propargyl Amines, Isothiocyanates, and Alkyl 2-Bromoacetates was written by Tarasova, Olga A.;Nedolya, Nina A.;Albanov, Alexander I.;Trofimov, Boris A.. And the article was included in Synthesis in 2019.Safety of Isopropylisothiocyanate The following contents are mentioned in the article:

The compounds 2-[(5-Amino-1 H-pyrrol-2-yl)sulfanyl]acetic acid esters I (R = R¹ = Me, Et, Pr; RR¹ = -(CH₂)₄-, -(CH₂)₅-, -(CH₂)₂O(CH₂)₂-; R² = Me, Et, i-Pr, n-Bu, CH₂CH₂OCH=CH₂; R³ = Me, Et, i-Pr, t-Bu, Bn) have been synthesized in up to 77% yield by the one-pot reaction of lithiated propargylamines RR¹NCH₂CCH with isothiocyanates R²N=C=S followed by sequential treatment with t-BuOK-DMSO and alkyl 2-bromoacetates BrCH₂CO₂R³. The process occurs through the initial formation of the thiophene core, followed by its recyclization into the pyrrole nucleus at a higher temperature (ca. 45-60 °C). This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Safety of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Safety of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Base-controlled chemoselectivity reaction of vinylanilines with isothiocyanates for synthesis of quinolino-2-thione and 2-aminoquinoline derivatives was written by Zhang, Xi;Wang, Tong-Lin;Huo, Cong-De;Wang, Xi-Cun;Quan, Zheng-Jun. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Formula: C4H7NS The following contents are mentioned in the article:

A base-controlled chemo-selective reaction of vinylanilines with alkyl/aryl isothiocyanates to afford quinoline-2-thione and 2-aminoquinoline derivatives, is reported/. Quinoline-2-thiones I (R = Me, MeO, Cl, etc.; Ar = Ph, 4-MeOC₆H₄, 4-MeC₆H₄, 4-ClC₆H₄, etc.) could be obtained in high yields in the presence of Et₃N. Particularly interesting is that the reaction could produce the 2-aminoquinolines II (R¹ = Me, MeO, Cl, etc.; R² = Ph, 3-MeC₆H₄, 4-FC₆H₄, 4-pentylC₆H₄; R³ = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.) in the presence of K₃PO₄ with high selectivity. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

External oxidant-free electrooxidative intramolecular S-N bond formation for one-pot synthesis for 3,5-disubstituted 1,2,4-thiadiazoles was written by Zhong, Qihao;Sheng, Shouri;Chen, Junmin. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2020.Safety of Isopropylisothiocyanate The following contents are mentioned in the article:

An electrochem. oxidative reaction protocol for the synthesis of 5-amino and 3,5-diamino substituted 1,2,4-thiadiazole derivatives I (R¹ = Ph, cyclopropyl, phenylaminyl, etc.; R² = Ph, pyridin-4-yl, propan-2-yl, etc.) has been developed under undivided electrolytic conditions. The newly developed one-pot methodol. involves the reaction of isothiocyanates R²NCS with amidines or guanidines R¹C(=NH)NH₂. HCl to give the corresponding imidoyl thioureas, which are further cyclized in situ via electrooxidative intramol. S-N bond formation to promote the final products. This protocol features a metal- and external oxidant-free approach, broad substrate scope, good functional group tolerance, excellent yields, and one-pot operation/reaction without the isolation of the intermediates. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Safety of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Safety of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

External oxidant-free electrooxidative intramolecular S-N bond formation for one-pot synthesis for 3,5-disubstituted 1,2,4-thiadiazoles was written by Zhong, Qihao;Sheng, Shouri;Chen, Junmin. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2020.Category: esters-buliding-blocks The following contents are mentioned in the article:

An electrochem. oxidative reaction protocol for the synthesis of 5-amino and 3,5-diamino substituted 1,2,4-thiadiazole derivatives I (R¹ = Ph, cyclopropyl, phenylaminyl, etc.; R² = Ph, pyridin-4-yl, propan-2-yl, etc.) has been developed under undivided electrolytic conditions. The newly developed one-pot methodol. involves the reaction of isothiocyanates R²NCS with amidines or guanidines R¹C(=NH)NH₂. HCl to give the corresponding imidoyl thioureas, which are further cyclized in situ via electrooxidative intramol. S-N bond formation to promote the final products. This protocol features a metal- and external oxidant-free approach, broad substrate scope, good functional group tolerance, excellent yields, and one-pot operation/reaction without the isolation of the intermediates. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Category: esters-buliding-blocks).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and anxiolytic activity of some novel benzotriazole derivatives was written by Singh, V. K.;Bharadwaj, Peeyush;Rishishwar, Poonam. And the article was included in Journal of Drug Delivery and Therapeutics in 2019.Recommanded Product: 2253-73-8 The following contents are mentioned in the article:

1,2,3-Benzotriazole (BTA) is a heterocyclic compound with three nitrogen atoms. It is a polar and colorless compound which can be used for its great versatility. The enormous investigations on derivatives of benzotriazole reveal wide applicability for tagging and delivering a number of heterocyclic nuclei with this mol. In the present work synthesis of several derivatives of 1-(substituted)-5-[(N-benzotriazolomethyl)-1,3, 4-thiadiazolyl]- imidazole-2-thione has been synthesized and are evaluated for their anxiolytic activity. The antianxiety activities of the synthesized derivatives were evaluated using EPM test and Bright and dark box test exptl. models of anxiety. All results were expressed as mean± standard error mean (SEM) and analyzed by one-way ANOVA. Post-hoc comparisons were performed by applying Dunnet′s test. P <0.05 was considered statistically significant. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Recommanded Product: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and anxiolytic activity of some novel benzotriazole derivatives was written by Singh, V. K.;Bharadwaj, Peeyush;Rishishwar, Poonam. And the article was included in Journal of Drug Delivery and Therapeutics in 2019.Synthetic Route of C4H7NS The following contents are mentioned in the article:

1,2,3-Benzotriazole (BTA) is a heterocyclic compound with three nitrogen atoms. It is a polar and colorless compound which can be used for its great versatility. The enormous investigations on derivatives of benzotriazole reveal wide applicability for tagging and delivering a number of heterocyclic nuclei with this mol. In the present work synthesis of several derivatives of 1-(substituted)-5-[(N-benzotriazolomethyl)-1,3, 4-thiadiazolyl]- imidazole-2-thione has been synthesized and are evaluated for their anxiolytic activity. The antianxiety activities of the synthesized derivatives were evaluated using EPM test and Bright and dark box test exptl. models of anxiety. All results were expressed as mean± standard error mean (SEM) and analyzed by one-way ANOVA. Post-hoc comparisons were performed by applying Dunnet′s test. P <0.05 was considered statistically significant. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Synthetic Route of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Synthetic Route of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Copper Complexes of 1,4-Naphthoquinone Containing Thiosemicarbazide and Triphenylphosphine Oxide Moieties; Synthesis and Identification by NMR, IR, Mass, UV Spectra, and DFT Calculations was written by Alshammari, Mohammed B.;Aly, Ashraf A.;Brase, Stefan;Nieger, Martin;Ibrahim, Mahmoud A. A.;Abd El-Haleem, Lamiaa E.. And the article was included in ACS Omega in 2022.Application of 2253-73-8 The following contents are mentioned in the article:

New 1,4-naphthoquinone derived by triphenylphosphaneylidene (Ph₃P) and N-substituted-hydrazine-1-carbothioamides were obtained during a one-pot reaction of 2,3-dichloro-1,4-naphthoquinone with thiosemicarbazides, Ph₃P and in the presence of tri-Et amine (Et₃N) as a catalyst. The structure of the ligands was established by ESI, IR, and NMR spectra, in addition to elemental analyses and X-ray structure anal. On subjecting the newly prepared ligands with CuCl₂ and Ph₃P, autoxidation occurs, and (E)-(2-(1,4-dioxo-3-(tri-Ph phosphanylidene)-3,4-dihydronaphthalen-2(1H)-ylidene)carbamothioyl)hydrazinyl-((triphenylphosphanyl)oxy)copper derivatives were formed in very good yields. The structure of the obtained complexes was proved by ESI, IR, NMR, and UV spectra, in addition to elemental analyses and theor. calculations This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Application of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics