Category: 1877-71-0

Xu, Shujing; Sun, Lin; Dick, Alexej; Zalloum, Waleed A.; Huang, Tianguang; Meuser, Megan E.; Zhang, Xujie; Tao, Yucen; Cherukupalli, Srinivasulu; Ding, Dang; Ding, Xiao; Gao, Shenghua; Jiang, Xiangyi; Kang, Dongwei; De Clercq, Erik; Pannecouque, Christophe; Cocklin, Simon; Liu, Xinyong; Zhan, Peng published an article on January 5 ,2022. The article was titled 《Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability》, and you may find the article in European Journal of Medicinal Chemistry.Recommanded Product: 3-(Methoxycarbonyl)benzoic acid The information in the text is summarized as follows:

Further clin. development of I, a lead compound targeting HIV-1 capsid, is impeded by low antiviral activity and inferior metabolic stability. By modifying the benzene (region I) and indole of I, we identified two potent compounds II [R = propargyl, 4-NH2Ph] with significantly improved metabolic stability. Compared to PF74, II [R = 4-NH2Ph] displayed greater metabolic stability in human liver microsomes (HLMs) with half-life (t1/2) 109-fold that of PF74. Moreover, mechanism of action (MOA) studies demonstrated that II [R = propargyl, 4-NH2Ph] effectively mirrored the MOA of compounds that interact within the I interprotomer pocket, showing direct and robust interactions with recombinant CA, and 7u displaying antiviral effects in both the early and late stages of HIV-1 replication. Furthermore, MD simulation corroborated that II [R = 4-NH2Ph] was bound to the I binding site, and the results of the online molinspiration software predicted that II [R = propargyl, 4-NH2Ph] had desirable physicochem. properties. Unexpectedly, this series of compounds exhibited better antiviral activity than I against HIV-2, represented by compound II [R = propargyl] whose anti-HIV-2 activity was almost 5 times increased potency over I. Therefore, we have rationally redesigned the I chemotype to inhibitors with novel structures and enhanced metabolic stability in this study. We hope that these new compounds can serve as a blueprint for developing a new generation of HIV treatment regimens. The experimental process involved the reaction of 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Recommanded Product: 3-(Methoxycarbonyl)benzoic acid)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Recommanded Product: 3-(Methoxycarbonyl)benzoic acid They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ghazy, Ehab; Heimburg, Tino; Lancelot, Julien; Zeyen, Patrik; Schmidtkunz, Karin; Truhn, Anne; Darwish, Salma; Simoben, Conrad V.; Shaik, Tajith B.; Erdmann, Frank; Schmidt, Matthias; Robaa, Dina; Romier, Christophe; Jung, Manfred; Pierce, Raymond; Sippl, Wolfgang published their research in European Journal of Medicinal Chemistry on December 5 ,2021. The article was titled 《Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis》.COA of Formula: C9H8O4 The article contains the following contents:

In this study, the previously reported benzhydroxamate-based inhibitors I, II [X = H, chloro, methoxy, etc;R = 4-biphenyl, 3-benzyloxyphenyl, 4-propoxyphenyl, etc.] of Schistosoma mansoni histone deacetylase 8 (smHDAC8) were chem. optimized. Crystallog. anal. provided insights into the inhibition mode of smHDAC8 activity by the highly potent inhibitor I[X = methoxy;R = 4-Dibenzofuranyl]. Structure-based optimization of the novel inhibitors was carried out using the available crystal structures as well as docking studies on smHDAC8. The compounds were evaluated in screens for inhibitory activity against schistosome and human HDACs (hHDAC). The in vitro and docking results were used for detailed structure activity relationships. The synthesized compounds were further investigated for their lethality against the schistosome larval stage using a fluorescence-based assay. The most promising inhibitor I[X = methoxy;R = 4-Dibenzofuranyl] showed significant dose-dependent killing of the schistosome larvae and markedly impaired egg laying of adult worm pairs maintained in culture. In the experimental materials used by the author, we found 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0COA of Formula: C9H8O4)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.COA of Formula: C9H8O4 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 1877-71-0On September 15, 2019 ,《Targeting dihydrofolate reductase: Design, synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as nonclassical antifolates and as potential antitumor agents》 was published in European Journal of Medicinal Chemistry. The article was written by Gao, Tianfeng; Zhang, Congying; Shi, Xiaowei; Guo, Ran; Zhang, Kai; Gu, Jianmin; Li, Lin; Li, Shuolei; Zheng, Qianqian; Cui, Mengyu; Cui, Miao; Gao, Xingmei; Liu, Yi; Wang, Lei. The article contains the following contents:

A novel series of 6-substituted pyrrolo[2,3-d]pyrimidines with reversed amide moieties from the lead compound I (R = 4-pyridyl) were designed and synthesized as nonclassical antifolates and as potential antitumor agents. Target compounds II were successfully obtained through two sequential condensation reactions from the key intermediate 2-amino-6-(2-aminoethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one. In preliminary antiproliferation assay, all compounds demonstrated submicromolar to nanomolar inhibitory effects against KB tumor cells, whereas compounds I (R = 2-, 3-, 4-pyridyl) also exhibited nanomolar antiproliferative activities toward SW620 and A549 cells. In particular, compounds I (R = 2-, 3-, 4-pyridyl) were significantly more potent than the pos. control methotrexate (MTX) and pemetrexed (PMX) to A549 cells. The growth inhibition induced cell cycle arrest at G1-phase with S-phase suppression. Along with the results of nucleoside protection assays, inhibition assays of dihydrofolate reductase (DHFR) clearly elucidated that the intracellular target of the designed compounds was DHFR. Mol. modeling studies suggested two binding modes of the target compounds with DHFR. In the part of experimental materials, we found many familiar compounds, such as 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Application of 1877-71-0)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Application of 1877-71-0 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Cu-Mediated Amination of (Hetero)Aryl C-H bonds with NH Azaheterocycles》 was published in Angewandte Chemie, International Edition in 2019. These research results belong to Yu, Jin-Feng; Li, Jian-Jun; Wang, Peng; Yu, Jin-Quan. Application In Synthesis of 3-(Methoxycarbonyl)benzoic acid The article mentions the following:

Direct synthesis of N-(hetero)arylated heteroarenes has been realized through Cu-mediated C-N coupling of NH azaheterocycles with aryl C-H bonds under aerobic conditions. This method features a broad scope of both heterocyclic arenes (pyridine, quinoline, pyrazole, imidazole, furan, thiophene, benzofuran, and indole) and NH azaheterocycles (imidazole, pyrazole, indole, azaindole, purine, indazole, benzimidazole, pyridone, carbazole), providing a versatile method for the synthesis of pharmaceutically important N-(hetero)arylated heteroarenes. The versatility of this reaction was further demonstrated through late-stage modification of marketed drugs and the synthesis of a key intermediate for accessing a class of angiotensin II receptor 1 antagonists. In the part of experimental materials, we found many familiar compounds, such as 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Application In Synthesis of 3-(Methoxycarbonyl)benzoic acid)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Application In Synthesis of 3-(Methoxycarbonyl)benzoic acid Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Name: 3-(Methoxycarbonyl)benzoic acidOn March 28, 2022, Ward, Lucy C.; McCue, Hannah V.; Rigden, Daniel J.; Kershaw, Neil M.; Ashbrook, Chloe; Hatton, Harry; Goulding, Ellie; Johnson, James R.; Carnell, Andrew J. published an article in Angewandte Chemie, International Edition. The article was 《Carboxyl Methyltransferase Catalysed Formation of Mono- and Dimethyl Esters under Aqueous Conditions: Application in Cascade Biocatalysis》. The article mentions the following:

Carboxyl methyltransferase (CMT) enzymes catalyze the biomethylation of carboxylic acids under aqueous conditions and have potential for use in synthetic enzyme cascades. Herein we report that the enzyme FtpM from Aspergillus fumigatus can methylate a broad range of aromatic mono- and dicarboxylic acids in good to excellent conversions. The enzyme shows high regioselectivity on its natural substrate fumaryl-L-tyrosine, trans, trans-muconic acid and a number of the dicarboxylic acids tested. Dicarboxylic acids are generally better substrates than monocarboxylic acids, although some substituents are able to compensate for the absence of a second acid group. For dicarboxylic acids, the second methylation shows strong pH dependency with an optimum at pH 5.5-6. Potential for application in industrial biotechnol. was demonstrated in a cascade for the production of a bioplastics precursor (FDME) from bioderived 5-hydroxymethylfurfural (HMF). In the experiment, the researchers used 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Name: 3-(Methoxycarbonyl)benzoic acid)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Name: 3-(Methoxycarbonyl)benzoic acid They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Deoxygenative Deuteration of Carboxylic Acids with D2O》 was published in Angewandte Chemie, International Edition in 2019. These research results belong to Zhang, Muliang; Yuan, Xiang-Ai; Zhu, Chengjian; Xie, Jin. HPLC of Formula: 1877-71-0 The article mentions the following:

C1-Deuterated aryl and alkyl aldehydes such as 4-PhC6H4CDO and PhCH2CH2CDO were prepared chemoselectively with 58-96% deuterium incorporation by reduction of aromatic and aliphatic carboxylic acids using iridium photocatalysts, either Ph3P or Ph2OEt as an oxygen acceptor, 2,4,6-i-Pr3C6H2SH as a hydrogen atom donor, and using D2O as an inexpensive deuterium source. The method was used for the preparation of deuterated derivatives of pharmaceuticals and natural products containing aromatic carboxylic acid moieties. The method was also used for chemoselective reduction of aryl and alkyl carboxylic acids to the corresponding aldehydes using H2O as a hydrogen atom source. In the experiment, the researchers used many compounds, for example, 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0HPLC of Formula: 1877-71-0)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. Esters are more polar than ethers but less polar than alcohols. HPLC of Formula: 1877-71-0 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zogota, Rimants; Kinena, Linda; Withers-Martinez, Chrislaine; Blackman, Michael J.; Bobrovs, Raitis; Pantelejevs, Teodors; Kanepe-Lapsa, Iveta; Ozola, Vita; Jaudzems, Kristaps; Suna, Edgars; Jirgensons, Aigars published an article on February 1 ,2019. The article was titled 《Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D》, and you may find the article in European Journal of Medicinal Chemistry.Product Details of 1877-71-0 The information in the text is summarized as follows:

Following up the open initiative of anti-malarial drug discovery, a GlaxoSmithKline (GSK) phenotypic screening hit was developed to generate hydroxyethylamine based plasmepsin (Plm) inhibitors exhibiting growth inhibition of the malaria parasite Plasmodium falciparum at nanomolar concentrations Lead optimization studies were performed with the aim of improving Plm inhibition selectivity vs. the related human aspartic protease cathepsin D (Cat D). Optimization studies were performed using Plm IV as a readily accessible model protein, the inhibition of which correlates with anti-malarial activity. Guided by sequence alignment of Plms and Cat D, selectivity-inducing structural motifs were modified in the S3 and S4 sub-pocket occupying substituents of the hydroxyethylamine inhibitors. This resulted in potent anti-malarials with an up to 50-fold Plm IV/Cat D selectivity factor. More detailed investigation of the mechanism of action of the selected compounds revealed that they inhibit maturation of the P. falciparum subtilisin-like protease SUB1, and also inhibit parasite egress from erythrocytes. Our results indicate that the anti-malarial activity of the compounds is linked to inhibition of the SUB1 maturase plasmepsin subtype Plm X. In the experiment, the researchers used 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Product Details of 1877-71-0)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.Product Details of 1877-71-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Angewandte Chemie, International Edition included an article by Zhang, Guodong; Hu, Zhiyong; Belitz, Florian; Ou, Yang; Pirkl, Nico; Goossen, Lukas J.. SDS of cas: 1877-71-0. The article was titled 《Rhodium-Catalyzed Annelation of Benzoic Acids with α,β-Unsaturated Ketones with Cleavage of C-H, CO-OH, and C-C Bonds》. The information in the text is summarized as follows:

In the presence of a [Cp*RhCl2]2 catalyst, the Lewis acid In(OTf)3, and the mild base Na2CO3, aromatic carboxylates and α,β-unsaturated ketones undergo a unique hydroarylation/Claisen/retro-Claisen process to give the corresponding indanones. In this carboxylate-directed ortho-C-H annelation, the C-COR bond of the ketone and the CO-OH group of the aromatic carboxylate are cleaved, and the hydroxy group is transferred from the aromatic to the aliphatic acyl residue. This reactivity is synthetically useful, particularly when starting from cyclic ketones, which are converted into indanones bearing aliphatic carboxylate side chains, thus greatly increasing the mol. complexity of aromatic carboxylates in a single step.3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0SDS of cas: 1877-71-0) was used in this study.

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.SDS of cas: 1877-71-0 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Name: 3-(Methoxycarbonyl)benzoic acidOn September 1, 2019 ,《Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model》 was published in European Journal of Medicinal Chemistry. The article was written by Bollenbach, Maud; Lugnier, Claire; Kremer, Melanie; Salvat, Eric; Megat, Salim; Bihel, Frederic; Bourguignon, Jean-Jacques; Barrot, Michel; Schmitt, Martine. The article contains the following contents:

Herein, a series of aminophthalazine I [R = H, Ph, 1-piperidyl, etc.; R1 = H, CF3; R2 = 3-ClC6H4NH, 4-MeOC6H4CH2NH, Ph(CH2)2NH, etc.] and aminoindazole derivatives II [R3 = H, Cl, CF3; R4 = H, Me, Ph, etc.; R5 = 3-ClC6H4, 4-MeOC6H4CH2, 3-F-4-MeOC6H3CH2, etc.] were synthesized and evaluated for their inhibitory activity toward PDE5. Selectivity profiles towards other PDE1-4 isoenzymes, water solubility and stability in acidic medium of the most potent PDE5 inhibitors were determined and the aminophthalazine I [R = Ph, R1 = CF3, R2 = 4-OMeC6H4CH2NH] and its mimetic compound II [R3 = CF3, R4 = 3-pyridyl, R5 = 4-OMeC6H4CH2NH] were evaluated in comparison to MY 5445 in vivo in a model of neuropathic pain induced by sciatic nerve cuffing in mice (3 and 0.5 mg/kg, i.p. twice a day). Both compounds showed the same efficacy on neuropathic allodynia as MY 5445 and thus produced a significant relief of mech. hypersensitivity after 12 days of treatment. In the experimental materials used by the author, we found 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Name: 3-(Methoxycarbonyl)benzoic acid)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Name: 3-(Methoxycarbonyl)benzoic acid They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Angewandte Chemie, International Edition included an article by Ronson, Thomas O.; Renders, Evelien; Van Steijvoort, Ben F.; Wang, Xubin; Wybon, Clarence C. D.; Prokopcova, Hana; Meerpoel, Lieven; Maes, Bert U. W.. Reference of 3-(Methoxycarbonyl)benzoic acid. The article was titled 《Ruthenium-Catalyzed Reductive Arylation of N-(2-Pyridinyl)amides with Isopropanol and Arylboronate Esters》. The information in the text is summarized as follows:

A new three-component reductive arylation of amides with stable reactants (iPrOH and arylboronate esters), making use of a 2-pyridinyl (Py) directing group, is described. The N-Py-amide substrates are readily prepared from carboxylic acids and PyNH2, and the resulting N-Py-1-arylalkanamine reaction products are easily transformed into the corresponding chlorides by substitution of the HN-Py group with HCl. The 1-aryl-1-chloroalkane products allow substitution and cross-coupling reactions. Therefore, a general protocol for the transformation of carboxylic acids into a variety of functionalities is obtained. The Py-NH2 byproduct can be recycled. In the experiment, the researchers used 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Reference of 3-(Methoxycarbonyl)benzoic acid)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Reference of 3-(Methoxycarbonyl)benzoic acid Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics