Category: 2253-73-8

Organo-catalytic synthesis of oxathianes from isocyanides, isothiocyanates, and oxiranes was written by Keshtegar, Zahra;Heydari, Reza;Samzadeh-Kermani, Alireza. And the article was included in Journal of Sulfur Chemistry in 2021.Electric Literature of C4H7NS The following contents are mentioned in the article:

A novel three-component reaction between isocyanides, isothiocyanates, and oxiranes has been developed for the synthesis of substituted oxathianes I (R¹ = t-Bu, Cy, 2,6-Me₂C₆H₃; R² = i-Pr, Ph, 4-BrC₆H₄, etc.; R³ = Me, n-Bu, Me₂CHOCH₂, etc.; R⁴ = H, Me, Ph, 4-MeC₆H₄; R⁵ = H, Me, CH₃OCO; R⁶ = H, Me) in acceptable to good yields. The product of the reaction could be modulated by using either Bu₃P or tetrabutylphosphonium acetate (TBPAc) as an organocatalyst. This work offers an opportunity for the further implementation of isocyanides in library design. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Electric Literature of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Electric Literature of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Organo-catalytic synthesis of oxathianes from isocyanides, isothiocyanates, and oxiranes was written by Keshtegar, Zahra;Heydari, Reza;Samzadeh-Kermani, Alireza. And the article was included in Journal of Sulfur Chemistry in 2021.SDS of cas: 2253-73-8 The following contents are mentioned in the article:

A novel three-component reaction between isocyanides, isothiocyanates, and oxiranes has been developed for the synthesis of substituted oxathianes I (R¹ = t-Bu, Cy, 2,6-Me₂C₆H₃; R² = i-Pr, Ph, 4-BrC₆H₄, etc.; R³ = Me, n-Bu, Me₂CHOCH₂, etc.; R⁴ = H, Me, Ph, 4-MeC₆H₄; R⁵ = H, Me, CH₃OCO; R⁶ = H, Me) in acceptable to good yields. The product of the reaction could be modulated by using either Bu₃P or tetrabutylphosphonium acetate (TBPAc) as an organocatalyst. This work offers an opportunity for the further implementation of isocyanides in library design. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8SDS of cas: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.SDS of cas: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Base-Promoted [3+2] Cycloaddition of In Situ Formed Azaoxyallyl Cations with Isothiocyanates was written by Zhao, Hong-Wu;Zhao, Yu-Di;Liu, Yue-Yang;Du, Juan;Pang, Hai-Liang;Chen, Xiao-Qin;Song, Xiu-Qing;Feng, Ning-Ning. And the article was included in European Journal of Organic Chemistry in 2017.Product Details of 2253-73-8 The following contents are mentioned in the article:

The [3+2] cycloaddition of azaoxyallyl cations, in situ generated from α-halohydroxamates R¹R²CXC(O)NHOCH₂Ph [R¹ = H, Me, Cl; R² = Cl, Me, Ph; R¹R² = (CH₂)₅; X = Br, Cl], with isothiocyanates R²NCS (R² = Me, i-Pr, cyclohexyl, Ph, PhCH₂, etc.) proceeded smoothly in the presence of Na₂CO₃ and furnished the corresponding (Z)-3-(benzyloxy)-2-imino-thiazolidin-4-ones I in 25-99% yields. The structure of iminothiazolidinone I [R¹ = R² = Me; R³ = 1,5-Me₂-2-oxoindolin-3-yl] was confirmed by X-ray single-crystal structure anal. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Product Details of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis, characterization, biological evaluation, and computational study of benzimidazole hybrid thiosemicarbazide derivatives was written by Acharya, Prachi T.;Bhavsar, Zeel A.;Jethava, Divya J.;Rajani, Dhanji P.;Pithawala, Edwin;Patel, Hitesh D.. And the article was included in Journal of Heterocyclic Chemistry.Product Details of 2253-73-8 The following contents are mentioned in the article:

The antimicrobial, antitubercular, antimalarial, and antioxidant properties of a series of benzimidazole hybrid thiosemicarbazide derivatives I (R = H, tert-Bu, cyclohexyl, Ph, 2-MeOC₆H₄, etc., R¹ = NO₂, Br) were investigated in vitro. The majority of the compounds studied have excellent antibacterial and antioxidant properties. In addition, an in silico investigation was conducted. By calculating ADME-Tox descriptors, all freshly synthesized mols. were shown to have outstanding pharmacokinetic properties, indicating that these derivatives could be used as a basis for the development of some novel active drugs. The SAR (structure-activity relationship) was also briefly described. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Product Details of 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Product Details of 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Olefin-Oriented Selective Synthesis of Linear and Branched N-Alkylated Heterocycles by Hydroamination was written by Sushmita;Aggarwal, Trapti;Saini, Kapil Mohan;Verma, Akhilesh K.. And the article was included in European Journal of Organic Chemistry in 2020.Formula: C4H7NS The following contents are mentioned in the article:

An effective base-induced selective approach for the synthesis of linear and branched N-alkylated heterocycles by hydroamination of olefins has been described. The designed C-N bond formation method was directed through the olefin, as with styrenes only linear N-alkylated product was obtained, and acrylates gave linear as well as branched alkylated heterocycles. This protocol provided the synthesis of exclusive N-alkylated product instead of the C-3 Michael addition product. The reaction was also compatible with Ph vinyl sulfone, thus leading to the formation of sulfone substituted heterocycles in good yield. Further, the method was utilized for the synthesis of medicinally important analogs of CB1 Cannabinoid receptor and Dimebon analog in short reaction sequence. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Olefin-Oriented Selective Synthesis of Linear and Branched N-Alkylated Heterocycles by Hydroamination was written by Sushmita;Aggarwal, Trapti;Saini, Kapil Mohan;Verma, Akhilesh K.. And the article was included in European Journal of Organic Chemistry in 2020.Formula: C4H7NS The following contents are mentioned in the article:

An effective base-induced selective approach for the synthesis of linear and branched N-alkylated heterocycles by hydroamination of olefins has been described. The designed C-N bond formation method was directed through the olefin, as with styrenes only linear N-alkylated product was obtained, and acrylates gave linear as well as branched alkylated heterocycles. This protocol provided the synthesis of exclusive N-alkylated product instead of the C-3 Michael addition product. The reaction was also compatible with Ph vinyl sulfone, thus leading to the formation of sulfone substituted heterocycles in good yield. Further, the method was utilized for the synthesis of medicinally important analogs of CB1 Cannabinoid receptor and Dimebon analog in short reaction sequence. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Formula: C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Formula: C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identifying new lead structures to enhance tolerance towards drought stress via high-throughput screening giving crops a quantum of solace was written by Frackenpohl, Jens;Schneider, Linn;Decker, Luka J. B.;Dittgen, Jan;Fenkl, Franz;Fischer, Christian;Franke, Jana;Freigang, Joerg;Getachew, Rahel;Gonzalez Fernandez-Nino, Susana M.;Helmke, Hendrik;Hills, Martin J.;Hohmann, Sabine;Kleemann, Jochen;Kurowski, Karoline;Lange, Gudrun;Luemmen, Peter;Meyering, Nicole;Poree, Fabien;Schmutzler, Dirk;Wrede, Sebastian. And the article was included in Bioorganic & Medicinal Chemistry in 2019.SDS of cas: 2253-73-8 The following contents are mentioned in the article:

Novel synthetic lead structures interacting with RCAR/(PYR/PYL) receptor proteins were identified based on the results of a high-throughput screening campaign of a large compound library followed by focused SAR studies of the three most promising hit clusters. While indolinylmethyl sulfonamides 8y,z and phenylsulfonyl ethylenediamines 9y,z showed strong affinities for RCAR/ (PYR/PYL) receptor proteins in wheat, thiotriazolyl acetamides 7f,s exhibited promising efficacy against drought stress in vivo (wheat, corn and canola) combined with confirmed target interaction in wheat and arabidopsis thaliana. Remarkably, binding affinities of several representatives of 8 and 9 were on the same level or even better than the essential plant hormone abscisic acid (ABA). This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8SDS of cas: 2253-73-8).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.SDS of cas: 2253-73-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identifying new lead structures to enhance tolerance towards drought stress via high-throughput screening giving crops a quantum of solace was written by Frackenpohl, Jens;Schneider, Linn;Decker, Luka J. B.;Dittgen, Jan;Fenkl, Franz;Fischer, Christian;Franke, Jana;Freigang, Joerg;Getachew, Rahel;Gonzalez Fernandez-Nino, Susana M.;Helmke, Hendrik;Hills, Martin J.;Hohmann, Sabine;Kleemann, Jochen;Kurowski, Karoline;Lange, Gudrun;Luemmen, Peter;Meyering, Nicole;Poree, Fabien;Schmutzler, Dirk;Wrede, Sebastian. And the article was included in Bioorganic & Medicinal Chemistry in 2019.Synthetic Route of C4H7NS The following contents are mentioned in the article:

Novel synthetic lead structures interacting with RCAR/(PYR/PYL) receptor proteins were identified based on the results of a high-throughput screening campaign of a large compound library followed by focused SAR studies of the three most promising hit clusters. While indolinylmethyl sulfonamides 8y,z and phenylsulfonyl ethylenediamines 9y,z showed strong affinities for RCAR/ (PYR/PYL) receptor proteins in wheat, thiotriazolyl acetamides 7f,s exhibited promising efficacy against drought stress in vivo (wheat, corn and canola) combined with confirmed target interaction in wheat and arabidopsis thaliana. Remarkably, binding affinities of several representatives of 8 and 9 were on the same level or even better than the essential plant hormone abscisic acid (ABA). This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Synthetic Route of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Synthetic Route of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Environment-friendly and efficient synthesis of 2-aminobenzo-oxazoles and 2-aminobenzothiazoles catalyzed by Vitreoscilla hemoglobin incorporating a cobalt porphyrin cofactor was written by Xu, Yaning;Li, Fengxi;Zhao, Nan;Su, Jiali;Wang, Chunyu;Wang, Ciduo;Li, Zhengqiang;Wang, Lei. And the article was included in Green Chemistry in 2021.Synthetic Route of C4H7NS The following contents are mentioned in the article:

In this study, an environment-friendly and efficient artificial Vitreoscilla Hb (VHb) for the synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles has been reported. Authors demonstrate an expression-based porphyrin substitution strategy to produce VHb containing cobalt porphyrin instead of native hemin, which can catalyze the oxidative cyclization of corresponding 2-aminobenzoxazoles and 2-aminobenthiazoles with up to 97% yield and 4850 catalytic turnovers in water under aerobic conditions. Hence, authors provide a green and mild method for the synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles. In addition, authors indicate the value of porphyrin ligand substitution as a strategy to tune and enhance the catalytic properties of hemoproteins in non-natural reactions. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Synthetic Route of C4H7NS).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Synthetic Route of C4H7NS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Environment-friendly and efficient synthesis of 2-aminobenzo-oxazoles and 2-aminobenzothiazoles catalyzed by Vitreoscilla hemoglobin incorporating a cobalt porphyrin cofactor was written by Xu, Yaning;Li, Fengxi;Zhao, Nan;Su, Jiali;Wang, Chunyu;Wang, Ciduo;Li, Zhengqiang;Wang, Lei. And the article was included in Green Chemistry in 2021.Safety of Isopropylisothiocyanate The following contents are mentioned in the article:

In this study, an environment-friendly and efficient artificial Vitreoscilla Hb (VHb) for the synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles has been reported. Authors demonstrate an expression-based porphyrin substitution strategy to produce VHb containing cobalt porphyrin instead of native hemin, which can catalyze the oxidative cyclization of corresponding 2-aminobenzoxazoles and 2-aminobenthiazoles with up to 97% yield and 4850 catalytic turnovers in water under aerobic conditions. Hence, authors provide a green and mild method for the synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles. In addition, authors indicate the value of porphyrin ligand substitution as a strategy to tune and enhance the catalytic properties of hemoproteins in non-natural reactions. This study involved multiple reactions and reactants, such as Isopropylisothiocyanate (cas: 2253-73-8Safety of Isopropylisothiocyanate).

Isopropylisothiocyanate (cas: 2253-73-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Safety of Isopropylisothiocyanate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics