Category: 1877-71-0

In 2019,Chemical Science included an article by Liu, Chengwei; Qin, Zhi-Xin; Ji, Chong-Lei; Hong, Xin; Szostak, Michal. Computed Properties of C9H8O4. The article was titled 《Highly-chemoselective step-down reduction of carboxylic acids to aromatic hydrocarbons via palladium catalysis》. The information in the text is summarized as follows:

The highly selective method for the direct step-down reduction of carboxylic acids RCOOH (biphenyl-4-yl, 1-naphthyl, 1-methyl-1H-indole-3-yl, etc.) to arenes RH, proceeding via well-defined Pd(0)/(II) catalytic cycle was described. The method shows a remarkably broad substrate scope, enabling to direct the classical acyl reduction towards selective decarbonylation by a redox-neutral mechanism. The utility of this reaction is highlighted in the direct defunctionalization of pharmaceuticals and natural products, and further emphasized in a range of traceless processes using removable carboxylic acids under mild, redox-neutral conditions orthogonal to protodecarboxylation. Extensive DFT computations were conducted to demonstrate preferred selectivity for the reversible oxidative addition and indicated that a versatile hydrogen atom transfer (HAT) pathway is operable. The experimental part of the paper was very detailed, including the reaction process of 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Computed Properties of C9H8O4)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.Computed Properties of C9H8O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Palladium-Catalyzed Electrochemical C-H Bromination Using NH4Br as the Brominating Reagent》 was written by Yang, Qi-Liang; Wang, Xiang-Yang; Wang, Tong-Lin; Yang, Xiang; Liu, Dong; Tong, Xiaofeng; Wu, Xin-Yan; Mei, Tian-Sheng. Synthetic Route of C9H8O4 And the article was included in Organic Letters on April 19 ,2019. The article conveys some information:

The palladium-catalyzed electrochem. C-H bromination of benzamide derivatives under divided cells is developed, in which NH4Br serves as a brominating reagent and electrolyte. The protocol avoids the use of chem. oxidants and provides an alternative method for the synthesis of aryl bromides. After reading the article, we found that the author used 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Synthetic Route of C9H8O4)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Synthetic Route of C9H8O4 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Designed asymmetric coordination helicates with bis-β-diketonate ligands》 was published in Dalton Transactions in 2019. These research results belong to Diego, Rosa; Darawsheh, Mohanad; Barrios, Leoni A.; Sadurni, Anna; Garcia, Jordi; Lloyd-Williams, Paul; Teat, Simon J.; Roubeau, Olivier; Aguila, David; Aromi, Guillem. SDS of cas: 1877-71-0 The article mentions the following:

A new bis-(β-diketone) ligand featuring built-up structural asymmetry yields non-sym. Fe(III) and Ga(III) dinuclear, triple-stranded helicates by design. Their structural properties have been studied, both in solid state and in solution, and compared with their corresponding sym. analogs. The robustness observed shows the potential of this synthetic strategy to develop non-sym. helicoidal motifs with specific functional groups. In the experiment, the researchers used 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0SDS of cas: 1877-71-0)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. Esters are more polar than ethers but less polar than alcohols. SDS of cas: 1877-71-0 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《A Bronsted acidic, ionic liquid containing, heteropolyacid functionalized polysiloxane network as a highly selective catalyst for the esterification of dicarboxylic acids》 were Rajabi, Fatemeh; Wilhelm, Christian; Thiel, Werner R.. And the article was published in Green Chemistry in 2020. Recommanded Product: 1877-71-0 The author mentioned the following in the article:

A Bronsted acidic, ionic liquid containing, heteropolyanion functionalized polysiloxane network I [R = OEt/H] was formed by self-condensation of dodecatungstophosphoric acid and a zwitterionic organosilane precursor II containing both imidazolinium and sulfonate groups. The resulting hybrid material POS-HPA-IL I was investigated as a catalyst for the selective esterification of dicarboxylic acids such as benzene-1,4-dicarboxylic acid, citric acid, citraconic acid, etc.. In the part of experimental materials, we found many familiar compounds, such as 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Recommanded Product: 1877-71-0)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.Recommanded Product: 1877-71-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Yantao; Shao, Qianzhen; He, Hengchi; Zhu, Chengjian; Xue, Xiao-Song; Xie, Jin published their research in Nature Communications on December 31 ,2022. The article was titled 《Highly selective synthesis of all-carbon tetrasubstituted alkenes by deoxygenative alkenylation of carboxylic acids》.COA of Formula: C9H8O4 The article contains the following contents:

The synthesis of all-carbon tetrasubstituted olefins under mild reaction conditions is challenging because of the inevitable issues including significant steric hindrance and the uncontrolled Z/E stereoselectivity. In this paper, authors report the synthesis of all-carbon tetrasubstituted alkenes from readily available carboxylic acids and alkenyl triflates with the synergistic catalysis of cyclo-octa-1,5-diene(tetramethyl-1,4-benzoquinone)nickel and visible light under an air atm., thus avoiding the need for a glovebox or a Schlenk line. A wide range of aromatic carboxylic acids and cyclic and acyclic alkenyl triflates underwent the C-C coupling process smoothly, forming structurally diverse alkenes stereospecifically in moderate to good yields. The practicality of the method is further illustrated by the late-stage modification of complex mols., the one pot synthesis and gram-scale applications. This is an important step towards the valuable utilization of carboxylic acids, and it also simplifies the exptl. operation of metallophotoredox catalysis with moisture sensitive nickel(0) catalysis.3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0COA of Formula: C9H8O4) was used in this study.

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.COA of Formula: C9H8O4 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Guo-Quan; Zhang, Wei; Liao, Li-Li; Li, Li; Nie, Zi-Hao; Wu, Jin-Gui; Zhang, Zhen; Yu, Da-Gang published their research in Nature Communications on December 31 ,2021. The article was titled 《Nickel-catalyzed electrochemical carboxylation of unactivated aryl and alkyl halides with CO2》.SDS of cas: 1877-71-0 The article contains the following contents:

A general and practical electro-reductive Ni-catalytic system, realizing the electrocatalytic carboxylation of unactivated aryl chlorides and alkyl bromides with CO2 were reported. A variety of unactivated aryl bromides, iodides and sulfonates can also undergo such a reaction smoothly. Notably, realized the catalytic electrochem. carboxylation of aryl (pseudo)halides with CO2 avoiding the use of sacrificial electrodes. Moreover, this sustainable and economic strategy with electron as the clean reductant features mild conditions, inexpensive catalyst, safe and cheap electrodes, good functional group tolerance and broad substrate scope. Mechanistic investigations indicated that the reaction might proceed via oxidative addition of aryl halides to Ni(0) complex, the reduction of aryl-Ni(II) adduct to the Ni(I) species and following carboxylation with CO2.3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0SDS of cas: 1877-71-0) was used in this study.

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.SDS of cas: 1877-71-0 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ren, Shi-Chao; Yang, Xing; Mondal, Bivas; Mou, Chengli; Tian, Weiyi; Jin, Zhichao; Chi, Yonggui Robin published their research in Nature Communications on December 31 ,2022. The article was titled 《Carbene and photocatalyst-catalyzed decarboxylative radical coupling of carboxylic acids and acyl imidazoles to form ketones》.Name: 3-(Methoxycarbonyl)benzoic acid The article contains the following contents:

The carbene and photocatalyst co-catalyzed radical coupling of acyl electrophile and a radical precursor is emerging as attractive method for ketone synthesis. However, previous reports mainly limited to prefunctionalized radical precursors and two-component coupling. Herein, an N-heterocyclic carbene and photocatalyst catalyzed decarboxylative radical coupling of carboxylic acids and acyl imidazoles is disclosed, in which the carboxylic acids are directly used as radical precursors. The acyl imidazoles could also be generated in situ by reaction of a carboxylic acid with CDI thus furnishing a formally decarboxylative coupling of two carboxylic acids. In addition, the reaction is successfully extended to three-component coupling by using alkene as a third coupling partner via a radical relay process. The mild conditions, operational simplicity, and use of carboxylic acids as the reacting partners make our method a powerful strategy for construction of complex ketones from readily available starting materials, and late-stage modification of natural products and medicines. In the experiment, the researchers used 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Name: 3-(Methoxycarbonyl)benzoic acid)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.Name: 3-(Methoxycarbonyl)benzoic acid

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ruzi, Rehanguli; Liu, Kai; Zhu, Chengjian; Xie, Jin published their research in Nature Communications on December 31 ,2020. The article was titled 《Upgrading ketone synthesis direct from carboxylic acids and organohalides》.Synthetic Route of C9H8O4 The article contains the following contents:

A photoredox, nickel and phosphoranyl radical synergistic cross-electrophile coupling of com. available chems., aromatic acids RCO2H (R = 4-methylphenyl, thiophen-3-yl, naphthalen-2-yl, etc.) and aryl/alkyl bromides R1Br (R1 = 6-(trifluoromethyl)pyridin-3-yl, 2-cyanoethyl, quinolin-3-yl, etc.) was reported. This allows for concise synthesis of highly functionalized ketones RC(O)R1directly, without the preparation of activated carbonyl intermediates or organometallic compounds, and thus complements the conventional Weinreb ketone synthesis. Use of the appropriate photocatalyst, ligand amount and solvents can match the reaction rate required by any simple catalytic cycle. The practicality and synthetic robustness of the reaction are illustrated by the facile synthesis of complex ketones from readily available feedstock chems. In the experiment, the researchers used many compounds, for example, 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Synthetic Route of C9H8O4)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Synthetic Route of C9H8O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of C9H8O4On June 1, 2021, Ma, Fei; Li, Jie; Zhang, Shuning; Gu, Yuang; Tan, Tingting; Chen, Wanting; Wang, Shuyue; Ma, Peixiang; Xu, Hongtao; Yang, Guang; Lerner, Richard A. published an article in Chemistry – A European Journal. The article was 《DNA-Encoded Libraries: Hydrazide as a Pluripotent Precursor for On-DNA Synthesis of Various Azole Derivatives》. The article mentions the following:

A phylogenic chem. transformation strategy using DNA-conjugated benzoyl hydrazine as a common versatile precursor in azole chem. expansion of DNA-encoded combinatorial chem. library (DEL) has been described. DNA-compatible reactions deriving from the common benzoyl hydrazines, e.g., I (R = DNA) precursor showed excellent functional group tolerance with exceptional efficiency in the synthesis of various azoles, including oxadiazoles, e.g., II thiadiazoles, and triazoles, under mild reaction conditions. The phylogenic chem. transformation strategy provides DELs a facile way to expand into various unique chem. spaces with privileged scaffolds and pharmacophores. The experimental part of the paper was very detailed, including the reaction process of 3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Electric Literature of C9H8O4)

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Electric Literature of C9H8O4 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Wanwan; Cao, Zhongqiang; Cheng, Junjie; Chen, Feiyu; Li, Shuai; Huang, Yiwei; Zheng, Long Tai; Ye, Na published an article in Medicinal Chemistry Research. The title of the article was 《Discovery of N-phenyl-1-(phenylsulfonamido)cyclopropane-1-carboxamide analogs as NLRP3 inflammasome inhibitors》.Electric Literature of C9H8O4 The author mentioned the following in the article:

Two series of novel NLRP3 inflammasome inhibitors are designed, synthesized, and evaluated in an effort to develop diversified analogs based on the N-(phenylcarbamoyl)benzenesulfonamide scaffold. SAR studies reveal that the sulfonylurea linker can tolerate chem. modifications with either simply changing over the position of carbonyl and sulfonyl group or structurally flexibly inserting a cyclopropyl group, leading to identification of several more potent and diversified NLRP3 antagonists (e.g., 9) with low nanomolar inhibitory activities. Further studies indicate that these two series of compounds with low cytotoxicity exhibited weak effects on the generation of NO and TNF-a. The findings may serve as good starting points for the development of more potent NLRP3 inflammasome inhibitors as valuable pharmacol. probes or potential drug candidates.3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0Electric Literature of C9H8O4) was used in this study.

3-(Methoxycarbonyl)benzoic acid(cas: 1877-71-0) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Electric Literature of C9H8O4 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics