Category: 1877-71-0

Safety of 3-(Methoxycarbonyl)benzoic acidOn November 5, 2021 ,《Substitution Effect on 2-(Oxazolinyl)-phenols and 1,2,5-Chalcogenadiazole-Annulated Derivatives: Emission Color-Tunable, Minimalistic Excited-State Intramolecular Proton Transfer (ESIPT)-based Luminophores》 appeared in Journal of Organic Chemistry. The author of the article were Goebel, Dominik; Rusch, Pascal; Duvinage, Daniel; Stauch, Tim; Bigall, Nadja-C.; Nachtsheim, Boris J.. The article conveys some information:

Minimalistic 2-(oxazolinyl)-phenols substituted with different electron-donating and -withdrawing groups as well as 1,2,5-chalcogenadiazole-annulated derivatives thereof were synthesized and investigated toward their emission behavior in solution as well as in the solid state. Depending on the nature of the incorporated substituent and its position, emission efficiencies were increased or diminished, resulting in AIE- or ACQ-characteristics. Single crystal anal. revealed J- and H-type packing motifs and a so far undescribed isolation of ESIPT-based fluorophores in the keto form. The results came from multiple reactions, including the reaction of 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Safety of 3-(Methoxycarbonyl)benzoic acid)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Safety of 3-(Methoxycarbonyl)benzoic acid They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Safety of 3-(Methoxycarbonyl)benzoic acidOn March 14, 2019, Joshi, Sumedh; Fedoseyenko, Dmytro; Mahanta, Nilkamal; Ducati, Rodrigo G.; Feng, Mu; Schramm, Vern L.; Begley, Tadhg P. published an article in ACS Medicinal Chemistry Letters. The article was 《Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis》. The article mentions the following:

Aminofutalosine synthase (MqnE) catalyzes an important rearrangement reaction in menaquinone biosynthesis by the futalosine pathway. We report the identification of previously unreported inhibitors of MqnE using a mechanism-guided approach. The best inhibitor shows efficient inhibitory activity against Helicobacter pylori (IC50 = 1.8 ± 0.4 μM) and identifies MqnE as a promising target for antibiotic development. After reading the article, we found that the author used 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Safety of 3-(Methoxycarbonyl)benzoic acid)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Safety of 3-(Methoxycarbonyl)benzoic acid Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry》 was written by Aprile, Silvio; Riva, Beatrice; Bhela, Irene Preet; Cordero-Sanchez, Celia; Avino, Giulia; Genazzani, Armando A.; Serafini, Marta; Pirali, Tracey. COA of Formula: C9H8O4 And the article was included in ACS Medicinal Chemistry Letters on April 8 ,2021. The article conveys some information:

Store-operated calcium entry (SOCE) is a pivotal mechanism in calcium homeostasis, and, despite still being under investigation, its dysregulation is known to be associated with severe human disorders. SOCE modulators are therefore needed both as chem. probes and as therapeutic agents. While many small mols. have been described so far, their poor properties in terms of drug-likeness have limited their translation into the clin. practice. In this work, we describe the bioisosteric replacement of the ester moiety in pyrazole derivatives with a 1,2,4-oxadiazole ring as a means to afford a class of modulators with high metabolic stability. Moreover, among our derivatives, a compound able to increase the calcium entry was identified, further enriching the library of available SOCE activators. In addition to this study using 3-(Methoxycarbonyl)benzoic acid, there are many other studies that have used 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0COA of Formula: C9H8O4) was used in this study.

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. Esters are more polar than ethers but less polar than alcohols. COA of Formula: C9H8O4 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Serafini, Marta; Cordero-Sanchez, Celia; Di Paola, Rosanna; Bhela, Irene P.; Aprile, Silvio; Purghe, Beatrice; Fusco, Roberta; Cuzzocrea, Salvatore; Genazzani, Armando A.; Riva, Beatrice; Pirali, Tracey published their research in Journal of Medicinal Chemistry on December 10 ,2020. The article was titled 《Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors》.Category: esters-buliding-blocks The article contains the following contents:

Store-operated calcium entry (SOCE) is important in the maintenance of calcium homeostasis and alterations in this mechanism are responsible for several pathol. conditions, including acute pancreatitis. Since the discovery of SOCE, many inhibitors have been identified and extensively used as chem. probes to better elucidate the role played by this cellular mechanism. Nevertheless, only a few have demonstrated drug-like properties so far. Here, we report a class of biphenyl triazoles among which stands out a lead compound, 34, that is endowed with an inhibitory activity at nanomolar concentrations, suitable pharmacokinetic properties, and in vivo efficacy in a mouse model of acute pancreatitis. The experimental process involved the reaction of 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Category: esters-buliding-blocks)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Category: esters-buliding-blocks They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Saha, Rajib; Sekar, Govindasamy published their research in Applied Catalysis, B: Environmental on August 5 ,2019. The article was titled 《Selective oxidation of alkylarenes to aromatic acids/ketone in water by using reusable binaphthyl stabilized Pt nanoparticles (Pt-BNP) as catalyst》.Product Details of 1877-71-0 The article contains the following contents:

An efficient methodol. for the selective and controlled oxidation of petroleum waste methylarenes/alkylarenes to aromatic carboxylic acids/ketone using easily recoverable and recyclable binaphthyl stabilized Pt nanoparticles (Pt-BNP) as a catalyst has been developed. The greener oxidant aqueous tert-Bu hydroperoxide (TBHP) and green solvent water have been utilized in this oxidation reaction. The methodol. is well tolerated with different functional groups. The less reactive electron deficient toluenes are also oxidized by Pt-BNP and gave a good yield of corresponding carboxylic acids with a high turnover number (TON) 738-1448. The Pt-BNP catalyst was recovered and reused up to five catalytic cycles. The heterogeneous test suggested that the reaction is catalyzed by heterogeneous Pt-BNP catalysts. Based on control experiments and literature reports, a possible reaction mechanism has been proposed. After reading the article, we found that the author used 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Product Details of 1877-71-0)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Product Details of 1877-71-0 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Name: 3-(Methoxycarbonyl)benzoic acidOn May 11, 2020 ,《Formal C-H Carboxylation of Unactivated Arenes》 appeared in Chemistry – A European Journal. The author of the article were Gevorgyan, Ashot; Hopmann, Kathrin H.; Bayer, Annette. The article conveys some information:

A formal C-H carboxylation of unactivated arenes e.g., I using CO2 in green solvents is described. The present strategy combines a sterically controlled Ir-catalyzed C-H borylation followed by a Cu-catalyzed carboxylation of the in situ generated organoboronates. The reaction is highly regioselective for the C-H carboxylation of unactivated arenes e.g., I (1,3-disubstituted and 1,2,3-trisubstituted benzenes, 1,2- or 1,4-sym. substituted benzenes, fluorinated benzenes and different heterocycles). The developed methodol. was applied to the late-stage C-H carboxylation of com. drugs and ligands. In addition to this study using 3-(Methoxycarbonyl)benzoic acid, there are many other studies that have used 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Name: 3-(Methoxycarbonyl)benzoic acid) was used in this study.

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Name: 3-(Methoxycarbonyl)benzoic acid Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hu, Lijun; Ren, Qiang; Deng, Liming; Zhou, Zongtao; Cai, Zongyu; Wang, Bin; Li, Zheng published an article on February 5 ,2021. The article was titled 《Design, synthesis, and biological studies of novel 3-benzamidobenzoic acid derivatives as farnesoid X receptor partial agonist》, and you may find the article in European Journal of Medicinal Chemistry.Name: 3-(Methoxycarbonyl)benzoic acid The information in the text is summarized as follows:

Farnesoid X receptor (FXR), a bile acid-activated nuclear receptor, regulates the metabolism of bile acid and lipids as well as maintains the stability of internal environment. FXR was considered as a therapeutic target of liver disorders, such as drug-induced liver injury, fatty liver and cholestasis. The previous reported FXR partial agonist I was a suitable lead compound in terms of its high potent and low mol. size, while the docking study of compound I suggested a large unoccupied hydrophobic pocket, which might be provided more possibility of structure-activity relationship (SAR) study. In this study, we have performed comprehensive SAR and mol. modeling studies based on lead compound I. All of these efforts resulted in the identification of a novel series of FXR partial agonists. In this series, compound II revealed the best activity and strong interaction with binding pocket of FXR. Moreover, compound II protected mice against acetaminophen-induced hepatotoxicity by the regulation of FXR-related gene expression and improving antioxidant capacity. In summary, these results suggest that compound II is a promising FXR partial agonist suitable for further investigation. In the part of experimental materials, we found many familiar compounds, such as 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Name: 3-(Methoxycarbonyl)benzoic acid)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Name: 3-(Methoxycarbonyl)benzoic acid

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application In Synthesis of 3-(Methoxycarbonyl)benzoic acidOn November 12, 2020 ,《Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model》 appeared in Journal of Medicinal Chemistry. The author of the article were Horatscheck, Andre; Andrijevic, Ana; Nchinda, Aloysius T.; Le Manach, Claire; Paquet, Tanya; Khonde, Lutete Peguy; Dam, Jean; Pawar, Kailash; Taylor, Dale; Lawrence, Nina; Brunschwig, Christel; Gibhard, Liezl; Njoroge, Mathew; Reader, Janette; van der Watt, Mariette; Wicht, Kathryn; de Sousa, Ana Carolina C.; Okombo, John; Maepa, Keletso; Egan, Timothy J.; Birkholtz, Lyn-Marie; Basarab, Gregory S.; Wittlin, Sergio; Fish, Paul V.; Street, Leslie J.; Duffy, James; Chibale, Kelly. The article conveys some information:

A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood stage activity. During lead optimization, several issues were flagged such as cross-resistance against the multidrug-resistant K1 strain, in vitro cytotoxicity, and cardiotoxicity and were addressed through structure-activity and structure-property relationship studies. Pharmacokinetic properties were assessed in mice for compounds showing desirable in vitro activity, a selectivity window over cytotoxicity, and microsomal metabolic stability. Frontrunner compound 37(I) showed good exposure in mice combined with good in vitro activity against the malaria parasite, which translated into in vivo efficacy in the P. falciparum NOD-scid IL-2Rγnull (NSG) mouse model. Preliminary mechanistic studies suggest inhibition of hemozoin formation as a contributing mode of action. In the experiment, the researchers used many compounds, for example, 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Application In Synthesis of 3-(Methoxycarbonyl)benzoic acid)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Application In Synthesis of 3-(Methoxycarbonyl)benzoic acid Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

COA of Formula: C9H8O4On March 2, 2020, Zhang, Ji-Shu; Chen, Tieqiao; Han, Li-Biao published an article in European Journal of Organic Chemistry. The article was 《Palladium-Catalyzed Direct Decarbonylative Phosphorylation of Benzoic Acids with P(O)-H Compounds》. The article mentions the following:

A direct decarbonylative phosphorylation of benzoic acids catalyzed by palladium was disclosed. Under the reaction conditions, a wide range of benzoic acids coupled readily with all the three kinds of P(O)-H compounds, i.e. secondary phosphine oxides, H-phosphinates and H-phosphonates, producing the corresponding organophosphorus compounds in good to high yields. This reaction could be conducted at a gram scale and applied in the late-stage phosphorylative modification of carboxylic acids drug mols. These results well demonstrated the potential synthetic value of this new reaction in organic synthesis. In the experiment, the researchers used many compounds, for example, 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0COA of Formula: C9H8O4)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. Esters are more polar than ethers but less polar than alcohols. COA of Formula: C9H8O4 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: 3-(Methoxycarbonyl)benzoic acidOn October 25, 2021 ,《Facile Conversion of Molecularly Complex (Hetero)aryl Carboxylic Acids into Alkynes for Accelerated SAR Exploration》 was published in Chemistry – A European Journal. The article was written by Lutter, Ferdinand H.; Jouffroy, Matthieu. The article contains the following contents:

Herein, a functional-group-tolerant and operationally simple decarbonylative alkynylation that allows the conversion of complex (hetero)aryl carboxylic acids into alkynes were reported. Furthermore, the utility of this method was demonstrated in the preparation of a triazolo analog of the com. drug moclobemide. Lastly, mechanistic investigations using labeled carboxylic acid derivatives clearly show the decarbonylative nature of this transformation. After reading the article, we found that the author used 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Recommanded Product: 3-(Methoxycarbonyl)benzoic acid)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Recommanded Product: 3-(Methoxycarbonyl)benzoic acid They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics