Category: 1877-71-0

Ortiz, Pablo published the artcileCopper-Catalyzed Enantioselective Alkylation of Enolizable Ketimines with Organomagnesium Reagents, Category: esters-buliding-blocks, the publication is Angewandte Chemie, International Edition (2017), 56(11), 3041-3044, database is CAplus and MEDLINE.

Inexpensive and readily available organomagnesium reagents were used for the catalytic enantioselective alkylation of enolizable N-sulfonyl ketimines [e.g., I + HexMgBr → II (71% yield, 74% ee)]. The low reactivity and competing enolization of the ketimines was overcome by the use of a copper-phosphine chiral catalyst, which also rendered the transformation highly chemoselective and enantioselective for a broad range of ketimine substrates.

Angewandte Chemie, International Edition published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Serafini, Marta published the artcileStore-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors, Product Details of C9H8O4, the publication is Journal of Medicinal Chemistry (2020), 63(23), 14761-14779, database is CAplus and MEDLINE.

Store-operated calcium entry (SOCE) is important in the maintenance of calcium homeostasis and alterations in this mechanism are responsible for several pathol. conditions, including acute pancreatitis. Since the discovery of SOCE, many inhibitors have been identified and extensively used as chem. probes to better elucidate the role played by this cellular mechanism. Nevertheless, only a few have demonstrated drug-like properties so far. Here, we report a class of biphenyl triazoles among which stands out a lead compound, 34, that is endowed with an inhibitory activity at nanomolar concentrations, suitable pharmacokinetic properties, and in vivo efficacy in a mouse model of acute pancreatitis.

Journal of Medicinal Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C18H14BrNO5S2, Product Details of C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ruzi, Rehanguli published the artcileUpgrading ketone synthesis direct from carboxylic acids and organohalides, Product Details of C9H8O4, the publication is Nature Communications (2020), 11(1), 3312, database is CAplus and MEDLINE.

A photoredox, nickel and phosphoranyl radical synergistic cross-electrophile coupling of com. available chems., aromatic acids RCO₂H (R = 4-methylphenyl, thiophen-3-yl, naphthalen-2-yl, etc.) and aryl/alkyl bromides R¹Br (R¹ = 6-(trifluoromethyl)pyridin-3-yl, 2-cyanoethyl, quinolin-3-yl, etc.) was reported. This allows for concise synthesis of highly functionalized ketones RC(O)R¹directly, without the preparation of activated carbonyl intermediates or organometallic compounds, and thus complements the conventional Weinreb ketone synthesis. Use of the appropriate photocatalyst, ligand amount and solvents can match the reaction rate required by any simple catalytic cycle. The practicality and synthetic robustness of the reaction are illustrated by the facile synthesis of complex ketones from readily available feedstock chems.

Nature Communications published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Product Details of C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ji, Wei-Wei published the artcileHeteroannulation enabled by a bimetallic Rh(III)/Ag(I) relay catalysis: application in the total synthesis of aristolactam BII, Quality Control of 1877-71-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(41), 5665-5668, database is CAplus and MEDLINE.

A redox-neutral bimetallic Rh(III)/Ag(I) relay catalysis allowed the efficient construction of 3-alkylidene isoindolinones and 3-alkylidene isobenzofuranones. The Rh(III) catalyst was responsible for the C-H monofluoroalkenylation reaction, whereas the Ag(I) salt was an activator for the follow-up cyclization. The methodol. developed was applied as a key step in the rapid total synthesis of the natural product aristolactam BII.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Quality Control of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Huang, Yahui published the artcileIdentification of pyrazolopyridine derivatives as novel spleen tyrosine kinase inhibitors, Computed Properties of 1877-71-0, the publication is Archiv der Pharmazie (Weinheim, Germany) (2018), 351(8), n/a, database is CAplus and MEDLINE.

Inhibition of spleen tyrosine kinase (Syk) is a promising strategy for the treatment of various allergic and autoimmune disorders such as asthma, rheumatoid arthritis, and allergic rhinitis. Previously, a Syk inhibitor with novel indazole scaffold was discovered by structure-based virtual screening. Herein, the structure-activity relationship of the indazole Syk inhibitors was investigated. Several new inhibitors demonstrated potent activity against Syk. In particular, compound 18c showed good Syk inhibitory activity (IC₅₀ = 1.2 μM), representing a good lead compound for further optimization.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Computed Properties of 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yu, Jin-Feng published the artcileCu-Mediated Amination of (Hetero)Aryl C-H bonds with NH Azaheterocycles, HPLC of Formula: 1877-71-0, the publication is Angewandte Chemie, International Edition (2019), 58(50), 18141-18145, database is CAplus and MEDLINE.

Direct synthesis of N-(hetero)arylated heteroarenes has been realized through Cu-mediated C-N coupling of NH azaheterocycles with aryl C-H bonds under aerobic conditions. This method features a broad scope of both heterocyclic arenes (pyridine, quinoline, pyrazole, imidazole, furan, thiophene, benzofuran, and indole) and NH azaheterocycles (imidazole, pyrazole, indole, azaindole, purine, indazole, benzimidazole, pyridone, carbazole), providing a versatile method for the synthesis of pharmaceutically important N-(hetero)arylated heteroarenes. The versatility of this reaction was further demonstrated through late-stage modification of marketed drugs and the synthesis of a key intermediate for accessing a class of angiotensin II receptor 1 antagonists.

Angewandte Chemie, International Edition published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C10H15NO, HPLC of Formula: 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ma, Fei published the artcileDNA-Encoded Libraries: Hydrazide as a Pluripotent Precursor for On-DNA Synthesis of Various Azole Derivatives, COA of Formula: C9H8O4, the publication is Chemistry – A European Journal (2021), 27(31), 8214-8220, database is CAplus and MEDLINE.

A phylogenic chem. transformation strategy using DNA-conjugated benzoyl hydrazine as a common versatile precursor in azole chem. expansion of DNA-encoded combinatorial chem. library (DEL) has been described. DNA-compatible reactions deriving from the common benzoyl hydrazines, e.g., I (R = DNA) precursor showed excellent functional group tolerance with exceptional efficiency in the synthesis of various azoles, including oxadiazoles, e.g., II thiadiazoles, and triazoles, under mild reaction conditions. The phylogenic chem. transformation strategy provides DELs a facile way to expand into various unique chem. spaces with privileged scaffolds and pharmacophores.

Chemistry – A European Journal published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, COA of Formula: C9H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shi, Hongwei published the artcileCatalyst- and additive-free sunlight-induced autoxidation of aldehydes to carboxylic acids, Related Products of esters-buliding-blocks, the publication is Green Chemistry (2022), 24(15), 5835-5841, database is CAplus.

A catalyst- and additive-free sunlight-induced strategy for autoxidation of a wide range of aldehydes RCHO (R = Bu, cyclohexyl, Ph, pyridin-3-yl, etc.) to carboxylic acids RC(O)OH is described for the first time. In this oxidation system, air serves as the source of oxygen and sunlight as the light source, and the system includes the advantages of green, highly atom-efficient, and low-cost synthesis. This method was easily applied even at gram scale. The reaction proceeds smoothly even at lower temperature and in natural light.

Green Chemistry published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C8H16O2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Fang, Wan-Yin published the artcileSO₂F₂-Mediated One-Pot Synthesis of Aryl Carboxylic Acids and Esters from Phenols through a Pd-Catalyzed Insertion of Carbon Monoxide, Safety of 3-(Methoxycarbonyl)benzoic acid, the publication is Chemistry – An Asian Journal (2017), 12(17), 2323-2331, database is CAplus and MEDLINE.

A one-pot Pd-catalyzed carbonylation of phenols into their corresponding aryl carboxylic acids and esters through the insertion of carbon monoxide has been developed. This procedure offers a direct synthesis of aryl carboxylic acids and esters from inexpensive and abundant starting materials (phenols, SO₂F₂ and CO) under mild conditions. This method tolerates a broad range of functional groups and is also applicable for the modification of complicated natural products.

Chemistry – An Asian Journal published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, Safety of 3-(Methoxycarbonyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Liu, Ying published the artcileEnhanced photocatalytic activity over flower-like sphere Ag/Ag₂CO₃/BiVO₄ plasmonic heterojunction photocatalyst for tetracycline degradation, HPLC of Formula: 1877-71-0, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2018), 242-254, database is CAplus.

A novel ternary Ag/Ag₂CO₃/BiVO₄ plasmonic heterojunction photocatalyst was successfully fabricated by a precipitation method over BiVO₄, followed by light reduction The obtained composites were characterized by various measurements and the photocatalytic performances of the as-prepared composites were assessed by the degradation of tetracycline (TC) under visible-light illumination. The ternary plasmonic heterojunction photocatalyst exhibits higher and wider absorption in the visible and UV regions than the pure BiVO₄ and it displays superior performance in the degradation of tetracycline. The highest efficiency of Ag/Ag₂CO₃/BiVO₄ photocatalyst to degrade TC is up to 94.9% at 150 min. On the basis of the obtained exptl. results, the probable photocatalytic mechanism of the enhanced activity is discussed. The degradation of tetracycline is not only influenced by ^·OH, but also caused by valence-band holes (h⁺). Therefore, the improved photocatalytic activity of Ag/Ag₂CO₃/BiVO₄ is due to the enhanced absorbance under the visible light, the facilitated charge transfer and the inhibited recombination of electron-hole pairs. The likely degradation pathway was proposed on the basis of the intermediate products detected by GC-MS. Moreover, the surface plasmon resonance and the elec. field enhancement were simulated by the three dimensional finite difference time domain (FDTD) method.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 1877-71-0. 1877-71-0 belongs to esters-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Ester, name is 3-(Methoxycarbonyl)benzoic acid, and the molecular formula is C9H8O4, HPLC of Formula: 1877-71-0.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics