Category: 2044-85-1

Shen, Hao published the artcileOriented immobilization of enzyme-DNA conjugates on magnetic Janus particles for constructing a multicompartment multienzyme system with high activity and stability, HPLC of Formula: 2044-85-1, the main research area is immobilization enzyme DNA magnetic Janus particle.

Various organelles (e.g., mitochondria and chloroplasts) have a multicompartment structure, providing superior function of material transformation, selective segregation and energy conversion. Enlightened by the elegant evolution of nature, intended isolation of the biochem. process by cooperative multicompartments in cells has become an appealing blueprint to construct bioreactors. In this study, we develop a “”soft separation”” way to establish a delicate multicompartment multienzyme system (MMS) with polyphenol-encapsulated enzyme-DNA conjugates, which are anchored on magnetic Janus particles, providing a biomimetic catalysis network with the model cascade reactions in confinement. The well-designed MMS exhibits preferable bioactivity benefitting from the dependable DNA bridges and the oriented immobilization of enzymes, while the polyphenol shell further protects the anchored enzymes from exterior attacks, such as heat and enzymic degradation Moreover, by applying the MMS as nanomotors, the asym. distribution of enzymes on Janus particles is found to improve mutual elevation between the self-driven locomotion and enzyme-mediated reactions, delivering enhanced dispersal ability and bioactivity. Owing to the excellent enzymic activity, promoted stability and satisfying biocompatibility, the assembled MMS is proved to be promising for the in vitro and intracellular sensing of glucose, showing significant potential for biochem. anal. applications.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about Blood analysis. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, HPLC of Formula: 2044-85-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Masi, Marco published the artcileIsolation and Biological Characterization of Homoisoflavanoids and the Alkylamide N-p-Coumaroyltyramine from Crinum biflorum Rottb., an Amaryllidaceae Species Collected in Senegal, Related Products of esters-buliding-blocks, the main research area is Isolation Biol Homoisoflavanoids Alkylamide Crinum biflorum; Crinum biflorum; alkylamides; antidiabetic and anti-acetylcholinesterase activities; antioxidant; cytotoxicity; homoisoflavanoids.

Four homoisoflavonoids (1-4) and one alkylamide (5) were isolated and characterized as 5,6,7-trimethoxy-3-(4-hydroxybenzyl)chroman-4-one (1), as 3-hydroxy-5,6,7-trimethoxy-3-(4-hydroxybenzyl)chroman-4-one (2), as 3-hydroxy-5,6,7-trimethoxy-3-(4-methoxybenzyl)chroman-4-one (3) and as 5,6,7-trimethoxy-3-(4-methoxybenzyl)chroman-4-one (4), and the alkylamide as (E)-N-(4-hydroxyphenethyl)-3-(4-hydroxyphenyl)acrylamide (5), commonly named N-p-coumaroyltyramine. The relative configuration of compound 1 was verified thanks to the X-ray anal. which also allowed us to confirm its racemic nature. The absolute configurations of compounds 2 and 3 were assigned by comparing their ECD spectra with those previously reported for urgineanins A and B. Flavanoids 1, 3 and 4 showed promising anticancer properties being cytotoxic at low micromolar concentrations towards HeLa and A431 human cancer cell lines. The N-p-coumaroyltyramine (5) was selectively toxic to A431 and HeLa cancer cells while it protected immortalized HaCaT cells against oxidative stress induced by hydrogen peroxide. Compounds 1-4 also inhibited acetylcholinesterase activity with compound 3 being the most potent. The anti-amylase and the strong anti-glucosidase activity of compound 5 were confirmed. Our results show that C. biflorum produces compounds of therapeutic interest with anti-diabetic, anti-tumoral and anti-acetylcholinesterase properties.

Biomolecules published new progress about Amaryllidaceae. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, Related Products of esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Binbin published the artcileActivatable smart nanoprobe for sensitive endogenous MMP2 detection and fluorescence imaging-guided phototherapies, Recommanded Product: 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, the main research area is activatable smart nanoprobe MMP2 fluorescence imaging guided phototherapy synergism.

A stimuli-activatable theranostic system enabling selective imaging and controlled phototherapies is highly essential for precise cancer diagnosis and treatment. Herein, we designed a smart theranostic nanoprobe that comprised a photosensitizer (PS), gold nanorods (AuNRs) and a matrix metalloproteinase 2 (MMP2)-responsive peptide linker. Apart from being applied for photodynamic therapy (PDT), PS has also been widely used for fluorescence imaging. Spatiotemporal control of the photoactivity of PS is of great importance for cancer theranostics. In the present work, due to the presence of Förster resonance energy transfer (FRET) between PS and AuNRs, the fluorescence and 1O2 production of PS were suppressed during the circulation, avoiding adverse damage to normal tissues; however, the nanoprobe could be activated for targeted imaging and selective PDT when the peptide linker was cleaved by overexpressed MMP2 in cancer cells. More importantly, the restored fluorescence could be successfully used to quant. detect MMP2 with a detection limit of 29 pM and to light up cancer cells, further guiding synergistically activated PDT/PTT (photothermal therapy) for highly efficient and special killing of cancer cells. This study can help design smart cancer-related biomarker-activatable theranostic probes for mol. sensing and site-specific cancer treatment.

Inorganic Chemistry Frontiers published new progress about Biocompatibility. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, Recommanded Product: 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Hao published the artcileUltra-stable tellurium-doped carbon quantum dots for cell protection and near-infrared photodynamic application, Computed Properties of 2044-85-1, the main research area is cervical cancer tellurium carbon quantum dot near IR photodynamic.

It is important to regulate the concentration of reactive oxygen species (ROS) in cells since they play important roles in metabolism Thus, developing nanoreagents to control the ROS is critical Herein, tellurium-doped carbon quantum dots (Te-CDs) were developed by a simple and efficient hydrothermal method, which can scavenge H2O2 to protect cells under ambient condition, but generate ·OH under 808 nm irradiation as photodynamic application. This contribution presented a kind of novel CDs with dual-functions, which can potentially regulate ROS under different conditions.

Science Bulletin published new progress about Biocompatibility. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, Computed Properties of 2044-85-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wei, Zhiwei published the artcilePhotoenhanced Dual-Functional Nanomedicine for Promoting Wound Healing: Shifting Focus from Bacteria Eradication to Host Microenvironment Modulation, Application In Synthesis of 2044-85-1, the main research area is dual functional nanomedicine bacteria eradicationmicroenvironment modulation; chemo-photothermal disinfection; dual-functional nanomedicine; host microenvironment regulation; photoenhanced ROS scavenging activity; wound healing.

Pathogenic bacterial infection has become a serious medical threat to global public health. Once the skin has serious defects, bacterial invasion and the following chain reactions will be a thorny clin. conundrum, which takes a long time to heal. Although various strategies have been used to eradicate bacteria, the treatment which can simultaneously disinfect and regulate the infection-related host responses is rarely reported. Herein, inspired by the host microenvironment, a photoenhanced dual-functional nanomedicine is constructed (Hemin@Phmg-TA-MSN) for localized bacterial ablation and host microenvironment modulation. The “”NIR-triggered local microthermal therapy”” and pos. charged surface endow the nanomedicine with excellent bacterial capture and killing activities. Meanwhile, the nanomedicine exhibits broad-spectrum reactive oxygen species (ROS) scavenging activity via the synergistic effect of hemin and tannic acid with photoenhanced electron and hydrogen transfers. Furthermore, the in vivo experiments demonstrate that the dual-functional nanomedicine not only presents robust bacterial eradication capability, but also triggers the oxidative stress and inflammatory microenvironment regulation. The work not only shows a facile and effective way for infected wound management but also provides a new horizon for designing novel and efficient anti-infection therapy shifting focus from bacteria treatment to host microenvironment modulation.

ACS Applied Materials & Interfaces published new progress about Biocompatibility. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, Application In Synthesis of 2044-85-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Qingbo published the artcileManganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis inhypoxic tumors, Category: esters-buliding-blocks, the main research area is manganese porphyrin metal organic framework sonodynamic therapy ferroptosis; GSH depletion; catalase-like activity; ferroptosis; metal-organic framework; reactive oxygen species; sonodynamic therapy.

Development of efficient therapeutic strategy to incorporate ultrasound (US)-triggered sonodynamic therapy (SDT) and ferroptosis is highly promising in cancer therapy. However, the SDT efficacy is severely limited by the hypoxia and high glutathione (GSH) in the tumor microenvironment, and ferroptosis is highly associated with reactive oxygen species (ROS) and GSH depletion. A manganese porphyrin-based metal-organic framework (Mn-MOF) was constructed as a nanosensitizer to self-supply oxygen (O2) and decrease GSH for enhanced SDT and ferroptosis. In vitro and in vivo anal., including characterization, O2 generation, GSH depletion, ROS generation, lipid peroxidation, antitumor efficacy and tumor immune microenvironment were systematically evaluated. Mn-MOF exhibited catalase-like and GSH decreasing activity in vitro. After efficient internalization into cancer cells, Mn-MOF persistently catalyzed tumor-overexpressed H2O2 to in-situ produce O2 to relieve tumor hypoxia and decrease GSH and GPX4, which facilitated the formation of ROS and ferroptosis to kill cancer cells upon US irradiation in hypoxic tumors. Thus, strong anticancer and anti-metastatic activity was found in H22 and 4T1 tumor-bearing mice after a single administration of Mn-MOF upon a single US irradiation In addition, Mn-MOF showed strong antitumor immunity and improved immunosuppressive microenvironment upon US irradiation by increasing the numbers of activated CD8+ T cells and matured dendritic cells and decreaing the numbers of myeloid-derived suppressor cells in tumor tissues. Mn-MOF holds great potential for hypoxic cancer therapy.

Theranostics published new progress about Antitumor agents. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reiniers, Megan J. published the artcileAnalysis and optimization of conditions for the use of 2′,7′-dichlorofluorescein diacetate in cultured hepatocytes, HPLC of Formula: 2044-85-1, the main research area is hepatocyte oxidative stress 2 7 dichlorofluorescein diacetate optimization; anoxia and reoxygenation; cellular uptake and export; fluorogenic redox probe; hepatocytes; intravital fluorescence imaging; liver diseases; oxidative and nitrosative stress.

Numerous liver pathologies encompass oxidative stress as mol. basis of disease. The use of 2′,7′-dichlorodihydrofluorescein-diacetate (DCFH2-DA) as fluorogenic redox probe is problematic in liver cell lines because of membrane transport proteins that interfere with probe kinetics, among other reasons. The properties of DCFH2-DA were analyzed in hepatocytes (HepG2, HepaRG) to characterize methodol. issues that could hamper data interpretation and falsely skew conclusions. Experiments were focused on probe stability in relevant media, cellular probe uptake/retention/excretion, and basal oxidant formation and metabolism DCFH2-DA was used under optimized exptl. conditions to intravitally visualize and quantify oxidative stress in real-time in HepG2 cells subjected to anoxia/reoxygenation. The most important findings were that: (1) the non-fluorescent DCFH2-DA and the fluorescent DCF are rapidly taken up by hepatocytes, (2) DCF is poorly retained in hepatocytes, and (3) DCFH2 oxidation kinetics are cell type-specific. Furthermore, (4) DCF fluorescence intensity was pH-dependent at pH < 7 and (5) the stability of DCFH2-DA in cell culture medium relied on medium composition The use of DCFH2-DA to measure oxidative stress in cultured hepatocytes comes with methodol. and tech. challenges, which were characterized and solved. Optimized in vitro and intravital imaging protocols were formulated to help researchers conduct proper experiments and draw robust conclusions. Antioxidants published new progress about Antitumor agents. 2044-85-1 belongs to class esters-buliding-blocks, name is 2',7'-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl diacetate, and the molecular formula is C24H14Cl2O7, HPLC of Formula: 2044-85-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abeesh, Prathapan published the artcilePreparation and characterization of beta sitosterol encapsulated nanoliposomal formulation for improved delivery to cancer cells and evaluation of its anti-tumor activities against Daltons Lymphoma Ascites tumor models, Application of 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, the main research area is beta sitosterol nanoliposome lymphoma cell apoptosis tumor mitigation.

Beta sitosterol (BS) is a dietary phytosterol with promising therapeutic applications. The low bioavailability and rapid degradation of BS is the main challenges for their use in the food and pharmaceutical industries. Liposome mediated drug delivery systems are the useful approaches to improve the biopharmaceutical properties of BS. In this study, we had prepared nanoliposome encapsulated beta sitosterol (LBS) with improved bioavailability and stability. The prepared nanoliposomes had spherical vesicles, with mean particle size of 114.5 nm and had an encapsulation efficiency of 86%. Our in vitro study results showed that LBS treatment could induce apoptosis in lymphoma cell lines as evidenced by acridine orange/ethidium bromide and nuclear staining. Our in vivo studies involving exptl. tumor models revealed that LBS treatment could significantly (p < 0.01) reduce the tumor loads, improve the survival rate, and stabilize the body weights in Dalton's Lymphoma Ascites (DLA) tumor bearing mice when compared to BS. Hematol. and serum biochem. parameters also improved significantly (p < 0.01) after LBS administration than free drug. The overall study results revealed that LBS exhibits promising therapeutic efficacy in comparison with non-encapsulated BS in regulating exptl. tumor development as well as induction of lymphoma cell apoptosis. Journal of Drug Delivery Science and Technology published new progress about Antitumor agents. 2044-85-1 belongs to class esters-buliding-blocks, name is 2',7'-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl diacetate, and the molecular formula is C24H14Cl2O7, Application of 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nguyen, Duc Ba published the artcileApplication of plasma jet to the inhibition of the proliferation of hepatic malignant cells via reactive oxygen species generation, Safety of 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, the main research area is hepatic malignant cell proliferation dielec barrier plasma jet discharge.

In vitro treatment of hepatic malignant cells with plasma-activated medium conjugated with gemcitabine was investigated with a He plasma jet generated by a two-ring dielec. barrier discharge (DBD) reactor. The DBD reactor was operated by high-voltage pulses of alternating polarity (frequency: 20 kHz; pulse width: 4 us). The electron d. of plasma plume was estimated to be 9×1012 to 10×1012 cm-3, and the jet temperature was around 36°C. The plasma jet exhibited the inhibitory effects on the growth of hepatic malignant cells via the generation of reactive oxygen species, which could be potentially applicative in anticancer therapies. The optimization of the operating parameters and configuration of the plasma jet would help increase the possibility in practical cancer treatments.

Plasma Processes and Polymers published new progress about Antitumor agents. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, Safety of 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Olvera-Guillen, Roberto published the artcileSupramolecular poly(vinyl alcohol)-folate structure as functional layer and colloidal stabilizer of poly(vinyl acetate) nanoparticles with potential use as nanocarrier for hydrophobic antitumor agents, Formula: C24H14Cl2O7, the main research area is polyvinyl alc acetate folate nanoparticle stabilizer hydrophobic antitumor agent.

Poly(vinyl acetate) nanoparticles 50 ± 20 nm in diameter were synthesized by emulsion polymerization using poly(vinyl alc.) (PVA) as stabilizer, loaded with eugenol and phys. functionalized with folate in a post-reaction step. Interfacial tension and zeta potential measurements were done to provide evidence about the association between PVA and folate. In order to obtain the target particle size, the effect of the PVA molar mass on the colloidal stability of the latex was studied. The cytotoxic effect of these NPs was evaluated in vitro in the breast triple-neg. cancer cell line MDA-MB-231, and an apoptosis/necrosis assay by flow cytometry was carried out. The capability of the nanocarrier to increase the production of reactive oxygen species in cancer cells was determined by flow cytometry. Nanotoxicol. assessments of the NPs revealed that unloaded NPs were not cytotoxic, that functionalized-loaded NPs induced a decrease in cell viability by up to 70%, and that they induced apoptosis of breast cancer cells due to oxidative stress damage. Cytotoxicity significantly decreased in the absence of folate, suggesting the success of the phys. functionalization in the receptor-mediated drug delivery mechanism.

Journal of Nanoparticle Research published new progress about Antitumor agents. 2044-85-1 belongs to class esters-buliding-blocks, name is 2′,7′-Dichloro-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-diyl diacetate, and the molecular formula is C24H14Cl2O7, Formula: C24H14Cl2O7.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics