Category: 19788-49-9

Xia, Yong published the artcileDiversity-Oriented Desulfonylative Functionalization of Alkyl Allyl Sulfones, HPLC of Formula: 19788-49-9, the publication is Angewandte Chemie, International Edition (2019), 58(29), 9836-9840, database is CAplus and MEDLINE.

The diversity-oriented desulfonylative functionalization of alkyl allyl sulfones with various sulfone-type reagents by radical chem. has been developed. The readily installed allylsulfonyl moiety acts as a C-radical precursor, which is substituted by various functionalities using sulfur-based radical trapping reagents. The generality of this approach is documented by the successful desulfonylative alkynylation, azidation, trifluoromethylthiolation, sulfenylation, trifluoromethylselenylation, halogenation, and deuteration. The method is compatible with a wide range of functional groups. Considering the deuteration, products are obtained in good yields with a high level of deuterium incorporation.

Angewandte Chemie, International Edition published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C13H18N2, HPLC of Formula: 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sourabie, Alain M. published the artcileIdentification of a Powerful Aroma Compound in Munster and Camembert Cheeses: Ethyl 3-Mercaptopropionate, Synthetic Route of 19788-49-9, the publication is Journal of Agricultural and Food Chemistry (2008), 56(12), 4674-4680, database is CAplus and MEDLINE.

With the view to investigate the presence of thiols in cheese, the use of different methods of preparation and extraction with an organomercuric compound (p-hydroxymercuribenzoate) enabled the isolation of a new compound The anal. of cheese extracts by gas chromatog. coupled with pulse flame photometry, mass spectrometry, and olfactometry detections led to the identification of Et 3-mercaptopropionate in Munster and Camembert cheeses. This compound, described at low concentrations as having pleasant, fruity, grapy, rhubarb, and empyreumatic characters, has previously been reported in wine and Concord grape but was never mentioned before in cheese. A possible route for the formation of this compound in relation with the catabolism of sulfur amino acids is proposed.

Journal of Agricultural and Food Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C10H12O4S, Synthetic Route of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sourabie, A. M. published the artcileRecent advances in volatile sulfur compounds in cheese: thiols and thioesters, Recommanded Product: Ethyl 2-mercaptopropanoate, the publication is ACS Symposium Series (2011), 119-135, database is CAplus.

A review. Among the numerous compounds involved in cheese aroma, sulfur compounds are of particular interest because of their very powerful odors and low perception thresholds. Nevertheless, little attention has been focused until now on the possible presence of polyfunctional thiols in cheese, even if these compounds have been found to be associated with the flavor of different foods, including fermented ones. The difficulty in isolating volatile thiols in cheeses is probably due to the complexity of this matrix and to the very low concentrations of these compounds that make them undetectable using classic means. Consequently, different methods of sample preparation followed by extractions with p-hydroxymercuribenzoate were used to investigate the possible occurrence of thiol compounds in ripened cheeses. The anal. of cheese extracts by GC coupled with pulse flame photometry, MS and olfactometry detections made it possible to identify Et 2-mercaptopropionate (ET2MP) and Et 3-mercaptopropionate (ET3MP) in smear and mold-ripened cheeses for the first time. The presence of ET3MP in cheeses at concentrations of around 3 μg/kg, significantly higher than its perception threshold in cream (723 ppt), suggests that this thiol may significantly contribute to the aroma of these cheeses. Concerning other potent odors that contribute to the aroma of numerous cheeses, we also investigated the ability of Brevibacteria strains to produce S-Me thioesters in the presence of (i) methanethiol, (ii) fatty acids, or (iii) branched-chain amino acids as precursors. All the strains studied were able to yield the corresponding S-Me thioesters (i.e., S-Me thioisovalerate from L-leucine) from precursors. It was interesting to note that the data also showed that other S-Me thioesters e.g., S-Me thioacetate or S-Me thioisobutyrate, were also produced following the addition of an individual precursor (e.g., L-leucine). Enzymic and tracing experiments allowed us to propose the catabolic pathways used by the strains to produce S-Me thioesters.

ACS Symposium Series published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C8H15ClN2, Recommanded Product: Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sun, Xianwei published the artcile[1,4]-S- to O-Silyl Migration: Multicomponent Synthesis of α-Thio-Ketones through Chemoselective Transformation of Esters to Ketones with Organolithium Reagents, Recommanded Product: Ethyl 2-mercaptopropanoate, the publication is Chemistry – A European Journal (2013), 19(51), 17589-17594, database is CAplus and MEDLINE.

A [1,4]-S-to-O-silyl migration has been exploited to chemoselectively transform esters into ketones by using organolithium reagents, allowing a multicomponent synthesis of α-(thio)ketones. Mechanistic studies reveal that this migration proceeds in an intramol. manner and is more favorable than a corresponding [1,5]-S-to-O-silyl migration and [1,3]-C-to-O-silyl migration. The resulting α-(thio)alkanone derivatives are valuable building blocks for the synthesis of cyclic or multifunctionalized organosulfur compounds The synthesis of the target compounds was achieved using [(trimethylsilyl)thio]alkanoic acid esters and (alkyl)lithium compounds and alkyl bromides, allyl bromides, iodomethane, propargyl bromide, 2-(bromomethyl)oxirane, 7-oxabicyclo[4.1.0]heptan-2-one (cyclohexene epoxide), etc. as starting materials. The title compounds thus formed included 1-[(phenylmethyl)thio]-2-hexanone, 1-(methylthio)-2-hexanone, 1-[(2-propenyl)thio]-2-propanone, 1-phenyl-2-[(2-propenyl)thio]ethanone, dihydro-3(2H)-thiophenone derivatives The application of this strategy toward a reaction of (thioalkyl)alkanone with amines was demonstrated by the synthesis of 3-(alkylthio)-1H-indole derivatives (Gassman indolization).

Chemistry – A European Journal published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C23H43NP2, Recommanded Product: Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nomura, Naoki published the artcileEmulsion polymerization of vinyl acetate using iodine-transfer and RAFT radical polymerizations, Related Products of esters-buliding-blocks, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2013), 51(3), 534-545, database is CAplus.

This study deals with control of the mol. weight and mol. weight distribution of poly(vinyl acetate) by iodine-transfer radical polymerization and reversible addition-fragmentation transfer (RAFT) emulsion polymerizations as the first example. Emulsion polymerization using Et iodoacetate as the chain transfer agent more closely approximated the theor. mol. weights than did the free radical polymerization Although ¹H NMR spectra indicated that the peaks of α- and ω-terminal groups were observed, the mol. weight distributions show a relatively broad range (M_w/M_n = 2.2-4.0). On the other hand, RAFT polymerizations revealed that the dithiocarbamate 7 is an excellent candidate to control the polymer mol. weight (M_n = 9.1 × 10³, M_w/M_n = 1.48), more so than xanthate 1 (M_n = 10.0 × 10³, M_w/M_n = 1.89) under same condition, with accompanied stable emulsions produced. In the M_n vs. conversion plot, M_n increased linearly as a function of conversion. We also performed seed-emulsion polymerization using poly(nonamethylene L-tartrate) as the chiral polyester seed to fabricate emulsions with core-shell structures. The control of polymer mol. weight and emulsion stability, as well as stereoregularity, is also discussed. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Soelter, Jan published the artcileComputational exploration of molecular receptive fields in the olfactory bulb reveals a glomerulus-centric chemical map, Synthetic Route of 19788-49-9, the publication is Scientific Reports (2020), 10(1), 77, database is CAplus and MEDLINE.

Progress in olfactory research is currently hampered by incomplete knowledge about chem. receptive ranges of primary receptors. Moreover, the chem. logic underlying the arrangement of computational units in the olfactory bulb has still not been resolved. We undertook a large-scale approach at characterizing mol. receptive ranges (MRRs) of glomeruli in the dorsal olfactory bulb (dOB) innervated by the MOR18-2 olfactory receptor, also known as Olfr78, with human ortholog OR51E2. Guided by an iterative approach that combined biol. screening and machine learning, we selected 214 odorants to characterize the response of MOR18-2 and its neighboring glomeruli. We found that a combination of conventional physico-chem. and vibrational mol. descriptors performed best in predicting glomerular responses using nonlinear Support-Vector Regression. We also discovered several previously unknown odorants activating MOR18-2 glomeruli, and obtained detailed MRRs of MOR18-2 glomeruli and their neighbors. Our results confirm earlier findings that demonstrated tunotopy, i.e., glomeruli with similar tuning curves tend to be located in spatial proximity in the dOB. In addition, our results indicate chemotopy, i.e., a preference for glomeruli with similar physico-chem. MRR descriptions being located in spatial proximity. Together, these findings suggest the existence of a partial chem. map underlying glomerular arrangement in the dOB. Our methodol. that combines machine learning and physiol. measurements lights the way towards future high-throughput studies to deorphanise and characterize structure-activity relationships in olfaction.

Scientific Reports published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C12H16O3, Synthetic Route of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Pietrasiak, Ewa published the artcileSynthesis of 2-Substituted Aziridine-2-Carboxylic Esters via Michael-Induced Ring-Closure Strategy, Computed Properties of 19788-49-9, the publication is Synlett (2017), 28(16), 2115-2120, database is CAplus.

A Michael-induced ring-closure (MIRC) strategy allowing the synthesis of 2-substituted aziridine-2-carboxylic esters was presented. A broad spectrum of nucleophiles was applied, leading to large diversity of products which were subjected to further structural modifications. Diastereoselective ring closure was observed in the case of chiral substrates.

Synlett published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Computed Properties of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shi, Shuai published the artcileThree-component radical homo Mannich reaction, Synthetic Route of 19788-49-9, the publication is Nature Communications (2021), 12(1), 1006, database is CAplus and MEDLINE.

By employing a radical process, enolizable aldehydes were utilized as substrates in the three-component radical homo-Mannich reaction for the streamlined synthesis of γ-amino-carbonyl compounds. The electrophilic radicals were generated from thiols HSCHR¹C(O)R² (R¹ = H, Me; R² = Me, EtO, PhCH₂O, 1-adamantyl, Et₂N, etc.) via the desulfurization process facilitated by visible-light, and then added to the electron-rich double bonds of enamines, formed in-situ from aldehydes or ketones R³CH₂C(O)R⁴ [R³ = H, Et, MeSCH₂, Ph, PhCH₂, etc., R⁴ = H; R³ = H, R⁴ = Ph, 3-FC₆H₄, etc.; R³R⁴ = (CH₂)₅, CH₂CHPhCH₂CH₂, CH₂N(CH₂Ph)CH₂CH₂, etc.] and amines R⁵NHR⁶ [R⁵ = Me, R⁶ = H₂C:CHCH₂, PhCH₂, cyclohexyl, etc.; R⁵ = PhCH₂, R⁶ = PhCH₂, EtO₂CCH₂, etc.; R⁵R⁶ = (CH₂)₄, CHPh(CH₂)₃, etc.] to provide the products I in a single step. The broad scope, mild conditions, high functional group tolerance, and modularity of this metal-free approach for the synthesis of complex tertiary amine scaffolds will likely be of great utility to chemists in both academia and industry.

Nature Communications published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C6H13N3O2, Synthetic Route of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Huang, Sijia published the artcileChemical recycling of poly(thiourethane) thermosets enabled by dynamic thiourethane bonds, Category: esters-buliding-blocks, the publication is Polymer Chemistry (2020), 11(43), 6879-6883, database is CAplus.

Recycling of polyurethanes is largely infeasible due to the harsh reprocessing conditions and associated risks of side reactions and degradation whereas polymer networks incorporating dynamic covalent bonds represent an attractive approach to the design of recyclable materials. Here, we report findings on the dynamic nature of thiourethanes, and their application as a new class of recyclable analogs of urethane materials. A series of small mol. experiments was initially conducted to determine the equilibrium constant and exchange reaction kinetic constant for the thiol-isocyanate reaction. Furthermore, incorporating those thiourethane moieties into a cross-linked network resulted in thermoset materials that are readily depolymerized to liquid oligomers. The resultant oligomers can be re-crosslinked to thiourethanes without any loss of performance nor change in mech. properties (peak stress of 25 MPa with max strain of 200%). Moreover, the recycled thiol oligomers from thiourethane network polymers could potentially be transformed into other materials with mech. properties that exceed those of the initial, pristine thiourethane materials. Overall, the ease with which these polythiourethanes are polymerized, recycled and reformulated gives a new direction and hope in the design of sustainable polymers.

Polymer Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Markovic, Rade published the artcileAn expedient solvent-free synthesis of (Z)-2-alkylidene-4-oxothiazolidine derivatives under microwave irradiation, COA of Formula: C5H10O2S, the publication is ARKIVOC (Gainesville, FL, United States) (2006), 83-90, database is CAplus.

A new and efficient microwave-assisted synthesis of (Z)-2-alkylidene-4-oxothiazolidines under solvent-free conditions and without solid support, is described. In comparison to conventional technique, exptl. evidence reveals the benefits of the MW-promoted synthesis of functionalized 4-oxothiazolidine derivatives in terms of simple workup, efficiency, and safe reproducibility. The method, as environmentally cleaner, was shown to be potentially applicable to similar chem. processes, such as the preparation of not easily obtainable 4-oxo-1,3-thiazinan-2-ylidenes.

ARKIVOC (Gainesville, FL, United States) published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, COA of Formula: C5H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics