Category: 1877-71-0

Liu, Chengwei published the artcileDecarbonylative Phosphorylation of Carboxylic Acids via Redox-Neutral Palladium Catalysis, COA of Formula: C9H8O4, the publication is Organic Letters (2019), 21(22), 9256-9261, database is CAplus and MEDLINE.

We describe the direct synthesis of organophosphorus compounds from ubiquitous aryl and vinyl carboxylic acids via decarbonylative palladium catalysis. The catalytic system shows excellent scope and tolerates a wide range of functional groups (>50 examples). The utility of this powerful methodol. is highlighted in the late-stage derivatization directly exploiting the presence of the prevalent carboxylic acid functional group. DFT studies provided insight into the origin of high bond activation selectivity and P(O)-H isomerization pathway.

Organic Letters published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, COA of Formula: C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Guodong published the artcileRegioselective C-H Alkylation via Carboxylate-Directed Hydroarylation in Water, Safety of 3-(Methoxycarbonyl)benzoic acid, the publication is Chemistry – A European Journal (2018), 24(18), 4537-4541, database is CAplus and MEDLINE.

In the presence of catalytic [RuCl₂(p-cym)]₂ and using Li₃PO₄ as the base, benzoic acids react with olefins in water to afford the corresponding 2-alkylbenzoic acids in moderate to excellent yields. This C-H alkylation process is generally applicable to diversely substituted electron-rich and electron-deficient benzoic acids, along with α,β-unsaturated olefins including unprotected acrylic acid. The widely available carboxylate directing group can be removed or used for further derivatization. Mechanistic studies revealed that the transformation proceeds via a ruthenacycle intermediate.

Chemistry – A European Journal published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C14H10O4, Safety of 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Garrido-Gonzalez, Jose J. published the artcileAn Enzyme Model Which Mimics Chymotrypsin and N-Terminal Hydrolases, SDS of cas: 1877-71-0, the publication is ACS Catalysis (2020), 10(19), 11162-11170, database is CAplus.

Enzymes are the most efficient and specific catalysts to date. Although they have been thoroughly studied for years, building a true enzyme mimic remains a challenging and necessary task. Here, we show how a three-dimensional geometry anal. of the key catalytic residues in natural hydrolases has been exploited to design and synthesize small-mol. artificial enzymes which mimic the active centers of chymotrypsin and N-terminal hydrolases. The optimized prototype catalyzes the methanolysis of the acyl enzyme mimic with a half-life of only 3.7 min at 20 °C, and it is also able to perform the transesterification of vinyl acetate at room temperature DFT studies and X-ray diffraction anal. of the catalyst bound to a transition state analog proves the similarity with the geometry of natural hydrolases.

ACS Catalysis published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, SDS of cas: 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yang, Jingshu published the artcileCp*Co^III-catalyzed formal [4+2] cycloaddition of benzamides to afford quinazolinone derivatives, Related Products of esters-buliding-blocks, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(92), 13840-13843, database is CAplus and MEDLINE.

A Cp*CoIII-catalyzed arene C-H bond amidation/annulation of benzamides was developed to afford quinazolinone derivatives in one-pot with high yields and broad substrate scope. This method could be applied to the synthesis of quinazolinone drugs and late-stage modification of natural products.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hu, Zhiyong published the artcileRing-Opening Ortho-C-H Allylation of Benzoic Acids with Vinylcyclopropanes: Merging Catalytic C-H and C-C Activation Concepts, Synthetic Route of 1877-71-0, the publication is Organic Letters (2019), 21(17), 6770-6773, database is CAplus and MEDLINE.

A Ru-catalyzed selective and atom-economic ortho-C-H allylation of aromatic acids with vinylcyclopropanes is reported. The reaction proceeds with selective cleavage of both a C-H and a C-C bond. A wide range of allylarenes were synthesized in high yields and stereoselectivities. The vinylcyclopropane substrates can optionally be generated in situ from a diazo compound and 1,3-butadiene. Concise syntheses of isocoumarin and 3,4-dihydroisocoumarin derivatives underline the synthetic utility of the reaction.

Organic Letters published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Synthetic Route of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hu, Xiao-Qiang published the artcileCarboxylate-directed C-H allylation with allyl alcohols or ethers, Formula: C9H8O4, the publication is Chemical Science (2018), 9(23), 5289-5294, database is CAplus and MEDLINE.

A [Ru(p-cymene)Cl₂]₂ catalyst activated allyl alcs. and ethers for the regioselective ortho-C-H allylation of aromatic and heteroaromatic carboxylates. The reaction was orthogonal to most C-H functionalizations with allyl alcs. in that allyl arenes rather than carbonyl compounds were obtained. A wide range of substrates were thus smoothly transformed to allylarenes at 50 ° in phosphate-buffered 2,2,2-trichloroethanol. The reaction concept combined the use of abundant reagents and directing groups in a sustainable, waste-minimized method for C-C bond formation.

Chemical Science published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Formula: C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Guodong published the artcileRhodium-Catalyzed Annelation of Benzoic Acids with α,β-Unsaturated Ketones with Cleavage of C-H, CO-OH, and C-C Bonds, Related Products of esters-buliding-blocks, the publication is Angewandte Chemie, International Edition (2019), 58(19), 6435-6439, database is CAplus and MEDLINE.

In the presence of a [Cp*RhCl₂]₂ catalyst, the Lewis acid In(OTf)₃, and the mild base Na₂CO₃, aromatic carboxylates and α,β-unsaturated ketones undergo a unique hydroarylation/Claisen/retro-Claisen process to give the corresponding indanones. In this carboxylate-directed ortho-C-H annelation, the C-COR bond of the ketone and the CO-OH group of the aromatic carboxylate are cleaved, and the hydroxy group is transferred from the aromatic to the aliphatic acyl residue. This reactivity is synthetically useful, particularly when starting from cyclic ketones, which are converted into indanones bearing aliphatic carboxylate side chains, thus greatly increasing the mol. complexity of aromatic carboxylates in a single step.

Angewandte Chemie, International Edition published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C12H16O3, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gevorgyan, Ashot published the artcileFormal C-H Carboxylation of Unactivated Arenes, Safety of 3-(Methoxycarbonyl)benzoic acid, the publication is Chemistry – A European Journal (2020), 26(27), 6064-6069, database is CAplus and MEDLINE.

A formal C-H carboxylation of unactivated arenes e.g., I using CO₂ in green solvents is described. The present strategy combines a sterically controlled Ir-catalyzed C-H borylation followed by a Cu-catalyzed carboxylation of the in situ generated organoboronates. The reaction is highly regioselective for the C-H carboxylation of unactivated arenes e.g., I (1,3-disubstituted and 1,2,3-trisubstituted benzenes, 1,2- or 1,4-sym. substituted benzenes, fluorinated benzenes and different heterocycles). The developed methodol. was applied to the late-stage C-H carboxylation of com. drugs and ligands.

Chemistry – A European Journal published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Safety of 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Yunqi published the artcileModification and biological evaluation of a series of 1,5-diaryl-1,2,4-triazole compounds as novel agents against pancreatic cancer metastasis through targeting myoferlin, Category: esters-buliding-blocks, the publication is Journal of Medicinal Chemistry (2019), 62(10), 4949-4966, database is CAplus and MEDLINE.

Pancreatic cancer is one of the most common cancers with an extremely low survival rate. Metastasis, as one of the key reasons of cancer-related death, is found in more than 50% pancreatic cancer patients at diagnosis. Novel therapeutic targets and drugs blocking cancer metastasis are urgently needed. Herein, we report a series of 1,5-diaryl-1,2,4-triazole derivatives as potent antimetastatic agents. Lead compound 3-(3-ethyl-5-(5-methoxy-2-pyrimidinyl)-1H-1,2,4-triazolyl)-N-(4-phenylbutyl)benzamide (6y) displayed effective antimetastatic activities in pancreatic cancer in vitro and in vivo. Concomitant studies indicated that 6y probably binds with myoferlin (MYOF), a novel potential antitumor metastasis target, which regulates vesicle trafficking and metastasis-related proteins. Subsequent biophys. and biochem. methods verified that 6y bound to MYOF. Mechanism studies revealed that 6y inhibited pancreatic cancer metastasis through reversing the epithelial mesenchymal transition, inhibiting the secretions of matrix metalloproteinase and blocking the receptor tyrosine kinases. Our findings suggest that targeting MYOF with 6y may be a promising therapeutic strategy to prevent pancreatic cancer metastasis.

Journal of Medicinal Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Choudhary, A. published the artcileCorrelation analysis of reactivity in the oxidation of substituted benzaldehydes by quinolinium chlorochro mate: a kinetic approach, SDS of cas: 1877-71-0, the publication is International Journal of Chemistry (Mumbai, India) (2016), 5(2), 189-200, database is CAplus.

Oxidation of thirty six mo nosubsti tuted benzaldehydes by quinolinium chlorochromate (QCC) in dimethylsulfoxide (DMSO), leads to the formation of corresponding benzoic acids. The reaction is of first order with respect to QCC. A Michaelis-Menten type kinetics was observed with respect to the reactants. The reaction is promoted by hydrogen ions; the hydrogen ion dependence has the form k_obs = a + b[H⁺]. The oxidation of benzaldehyde (PhCDO) exhibited a substantial primary kinetic isotope effect. The reaction was studied in nineteen different organic solvents and the efiect of solvent was analyzed using Taft’s and Swain’s main-parametric equations. The rates of the oxidation of para and meta substituted benzaldehydes showed excellent correlation in terms of Charton’s triparametric LDR equation, whereas the oxidation of ortho-substi tu ted benzaldehydes were correlated well with tetraperametric LDRS equation. The oxidation of para-substituted benzaldehydes is more susceptible to the delocalized effect than the oxidation of ortho- and meta-substituted compounds, which display a greater dependence on the field effect. The pos. value of h suggests the presence of an electron-deficient reaction center in the rate-determining step. The reaction is subjected to steric acceleration by the ortho-substituents. A suitable mechanism has been proposed.

International Journal of Chemistry (Mumbai, India) published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, SDS of cas: 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics